☆ 4.6 Review

Innate lymphoid cells: potential targets for cancer therapeutics

TRENDS IN CANCER (2023)

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Article Respiratory System

Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures

Arutha Kulasinghe et al.

Summary: Spatial transcriptomics is a powerful tool to identify novel gene signatures within tissues, offering new insights into the pathogenesis of SARS-COV-2 to aid in patient triage and treatment. This study used targeted transcriptomics of formalin-fixed paraffin-embedded tissue to examine the pulmonary transcriptional landscape of COVID-19 patients. The results showed significant upregulation of genes associated with inflammation, type I interferon production, coagulation, and angiogenesis in the lungs of COVID-19 patients compared to non-infected controls. Additionally, the study found that the gene IFI27, previously identified as a useful blood biomarker for differentiating bacterial and viral lung infections, was significantly upregulated in the lungs of COVID-19 patients compared to patients with influenza.

EUROPEAN RESPIRATORY JOURNAL (2022)

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Article Immunology

Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses

Melanie Bruchard et al.

Summary: This study reveals the essential function of type 3 innate lymphoid cells (ILC3s) in recruiting T cells to the tumor microenvironment and enhancing antitumor immune responses.

NATURE IMMUNOLOGY (2022)

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Article Multidisciplinary Sciences

Programme of self-reactive innate-like T cell-mediated cancer immunity

Chun Chou et al.

Summary: A new class of tumor-infiltrating T cells (ILTCKs) has been identified, which are alpha beta T cell receptor (TCR)-positive and express FCER1G, with high cytotoxic potential. ILTCKs react broadly to unmutated self-antigens, arise from distinct thymic progenitors following early encounter with cognate antigens, and are continuously replenished by thymic progenitors during tumor progression. ILTCKs' expansion and effector differentiation depend on interleukin-15 (IL-15) expression in cancer cells, and inducible activation of IL-15 signaling suppresses tumor growth. This distinguishes ILTCKs from conventional cytotoxic T cells.

NATURE (2022)

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Review Immunology

Innate lymphoid cells and cancer

Nicolas Jacquelot et al.

Summary: Innate lymphoid cells (ILCs) play a role in immune responses and have been found to have pleiotropic effects in various tissues, including both tissue repair and immunopathology toward allergens and promotion of tumorigenesis. Recent studies suggest that non-NK ILCs might be harnessed for anti-tumor responses. Gabrielle Belz and colleagues review the influence of ILCs on cancer immune responses.

NATURE IMMUNOLOGY (2022)

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Article Immunology

Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies

Emily R. Kansler et al.

Summary: This study reveals an innate immune surveillance response mediated by cytotoxic ILC1 sensing of cancer cell-expressed IL-15, which is associated with patient survival and contributes to tumor suppression.

NATURE IMMUNOLOGY (2022)

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Article Biochemical Research Methods

Identification of cell types in multiplexed in situ images by combining protein expression and spatial information using CELESTA

Weiruo Zhang et al.

Summary: CELESTA is an unsupervised machine learning algorithm that identifies cell types based on markers and spatial information. By applying CELESTA to imaging data of colorectal cancer and head and neck squamous cell carcinoma, researchers identified tissue architecture associated with lymph node metastasis and validated their findings through cell-cell interaction analysis.

NATURE METHODS (2022)

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Article Multidisciplinary Sciences

Trained ILC3 responses promote intestinal defense

Nicolas Serafini et al.

Summary: Group 3 innate lymphoid cells (ILC3s) in the intestine remain activated for months after exposure to Citrobacter rodentium, leading to enhanced immune response and defense capability. These trained ILC3s undergo metabolic changes and exhibit enhanced proliferative capacity and IL-22 production.

SCIENCE (2022)

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Review Immunology

Heterogeneity of ILC2s in the Intestine; Homeostasis and Pathology

Shogo Sunaga et al.

