期刊
CHEMICAL COMMUNICATIONS
卷 59, 期 65, 页码 9900-9903出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3cc02423g
关键词
-
A Lewis-acid-mediated azidation of C2-substituted glycals with high regio- and stereoselectivity is described. This method offers excellent, scalable, and mild reaction conditions for introducing the azido group at the C3-position of various C2-substituted glycals. The electron-withdrawing nature of the C2-substituent is found to be crucial for the C3-selectivity. The installed azido group can be used for the synthesis of various C3-glycoconjugates and α-chiral azido naphthalene polyols.
A Lewis-acid-mediated highly regio- and stereoselective chiral azidation of C2-substituted glycals is reported. This strategy provides excellent, scalable, and mild reaction conditions for the stereoselective introduction of the azido group at the C3-position of various C2-substituted glycals. The reactivity of the various glycals reveals that the electron-withdrawing behavior of the C2-group is crucial for C3-selectivity. The newly installed azido group was used as a handle for the synthesis of various C3-glycoconjugates and & alpha;-chiral azido naphthalene polyols.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据