期刊
JAPANESE DENTAL SCIENCE REVIEW
卷 59, 期 -, 页码 181-190出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jdsr.2023.06.005
关键词
Biomineralization; Calcium phosphate; Endoplasmic Reticulum; Mitochondria; Matrix vesicles; Extracellular matrix
Biomineralization is a regulated process involving intracellular processes and extracellular deposition of calcium phosphate particles. Recent studies have made progress in understanding the dynamic formation of amorphous calcium phosphate precursors and their relationship with physicochemical structure development. However, the precise mechanisms and integration with extracellular mineralization remain unclear.
Biomineralization is a highly regulated process that results in the deposition of minerals in a precise manner, ultimately producing skeletal and dental hard tissues. Recent studies have highlighted the crucial role played by intracellular processes in initiating biomineralization. These processes involve various organelles, such as the endoplasmic reticulum(ER), mitochondria, and lysosomes, in the formation, accumulation, maturation, and secretion of calcium phosphate (CaP) particles. Particularly, the recent in-depth study of the dynamic process of the formation of amorphous calcium phosphate(ACP) precursors among organelles has made great progress in the development of the integrity of the biomineralization chain. However, the precise mechanisms underlying these intracellular processes remain unclear, and they cannot be fully integrated with the extracellular mineralization mechanism and the physicochemical structure development of the mineralization particles. In this review, we aim to focus on the recent progress made in understanding intracellular mineralization organelles' processes and their relationship with the physicochemical structure development of CaP and extracellular deposition of CaP particles.& COPY; 2023 Published by Elsevier Ltd on behalf of The Japanese Association for Dental Science. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据