☆ 4.7 Review

Inflammation, Dopaminergic Brain and Bilirubin

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Summary: Dopamine plays a crucial role in CNS function, regulating reward, movement, and cognition. It also regulates vital functions in peripheral organs and acts as an immunoregulatory factor. Despite inconsistent and poorly understood data, targeting dopaminergic pathways could be promising for inflammation and disease treatment. This review integrates current knowledge on the role of dopamine in immune cell function and inflammatory signaling across systems and highlights its importance in various diseases. Rating: 8/10.

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Article Chemistry, Multidisciplinary

Bilirubin Nanomedicine Rescues Intestinal Barrier Destruction and Restores Mucosal Immunity in Colitis

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Summary: This study reports a nanomedicine composed of bilirubin-attached low-molecular-weight, water-soluble chitosan nanoparticles that can promote restoration of intestinal barrier, mucosal immunity, and gut microbiome homeostasis, thereby exhibiting robust therapeutic efficacy.

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Role of Dopamine in the Heart in Health and Disease

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Summary: Dopamine has various effects on the mammalian heart, including increased contraction force, elevated heart rate, and coronary artery constriction. Dopamine acts on both dopamine receptors and adrenergic receptors in the heart. The role of dopamine receptors in the human heart is clinically relevant and important in understanding cardiac diseases.

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Bile duct ligation increased dopamine levels in the cerebral cortex of rats partly due to induction of tyrosine hydroxylase

Weimin Kong et al.

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Bilirubin-Induced Transcriptomic Imprinting in Neonatal Hyperbilirubinemia

John Paul Llido et al.

Summary: Severe neonatal hyperbilirubinemia can lead to brain damage and cause motor, cognitive, and auditory abnormalities. Bilirubin has been found to control the genetic development of the cerebellum, which is susceptible to bilirubin-induced damage. This study expands the research on the impact of bilirubin on postnatal brain development in regions that correlate with human symptoms. The findings show temporary alterations in gene expression in areas related to memory, learning, cognition, and auditory functions, but permanent changes in areas controlling movements, which coincide with clinical descriptions of bilirubin-induced neurotoxicity.

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Article Biochemistry & Molecular Biology

Dopaminergic Neuronal Death in Substantia Nigra Associates with Serum Levels of Total Bilirubin, Selenium, and Zinc: Evidences from 6-Hydroxydopamine Animal Model of Parkinson's Disease

Mohammad Sophiabadi et al.

Summary: In the 6-OHDA-treated rats, the severity of behavioral symptoms and total bilirubin levels progressively increased, while selenium and zinc levels were lower than in the control group. Changes in TB, Se, and Zn levels were associated with SNc DA neuronal loss, but not with its severity. Significant changes in serum levels of TB, Se, and Zn in mild SNc DA neuronal loss suggest them as valuable parameters for early detection of PD.

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Mingan Li et al.

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Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson's disease

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Summary: This study reveals that dopamine inhibits the activation of NLRP3 inflammasome in primary human microglia, providing insights into the potential therapeutic target for Parkinson's disease.

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Review Nutrition & Dietetics

Effects of Caffeine Consumption on Attention Deficit Hyperactivity Disorder (ADHD) Treatment: A Systematic Review of Animal Studies

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Summary: This article focuses on the role of gut microbiota in modulating dopamine activity and bioavailability, as well as the impact of gut dysbiosis on dopamine-related pathological conditions.

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Normalizing hyperactivity of the Gunn rat with bilirubin-induced neurological disorders via ketanserin

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Summary: This study identified serotonergic dysfunction in Gunn rats and demonstrated the relationship between serotonergic dysregulation and hyperlocomotion in these rats. The findings suggest that restoring brain regions affected by serotonergic dysfunction could be a potential therapeutic strategy for bilirubin-induced neurologic dysfunction (BIND).

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Exogenous glutathione exerts a therapeutic effect in ischemic stroke rats by interacting with intrastriatal dopamine

He Wang et al.

Summary: The study demonstrates that exogenous GSH exerts a therapeutic effect on ischemic stroke by increasing intrastriatal DA levels in rats. The accumulated DA enhances the exposure of GSH and its related substances, thereby promoting the therapeutic effect of GSH.

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Reframing dopamine signaling at the intersection of glial networks in the aged Parkinsonian brain as innate Nrf2/Wnt driver: Therapeutical implications

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Summary: This article discusses the multifunctional role of dopamine (DA) signaling in neuroendocrine-immune modulation and its involvement in Parkinson's disease (PD). The degeneration of DA nigrostriatal pathway in PD leads to the loss of substantia nigra pars compacta (SNpc) neurons and disruption of glial inflammatory networks. The article emphasizes the reciprocal modulation between DA and glial cells, as well as the impact of gene-environment interactions on PD vulnerability. Additionally, the article introduces the role of DA as an endogenous modulator in the regulation of oxidative stress and inflammation, and explores the potential application of DA receptor agonists as immune modifiers in the clinic.

