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Polyhydroxyalkanoates: the natural biopolyester for future medical innovations

BIOMATERIALS SCIENCE (2023)

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Article Chemistry, Multidisciplinary

Injectable Biomimetic Hydrogel Guided Functional Bone Regeneration by Adapting Material Degradation to Tissue Healing

Yamin Li et al.

Summary: This study aims to develop an injectable biomaterial with bone regeneration-adapted degradability to facilitate functional bone regeneration. A hybrid hydrogel (LP-CPC@gelatin, LC) is synthesized by incorporating laponite and CPC into gelatin hydrogel, with the LC gel degradation rate controlled to match the bone regeneration rate. The LC hydrogel shows good osteoinduction, osteoconduction, and angiogenesis effects, providing a strategy for functional bone regeneration and skeletal muscle repair.

ADVANCED FUNCTIONAL MATERIALS (2023)

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Article Polymer Science

Recent advances of sustainable Short-chain length polyhydroxyalkanoates (Scl-PHAs) - Plant biomass composites

Joseph Kinyanjui Muiruri et al.

Summary: Plastic pollution is a global threat, and the adoption of biobased plastics as a replacement for fossil-based plastics is gaining attention. However, the high production cost and properties performance gap of biobased plastics need to be addressed. The incorporation of renewable fillers seems to be the most promising solution.

EUROPEAN POLYMER JOURNAL (2023)

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Article Multidisciplinary Sciences

Closed-loop recyclable membranes enabled by covalent adaptable networks for water purification

Bofan Li et al.

Summary: In the state-of-the-art membrane industry, sustainable and closed-loop recyclable membranes have been innovated using covalent adaptable networks (CANs) with thermally reversible Diels-Alder (DA) adducts. These membranes exhibit excellent mechanical properties, thermal and chemical stabilities, and separation performance comparable to or even higher than nonrecyclable membranes. The used membranes can be depolymerized to remove contaminants and refabricated into new membranes, filling in the gaps in closed-loop recycling and promoting the advancement of sustainable membranes for a green membrane industry.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2023)

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Article Engineering, Environmental

Expanded polytetrafluoroethylene/poly(3-hydroxybutyrate) (ePTFE/PHB) triboelectric nanogenerators and their potential applications as self-powered and sensing vascular grafts

Dongfang Wang et al.

Summary: A double-layer TENG was constructed using poly(3-hydroxybutyrate) membrane and expanded polytetrafluoroethylene membrane for self-powered and real-time sensing of vascular graft applications. The TENG was capable of power generation, charging, supporting cell growth, and monitoring hemodynamic conditions.

CHEMICAL ENGINEERING JOURNAL (2023)

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Article Materials Science, Biomaterials

Preparation of protein nanoparticle-coated poly(hydroxybutyrate) electrospun nanofiber based scaffold for biomedical applications

Zhanwen Du et al.

Summary: In this study, soybean protein nanoparticles were incorporated into poly(hydroxybutyrate) electrospun nanofiber scaffolds, which showed improved cytocompatibility and potential for biomedical applications through various characterization tests including SEM, EDS, XPS, FTIR, XRD, DMA, WCA, tensile test, water uptake capacity measurements, biodegradation tests in simulated body fluid, and cell culture studies.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2022)

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Article Materials Science, Multidisciplinary

Coaxial bioelectrospinning of P34HB/PVA microfibers biomimetic scaffolds with simultaneity cell-laden for improving bone regeneration

Long Yang et al.

Summary: Bioelectrospinning technology offers a solution to the challenges in bone tissue engineering, enabling simultaneous spinning of cells and materials to create a suitable 3D microenvironment for cell adhesion, proliferation, and differentiation.

MATERIALS & DESIGN (2022)

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Article Biochemistry & Molecular Biology

Beta-tricalcium phosphate enhanced mechanical and biological properties of 3D-printed polyhydroxyalkanoates scaffold for bone tissue engineering

Xiangling Ye et al.

Summary: In this study, 3D-printed PHA/β-TCP scaffolds were successfully prepared by adding beta-TCP to PHA and using a twin-screw extruder and fused deposition modeling technique. The scaffolds exhibited good mechanical properties and biocompatibility, and promoted cell proliferation, adhesion, and migration, as well as enhanced osteogenesis-related gene expression.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Polymer Science

Poly 3-Hydroxybutyrate 4-hydroxybutyrate (P34HB) as a Potential Polymer for Drug-Eluting Coatings on Metal Coronary Stents

Yihui Jian et al.

