☆ 4.6 Review

The heterocellular heart: identities, interactions, and implications for cardiology

BASIC RESEARCH IN CARDIOLOGY (2023)

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Review Cardiac & Cardiovascular Systems

Single-cell transcriptomics for the assessment of cardiac disease

Antonio M. A. Miranda et al.

Summary: Cardiovascular disease is the leading cause of death globally. Understanding its mechanisms through advanced single-cell and single-nucleus transcriptomics studies is crucial for improving therapeutic strategies and patient risk assessment. This review provides an overview of the challenges and inferences in experimental design, as well as novel findings and applications in cardiac cell types and states. It also discusses the need for standardization and the translational and clinical implications of these technologies in diagnosing and treating heart disease.

NATURE REVIEWS CARDIOLOGY (2023)

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Editorial Material Cardiac & Cardiovascular Systems

Scientists Identify Molecular Alterations in Failing Hearts at Single-Cell Resolution

Tracy Hampton

CIRCULATION (2023)

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Review Cardiac & Cardiovascular Systems

Modeling Heart Diseases on a Chip: Advantages and Future Opportunities

Omar Mourad et al.

Summary: Heart disease is a major healthcare burden and leading cause of death worldwide. To improve understanding and development of treatments, high quality disease models are needed. Heart-on-a-chip technology, which uses cells from the heart to generate microtissues, has shown great promise as disease modeling platforms and important tools in drug development.

CIRCULATION RESEARCH (2023)

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Article Cardiac & Cardiovascular Systems

Innate Immunity System in Patients With Cardiovascular and Kidney Disease

Carmine Zoccali et al.

Summary: With a global burden of 844 million, chronic kidney disease (CKD) is now considered a public health priority. Low-grade systemic inflammation plays a crucial role in adverse cardiovascular outcomes in CKD patients. Various factors, including cellular senescence, gut microbiota-dependent immune activation, lipoprotein modifications, and neuroimmune interactions, contribute to the unique severity of inflammation in CKD.

CIRCULATION RESEARCH (2023)

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Article Cardiac & Cardiovascular Systems

High-quality nuclei isolation from postmortem human heart muscle tissues for single-cell studies

Sarah Araten et al.

Summary: Single-cell approaches are popular for studying genetic factors in diseases. In this study, we isolated single nuclei from postmortem heart tissues and analyzed their DNA and RNA. The study provides a method for single-nuclei isolation from cardiac tissue, along with quality control measures for DNA amplification.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2023)

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Article Neurosciences

Diversity of cells and signals in the cardiovascular system

Eleonora Grandi et al.

Summary: This white paper summarises the outcomes of the seventh UC Davis Cardiovascular Research Symposium on Systems Approach to Understanding Cardiovascular Disease and Arrhythmia. The Symposium aimed to bring together experts in cardiovascular biomedicine to focus on the diversity and signaling involved in cardiovascular function. The paper presents an overview of major cell types, explores the complexity of cardiovascular development and disease at various levels, and discusses technological innovations for advancing understanding of integrated cardiovascular function and dysfunction.

JOURNAL OF PHYSIOLOGY-LONDON (2023)

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Review Neurosciences

A tight squeeze: how do we make sense of small changes in microvascular diameter?

Harvey Davis et al.

Summary: The brain's energy demand requires constant regulation of its blood flow, with recent research suggesting a critical role for capillary pericytes. This article explains why pericytes have the potential for greater control over cerebral blood flow compared to arterioles, due to their smaller starting diameter. Additionally, the faster dilation response of low branch order capillary pericytes allows them to regulate blood flow in a more timely manner compared to slower responding arterioles. The role of pericytes in capillary stalling is also discussed.

JOURNAL OF PHYSIOLOGY-LONDON (2023)

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Article Biochemistry & Molecular Biology

Inferring cell diversity in single cell data using consortium-scale epigenetic data as a biological anchor for cell identity

Yuliangzi Sun et al.

Summary: This article introduces a method called TRIAGE-Cluster that utilizes genome-wide epigenetic data to identify genes that delineate cell diversity in scRNA-seq data. By integrating repressive chromatin patterns with weighted density estimation, TRIAGE-Cluster determines cell type clusters in a 2D UMAP space. The article also presents TRIAGE-ParseR, a machine learning method that evaluates gene expression rank lists to define gene groups governing the identity and function of cell types.

NUCLEIC ACIDS RESEARCH (2023)

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Article Cell Biology

Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure

Bridget Simonson et al.

Summary: Using single-nucleus RNA sequencing and computational analysis, the cellular and molecular signature of ischemic cardiomyopathy (ICM) was investigated. The study revealed alterations in the cellular composition of the ischemic heart, with decreased cardiomyocytes and increased proportions of lymphatic, angiogenic, and arterial endothelial cells in ICM patients. Furthermore, increased LAMININ signaling from endothelial cells and similarities in transcriptional changes were observed between ICM, hypertrophic, and dilated cardiomyopathies, which may help identify potential drug targets for end-stage heart failure.

CELL REPORTS (2023)

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Article Biology

Single-cell RNA-seq of heart reveals intercellular communication drivers of myocardial fibrosis in diabetic cardiomyopathy

Wei Li et al.

Summary: Researchers investigated the drivers of intercellular communication in diabetic myocardial fibrosis at single-cell resolution in mouse hearts. Critical changes in ligand-receptor interactions were identified, and the specific inhibition of the Pdgfra axis was found to significantly improve diabetic myocardial fibrosis.

ELIFE (2023)

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Article Multidisciplinary Sciences

Spatially resolved multiomics of human cardiac niches

Kazumasa Kanemaru et al.

Summary: In this study, single-cell and spatial transcriptomics data were used to explore cellular niches in eight regions of the human heart. Specific ion channels, G-protein-coupled receptors, and regulatory networks were identified in different cell types, highlighting the importance of FOXP2 in pacemaker cells. The sinoatrial node was found to be compartmentalized, with glial cells and fibroblasts supporting glutamatergic signaling. The study also introduced a drug target prediction tool, drug2cell, and revealed the presence of immune niches in the epicardium.

NATURE (2023)

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Review Cardiac & Cardiovascular Systems

Nonmyocytes as electrophysiological contributors to cardiac excitation and conduction

Ana Simon-Chica et al.

Summary: This review provides an overview of heterocellular electrical communication in the heart, highlighting the roles of cardiac fibroblasts and macrophages in cardiac electrophysiology and arrhythmogenesis.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2023)

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Article Cardiac & Cardiovascular Systems

Membrane remodelling triggers maturation of excitation-contraction coupling in 3D-shaped human-induced pluripotent stem cell-derived cardiomyocytes

Fatemeh Kermani et al.

Summary: The prospective use of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) for cardiac regenerative medicine strongly depends on the electro-mechanical properties of these cells, especially regarding the Ca2+-dependent excitation-contraction (EC) coupling mechanism. Currently, the immature structural and functional features of hiPSC-CM limit the progression towards clinical applications. Here, we show that a specific microarchitecture is essential for functional maturation of hiPSC-CM.