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Summary: This study demonstrated the effectiveness of encapsulated bilirubin nanoparticles in promoting wound healing, as compared to native bulk bilirubin. The nanoparticles, formed using Pluronic F-127, showed promising results in accelerating wound closure, reducing inflammation, and promoting tissue regeneration. These findings highlight the potential of encapsulated bilirubin nanoparticles as a novel biomaterial for wound healing in the future.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Obesity and dietary fat influence dopamine neurotransmission: exploring the convergence of metabolic state, physiological stress, and inflammation on dopaminergic control of food intake

Conner W. Wallace et al.

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Bilirubin Prevents the TH+ Dopaminergic Neuron Loss in a Parkinson's Disease Model by Acting on TNF-α

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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The alterations of cerebrospinal fluid TNF-alpha and TGF-beta2 levels in early relapsing-remitting multiple sclerosis

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Roberta J. Ward et al.

Summary: Disturbance of brain homeostasis leads to inflammation and cell death. Inflammation and iron metabolism interact, leading to iron deposition in brain cells. Reactive oxygen and nitrogen species play a role in inflammation and iron metabolism. Mechanisms to regulate iron homeostasis are important, and therapeutic approaches include N-acetyl cysteine, anti-inflammatory compounds, and iron chelation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Medicine, General & Internal

Persistent Inflammation in Cerebral Palsy: Pathogenic Mediator or Comorbidity? A Scoping Review

Madison C. B. Paton et al.

Summary: Research has shown that inflammation plays a role in brain injury and the development of cerebral palsy (CP). It is believed that inflammation may persist as a comorbidity in CP, contributing to ongoing functional impairments. Studies have found significant differences in inflammatory markers between CP patients and controls, particularly cytokines such as tumor necrosis factor, Interleukin (IL)-6, and IL-10. These differences in inflammation may also vary among different subgroups of CP. Further research is needed to fully understand the complexity of inflammation and its long-term effects.

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Editorial Material Neurosciences

It's Dopamine and Schizophrenia All Over Again

Daniel R. Weinberger

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Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers

Yasmin Zakiniaeiz et al.

Summary: The interactions between the immune system and the brain play a significant role in addiction. This study found that LPS-induced systemic inflammation can amplify the elevation of dopamine levels in smokers when they use methylphenidate. These findings have important implications for understanding the mechanisms of drug abuse and addiction treatment.

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Gut Bacteria and Neurotransmitters

Leon M. T. Dicks

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Xiaoyun Sun et al.

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JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN (2022)

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Novel case of Parkinson's disease and schizophrenia: challenges in the management

Amna Ramzan et al.

Summary: The coexistence of idiopathic Parkinson's disease (iPD) and schizophrenia presents diagnostic and therapeutic challenges. A delicate pharmacologic balance is needed for managing both conditions, with clozapine being a better choice for psychosis in these patients.

BMJ CASE REPORTS (2021)

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Bilirubin as a metabolic hormone: the physiological relevance of low levels

Justin F. Creeden et al.

Summary: Recent research indicates that bilirubin may have a new role as a metabolic hormone, potentially leading to cardiovascular complications for patients with low levels. Protective mechanisms at mildly elevated levels of bilirubin could offer treatment possibilities for those with hypobilirubinemia.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2021)

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Relationship between TNF-α levels and psychiatric symptoms in first-episode drug-naive patients with schizophrenia before and after risperidone treatment and in chronic patients

Chen Lin et al.

Summary: This study found that first-episode drug-naive schizophrenia patients had higher TNF-alpha levels before treatment, which were positively correlated with negative symptoms of the disease. In contrast, TNF-alpha levels in chronic patients were negatively correlated with general psychopathology subscales and total scores.

BMC PSYCHIATRY (2021)

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The distinct roles of monoamines in multiple sclerosis: A bridge between the immune and nervous systems?

Tiziana Carandini et al.

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Bilirubin nanomedicine ameliorates the progression of experimental autoimmune encephalomyelitis by modulating dendritic cells

Tae Woo Kim et al.

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Oscar Bergens et al.

Summary: The study found that prolonged sedentary time in older adults has different effects on inflammatory biomarkers, with men being impacted in anti-inflammatory marker IL-10 and women in pro-inflammatory marker fibrinogen.

FRONTIERS IN PHYSIOLOGY (2021)

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Dopamine Modulation of Motor and Sensory Cortical Plasticity among Vertebrates

Matheus Macedo-Lima et al.

Summary: Goal-directed learning is crucial for evolutionary fitness in animals, with dopamine playing a significant role in mediating this process. Research on dopamine's role in higher order cortical regions is mainly focused on rodents and primates, limiting our understanding in other vertebrate groups. More studies on non-mammalian species are needed to further elucidate how dopamine has evolved across vertebrates to shape their brain structures and behaviors.

