期刊
WORLD NEUROSURGERY
卷 96, 期 -, 页码 215-221出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.wneu.2016.04.002
关键词
Coagulopathy; Functional outcome; Hypercoagulable state; Platelet; Subarachnoid hemorrhage; Thromboeleastography
资金
- National Institute of Child Health and Human Development [R21HD072326]
- Boston University Reproductive, Perinatal and Pediatric Epidemiology training grant (National Institute of Child Health and Human Development) [T32 HD052458]
- Haemonetics
OBJECTIVE: Hypercoagulability after subarachnoid hemorrhage (SAH) is well described and may be platelet mediated. Thromboelastography (TEG) provides a global assessment of coagulation. We sought to determine whether the maximum amplitude (MA) parameter of TEG, a measure of platelet strength and function, is associated with outcome after SAH. METHODS: One hundred ten TEG analyses were performed for patients with moderate-to-severe SAH and comparedwith 6 healthy age- and sex-matched controls. TEG indices included MA, G value (G), alpha angle, and thrombus generation and were correlated to functional outcomes and laboratory tests including complete blood count, erythrocyte sedimentation rate, high sensitivity C-reactive protein, fibrinogen, and D-dimer, obtained on post-bleed days (PBDs) 1, 3, 5, 7, and 10. RESULTS: MA was significantly elevated compared with controls on PBD 3 (70.0 mm +/- 4.5 mm vs. 64.1 mm +/- 6.5 mm; P = 0.02), PBD 5 (72.6 mm +/- 5.3 mm vs. 64.1 mm +/- 6.5 mm; P = 0.003), PBD 7 (73.0 mm +/- 5.4 mm vs. 64.1 mm +/- 6.5 mm; P = 0.003), and PBD 10 (73.4 mm +/- 6.0 mm vs. 64.1 mm +/- 6.5 mm; P = 0.005). G was significantly elevated compared with controls on PBD 3 (P = 0.03), PBD 5 (P = 0.01), PBD 7 (P = 0.01), and PBD 10 (P = 0.02). The only biomarker associated with poor outcome was CRP. Multivariate logistic regression demonstrated an association between elevated MA and outcome (odds ratio 39.1, P = 0.006) independent of CRP, age, Hunt Hess grade, and transfusion. CONCLUSIONS: TEG indices are associated with poor outcome after SAH and may identify a platelet-mediated hypercoagulable state. The association between MA and outcome was stronger than that between traditional bio-markers and was independent of age and Hunt Hess grade.
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