BASIC RESEARCH IN CARDIOLOGY (2023)

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Article Hematology

Pericyte Progenitor Coupling to the Emerging Endothelium During Vasculogenesis via Connexin 43

Laura Beth Payne et al.

Summary: This study found that a distinct lineage of pericytes emerges alongside vasculogenesis and directly communicates with nascent endothelial cells via Cx43. Loss of Cx43/Gja1 in pericyte progenitors can cause embryonic vessel dysmorphogenesis, but other connexin isoforms may compensate.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2022)

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Review Pharmacology & Pharmacy

Novel non-steroidal mineralocorticoid receptor antagonists in cardiorenal disease

Ulrich Kintscher et al.

Summary: This review provides information on the molecular pharmacology and relevant clinical data of a new class of non-steroidal MRAs, discussing their cardiorenal outcomes. These compounds have an improved benefit-risk profile in treating cardiovascular diseases, and finerenone has a novel indication.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

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Review Pharmacology & Pharmacy

Approaches towards tissue-selective pharmacology of the mineralocorticoid receptor

Dorien Clarisse et al.

Summary: Mineralocorticoid receptor antagonists are effective therapies for cardiovascular and renal diseases, but their widespread clinical use is limited by the risk of hyperkalaemia. New strategies are needed to selectively target the harmful effects of the mineralocorticoid receptor while preserving its physiological function.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

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Review Cardiac & Cardiovascular Systems

Immune cells in cardiac homeostasis and disease: emerging insights from novel technologies

Sabine Steffens et al.

Summary: The use of single-cell immune profiling and advanced microscopic imaging technologies has enhanced our understanding of the cardiac immune system and its role in cardiac diseases.

EUROPEAN HEART JOURNAL (2022)

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Review Biochemistry & Molecular Biology

Fibroblast-mediated intercellular crosstalk in the healthy and diseased heart

Luka Nicin et al.

Summary: Cardiac fibroblasts are a major cell population in the heart, secreting signals that influence other cells and potentially contributing to disease. Research focuses on interactions between fibroblasts and other heart cells, particularly through paracrine, electrical, and exosomal communication.

FEBS LETTERS (2022)

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Article Multidisciplinary Sciences

CAR T cells produced in vivo to treat cardiac injury

Joel G. Rurik et al.

Summary: This study developed a therapeutic approach to generate antifibrotic CAR T cells in vivo by delivering modified mRNA in T cell-targeted nanoparticles. The efficacy of these in vivo-reprogrammed CAR T cells was evaluated in a mouse model of heart failure.

SCIENCE (2022)

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Article Cardiac & Cardiovascular Systems

Remodelling of adult cardiac tissue subjected to physiological and pathological mechanical load in vitro

Fotios G. Pitoulis et al.

Summary: We developed a novel methodology to study chronic load in vitro by using a bioreactor that can recreate the electromechanical events of in vivo pressure-volume loops. Rat living myocardial slices (LMS) were cultured for 3 days with the bioreactor to simulate physiological load, pressure-overload, or volume-overload. The results showed that both pressure- and volume-overloaded LMS exhibited decreased contractility, with volume-overload showing more pronounced effects. Cardiomyocyte hypertrophy and dysregulation of signaling pathways were also observed.

CARDIOVASCULAR RESEARCH (2022)

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Article Cell Biology

Consecutive-Day Ventricular and Atrial Cardiomyocyte Isolations from the Same Heart: Shifting the Cost-Benefit Balance of Cardiac Primary Cell Research

Joachim Greiner et al.

Summary: Freshly isolated primary cardiomyocytes (CM) are essential for cardiac research, but their short viability limits their use. This study presents a method of multi-day CM isolation, which prolongs cell viability and allows for exploration of regional differences in the heart.

CELLS (2022)

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Article Neurosciences

Nerve growth factor transfer from cardiomyocytes to innervating sympathetic neurons activates TrkA receptors at the neuro-cardiac junction

Lolita Dokshokova et al.

Summary: Cardiomyocytes release nerve growth factor (NGF) to support innervating sympathetic neurons in the heart, with neuro-cardiac junctions (NCJ) playing a crucial role in supporting retrograde neurotrophic signaling. The direct link between sympathetic neuron survival and neurotrophin release by cardiomyocytes is essential for heart cellular homeostasis.

JOURNAL OF PHYSIOLOGY-LONDON (2022)

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Review Cardiac & Cardiovascular Systems

Electron microscopy of cardiac 3D nanodynamics: form, function, future

Peter Kohl et al.

Summary: This Review discusses the latest insight into the 3D nanostructure of the heart and its impact on cellular function during contraction and relaxation. Technological breakthroughs in biological sample preparation, 3D imaging, and data analysis have provided access to new data and driven the development of smart image-analysis algorithms. The authors highlight the scientific discovery and potential clinical relevance of understanding 3D cardiac nanodynamics, as well as predict further progress in the next decade.

NATURE REVIEWS CARDIOLOGY (2022)

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Review Cardiac & Cardiovascular Systems

Epicardial adipose tissue in contemporary cardiology

Gianluca Iacobellis

Summary: There is growing interest in the role of epicardial adipose tissue (EAT) in cardiovascular disease. EAT has a protective effect on the myocardium through thermogenic function and can also be harmful by secreting inflammatory and fibrotic cytokines. EAT may also be involved in COVID-19-related cardiac syndrome. It is a modifiable risk factor that can be assessed using different imaging techniques.

NATURE REVIEWS CARDIOLOGY (2022)

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Article Multidisciplinary Sciences

Mapping the cardiac vascular niche in heart failure

Fabian Peisker et al.

Summary: This study investigates the cellular heterogeneity and transcriptomic changes in the cardiac vascular and perivascular niche during heart failure. The researchers identify specific fibroblast and endothelial cell subpopulations that play important roles in cardiac fibrosis and response to injury, respectively. The findings contribute to a better understanding of hypertrophic cardiac remodeling.

NATURE COMMUNICATIONS (2022)

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Review Cell Biology

Fibrotic Signaling in Cardiac Fibroblasts and Vascular Smooth Muscle Cells: The Dual Roles of Fibrosis in HFpEF and CAD

Julian C. Bachmann et al.

Summary: Patients with heart failure and atherosclerosis-driven coronary artery disease experience fibrotic remodeling in both the heart and atherosclerotic plaques. However, the effects of fibrosis differ in these locations. While cardiac fibrosis compromises cardiac function, fibrotic remodeling stabilizes atherosclerotic plaques. Current research is focused on drugs targeting cardiac fibrosis, taking these considerations into account. This review explores the signaling pathways activated in human cardiac fibroblasts and vascular smooth muscle cells, highlighting the overlap and context-dependent effects on extracellular matrix remodeling.

CELLS (2022)

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Review Biochemistry & Molecular Biology

What is a cell type and how to define it?

Hongkui Zeng

Summary: Cell types are the fundamental units of an organism's function and exhibit diverse phenotypic properties. This review provides an overview of the principles of cell types rooted in evolution and development, focusing on the mammalian brain. It discusses approaches to characterize and classify cell types and proposes a roadmap for understanding the dynamic changes in cellular function under different conditions.