Summary: Group 2 innate lymphoid cells (ILC2s) are a novel subset of lymphocytes that lack antigen receptors. They play essential roles in maintaining tissue homeostasis and inducing local immune responses characterized by type 2 cytokines. ILC2s are distributed across various organs, including the intestine, where they are activated by luminal antigens and regulated by intestinal epithelial cells and neuronal systems. They contribute to epithelial barrier function, clearance of luminal antigens, tissue repair, inflammation, and tissue fibrosis. Recent studies have highlighted their involvement in inflammatory bowel diseases. Single-cell analysis techniques provide insights into ILC2 heterogeneity and their regulatory roles in different tissues.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Tissue Resident and Migratory Group 2 Innate Lymphoid Cells

Laura Mathae et al.

Summary: Group 2 innate lymphoid cells (ILC2s) are present in mucosal and non-mucosal tissues in both mice and humans, and are involved in initiating type 2 inflammation. Recent studies have shown that ILC2s have the ability to circulate between different organs during inflammation and may play roles in mediating multiple type 2 diseases.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Cytotoxic granzyme C-expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity

Briana G. Nixon et al.

Summary: Innate lymphocytes are important components of the cellular immune system. They can defend the host against various challenges and can lead to immunopathology when dysregulated. This study found that granzyme C, a cytolytic molecule, was expressed in a specific type of innate lymphoid cells (ILC1s) in the liver and salivary gland of mice. These granzyme C-expressing ILC1s were derived from ILC progenitors and did not convert into NK cells, ILC2s, or ILC3s. Granzyme C marked a maturation state of ILC1s, and its expression in ILC1s required specific transcription factors and support from transforming growth factor-beta signaling. Depleting ILC1s in a mouse breast cancer model resulted in accelerated tumor growth. IL-15 stimulation induced granzyme C expression in ILC1s, enabling them to exhibit perforin-mediated cytotoxicity. However, constitutive activation of STAT5 in granzyme C-expressing ILC1s led to lethal perforin-dependent autoimmunity in neonatal mice. This study broadens the understanding of the function of ILC1s beyond helper-like lymphocytes.

SCIENCE IMMUNOLOGY (2022)

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Article Immunology

Profiling of epigenetic marker regions in murine ILCs under homeostatic and inflammatory conditions

Michael Beckstette et al.

Summary: This study identified differentially methylated regions (DMRs) and epigenetic marker regions in murine lymph node-derived ILCs using genome-wide DNA methylation profiling. The marker regions showed strong correlation with the expression of associated genes, suggesting their functional relevance. These epigenetic markers can serve as a tool to study phenotypic and functional properties of ILCs.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

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Review Immunology

Innate lymphoid cells in early tumor development

Kathrin Warner et al.

Summary: Innate lymphoid cells (ILCs), the innate counterparts of T cells, play a crucial role in immune responses and have a profound impact on diseases like cancer. ILCs can influence early tumor development.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Tissue-Specific Diversity of Group 2 Innate Lymphoid Cells in the Skin

Tetsuro Kobayashi et al.

Summary: This review discusses the phenotypical and functional heterogeneity of skin ILCs reported in recent years, highlighting their roles in tissue-specificity and disease pathogenesis.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

An innate IL-25-ILC2-MDSC axis creates a cancer-permissive microenvironment for Apc mutation-driven intestinal tumorigenesis

Eric Jou et al.

Summary: Intestinal IL-25-activated ILC2s create a cancer-permissive microenvironment, associated with reduced survival and increased MDSCs in colorectal cancer patients. Ablation of IL-25 signaling reduces tumors and extends lifespan, while therapeutic antibody blockade enhances antitumor immunity.

SCIENCE IMMUNOLOGY (2022)

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Article Immunology

Innate and Innate-like Effector Lymphocytes in Health and Disease

Luc Van Kaer et al.

Summary: Lymphocytes can be divided into subsets belonging to the innate or adaptive arms of the immune system. Innate and innate-like lymphocytes can respond rapidly to pathogenic insults but lack classical immunological memory. They integrate danger and stress signals to generate specialized immune responses.