INTEGRATIVE AND COMPARATIVE BIOLOGY (2021)

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Dopaminergic Receptor Targeting in Multiple Sclerosis: Is There Therapeutic Potential?

Mikhail Melnikov et al.

Summary: Dopamine functions as a neurotransmitter in the central nervous system and has modulatory effects on both innate and adaptive immune system cells. It plays a critical role in regulating neuroinflammation in multiple sclerosis, and holds therapeutic potential for MS treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Inflammation, Anxiety, and Stress in Attention-Deficit/Hyperactivity Disorder

Luigi F. Saccaro et al.

Summary: ADHD is a prevalent neurodevelopmental disorder characterized by symptoms of inattention and/or hyperactivity/impulsivity. Chronic stress, childhood stress, anxiety, and inflammation are all involved in the development of ADHD. Understanding the interplay between stress, anxiety, and immune dysregulation in ADHD can have significant diagnostic, therapeutic, and prognostic implications for patients.

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Clinical implications for dopaminergic and functional neuroimage research in cognitive symptoms of Parkinson's disease

Shigeki Hirano

Summary: Evidence from dopaminergic imaging and cerebral blood flow/metabolism images has provided insights into the cognitive symptoms of healthy individuals and Parkinson's disease patients. Cognitive impairment in Parkinson's disease is characterized by executive, visuospatial, and attentional disturbances. The dopaminergic system consists of three parallel pathways, each responsible for different functions and affected by dopamine levels.

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6,7,4′-Trihydroxyflavanone Mitigates Methamphetamine-Induced Neurotoxicity in SH-SY5y Cells via Nrf2/heme Oxyganase-1 and PI3K/Akt/mTOR Signaling Pathways

Hyun-Su Lee et al.

Summary: Methamphetamine-induced neurotoxicity can lead to neurodegenerative diseases, but the flavanone derivative 6,7,4'-trihydroxyflavanone (THF) has been shown to protect neuronal cells by modulating apoptosis-related proteins, oxidative stress, and the PI3K/Akt/mTOR signaling pathway; THF's protective mechanism involves upregulating HO-1 expression through the Nrf2 and PI3K/Akt/mTOR signaling pathways to attenuate METH-induced neurotoxicity.

MOLECULES (2021)

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Plasma bilirubin levels are reduced in first-episode psychosis patients and associates to working memory and duration of untreated psychosis

Meneca Becklen et al.

Summary: A recent study found that individuals with first-episode psychosis had lower levels of bilirubin, which may contribute to memory impairments. The study also showed that bilirubin levels were related to cognitive function, symptoms and duration of untreated psychosis in these patients.

SCIENTIFIC REPORTS (2021)

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Immunomodulatory Effects of Dopamine in Inflammatory Diseases

Yifei Feng et al.

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Alessandro Tozzi et al.

Summary: The study identified that alpha-synuclein disrupts dopamine system and striatal synaptic plasticity in early stages of Parkinson's disease. Subchronic treatment with L-DOPA was able to rescue alpha-synuclein-induced alterations, showing the critical role of dysfunctional dopamine system in disease progression.

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Sri Jayanti et al.

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Velda X. Han et al.

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Nicotine inhibits the VTA-to-amygdala dopamine pathway to promote anxiety

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James D. Adams

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Disruption of brainstem monoaminergic fibre tracts in multiple sclerosis as a putative mechanism for cognitive fatigue: a fixel-based analysis

Tiziana Carandini et al.

Summary: This study compared the integrity of monoaminergic white matter fibre tracts in MS patients and healthy controls, revealing significant axonal damage in MS patients, particularly in the dopaminergic and noradrenergic pathways. Furthermore, strong correlations were observed between cognitive fatigue severity and axonal damage within specific brainstem tracts in MS patients, suggesting a potential contribution of dopaminergic and noradrenergic pathways to central fatigue in MS.

NEUROIMAGE-CLINICAL (2021)

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Zunera Zareen et al.

Summary: Children with cerebral palsy showed altered cytokine responses compared with age-matched controls, indicating a potential target for therapy to address ongoing sequelae. The study found significantly higher erythropoietin levels in children with CP at baseline, as well as hyporesponsiveness to lipopolysaccharide for certain cytokines.