CELL (2022)

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Article Cardiac & Cardiovascular Systems

CRISPR Modeling and Correction of Cardiovascular Disease

Ning Liu et al.

Summary: Cardiovascular disease is the leading cause of deaths and illnesses in developed countries. Mouse models have played a significant role in studying the complex signaling pathways, genetic and epigenetic regulations, and multicellular interactions involved in cardiovascular disease. The advent of CRISPR genome editing has revolutionized cardiovascular research, allowing for rapid modeling and potential genetic correction of disease-causing mutations.

CIRCULATION RESEARCH (2022)

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Review Cardiac & Cardiovascular Systems

Accelerating cardiovascular research: recent advances in translational 2D and 3D heart models

Elisa Mohr et al.

Summary: In vitro modeling of the heart is a challenging task in cardiovascular research. Three-dimensional cultivation methods have emerged as a solution to overcome the limitations of traditional two-dimensional cultivation. These methods aim to study the fundamental features of the heart and have great potential in disease research, drug screening, and regenerative therapy. However, there is a need for continuous improvement and adaptation to address limitations such as cardiomyocyte maturation and vascularization.

EUROPEAN JOURNAL OF HEART FAILURE (2022)

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Article Multidisciplinary Sciences

Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages

Wei Feng et al.

Summary: A detailed single cell atlas of heart development using a large dataset of cells from embryonic and neonatal hearts provides insights into the stage and chamber specific features. The analysis reveals transcriptional profiles, cell type-specific gene expression, and ligand-receptor interactions during heart development, which contributes to our understanding of heart development and congenital heart defects.

NATURE COMMUNICATIONS (2022)

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Article Biotechnology & Applied Microbiology

AAV capsid engineering identified two novel variants with improved in vivo tropism for cardiomyocytes

Laura Rode et al.

Summary: AAV2-THGTPAD and AAV2-NLPGSGD are promising novel tools for cardiac-directed gene therapy, outperforming AAV2 and AAV9 in terms of cardiac tissue tropism and transduction efficiency.

MOLECULAR THERAPY (2022)

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Article Multidisciplinary Sciences

Spatial multi-omic map of human myocardial infarction

Christoph Kuppe et al.

Summary: In this study, an integrative molecular map of human myocardial infarction was generated using multiple analysis methods. The results elucidated the molecular principles of cardiac tissue organization and provided an important reference for mechanistic and therapeutic studies of cardiac disease.

NATURE (2022)

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Review Genetics & Heredity

Characterizing cis-regulatory elements using single-cell epigenomics

Sebastian Preissl et al.

Summary: This article discusses cell type-specific gene regulation and its changes during development and disease. Single-cell epigenomic methods and data analysis tools provide a deeper understanding of gene regulatory programs and their roles in different environments and diseases.

NATURE REVIEWS GENETICS (2022)

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Article Multidisciplinary Sciences

Pathogenic variants damage cell composition and single-cell transcription in cardiomyopathies

Daniel Reichart et al.

SCIENCE (2022)

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Article Cardiac & Cardiovascular Systems

Histone Deacetylase 6 Inhibitor JS28 Prevents Pathological Gene Expression in Cardiac Myocytes

Vivien Ngo et al.

Summary: This study evaluated the potential of 4 epigenetic drugs to prevent adverse gene expression in cardiac myocytes. The HDAC6 inhibitor JS28 was found to be the most effective in preventing pathological gene expression with minimal impact on physiological gene expression. Genome-wide chromatin binding profiles revealed distinct effects of HDAC6 and BRD4 inhibitors on gene expression.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2022)

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Review Cardiac & Cardiovascular Systems

Utilization and Potential of RNA-Based Therapies in Cardiovascular Disease

Emma Louise Robinson et al.

Summary: This review provides an overview of the development of cardiovascular disease, the application of nucleic acid therapies in treating cardiovascular disease, and the challenges and obstacles that need to be overcome.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2022)

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Article Biochemical Research Methods

Challenges and opportunities for the next generation of cardiovascular tissue engineering

Sangkyun Cho et al.

Summary: This Perspective discusses the technologies and challenges in cardiac tissue engineering, and proposes strategies to overcome these challenges. Engineered cardiac tissues derived from human induced pluripotent stem cells offer unique opportunities for personalized disease modeling, drug discovery, and cardiac repair. However, there are still major obstacles to be addressed before the field can move towards commercial and clinical translation.

NATURE METHODS (2022)

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Review Multidisciplinary Sciences

A coalition to heal-the impact of the cardiac microenvironment

Eldad Tzahor et al.

Summary: Heart regenerative medicine challenges the traditional view of the heart as a non-regenerative organ, highlighting the importance of cellular communication between different cardiac cell types. Specific therapies are being developed to target the hostile cardiac environment under pathological conditions.

SCIENCE (2022)

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Review Cardiac & Cardiovascular Systems

AAV-mediated gene therapy: Advancing cardiovascular disease treatment

Huili Zhang et al.

Summary: Gene therapy has brought significant advancements to the field of medicine, offering hope for patients with various diseases. Adeno-associated virus (AAV) has shown great potential as a treatment tool due to its safety, sustainable gene expression, and low immunogenicity, especially in the field of cardiovascular disease.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

Chemical and mechanical activation of resident cardiac macrophages in the living myocardial slice ex vivo model

F. J. G. Waleczek et al.

Summary: Resident cardiac macrophages (rcMACs) exhibit plasticity and activation in response to changes in the microenvironment, which is essential for in vitro experimentation. The ex vivo model of living myocardial slices (LMS) provides a tool to investigate rcMACs response to immunomodulatory and mechanical stimulations without the interference of other cells. The study identified potential marker genes for inflammation in rcMACs and microRNAs associated with transcriptomic changes, contributing to the understanding of load-triggered cardiac inflammation.

BASIC RESEARCH IN CARDIOLOGY (2022)

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Article Multidisciplinary Sciences

Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy

Mark Chaffin et al.

Summary: The study identified extensive molecular alterations in failing hearts through single-nucleus RNA sequencing, including changes in transcriptional profiles and the presence of a unique population of activated fibroblasts that are almost absent from non-failing samples. The findings provide new insights into the transcriptional diversity of the human heart in health and disease, as well as potential therapeutic targets and biomarkers for heart failure.

NATURE (2022)

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Review Physiology

CARDIAC MECHANO-ELECTRIC COUPLING: ACUTE EFFECTS OF MECHANICAL STIMULATION ON HEART RATE AND RHYTHM

T. Alexander Quinn et al.

Summary: The heart is crucial for biological function and its continuous beating requires precise coordination of billions of cells. Mechano-electric coupling plays a key role in regulating cardiac function, providing acute beat-by-beat feedback from the local mechanical environment to electrical activity. This process is essential for understanding both healthy and diseased states of the heart.

PHYSIOLOGICAL REVIEWS (2021)

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Review Biotechnology & Applied Microbiology

Uncovering an Organ's Molecular Architecture at Single-Cell Resolution by Spatially Resolved Transcriptomics

Jie Liao et al.