JOURNAL OF IMMUNOLOGY (2022)

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Article Immunology

Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia

Adeline Crinier et al.

Summary: NK cells in human bone marrow can be classified into three subpopulations, with NK0 cells believed to be precursors of circulating CD56(dim) NK1-like NK cells and CD56(bright) NK2-like NK cells under physiological conditions. Transcriptomic analysis showed stress-induced repression of NK cell effector functions in bone marrow NK cells from patients with acute myeloid leukemia (AML), with reduced levels of CD160, but higher survival rates in the CD160(high) group.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Inference and analysis of cell-cell communication using CellChat

Suoqin Jin et al.

Summary: By constructing an interaction database and developing the tool CellChat, the authors quantitatively inferred and analyzed cell-cell communication networks, revealing important signaling inputs and outputs between cells, and achieved classification of conserved and context-specific pathways.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Dissection of intercellular communication using the transcriptome-based framework ICELLNET

Floriane Noel et al.

Summary: ICELLNET is a transcriptomic-based framework that helps dissect cell communication by globally integrating cell-to-cell communication, quantifying communication scores, visualizing results, and connecting to reference human cell types, revealing the key role of cell communication.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling

Lauren Brady et al.

Summary: The study investigates the inter- and intra-tumor heterogeneity of metastatic prostate cancer (mPC) using Digital Spatial Profiling, identifying high intra-patient homogeneity in tumor phenotype with exceptions. It also highlights the expression of the immune checkpoint protein B7-H3/CD276 in some mPCs with high androgen receptor (AR) activity, suggesting potential immunotherapy targets.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Multiplexed histology analyses for the phenotypic and spatial characterization of human innate lymphoid cells

Anna Pascual-Reguant et al.

Summary: ILCs are essential regulators of biological processes. The study combines multiplexed imaging and computational pipelines to identify tonsillar IRF4 (+) ILC3s and conserved stromal landmarks for ILC localization, offering a platform for future ILC research.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

PPAR? drives IL-33-dependent ILC2 pro-tumoral functions

Giuseppe Ercolano et al.

Summary: The expression of PPARγ in ILC2s sustains type-2 cytokines secretion and supports their pro-tumorigenic role in preclinical cancer models. Pharmacologic inhibition or genetic deletion of PPARγ in ILC2s significantly impair IL-33-induced Type-2 cytokine production and mitochondrial fitness.

NATURE COMMUNICATIONS (2021)

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Review Neurosciences

Neuroimmune Interactions and Rhythmic Regulation of Innate Lymphoid Cells

Nicolas Jacquelot et al.

Summary: The Earth's rotation creates biological clocks that regulate physiological processes and immune system. Neuroimmune interactions play a role in rhythmic activity of immune cells, and disruption of these rhythms can lead to chronic inflammation in murine models.

FRONTIERS IN NEUROSCIENCE (2021)

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Editorial Material Oncology

Innate immune cells in the tumor microenvironment

Ming O. Li et al.

Summary: The tumor immune microenvironment (TIME) is a complex ecosystem that consists of adaptive and innate immune cells with both tumor-promoting and anti-tumor effects. Further research is needed to understand the diversity and functions of innate immune cells in the TIME, and their roles in response to immunotherapies. Experts discuss recent advances in this field and potential therapeutic approaches.

CANCER CELL (2021)

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Article Oncology

Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity

Sharon Grisaru-Tal et al.

Summary: Research has found that eosinophils exhibit antitumor activities in the metastatic tumor microenvironment, and can be trained by the TME to adopt antitumorigenic properties, potentially leading to the development of eosinophil-targeted therapeutics.

CANCER RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer

Jeremy Goc et al.

Summary: Research shows that ILC3s play a protective role in cancer, and alterations in CRC may lead to dysfunctional adaptive immunity, tumor progression, and immunotherapy resistance.

