期刊
LATIN AMERICAN JOURNAL OF PHARMACY
卷 42, 期 7, 页码 1451-1459出版社
COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
关键词
alkaloidal; Curculigo orchioides; ethnobotanicals; in vitro anti-inflammatory assays; non-alkaloidal
Rhizomes of Curculigo orchioides Gaerten. (Hypoxidaceae) were extracted with hydroalcoholic solvent and separated into alkaloidal and non-alkaloidal fractions. Both fractions showed dose-dependent anti-inflammatory effects, with the alkaloidal fraction being more effective in HRBC method and the non-alkaloidal fraction being more effective in PD method. The study also identified various phytochemicals in C. orchioides that may contribute to its anti-inflammatory action.
Rhizomes of Curculigo orchioides Gaerten. (Hypoxidaceae) were extracted with hydroalcoholic (90% ethanol) solvent by Soxhlet extraction. This hydroalcoholic extract of C. orchioides was separated into alkaloidal (AFCO) and non-alkaloidal (NAFCO) fractions and were evaluated as in-vitro anti-inflammatory activities by using human red blood cell (HRBC) membrane stability test and inhibition of protein denaturation (PD) assays at different levels (100-500 mu g/mL) and Diclofenac sodium (100 mu g/mL) was used as reference drug. The result showed that AFCO showed a more potent anti-inflammatory effect than NAFCO fraction in the HRBC method and NAFCO showed a more potent anti-inflammatory effect than AFCO fraction in the PD method in dose-dependent action of both fractions. The maximum inhibition in HRBC membrane stability of AFCO fraction was found to be 76 % and NAFCO fraction was found to be 69% while the maximum inhibition of PD of AFCO fraction was found to be 62 % and NAFCO fraction was found to be 71% at a dose of 500 mu g/mL respectively and significantly (p < 0.01) protects the heat-induced PD and HRBC membrane stability test. The C. orchioides is rich in various phytochemicals such as alkaloids, saponins, flavonoids, steroids, polyphenols, glycosides, tannins, and terpenoids which could serve as a potential source of crude drugs. Alkaloids, flavonoids, phenols, and terpenoids may be accountable for their anti-inflammatory action. So, this study supports the use of AFCO and NAFCO fractions from C. orchoides for the prevention, and treatment of inflammation, and supports its traditional uses.
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