Summary: Spatially resolved transcriptomics techniques provide near-single-cell or even subcellular resolution within tissues, revealing fine-scale cellular heterogeneity and the functional and structural foundations of tissue architecture. Mapping the whole 3D transcriptional landscape of tissues with position-coordinating labels enables massive information across higher dimensions.

TRENDS IN BIOTECHNOLOGY (2021)

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Review Biology

Integration of substrate- and flow-derived stresses in endothelial cell mechanobiology

Claire A. Dessalles et al.

Summary: In this review, Dessalles and colleagues examine how vascular endothelial cells respond to mechanical forces from blood flow and physical contact with the basement membrane. They focus on how endothelial cells integrate and interpret different mechanical cues simultaneously, highlighting the importance of understanding these complex interactions in health and disease. The authors also discuss the challenges and open questions in the field of endothelial cell mechanobiology.

COMMUNICATIONS BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

MicroRNAs: New contributors to mechano-electric coupling and atrial fibrillation

Flavia Ravelli et al.

Summary: Atrial fibrillation is a multifactorial disease that often occurs in the presence of underlying cardiac abnormalities and is supported by electrophysiological and structural alterations. MicroRNAs are emerging as potential regulators in the pathogenesis of AF, particularly in modulating atrial electrical and structural remodeling. Abnormal substrates in various conditions such as hypertension, heart failure, obesity, and sleep apnea contribute to the predisposition to AF.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Mechanism and potential treatment of the no reflow phenomenon after acute myocardial infarction: role of pericytes and GPR39

Carmen Methner et al.

Summary: The no reflow phenomenon following treatment of acute myocardial infarction is associated with worse outcomes, with the mechanism remaining unknown. This study demonstrates that GPR39-mediated pericyte contraction during reduced coronary perfusion pressure leads to capillary constriction and subsequent no reflow. Smaller no reflow zones in GPR39-knockout animals and those treated with a GPR39 inhibitor are associated with reduced infarct size, indicating potential therapeutic implications.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Beat-by-Beat Cardiomyocyte T-Tubule Deformation Drives Tubular Content Exchange

Eva A. Rog-Zielinska et al.

Summary: The sarcolemma of cardiomyocytes contains important proteins essential for electromechanical function, with TT playing a crucial role in supporting electromechanical synchronicity within cells. This study suggests the presence of an advective component to TT content exchange, which assists in equilibration with bulk extracellular fluid. The mechanical state of cardiomyocytes affects the speed of diffusion within TT, with cyclic contractile activity accelerating TT diffusion dynamics.

CIRCULATION RESEARCH (2021)

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Article Biochemistry & Molecular Biology

A single-cell atlas of chromatin accessibility in the human genome

Kai Zhang et al.

Summary: This study utilized single-cell chromatin accessibility assays to analyze gene regulatory elements in diverse cell types and tissues in the human body, integrating data from adult and fetal tissue to reveal the specificity of cCREs in 222 distinct cell types. The findings provide a foundation for understanding gene regulatory programs across tissues, life stages, and organ systems in humans.

CELL (2021)

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Article Cardiac & Cardiovascular Systems

Autocrine Signaling in Cardiac Remodeling: A Rich Source of Therapeutic Targets

Vincent F. M. Segers et al.

Summary: The myocardium is composed of different cell types, including endothelial cells, cardiomyocytes, and fibroblasts, and communication between these cells is crucial for normal cardiac function. Studies have shown that many ligand-receptor pairs are present in most heart cells, indicating that autocrine signaling is a widespread phenomenon in cardiac remodeling and heart failure. Autocrine signaling is involved in various pathophysiological mechanisms observed in myocardial biology and disease, highlighting its essential role in heart health.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Article Cardiac & Cardiovascular Systems

HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling

Joshua G. Travers et al.

Summary: The study demonstrates the therapeutic potential of HDAC inhibition in reversing diastolic dysfunction and uncovers a new mechanism of cardiac fibrosis. The importance of evaluating cardiac fibrosis using diverse methodologies is highlighted through this research.

CIRCULATION (2021)

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Article Cardiac & Cardiovascular Systems

Proximity to injury, but neither number of nuclei nor ploidy define pathological adaptation and plasticity in cardiomyocytes

Michael Hesse et al.

Summary: Researchers investigated transcriptomes and cellular features of mononuclear and binuclear cardiomyocytes in adult mouse hearts, finding that mononuclear cardiomyocytes generally had a higher ploidy level. However, gene expression profiles and injury responses in cardiomyocytes were independent of the number of nuclei or ploidy levels.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Diabetes changes gene expression but not DNA methylation in cardiac cells

Achim Lother et al.

Summary: Diabetes affects gene expression and DNA methylation in cardiac cells, with stable methylation patterns despite changes in gene expression. Cell type-specific analysis reveals differentially regulated gene programs associated with distinct biological processes in diabetes, highlighting the importance of fibroblast and monocyte interactions in the diabetic heart.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2021)

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Review Cardiac & Cardiovascular Systems

The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy

Nicolas Ricard et al.

Summary: Endothelial cells play a crucial role in controlling oxygen, nutrient exchange, and cellular trafficking between blood and organs. The quiescent state of endothelium is actively regulated and constantly receives important signalling inputs. Understanding organ-specific pathways and their disruption in vascular pathologies can lead to the development of preventive strategies and new therapeutic targets.

NATURE REVIEWS CARDIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia

Tania Martins-Marques et al.

Summary: Cell-to-cell communication plays a crucial role in maintaining tissue homeostasis, and disruptions in this communication have been implicated in harmful consequences of heart ischemia and reperfusion, such as arrhythmias and heart failure. Targeting intercellular communication mechanisms may offer potential therapeutic strategies to prevent or repair these consequences and restore myocardial function.

TRENDS IN MOLECULAR MEDICINE (2021)

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Article Cell Biology

PDGFRb+ mesenchymal cells, but not NG2+ mural cells, contribute to cardiac fat

Zhen Jiang et al.

Summary: Studies have shown that cardiac mesenchymal cells (MCs) contribute to the formation of cardiac adipocytes (CAs), with PDGFRb(+) MCs identified as the major source. PDGFRb(+) cells are heterogeneous, and PDGFRa(+)PDGFRb(+) double-positive periendothelial fibroblasts play a significant role in contributing to intramyocardial adipocytes.

CELL REPORTS (2021)

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Review Cardiac & Cardiovascular Systems

Intrinsic cardiac autonomic nervous system: What do clinical electrophysiologists need to know about the heart brain?

Tolga Aksu et al.

Summary: The autonomic nervous system plays a major role in cardiac arrhythmias, with extrinsic and intrinsic parts affecting cardiac function. Catheter-based modulation of the intrinsic cardiac ANS is emerging as a novel therapy, but the distribution and functional properties of intrinsic cardiac neural elements are still not well understood. This review aims to integrate clinical and anatomical elements to guide clinical electrophysiologists and serve as a reference for further research.

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Periostin-expressing Schwann cells and endoneurial cardiac fibroblasts contribute to sympathetic nerve fasciculation after birth

Luis Hortells et al.