CELL (2021)

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Article Biochemistry & Molecular Biology

Spatially organized multicellular immune hubs in human colorectal cancer

Karin Pelka et al.

Summary: By analyzing the transcriptional profiles of cells in tumors, differences in immune responses between mismatch repair-deficient (MMRd) and mismatch repair-proficient (MMRp) tumors were identified, as well as the logic behind the interaction of malignant and immune cells discovered within tumors.

CELL (2021)

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Article Immunology

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Nicolas Jacquelot et al.

Summary: ILC2s play a critical role in melanoma immunity by producing cytokines that enhance antitumor responses. High infiltration of ILC2s in melanoma is associated with good clinical prognosis, but their antitumor functions may be restricted by programmed cell death protein-1.

NATURE IMMUNOLOGY (2021)

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Review Biochemical Research Methods

Spatial omics and multiplexed imaging to explore cancer biology

Sabrina M. Lewis et al.

Summary: Understanding intratumoral heterogeneity through single-cell analyses has revealed new biomarkers, but lacks information on cellular location within the tumor microenvironment. New technologies enabling detection of cancer subclones in their native spatial context promise to drive the next generation of cancer research, diagnosis, and therapeutic strategies.

NATURE METHODS (2021)

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Article Immunology

c-Rel Is Required for IL-33-Dependent Activation of ILC2s

Aidil Zaini et al.

Summary: The study identifies c-Rel, a member of the NF-kappa B family, as a critical component in the IL-33-dependent activation of ILC2s, particularly in the lung. Lack of c-Rel significantly reduces the lung inflammation induced by IL-33, and also impacts the expansion of ILC2 precursors and cytokine production by mature ILC2s in the lung.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Group 2 Innate Lymphoid Cells Exhibit Tissue-Specific Dynamic Behaviour During Type 2 Immune Responses

Laurence S. C. Lok et al.

Summary: ILC2s are crucial early effectors of mucosal type 2 immunity, producing IL-13 in lymphoid organs. In vivo imaging showed that ILC2s increase in size and movement after helminth infection, with increased interactions with T cells in the intestinal mucosa.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Genetics & Heredity

Deciphering cell-cell interactions and communication from gene expression

Erick Armingol et al.

Summary: Intercellular interactions and communication can be inferred from RNA sequencing data, such as ligand-receptor pairs, which has led to new insights and methodologies for studying cell-cell interactions.

NATURE REVIEWS GENETICS (2021)

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Article Multidisciplinary Sciences

ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity

John Alec Moral et al.

NATURE (2020)

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Article Biochemical Research Methods

CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes

Mirjana Efremova et al.

NATURE PROTOCOLS (2020)

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Review Cell Biology

Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity

Christoph S. N. Klose et al.

CELL RESEARCH (2020)

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Article Cell & Tissue Engineering

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

Arianna Fumagalli et al.

CELL STEM CELL (2020)

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Article Oncology

The Interleukin 22 Pathway Interacts with Mutant KRAS to Promote Poor Prognosis in Colon Cancer

Sarah McCuaig et al.

CLINICAL CANCER RESEARCH (2020)

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Article Cell & Tissue Engineering

A Rainbow Reporter Tracks Single Cells and Reveals Heterogeneous Cellular Dynamics among Pluripotent Stem Cells and Their Differentiated Derivatives

Danny El-Nachef et al.

STEM CELL REPORTS (2020)

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Review Immunology

NK Cell Development in Times of Innate Lymphoid Cell Diversity

Vladislava Stokic-Trtica et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Biochemistry & Molecular Biology

Single-cell sequencing techniques from individual to multiomics analyses

Yukie Kashima et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

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Article Multidisciplinary Sciences

Predicting cell-to-cell communication networks using NATMI

Rui Hou et al.

NATURE COMMUNICATIONS (2020)

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Editorial Material Immunology

The devil's in the detail: cell-specific role of PPARγ in ILC2 activation by IL-33

Henry J. McSorley et al.