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Earliest Mechanisms of Dopaminergic Neurons Sufferance in a Novel Slow Progressing Ex Vivo Model of Parkinson Disease in Rat Organotypic Cultures of Substantia Nigra

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Behavioral Sciences

Neuroinflammation in addiction: A review of neuroimaging studies and potential immunotherapies

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PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2019)

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Article Behavioral Sciences

Neuroinflammation as a risk factor for attention deficit hyperactivity disorder

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PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2019)

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Review Clinical Neurology

Neural mechanisms underlying adaptive and maladaptive consequences of stress: Roles of dopaminergic and inflammatory responses

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PSYCHIATRY AND CLINICAL NEUROSCIENCES (2019)

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Review Clinical Neurology

Infectious Etiologies of Parkinsonism: Pathomechanisms and Clinical Implications

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FRONTIERS IN NEUROLOGY (2019)

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Review Biochemistry & Molecular Biology

Selecting an Appropriate Animal Model of Depression

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Psychiatry

Association between inflammatory cytokines and ADHD symptoms in children and adolescents with obesity: A pilot study

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PSYCHIATRY RESEARCH (2019)

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The modulatory role of dopamine receptors in brain neuroinflammation

Qing-Peng Xia et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

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NEW ENGLAND JOURNAL OF MEDICINE (2019)

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D-T7 Peptide-Modified PEGylated Bilirubin Nanoparticles Loaded with Cediranib and Paclitaxel for Antiangiogenesis and Chemotherapy of Glioma

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ACS APPLIED MATERIALS & INTERFACES (2019)

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Dopamine: Functions, Signaling, and Association with Neurological Diseases

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CELLULAR AND MOLECULAR NEUROBIOLOGY (2019)

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Induction of Mild Hyperbilirubinemia: Hype or Real Therapeutic Opportunity?

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CLINICAL PHARMACOLOGY & THERAPEUTICS (2019)

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Article Genetics & Heredity

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

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NATURE GENETICS (2019)

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Increased bilirubin levels in Parkinson's disease

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PARKINSONISM & RELATED DISORDERS (2019)

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Review Pediatrics

Developmental influence of unconjugated hyperbilirubinemia and neurobehavioral disorders

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PEDIATRIC RESEARCH (2019)

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Effects of Dopamine on Motor Recovery and Training in Adults and Children With Nonprogressive Neurological Injuries: A Systematic Review

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NEUROREHABILITATION AND NEURAL REPAIR (2019)

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Defining the Locus of Dopaminergic Dysfunction in Schizophrenia: A Meta-analysis and Test of the Mesolimbic Hypothesis

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SCHIZOPHRENIA BULLETIN (2018)

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Review Gastroenterology & Hepatology

Biliverdin reductase and bilirubin in hepatic disease

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TNFα, disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice

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Exercise related anxiety-like behaviours are mediated by TNF receptor signaling, but not depression-like behaviours

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Review Biochemistry & Molecular Biology

Omega-3 fatty acids in obesity and metabolic syndrome: a mechanistic update

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Docosanoids Promote Neurogenesis and Angiogenesis, Blood-Brain Barrier Integrity, Penumbra Protection, and Neurobehavioral Recovery After Experimental Ischemic Stroke

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MOLECULAR NEUROBIOLOGY (2018)

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Review Endocrinology & Metabolism

A Review on the Role of Inflammation in Attention-Deficit/Hyperactivity Disorder

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The centennial lesson of encephalitis lethargica

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NEUROLOGY (2018)

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Review Cell Biology

Unraveling the Burden of Iron in Neurodegeneration: Intersections with Amyloid Beta Peptide Pathology

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Editorial Material Clinical Neurology

The Parkinson Pandemic-A Call to Action

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JAMA NEUROLOGY (2018)

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Hemispheric brain asymmetry differences in youths with attention-deficit/hyperactivity disorder

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NEUROIMAGE-CLINICAL (2018)

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Article Medicine, General & Internal

Genetic Variation in the Dopamine System Influences Intervention Outcome in Children with Cerebral Palsy

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EBIOMEDICINE (2018)

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Review Biochemistry & Molecular Biology

Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Multidisciplinary Sciences

Influence of bradykinin B2 receptor and dopamine D2 receptor on the oxidative stress, inflammatory response, and apoptotic process in human endothelial cells

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PLOS ONE (2018)

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Article Immunology

HIV-infected cannabis users have lower circulating CD16+ monocytes and IFN-γ-inducible protein 10 levels compared with nonusing HIV patients

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AIDS (2018)

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Longitudinal imaging of the availability of dopamine transporter and D2 receptor in rat striatum following mild ischemia

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Inflammation Effects on Motivation and Motor Activity: Role of Dopamine

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NEUROPSYCHOPHARMACOLOGY (2017)

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Review Clinical Neurology

Dopamine, T cells and multiple sclerosis (MS)

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Fatigue favors in vitro Th1 and Th17-like cell expansion and reduces corticoid sensitivity in MS patients

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Article Clinical Neurology

Brain iron concentrations in regions of interest and relation with serum iron levels in Parkinson disease

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Selective neuronal vulnerability in Parkinson disease

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Immunological cytokine profiling identifies TNF-α as a key molecule dysregulated in autistic children