Summary: This study investigates the origins, heterogeneity, and functions of cardiac SC and ECF during postnatal ICNS maturation, revealing different embryonic origins of these cells. Ablation of Postn+ cells leads to reduced fasciculation of cardiac sympathetic nerves, highlighting the importance of these cells in nerve development.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2021)

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Article Multidisciplinary Sciences

Spatiotemporal single-cell RNA sequencing of developing chicken hearts identifies interplay between cellular differentiation and morphogenesis

Madhav Mantri et al.

Summary: By utilizing single-cell and spatial transcriptomics in chicken hearts, the authors conducted a census of cellular interactions from early to late four-chambered heart stage, identifying a distinct epicardial-mesenchymal cell population with a migratory phenotype.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis

Jamie Francisco et al.

Summary: Fibrosis is a hallmark of heart disease and the mechanisms that regulate fibroblast differentiation and fibrotic responses are not fully understood. Studies show that overexpression of YAP in cardiac fibroblasts can lead to increased fibrosis and inflammation, negatively impacting cardiac function.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Cardiac cell type-specific gene regulatory programs and disease risk association

James D. Hocker et al.

Summary: This study identified cCREs in the human heart and found their associations with cardiac cell types and heart failure. It also discovered that genetic variants associated with cardiovascular diseases are enriched within these cCREs, with some potentially linked to atrial fibrillation.

SCIENCE ADVANCES (2021)

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Review Biochemistry & Molecular Biology

Fibroblasts: Origins, definitions, and functions in health and disease

Maksim Plikus et al.

Summary: Fibroblasts are diverse mesenchymal cells that play a role in tissue homeostasis and disease, producing complex extracellular matrix and creating signaling niches. They are transcriptionally and functionally heterogeneous across and within organs, encoding positional information and maintaining distinct cellular progeny. Their unique properties make them poised for tissue repair but can also drive fibrotic disorders if activated aberrantly.

CELL (2021)

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Article Biotechnology & Applied Microbiology

Noncoding RNA therapeutics - challenges and potential solutions

Melanie Winkle et al.

Summary: In recent years, RNA-based therapies have gained FDA approval, but there are still challenges in targeting ncRNAs. Therapeutic targeting of noncoding RNAs has the potential to become a new approach for treating diseases such as cancer.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Physiology

CARDIAC TRANSMEMBRANE ION CHANNELS AND ACTION POTENTIALS: CELLULAR PHYSIOLOGY AND ARRHYTHMOGENIC BEHAVIOR

Andras Varro et al.

Summary: Cardiac arrhythmias often stem from changes in the electro-physiological properties of cardiac cells and their ionic mechanisms. Understanding the pathophysiology of human cellular electrophysiology can aid in developing novel antiarrhythmic strategies.

PHYSIOLOGICAL REVIEWS (2021)

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Article Multidisciplinary Sciences

Mechanical forces regulate endothelial-to-mesenchymal transition and atherosclerosis via an Alk5-Shc mechanotransduction pathway

Vedanta Mehta et al.

Summary: The response of endothelial cells to mechanical forces plays a critical role in vascular health, and vascular pathologies may lead to endothelial-to-mesenchymal transition. This study identifies a unique mechanoreceptor, Alk5, and an Alk5-Shc pathway that are crucial for EndMT and atherosclerosis.

SCIENCE ADVANCES (2021)

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Article Cardiac & Cardiovascular Systems

Single-Cell RNA Sequencing of the Adult Mammalian Heart-State-of-the-Art and Future Perspectives

Monika M. Gladka

Summary: The application of scRNA-seq in cardiovascular research is growing, offering detailed insights into cardiac pathophysiology.

CURRENT HEART FAILURE REPORTS (2021)

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Review Oncology

Recent advances and discoveries in the mechanisms and functions of CAR T cells

Rebecca C. Larson et al.

Summary: This review summarizes the major advances that have been made in the efficacy and safety of CAR T cell therapies over the past 3 years and looks ahead to new findings that will impact the future of this immunotherapy.

NATURE REVIEWS CANCER (2021)

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Article Cardiac & Cardiovascular Systems

Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study

Jorg Taubel et al.

Summary: The study evaluated the safety and mechanism of action of CDR132L in patients with chronic ischemic heart failure, showing that CDR132L is safe and well tolerated, effectively reducing miR-132 levels and improving cardiac function.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study

Jorg Taubel et al.

Summary: The first-in-class miR-132 inhibitor, CDR132L, showed good safety and tolerability in HF patients. It effectively reduced miR-132 levels, decreased NT-proBNP levels, and potentially improved cardiac function.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Cardiac sympathetic nerve transdifferentiation reduces action potential heterogeneity after myocardial infarction

Lianguo Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

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Review Cardiac & Cardiovascular Systems

Myocardial slices come to age: an intermediate complexity in vitro cardiacmodel for translational research

Fotios G. Pitoulis et al.

CARDIOVASCULAR RESEARCH (2020)

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Review Cardiac & Cardiovascular Systems

The Role of the Epicardium During Heart Development and Repair

Pearl Quijada et al.

CIRCULATION RESEARCH (2020)

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Review Cardiac & Cardiovascular Systems

The Control of Diastolic Calcium in the Heart Basic Mechanisms and Functional Implications

David A. Eisner et al.

CIRCULATION RESEARCH (2020)

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Review Cardiac & Cardiovascular Systems

Cellular cross-talks in the diseased and aging heart

Julian U. G. Wagner et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Dissection of heterocellular cross-talk in vascularized cardiac tissue mimetics

Julian Uwe Gabriel Wagner et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

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Article Neurosciences

Mechano-electric and mechano-chemo-transduction in cardiomyocytes

Leighton T. Izu et al.

JOURNAL OF PHYSIOLOGY-LONDON (2020)

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Article Biochemistry & Molecular Biology

Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy

A. Moretti et al.

NATURE MEDICINE (2020)

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Review Physiology

CONNEXINS: KEY PLAYERS IN THE CONTROL OF VASCULAR PLASTICITY AND FUNCTION

Ulrich Pohl

PHYSIOLOGICAL REVIEWS (2020)

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Article Cell Biology

HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction

Markus Wallner et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Review Biotechnology & Applied Microbiology

Engineering Targeting Materials for Therapeutic Cancer Vaccines

Priscilla S. Briquez et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Review Biochemistry & Molecular Biology

Targeting Strategies for Tissue-Specific Drug Delivery

Zongmin Zhao et al.

CELL (2020)

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Article Biology

Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

Ankit Jambusaria et al.

ELIFE (2020)

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Article Multidisciplinary Sciences

ATP- and voltage-dependent electro-metabolic signaling regulates blood flow in heart

Guiling Zhao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Physiology

The Lectin LecA Sensitizes the Human Stretch-Activated Channel TREK-1 but Not Piezo1 and Binds Selectively to Cardiac Non-myocytes

Elisa Darkow et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Review Physiology

Mechanisms Ensuring Endothelial Junction Integrity Beyond VE-Cadherin

Cao Nguyen Duong et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Article Medicine, General & Internal

Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol

Kausik K. Ray et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Cardiac & Cardiovascular Systems

Basic and Therapeutic Aspects of Angiogenesis Updated

Guy Eelen et al.