MUCOSAL IMMUNOLOGY (2020)

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Review Oncology

Group 2 Innate Lymphoid Cells: A Double-Edged Sword in Cancer?

Enrico Maggi et al.

CANCERS (2020)

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Review Biochemistry & Molecular Biology

Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy

Yuqing Cao et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Review Oncology

A new dawn for eosinophils in the tumour microenvironment

Sharon Grisaru-Tal et al.

NATURE REVIEWS CANCER (2020)

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Review Immunology

Plasticity of innate lymphoid cell subsets

Suzanne M. Bal et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Review Immunology

Sensing of physiological regulators by innate lymphoid cells

Cyril Seillet et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2019)

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Review Genetics & Heredity

Integrative single-cell analysis

Tim Stuart et al.

NATURE REVIEWS GENETICS (2019)

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Review Immunology

Innate lymphoid cells: A potential link between microbiota and immune responses against cancer

Santosh K. Panda et al.

SEMINARS IN IMMUNOLOGY (2019)

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Article Biochemistry & Molecular Biology

Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity

Laurent Gauthier et al.

CELL (2019)

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Article Immunology

Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues

Marina Cella et al.

NATURE IMMUNOLOGY (2019)

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Review Immunology

ILC2s: New Actors in Tumor Immunity

Giuseppe Ercolano et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

NKG2D and its ligands in cancer

Payal Dhar et al.

CURRENT OPINION IN IMMUNOLOGY (2018)

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Review Immunology

Unconventional T Cell Targets for Cancer Immunotherapy

Dale I. Godfrey et al.

IMMUNITY (2018)

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Article Cell Biology

Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis

Melissa Q. Reeves et al.

NATURE CELL BIOLOGY (2018)

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Review Immunology

Natural killer cell specificity for viral infections

Quirin Hammer et al.

NATURE IMMUNOLOGY (2018)

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Article Multidisciplinary Sciences

Pulmonary neuroendocrine cells amplify allergic asthma responses

Pengfei Sui et al.

SCIENCE (2018)

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Article Multidisciplinary Sciences

β2-adrenergic receptor-mediated negative regulation of group 2 innate lymphoid cell responses

Saya Moriyama et al.

SCIENCE (2018)

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Review Biochemistry & Molecular Biology

Innate Lymphoid Cells: 10 Years On

Eric Vivier et al.

CELL (2018)

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Article Biochemistry & Molecular Biology

Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging

Yury Goltsev et al.

CELL (2018)

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Article Immunology

Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells

Linda Quatrini et al.

NATURE IMMUNOLOGY (2018)

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Review Immunology

Neuroendocrine regulation of innate lymphoid cells

Linda Quatrini et al.

IMMUNOLOGICAL REVIEWS (2018)

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Review Immunology

Innate lymphoid cells in lung infection and immunity

Christina Stehle et al.

IMMUNOLOGICAL REVIEWS (2018)

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Review Immunology

Innate lymphoid cells, mediators of tissue homeostasis, adaptation and disease tolerance

Nora Branzk et al.

IMMUNOLOGICAL REVIEWS (2018)

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Article Immunology

Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency

Yannick Simoni et al.

IMMUNITY (2017)

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Article Medicine, Research & Experimental

ILC2-modulated T cell-to-MDSC balance is associated with bladder cancer recurrence

Mathieu F. Chevalier et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

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Article Immunology

Host resistance to endotoxic shock requires the neuroendocrine regulation of group 1 innate lymphoid cells

Linda Quatrini et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Article Immunology

Tissue microenvironment dictates the fate and tumorsuppressive function of type 3 ILCs

Kathrin Nussbaum et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Article Immunology

Androgen signaling negatively controls group 2 innate lymphoid cells

Sophie Laffont et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Article Multidisciplinary Sciences

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

Antonia Wallrapp et al.

NATURE (2017)

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Article Multidisciplinary Sciences

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

Christoph S. N. Klose et al.