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Evaluation of Oxidant/Antioxidant Status and Cytokine Levels in Patients with Cannabis Use Disorder

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Attention-Deficit/Hyperactivity Disorder And Inflammation: What Does Current Knowledge Tell Us? A Systematic Review

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FRONTIERS IN PSYCHIATRY (2017)

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Review Neurosciences

Pathway-Specific Dopamine Abnormalities in Schizophrenia

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PEGylated bilirubin nanoparticle as an anti-oxidative and anti- inflammatory demulcent in pancreatic islet xenotransplantation

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Article Psychiatry

Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis

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Neonatal Cytokine Profiles Associated With Autism Spectrum Disorder

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Microglia and neuroprotection

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Identification of novel biomarkers for Parkinson's disease by metabolomic technologies

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In Cellulo Mapping of Subcellular Localized Bilirubin

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ACS CHEMICAL BIOLOGY (2016)

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Iron and dopamine: a toxic couple

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Associations between cytokines, endocrine stress response, and gastrointestinal symptoms in autism spectrum disorder

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BRAIN BEHAVIOR AND IMMUNITY (2016)

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The epidemiology of Parkinson's disease: risk factors and prevention

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Practice guideline summary: Treatment of restless legs syndrome in adults Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology

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Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization

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IMPAIRED IMPLICIT LEARNING AND FEEDBACK PROCESSING AFTER STROKE

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Review Biochemistry & Molecular Biology

A Novel Perspective on the Biology of Bilirubin in Health and Disease

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TRENDS IN MOLECULAR MEDICINE (2016)

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The significance of routine biochemical markers in patients with major depressive disorder

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Review Psychology, Developmental

Dopaminergic reward sensitivity can promote adolescent health: A new perspective on the mechanism of ventral striatum activation

Eva H. Telzer

DEVELOPMENTAL COGNITIVE NEUROSCIENCE (2016)

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Review Psychiatry

Neuroinflammation and cytokine abnormality in major depression: Cause or consequence in that illness?

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WORLD JOURNAL OF PSYCHIATRY (2016)

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Review Pharmacology & Pharmacy

The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis

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Increased bilirubin levels in de novo Parkinson's disease

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EUROPEAN JOURNAL OF NEUROLOGY (2015)

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Inflammatory Cytokines: Potential Biomarkers of Immunologic Dysfunction in Autism Spectrum Disorders

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MEDIATORS OF INFLAMMATION (2015)

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Pathogenesis of Parkinson disease-the gut-brain axis and environmental factors

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Pleasure Systems in the Brain

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Motor Skill Learning Is Associated with Phase-Dependent Modifications in the Striatal cAMP/PKA/DARPP-32 Signaling Pathway in Rodents

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Review Pediatrics

Movement disorders due to bilirubin toxicity

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SEMINARS IN FETAL & NEONATAL MEDICINE (2015)

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Review Endocrinology & Metabolism

Biliverdin reductase isozymes in metabolism

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TRENDS IN ENDOCRINOLOGY AND METABOLISM (2015)

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Continuous de novo biosynthesis of haem and its rapid turnover to bilirubin are necessary for cytoprotection against cell damage

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SCIENTIFIC REPORTS (2015)

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Review Geriatrics & Gerontology

Dopamine Receptors and Neurodegeneration

Claudia Rangel-Barajas et al.

AGING AND DISEASE (2015)

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Review Clinical Neurology

The dopamine imbalance hypothesis of fatigue in multiple sclerosis and other neurological disorders

Ekaterina Dobryakova et al.

FRONTIERS IN NEUROLOGY (2015)

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Article Psychology, Developmental

Neonatal jaundice and increased risk of attention-deficit hyperactivity disorder: a population-based cohort study

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JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY (2015)

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Article Biochemistry & Molecular Biology

Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis

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MOLECULAR PSYCHIATRY (2015)

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Article Neurosciences

Decreased serum TNF-alpha levels in chronic schizophrenia patients on long-term antipsychotics: correlation with psychopathology and cognition

Meng Han Lv et al.

PSYCHOPHARMACOLOGY (2015)

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Review Psychiatry

Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment

Golam M. Khandaker et al.

LANCET PSYCHIATRY (2015)

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Editorial Material Hematology

Risk of Ischemic Stroke and Decreased Serum Bilirubin Levels Is There a Causal Link?

Giovanni Targher

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)

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Article Endocrinology & Metabolism

Bilirubin Increases Insulin Sensitivity in Leptin-Receptor Deficient and Diet-Induced Obese Mice Through Suppression of ER Stress and Chronic Inflammation

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ENDOCRINOLOGY (2014)

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Article Clinical Neurology

Volumetric, cortical thickness and white matter integrity alterations in bipolar disorder type I and II

Jerome J. Maller et al.