CIRCULATION RESEARCH (2020)

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Article Multidisciplinary Sciences

A Comprehensive Integrated Anatomical and Molecular Atlas of Rat Intrinsic Cardiac Nervous System

Sirisha Achanta et al.

ISCIENCE (2020)

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Article Endocrinology & Metabolism

Vascular endothelial growth factor B promotes transendothelial fatty acid transport into skeletal muscle via histone modifications during catch-up growth

Xiaodan Lu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2020)

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Article Biochemistry & Molecular Biology

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

Jose A. Nicolas-Avila et al.

CELL (2020)

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Article Multidisciplinary Sciences

A non-invasive far-red light-induced split-Cre recombinase system for controllable genome engineering in mice

Jiali Wu et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Cells of the adult human heart

Monika Litvinukova et al.

NATURE (2020)

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Review Physiology

Nitric Oxide and Mechano-Electrical Transduction in Cardiomyocytes

Hannah E. Boycott et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Review Immunology

Role of Vascular Smooth Muscle Cell Plasticity and Interactions in Vessel Wall Inflammation

Vitaly Sorokin et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Cardiac & Cardiovascular Systems

Autoregulation of Coronary Blood Supply in Response to Demand JACC Review Topic of the Week

Nils P. Johnson et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Article Mathematical & Computational Biology

A curated database reveals trends in single-cell transcriptomics

Valentine Svensson et al.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2020)

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Review Cardiac & Cardiovascular Systems

Biomarkers for the identification of cardiac fibroblast and myofibroblast cells

Emiri Tarbit et al.

HEART FAILURE REVIEWS (2019)

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Article Biochemistry & Molecular Biology

Endothelial cell-secreted MIF reduces pericyte contractility and enhances neutrophil extravasation

Amanda S. Pellowe et al.

FASEB JOURNAL (2019)

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Article Endocrinology & Metabolism

Endothelial cell mineralocorticoid receptors oppose VEGF-induced gene expression and angiogenesis

Achim Lother et al.

JOURNAL OF ENDOCRINOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Myocardial Slices: an Intermediate Complexity Platform for Translational Cardiovascular Research

Samuel A. Watson et al.

CARDIOVASCULAR DRUGS AND THERAPY (2019)

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Article Cardiac & Cardiovascular Systems

Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis

Carmen Methner et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2019)

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Article Neurosciences

Cardiac sympathetic innervation network shapes the myocardium by locally controlling cardiomyocyte size through the cellular proteolytic machinery

Nicola Pianca et al.

JOURNAL OF PHYSIOLOGY-LONDON (2019)

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Review Genetics & Heredity

Single-Cell RNA-Seq Technologies and Related Computational Data Analysis

Geng Chen et al.

FRONTIERS IN GENETICS (2019)

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Article Cardiac & Cardiovascular Systems

Myocardial ischemia: lack of coronary blood flow, myocardial oxygen supply-demand imbalance, or what?

Gerd Heusch

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2019)

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Review Cardiac & Cardiovascular Systems

The Extracellular Matrix in Ischemic and Nonischemic Heart Failure

Nikolaos G. Frangogiannis

CIRCULATION RESEARCH (2019)

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Review Developmental Biology

The evolving concept of cell identity in the single cell era

Samantha A. Morris

DEVELOPMENT (2019)

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Review Genetics & Heredity

RNA sequencing: the teenage years

Rory Stark et al.

NATURE REVIEWS GENETICS (2019)

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Article Multidisciplinary Sciences

Targeting cardiac fibrosis with engineered T cells

Haig Aghajanian et al.

NATURE (2019)

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Editorial Material Hematology

Endothelial Response to Pathophysiological Stress

Zekun Peng et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

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Review Cardiac & Cardiovascular Systems

Coronary microvascular obstruction: the new frontier in cardioprotection

Gerd Heusch

BASIC RESEARCH IN CARDIOLOGY (2019)

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Article Biochemistry & Molecular Biology

A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart

Michaela Asp et al.

CELL (2019)

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Review Physiology

CARDIAC DISORDERS AND PATHOPHYSIOLOGY OF SARCOMERIC PROTEINS

Jolanda van der Velden et al.

PHYSIOLOGICAL REVIEWS (2019)

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Article Hematology

Cardiac Endothelial Cell Transcriptome

Achim Lother et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

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Article Peripheral Vascular Disease

Selective Mineralocorticoid Receptor Cofactor Modulation as Molecular Basis for Finerenone's Antifibrotic Activity

Jana Grune et al.

HYPERTENSION (2018)

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Editorial Material Cardiac & Cardiovascular Systems

Dynamics of fibroblast activation in the infarcted heart

Alexandra Le Bras

NATURE REVIEWS CARDIOLOGY (2018)

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Review Cardiac & Cardiovascular Systems

Epicardial Adipose Tissue May Mediate Deleterious Effects of Obesity and Inflammation on the Myocardium

Milton Packer

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Review Cardiac & Cardiovascular Systems

Mechanisms of physiological and pathological cardiac hypertrophy

Michinari Nakamura et al.

NATURE REVIEWS CARDIOLOGY (2018)

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Review Cardiac & Cardiovascular Systems

The epicardium as a hub for heart regeneration

Jingli Cao et al.

NATURE REVIEWS CARDIOLOGY (2018)

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Article Medicine, General & Internal

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

D. Adams et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Multidisciplinary Sciences

Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo

Ralf Gilsbach et al.

NATURE COMMUNICATIONS (2018)

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Article Multidisciplinary Sciences

Arrhythmogenicity of fibro-fatty infiltrations

Tim De Coster et al.

SCIENTIFIC REPORTS (2018)

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Article Cell Biology

Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart

Daniel A. Skelly et al.

CELL REPORTS (2018)

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Article Cardiac & Cardiovascular Systems

In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia

Xiaolu Pan et al.

CIRCULATION RESEARCH (2018)

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Article Medicine, Research & Experimental

Endothelial cell CD36 optimizes tissue fatty acid uptake

Ni-Huiping Son et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Article Hematology

Endothelial-Specific Cre Mouse Models: Is Your Cre CREdibile?

Sophie Payne et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

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Article Multidisciplinary Sciences

Potassium channel-based optogenetic silencing

Yinth Andrea Bernal Sierra et al.

NATURE COMMUNICATIONS (2018)

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Review Physiology

Linking Arrhythmias and Adipocytes: Insights, Mechanisms, and Future Directions

Maria A. Pabon et al.

FRONTIERS IN PHYSIOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

Electrical coupling between ventricular myocytes and myofibroblasts in the infarcted mouse heart

Michael Rubart et al.

CARDIOVASCULAR RESEARCH (2018)

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Article Medicine, Research & Experimental

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

Xing Fu et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Article Cardiac & Cardiovascular Systems

An autofluorescence-based method for the isolation of highly purified ventricular cardiomyocytes

Veronica Larcher et al.