NATURE (2017)

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Article Multidisciplinary Sciences

Neuronal regulation of type 2 innate lymphoid cells via neuromedin U

Vania Cardoso et al.

NATURE (2017)

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Review Immunology

Friend or Foe? The Ambiguous Role of Innate Lymphoid Cells in Cancer Development

Jochen Mattner et al.

TRENDS IN IMMUNOLOGY (2017)

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Article Multidisciplinary Sciences

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis

Sara Trabanelli et al.

NATURE COMMUNICATIONS (2017)

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Article Cell Biology

Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation

Jacqueline-Yvonne Cephus et al.

CELL REPORTS (2017)

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Article Cell Biology

Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis

Takahiro Tsujikawa et al.

CELL REPORTS (2017)

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Article Immunology

Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells

Yulong Gao et al.

NATURE IMMUNOLOGY (2017)

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Article Oncology

RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers

Sheeba Irshad et al.

CANCER RESEARCH (2017)

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Article Immunology

Complementarity and redundancy of IL-22-producing innate lymphoid cells

Lucille C. Rankin et al.

NATURE IMMUNOLOGY (2016)

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Article Biochemistry & Molecular Biology

Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells

Saida Dadi et al.

CELL (2016)

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Review Immunology

Development and maturation of natural killer cells

Theresa L. Geiger et al.

CURRENT OPINION IN IMMUNOLOGY (2016)

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Article Multidisciplinary Sciences

Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence

Sales Ibiza et al.

NATURE (2016)

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Article Multidisciplinary Sciences

Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway

Yong Yu et al.

NATURE (2016)

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Article Immunology

IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity

Yoichiro Ohne et al.

NATURE IMMUNOLOGY (2016)

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Article Immunology

IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs

Suzanne M. Bal et al.

NATURE IMMUNOLOGY (2016)

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Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs

Jonathan S. Silver et al.

NATURE IMMUNOLOGY (2016)

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Review Endocrinology & Metabolism

A comprehensive overview of the role of the RET proto-oncogene in thyroid carcinoma

Cristina Romei et al.

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Review Oncology

NK cells and cancer: you can teach innate cells new tricks

Maelig G. Morvan et al.

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Letter Hematology

CD127+ innate lymphoid cells are dysregulated in treatment naive acute myeloid leukemia patients at diagnosis

Sara Trabanelli et al.

HAEMATOLOGICA (2015)

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Article Immunology

Interleukin-12 and-23 Control Plasticity of CD127+ Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria

Jochem H. Bernink et al.

IMMUNITY (2015)

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Article Immunology

Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets

Michelle L. Robinette et al.

NATURE IMMUNOLOGY (2015)

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Letter Hematology

CD127+ innate lymphoid cells are dysregulated in treatment naive acute myeloid leukemia patients at diagnosis

Sara Trabanelli et al.

HAEMATOLOGICA (2015)

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Review Oncology

Innate Lymphoid Cells in Cancer

Blandine Vallentin et al.

CANCER IMMUNOLOGY RESEARCH (2015)

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Review Immunology

Perforin and granzymes: function, dysfunction and human pathology

Ilia Voskoboinik et al.

NATURE REVIEWS IMMUNOLOGY (2015)

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Article Biochemistry & Molecular Biology

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

Christoph S. N. Klose et al.

CELL (2014)

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Article Biochemical Research Methods

Multiplexed immunohistochemistry, imaging, and quantitation: A review, with an assessment of Tyramide signal amplification, multispectral imaging and multiplex analysis

Edward C. Stack et al.

METHODS (2014)

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Review Physiology

CALCITONIN GENE-RELATED PEPTIDE: PHYSIOLOGY AND PATHOPHYSIOLOGY

F. A. Russell et al.

PHYSIOLOGICAL REVIEWS (2014)

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Article Immunology

Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12-and IL-15-Responsive IFN-γ-Producing Cells

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