JOURNAL OF AFFECTIVE DISORDERS (2014)

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Article Clinical Neurology

Psychosis in a Case of Schizophrenia and Parkinson’s Disease

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JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES (2014)

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Review Clinical Neurology

The role of iron in brain ageing and neurodegenerative disorders

Roberta Ward et al.

LANCET NEUROLOGY (2014)

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Article Clinical Neurology

Plasma levels of soluble tumor necrosis factor receptors are associated with cognitive performance in Parkinson's disease

Natalia Pessoa Rocha et al.

MOVEMENT DISORDERS (2014)

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Article Geriatrics & Gerontology

Age-specific transcriptional response to stroke

Matthias W. Sieber et al.

NEUROBIOLOGY OF AGING (2014)

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Article Pediatrics

Elevated blood levels of inflammation-related proteins are associated with an attention problem at age 24 mo in extremely preterm infants

T. Michael O'Shea et al.

PEDIATRIC RESEARCH (2014)

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Article Neurosciences

An association study between Heme oxygenase-1 genetic variants and Parkinson's disease

Pedro Ayuso et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

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Article Medicine, Research & Experimental

PPARα: A Master Regulator of Bilirubin Homeostasis

Cyril Bigo et al.

PPAR RESEARCH (2014)

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Article Genetics & Heredity

Statistical analysis of twenty years (1993 to 2012) of data from mainland China's first intervention center for children with autism spectrum disorder

Wei-Zhen Zhou et al.

MOLECULAR AUTISM (2014)

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Article Multidisciplinary Sciences

Adult neurobehavioral outcome of hyperbilirubinemia in full term neonates-a 30 year prospective follow-up study

Laura Hokkanen et al.

PEERJ (2014)

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Review Biochemistry & Molecular Biology

Dopamine signaling in food addiction: role of dopamine D2 receptors

Ja-Hyun Baik

BMB REPORTS (2013)

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Article Neurosciences

Physiological Role of Peroxisome Proliferator-Activated Receptors Type Alpha on Dopamine Systems

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CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2013)

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Article Multidisciplinary Sciences

Dopamine neurons modulate neural encoding and expression of depression-related behaviour

Kay M. Tye et al.

NATURE (2013)

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Article Clinical Neurology

Aldehyde dehydrogenase inhibition generates a reactive dopamine metabolite autotoxic to dopamine neurons

Jonathan A. Doorn et al.

PARKINSONISM & RELATED DISORDERS (2013)

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Article Psychiatry

Striatal Presynaptic Dopamine in Schizophrenia, Part II: Meta-Analysis of [18F/11C]-DOPA PET Studies

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SCHIZOPHRENIA BULLETIN (2013)

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Review Biochemistry & Molecular Biology

Parkinson's disease in the nuclear age of neuroinflammation

Yvonne M. Nolan et al.

TRENDS IN MOLECULAR MEDICINE (2013)

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Article Psychiatry

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression

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JAMA PSYCHIATRY (2013)

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Review Psychiatry

Areas of the Brain Modulated by Single-Dose Methylphenidate Treatment in Youth with ADHD During Task-Based fMRI: A Systematic Review

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HARVARD REVIEW OF PSYCHIATRY (2013)

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Review Clinical Neurology

Neurodegeneration with brain iron accumulation

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CURRENT OPINION IN NEUROLOGY (2012)

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Article Neurosciences

Schizophrenia-Like Features in Transgenic Mice Overexpressing Human HO-1 in the Astrocytic Compartment

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JOURNAL OF NEUROSCIENCE (2012)

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Article Neurosciences

Prolactin Regulates Tuberoinfundibular Dopamine Neuron Discharge Pattern: Novel Feedback Control Mechanisms in the Lactotrophic Axis

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JOURNAL OF NEUROSCIENCE (2012)

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Article Pharmacology & Pharmacy

Roles of Dopamine and Inflammation-Related Molecules in Behavioral Alterations Caused by Repeated Stress

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JOURNAL OF PHARMACOLOGICAL SCIENCES (2012)

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Article Neurosciences

Role of Dopamine Receptors in ADHD: A Systematic Meta-analysis

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MOLECULAR NEUROBIOLOGY (2012)

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Review Behavioral Sciences

The social motivation theory of autism

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TRENDS IN COGNITIVE SCIENCES (2012)

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Article Hematology

The Bilirubin-Increasing Drug Atazanavir Improves Endothelial Function in Patients With Type 2 Diabetes Mellitus

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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)

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Review Neurosciences

The Roles of Dopamine and Noradrenaline in the Pathophysiology and Treatment of Attention-Deficit/Hyperactivity Disorder

Natalia del Campo et al.

BIOLOGICAL PSYCHIATRY (2011)

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Article Psychiatry

Association between unconjugated bilirubin and schizophrenia

Rajiv Radhakrishnan et al.