CARDIOVASCULAR RESEARCH (2018)

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Review Immunology

Cardioimmunology: the immune system in cardiac homeostasis and disease

Filip K. Swirski et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Review Physiology

Endothelial dysfunction and vascular disease - a 30th anniversary update

P. M. Vanhoutte et al.

ACTA PHYSIOLOGICA (2017)

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Review Neurosciences

Cardiac sympathetic innervation, from a different point of (re)view

Tania Zaglia et al.

JOURNAL OF PHYSIOLOGY-LONDON (2017)

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Review Neurosciences

The role of epicardial adipose tissue in cardiac biology: classic concepts and emerging roles

Alexios S. Antonopoulos et al.

JOURNAL OF PHYSIOLOGY-LONDON (2017)

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Review Cardiac & Cardiovascular Systems

Redefining the identity of cardiac fibroblasts

Michelle D. Tallquist et al.

NATURE REVIEWS CARDIOLOGY (2017)

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Review Cell Biology

Vascular heterogeneity and specialization in development and disease

Michael Potente et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

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Review Pharmacology & Pharmacy

Contribution of pericyte paracrine regulation of the endothelium to angiogenesis

A. Caporali et al.

PHARMACOLOGY & THERAPEUTICS (2017)

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Article Cell Biology

BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure

Qiming Duan et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

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Article Biology

The Human Cell Atlas

Aviv Regev et al.

ELIFE (2017)

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Article Biology

Capillary pericytes mediate coronary no-reflow after myocardial ischaemia

Fergus M. O'Farrell et al.

ELIFE (2017)

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Review Cardiac & Cardiovascular Systems

Cardiovascular Adverse Events in Patients With Cancer Treated With Bevacizumab: A Meta-Analysis of More Than 20 000 Patients

Matthias Totzeck et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2017)

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Article Cardiac & Cardiovascular Systems

Multicellular Transcriptional Analysis of Mammalian Heart Regeneration

Gregory A. Quaife-Ryan et al.

CIRCULATION (2017)

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Article Cardiac & Cardiovascular Systems

Cardiomyocyte Regeneration A Consensus Statement

Thomas Eschenhagen et al.

CIRCULATION (2017)

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Review Cardiac & Cardiovascular Systems

Multimodal Regulation of Cardiac Myocyte Proliferation

Xuejun Yuan et al.

CIRCULATION RESEARCH (2017)

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Article Cardiac & Cardiovascular Systems

Increased collagen within the transverse tubules in human heart failure

David J. Crossman et al.

CARDIOVASCULAR RESEARCH (2017)

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Review Cardiac & Cardiovascular Systems

Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heartd

Cinzia Perrino et al.

CARDIOVASCULAR RESEARCH (2017)

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Article Biochemistry & Molecular Biology

Macrophages Facilitate Electrical Conduction in the Heart

Maarten Hulsmans et al.

CELL (2017)

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Article Cardiac & Cardiovascular Systems

Revisiting Cardiac Cellular Composition

Alexander R. Pinto et al.

CIRCULATION RESEARCH (2016)

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Editorial Material Endocrinology & Metabolism

What is a pericyte?

David Attwell et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2016)

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Article Cardiac & Cardiovascular Systems

Defining the major health modifiers causing atrial fibrillation: a roadmap to underpin personalized prevention and treatment

Larissa Fabritz et al.

NATURE REVIEWS CARDIOLOGY (2016)

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Article Biochemistry & Molecular Biology

The molecular and functional identities of atrial cardiomyocytes in health and disease

Soren Brandenburg et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

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Review Cardiac & Cardiovascular Systems

Cardiac Mechano-Gated Ion Channels and Arrhythmias

Remi Peyronnet et al.

CIRCULATION RESEARCH (2016)

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Review Cardiac & Cardiovascular Systems

Cardiac Fibrosis The Fibroblast Awakens

Joshua G. Travers et al.

CIRCULATION RESEARCH (2016)

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Article Cell Biology

Single-Cell Resolution of Temporal Gene Expression during Heart Development

Daniel M. DeLaughter et al.

DEVELOPMENTAL CELL (2016)

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Article Cell Biology

Transcriptomic Profiling Maps Anatomically Patterned Subpopulations among Single Embryonic Cardiac Cells

Guang Li et al.

DEVELOPMENTAL CELL (2016)

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Article Endocrinology & Metabolism

PGC-1α Coordinates Mitochondrial Respiratory Capacity and Muscular Fatty Acid Uptake via Regulation of VEGF-B

Annika Mehlem et al.

DIABETES (2016)

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Review Cell Biology

Genetic tools for identifying and manipulating fibroblasts in the mouse

Jessica M. Swonger et al.

DIFFERENTIATION (2016)

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Article Biochemistry & Molecular Biology

Systemic injection of AAV9 carrying a periostin promoter targets gene expression to a myofibroblast-like lineage in mouse hearts after reperfused myocardial infarction

B. A. Piras et al.

GENE THERAPY (2016)

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Article Medicine, Research & Experimental

Axial tubule junctions control rapid calcium signaling in atria

Soeren Brandenburg et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Review Pharmacology & Pharmacy

Pharmacology of heart failure: From basic science to novel therapies

Achim Lother et al.

PHARMACOLOGY & THERAPEUTICS (2016)

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Article Multidisciplinary Sciences

Electrotonic coupling of excitable and nonexcitable cells in the heart revealed by optogenetics

T. Alexander Quinn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Review Pharmacology & Pharmacy

Discovering cardiac pericyte biology: From physiopathological mechanisms to potential therapeutic applications in ischemic heart disease

Elisa Avolio et al.

VASCULAR PHARMACOLOGY (2016)

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Article Multidisciplinary Sciences

Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells

Qi Chen et al.

NATURE COMMUNICATIONS (2016)

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Article Multidisciplinary Sciences

Genetic lineage tracing defines myofibroblast origin and function in the injured heart

Onur Kanisicak et al.

NATURE COMMUNICATIONS (2016)

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Review Pharmacology & Pharmacy

Plasma vs heart tissue concentration in humans - literature data analysis of drugs distribution

Zofia Tylutki et al.

BIOPHARMACEUTICS & DRUG DISPOSITION (2015)

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Review Cardiac & Cardiovascular Systems

Gene therapy for cardiovascular disease: advances in vector development, targeting, and delivery for clinical translation

Melvin Y. Rincon et al.

CARDIOVASCULAR RESEARCH (2015)

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Article Biochemistry & Molecular Biology

No Evidence for Cardiomyocyte Number Expansion in Preadolescent Mice

Kanar Alkass et al.

CELL (2015)

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Article Biochemistry & Molecular Biology

Dynamics of Cell Generation and Turnover in the Human Heart

Olaf Bergmann et al.

CELL (2015)

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Article Cardiac & Cardiovascular Systems

Meox2/Tcf15 Heterodimers Program the Heart Capillary Endothelium for Cardiac Fatty Acid Uptake

Giulia Coppiello et al.

CIRCULATION (2015)

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Article Cardiac & Cardiovascular Systems

Deciphering the Epigenetic Code of Cardiac Myocyte Transcription

Sebastian Preissl et al.