PSYCHIATRY RESEARCH (2011)

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Article Psychiatry

Exposure to Prenatal Infection and Risk of Schizophrenia

Alan S. Brown

Frontiers in Psychiatry (2011)

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Review Psychology, Developmental

Is Neonatal Jaundice Associated with Autism Spectrum Disorders: A Systematic Review

Sanjiv B. Amin et al.

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS (2011)

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Review Psychiatry

Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies

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AMERICAN JOURNAL OF PSYCHIATRY (2010)

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Review Psychology, Developmental

Measured Gene-by-Environment Interaction in Relation to Attention-Deficit/Hyperactivity Disorder

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JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY (2010)

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Article Chemistry, Analytical

Discovery of Dopamine Glucuronide in Rat and Mouse Brain Microdialysis Samples Using Liquid Chromatography Tandem Mass Spectrometry

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ANALYTICAL CHEMISTRY (2009)

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Review Behavioral Sciences

The role of the basal ganglia in learning and memory: Neuropsychological studies

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BEHAVIOURAL BRAIN RESEARCH (2009)

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Review Behavioral Sciences

Immune involvement in schizophrenia and autism: Etiology, pathology and animal models

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BEHAVIOURAL BRAIN RESEARCH (2009)

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Article Biochemistry & Molecular Biology

A Humanized Version of Foxp2 Affects Cortico-Basal Ganglia Circuits in Mice

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CELL (2009)

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Review Pharmacology & Pharmacy

Bilirubin Chemistry and Metabolism; Harmful and Protective Aspects

Libor Vitek et al.

CURRENT PHARMACEUTICAL DESIGN (2009)

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Review Biochemistry & Molecular Biology

Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement

Hyman M. Schipper et al.

JOURNAL OF NEUROCHEMISTRY (2009)

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Article Neurosciences

Minocycline affects cocaine sensitization in mice

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NEUROSCIENCE LETTERS (2009)

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Article Endocrinology & Metabolism

Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance

Ming Li et al.

DIABETES (2008)

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Article Neurosciences

Inversion of dopamine responses in striatal medium spiny neurons and involuntary movements

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JOURNAL OF NEUROSCIENCE (2008)

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Article Pediatrics

Interaction of dopamine transporter genotype with prenatal smoke exposure on ADHD symptoms

Katja Becker et al.

JOURNAL OF PEDIATRICS (2008)

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Article Pharmacology & Pharmacy

Overexpression of Heme Oxygenase-1 Protects Dopaminergic Neurons against 1-Methyl-4-Phenylpyridinium-Induced Neurotoxicity

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MOLECULAR PHARMACOLOGY (2008)

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Article Pharmacology & Pharmacy

Pharmacological and Clinical Aspects of Heme Oxygenase

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PHARMACOLOGICAL REVIEWS (2008)

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Review Clinical Neurology

Parkinson's disease: a dual-hit hypothesis

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NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2007)

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Review Neurosciences

Behavioral functions of the mesolimbic dopaminergic system: An affective neuroethological perspective

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BRAIN RESEARCH REVIEWS (2007)

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Review Neurosciences

Neuroinflammatory mechanisms in Parkinson's disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention

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EXPERIMENTAL NEUROLOGY (2007)

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Review Developmental Biology

The effects of maternal inflammation on neuronal development: possible mechanisms

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INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2007)

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Article Neurosciences

Astroglia overexpressing heme oxygenase-1 predispose co-cultured PC12 cells to oxidative injury

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JOURNAL OF NEUROSCIENCE RESEARCH (2007)

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Article Neurosciences

Peroxisome proliferator-activated receptor gamma activation relieves expression of behavioral sensitization to methamphetamine in mice

Takehiko Maeda et al.

NEUROPSYCHOPHARMACOLOGY (2007)

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Article Neurosciences

Brain dopamine transporter levels in treatment and drug naive adults with ADHD

Nora D. Volkow et al.

NEUROIMAGE (2007)

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Review Medicine, General & Internal

Huntington's disease

Francis O. Walker

LANCET (2007)

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Review Neurosciences

Mesocortical dopamine modulation of executive functions: beyond working memory

Stan B. Floresco et al.

PSYCHOPHARMACOLOGY (2006)

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Article Clinical Neurology

Dopamine transporter genotype influences the physiological response to medication in ADHD

Donald L. Gilbert et al.

BRAIN (2006)

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Article Biochemistry & Molecular Biology

The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression:: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine

N Müller et al.

MOLECULAR PSYCHIATRY (2006)

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Article Biochemistry & Molecular Biology

Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate α-synuclein fibrilization

DA Bosco et al.

NATURE CHEMICAL BIOLOGY (2006)

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Review Physiology

Heme oxygenase-1/carbon monoxide: From basic science to therapeutic applications

SW Ryter et al.