CIRCULATION RESEARCH (2015)

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Article Biochemistry & Molecular Biology

Defining cell types and states with single-cell genomics

Cole Trapnell

GENOME RESEARCH (2015)

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Article Cell Biology

The volumes and transcript counts of single cells reveal concentration homeostasis and capture biological noise

Hermannus Kempe et al.

MOLECULAR BIOLOGY OF THE CELL (2015)

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Review Cell Biology

The selection and function of cell type-specific enhancers

Sven Heinz et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)

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Article Multidisciplinary Sciences

A draft network of ligand-receptor-mediated multicellular signalling in human

Jordan A. Ramilowski et al.

NATURE COMMUNICATIONS (2015)

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Review Pharmacology & Pharmacy

Advances and Challenges of Liposome Assisted Drug Delivery

Lisa Sercombe et al.

FRONTIERS IN PHARMACOLOGY (2015)

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Review Biochemistry & Molecular Biology

Mechanical Stretch-Induced Activation of ROS/RNS Signaling in Striated Muscle

Christopher W. Ward et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

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Editorial Material Cardiac & Cardiovascular Systems

Heterocellular signalling and crosstalk in the heart in ischaemia and heart failure

Emilio Hirsch et al.

CARDIOVASCULAR RESEARCH (2014)

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Review Cardiac & Cardiovascular Systems

Angiogenesis and Cardiac Hypertrophy Maintenance of Cardiac Function and Causative Roles in Heart Failure

Toru Oka et al.

CIRCULATION RESEARCH (2014)

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Article Cardiac & Cardiovascular Systems

Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction

Timo Heidt et al.

CIRCULATION RESEARCH (2014)

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Article Medicine, Research & Experimental

VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

Riikka Kivela et al.

EMBO MOLECULAR MEDICINE (2014)

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Article Immunology

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

Slava Epelman et al.

IMMUNITY (2014)

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Article Biophysics

Biomechanics of Cardiac Electromechanical Coupling and Mechanoelectric Feedback

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JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME (2014)

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Progressive replacement of embryo-derived cardiac macrophages with age

Kaaweh Molawi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

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Editorial Material Cardiac & Cardiovascular Systems

Structural and Functional Recoupling of Atrial and Ventricular Myocardium New Conduits for Electrical Flow

Peter Kohl

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)

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Article Cardiac & Cardiovascular Systems

Engineered Electrical Conduction Tract Restores Conduction in Complete Heart Block From In Vitro to In Vivo Proof of Concept

Eugenio Cingolani et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)

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Article Biochemistry & Molecular Biology

An emerging consensus on cardiac regeneration

Jop H. van Berlo et al.

NATURE MEDICINE (2014)

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Article Multidisciplinary Sciences

Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease

Ralf Gilsbach et al.

NATURE COMMUNICATIONS (2014)

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Review Cardiac & Cardiovascular Systems

Cardiac Metabolism in Heart Failure Implications Beyond ATP Production

Torsten Doenst et al.

CIRCULATION RESEARCH (2013)

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Review Cardiac & Cardiovascular Systems

Regulation of Endothelial Cell Differentiation and Specification

Kathrina L. Marcelo et al.

CIRCULATION RESEARCH (2013)

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Article Cardiac & Cardiovascular Systems

Rearrangement of Atrial Bundle Architecture and Consequent Changes in Anisotropy of Conduction Constitute the 3-Dimensional Substrate for Atrial Fibrillation

Bart Maesen et al.

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2013)

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Article Cell Biology

Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration

Daniel J. Nolan et al.

DEVELOPMENTAL CELL (2013)

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Article Multidisciplinary Sciences

Kissing and nanotunneling mediate intermitochondrial communication in the heart

Xiaohu Huang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Hematology

Smooth Muscle Phenotypic Modulation-A Personal Experience

Julie H. Campbell et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)

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Review Cardiac & Cardiovascular Systems

Cardiac-Specific Inducible and Conditional Gene Targeting in Mice

Thomas Doetschman et al.

CIRCULATION RESEARCH (2012)

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Article Multidisciplinary Sciences

The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy

Ahmet Ucar et al.

NATURE COMMUNICATIONS (2012)

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Review Cell Biology

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

Annika Armulik et al.

DEVELOPMENTAL CELL (2011)

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Article Cardiac & Cardiovascular Systems

Immunohistochemical characterization of the intrinsic cardiac neural plexus in whole-mount mouse heart preparations

Kristina Rysevaite et al.

HEART RHYTHM (2011)

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Article Cardiac & Cardiovascular Systems

Adult human heart slices are a multicellular system suitable for electrophysiological and pharmacological studies

Patrizia Camelliti et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2011)

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Review Cell Biology

Differential gene expressions in atrial and ventricular myocytes: insights into the road of applying embryonic stem cell-derived cardiomyocytes for future therapies

Sze Ying Ng et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2010)

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Review Cardiac & Cardiovascular Systems

Epicardial-Myocardial Signaling Directing Coronary Vasculogenesis

Harold E. Olivey et al.

CIRCULATION RESEARCH (2010)

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Article Multidisciplinary Sciences

Vascular endothelial growth factor B controls endothelial fatty acid uptake

Carolina E. Hagberg et al.

NATURE (2010)

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Review Cardiac & Cardiovascular Systems

Vascular control in humans: focus on the coronary microcirculation

Yanping Liu et al.

BASIC RESEARCH IN CARDIOLOGY (2009)

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Article Cardiac & Cardiovascular Systems

Axial Stretch of Rat Single Ventricular Cardiomyocytes Causes an Acute and Transient Increase in Ca2+ Spark Rate

Gentaro Iribe et al.

CIRCULATION RESEARCH (2009)

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Review Physiology

Regulation of coronary blood flow during exercise

Dirk J. Duncker et al.

PHYSIOLOGICAL REVIEWS (2008)

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Article Cardiac & Cardiovascular Systems

Determination of cell types and numbers during cardiac development in the neonatal and adult rat and mouse

Indroneal Banerjee et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)

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Article Biochemistry & Molecular Biology

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

Elisabeth M. Zeisberg et al.

NATURE MEDICINE (2007)

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Article Cardiac & Cardiovascular Systems

Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation

P Kohl et al.

JOURNAL OF ELECTROCARDIOLOGY (2005)

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Article Cell Biology

Propagation of Ca2+ release in cardiac myocytes:: Role of mitochondria

H Seguchi et al.

CELL CALCIUM (2005)

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Article Cardiac & Cardiovascular Systems

Myocardial contraction is 5-fold more economical in ventricular than in atrial human tissue

NA Narolska et al.

CARDIOVASCULAR RESEARCH (2005)

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Review Cardiac & Cardiovascular Systems

Structural and functional characterisation of cardiac fibroblasts

P Camelliti et al.

CARDIOVASCULAR RESEARCH (2005)

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Article Cardiac & Cardiovascular Systems

Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin

G Gaudesius et al.

CIRCULATION RESEARCH (2003)

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Review Multidisciplinary Sciences

Cardiac excitation-contraction coupling

DM Bers

NATURE (2002)

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Article Biophysics

Transport of Ca2+ from sarcoplasmic reticulum to mitochondria in rat ventricular myocytes

VK Sharma et al.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2000)

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