PHYSIOLOGICAL REVIEWS (2006)

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Article Biochemistry & Molecular Biology

Biliverdin reductase, a major physiologic cytoprotectant, suppresses experimental autoimmune encephalomyelitis

YR Liu et al.

FREE RADICAL BIOLOGY AND MEDICINE (2006)

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Review Physiology

New insights into biliverdin reductase functions: Linking heme metabolism to cell signaling

MD Maines

PHYSIOLOGY (2005)

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Article Clinical Neurology

Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease

HL Chen et al.

ANNALS OF NEUROLOGY (2005)

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Article Neurosciences

Effects of subchronic methamphetamine exposure on basal dopamine and stress-induced dopamine release in the nucleus accumbens shell of rats

SL Broom et al.

PSYCHOPHARMACOLOGY (2005)

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Article Biochemistry & Molecular Biology

Dopamine fails to regulate activation of peripheral blood lymphocytes from multiple sclerosis patients:: Effects of IFN-β

M Giorelli et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2005)

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Molecular genetics of attention-deficit/hyperactivity disorder

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BIOLOGICAL PSYCHIATRY (2005)

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Article Biochemistry & Molecular Biology

Dopaminergic neurons

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INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2005)

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Role of tumor necrosis factor-α in methamphetamine-induced drug dependence and neurotoxicity

A Nakajima et al.

JOURNAL OF NEUROSCIENCE (2004)

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Review Pharmacology & Pharmacy

Catecholamine metabolism: A contemporary view with implications for physiology and medicine

G Eisenhofer et al.

PHARMACOLOGICAL REVIEWS (2004)

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Review Neurosciences

Dopamine, learning and motivation

RA Wise

NATURE REVIEWS NEUROSCIENCE (2004)

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Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains

K Imamura et al.

ACTA NEUROPATHOLOGICA (2003)

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Pathways linking depression, adiposity, and inflammatory markers in healthy young adults

GE Miller et al.

BRAIN BEHAVIOR AND IMMUNITY (2003)

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Article Immunology

Bilirubin as a potent antioxidant suppresses experimental autoimmune encephalomyelitis: implications for the role of oxidative stress in the development of multiple sclerosis

YR Liu et al.

JOURNAL OF NEUROIMMUNOLOGY (2003)

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Article Biochemistry & Molecular Biology

Heme oxygenase-1 and heme oxygenase-2 have distinct roles in the proliferation and survival of olfactory receptor neurons mediated by cGMP and bilirubin, respectively

J Chen et al.

JOURNAL OF NEUROCHEMISTRY (2003)

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Article Neurosciences

Oxidative stress regulated genes in nigral dopaminergic neuronal cells: correlation with the known pathology in Parkinson's disease

MS Yoo et al.

MOLECULAR BRAIN RESEARCH (2003)

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Review Clinical Neurology

Oxidative stress in Parkinson's disease

P Jenner

ANNALS OF NEUROLOGY (2003)

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The effect of cingulate lesions on social behaviour and emotion

KA Hadland et al.

NEUROPSYCHOLOGIA (2003)

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Clinical depression and inflammatory risk markers for coronary heart disease

GE Miller et al.

AMERICAN JOURNAL OF CARDIOLOGY (2002)

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Biliverdin reductase:: A major physiologic cytoprotectant

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

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Article Clinical Neurology

Caudate nucleus volume asymmetry predicts attention-deficit hyperactivity disorder (ADHD) symptomatology in children

GW Schrimsher et al.

JOURNAL OF CHILD NEUROLOGY (2002)

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Catecholamine production and tyrosine hydroxylase expression in peripheral blood mononuclear cells from multiple sclerosis patients: effect of cell stimulation and possible relevance for activation-induced apoptosis

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JOURNAL OF NEUROIMMUNOLOGY (2002)

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Review Neurosciences

Microglia as a source and target of cytokines

UK Hanisch

GLIA (2002)

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Review Neurosciences

Dopamine and the regulation of cognition and attention

A Nieoullon

PROGRESS IN NEUROBIOLOGY (2002)

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Effects of light on low nocturnal bilirubin in winter depression: A preliminary report

DA Oren et al.

BIOLOGICAL PSYCHIATRY (2002)

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Tumor necrosis factor gene polymorphisms in patients with sporadic Parkinson's disease

M Nishimura et al.

NEUROSCIENCE LETTERS (2001)

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Heme oxygenase-1 plays an important protective role in experimental autoimmune encephalomyelitis

YR Liu et al.

NEUROREPORT (2001)

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Brain dopamine and obesity

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LANCET (2001)

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Dopamine induces the expression of heme oxygenase-1 by human endothelial cells in vitro

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KIDNEY INTERNATIONAL (2000)

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Schizophrenia-associated idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome)

T Miyaoka et al.

JOURNAL OF CLINICAL PSYCHIATRY (2000)

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