Summary: In this study, the biodegradable polymer P34HB was proposed as a coating material for drug-eluting stents. P34HB exhibited excellent solubility and stability in drug solutions, as well as good adhesion and resistance properties. It showed better drug release control compared to other candidates and is suitable for latent coating polymer of coronary stents.

POLYMERS (2022)

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Article Chemistry, Multidisciplinary

Poly(hydroxyalkanoates): Production, Applications and End-of-Life Strategies-Life Cycle Assessment Nexus

Joseph Kinyanjui Muiruri et al.

Summary: The excessive production and consumption of oil-based plastics are major contributors to global warming and increased carbon footprint. The majority of plastic waste ends up in the oceans, accounting for about 80% of marine debris. To address this pollution problem, a shift towards eco-friendly and marine-biodegradable plastics is necessary, with polyhydroxyalkanoates (PHAs) standing out as the best choice due to their ability to degrade in soil and marine environments. PHAs are also favored for their biocompatibility, structural variety, and similarity to conventional plastics in terms of physical properties. This article comprehensively explores the production, applications, and recycling strategies of PHA plastics, as well as the impact of end-of-life strategies and life cycle assessment (LCA) on the environment.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2022)

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Review Materials Science, Biomaterials

Advances in modified hyaluronic acid-based hydrogels for skin wound healing

Yan-Wen Ding et al.

Summary: Hyaluronic acid (HA) is a versatile polysaccharide that can be used to synthesize biomedical hydrogels for skin wound healing. Chemical modifications and crosslinking are necessary to create functional HA-based hydrogels. This review provides an overview of the latest advances in chemical modification and crosslinking strategies for HA-based hydrogels and discusses their potential applications in skin wound healing.

BIOMATERIALS SCIENCE (2022)

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Article Materials Science, Multidisciplinary

Microfluidic 3D printing polyhydroxyalkanoates-based bionic skin for wound healing

Wentai Guo et al.

Summary: In this study, a microfluidic 3D printing biomimetic scaffold with excellent mechanical properties and hierarchical porous structures was developed for enhanced wound healing. The scaffold showed good biocompatibility and promoted cell proliferation and adhesion in vitro. In vivo experiments demonstrated that the scaffold significantly promoted tissue regeneration, indicating its potential for skin repair and regeneration.

MATERIALS FUTURES (2022)

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Article Engineering, Biomedical

Load-bearing biodegradable PCL-PGA-beta TCP scaffolds for bone tissue regeneration

Alok Kumar et al.

Summary: A biodegradable composite structure of PCL-PGA with varying amounts of PGA was designed, showing potential for bone tissue engineering applications in bone defect repair. The porosity developed during PGA degradation compensated for the decrease in mechanical properties, making it a suitable candidate for bone reconstruction where strength and biodegradation are important.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2021)

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Review Polymer Science

Electrospinning nanofibers of microbial polyhydroxyalkanoates for applications in medical tissue engineering

Xiao-Hong Zhao et al.

Summary: Polyhydroxyalkanoates (PHAs) are natural bio-polymers that serve as excellent biomaterials candidates in tissue engineering and drug delivery. Electrospinning nanofibers can improve the mechanical properties of PHAs and mimic the structure and function of native extracellular matrix, making them widely used in various medical applications.

JOURNAL OF POLYMER SCIENCE (2021)

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Article Polymer Science

Incorporation of graphene oxide and calcium phosphate in the PCL/PHBV core-shell nanofibers as bone tissue scaffold

Vahid Kheiri Mollaqasem et al.

Summary: Core-shell nanofibers based on polycaprolactone and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with different concentrations of graphene oxide and calcium phosphate were prepared for bone scaffolds, exhibiting desired mechanical and bioactivity properties. The scaffolds showed good biocompatibility and promoted osteocyte differentiation and maturation within 21 days.

JOURNAL OF APPLIED POLYMER SCIENCE (2021)

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Article Engineering, Biomedical

Design and fabrication of bone tissue scaffolds based onPCL/PHBV containinghydroxyapatite nanoparticles:dual-leachingtechnique

Amir Nahanmoghadam et al.

Summary: The study developed a nano-composite scaffold based on PCL and PHBV, with the addition of n-HA nanoparticles. The scaffolds fabricated using the dual-leaching technique showed good morphology, uniform distribution of nanoparticles, and increased porosity. Mechanical properties analysis indicated that the addition of PHBV and HA nanoparticles led to a decrease in compression modulus and strength of the scaffolds.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

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Article Materials Science, Biomaterials

One-step electrospun scaffold of dual-sized gelatin/poly-3-hydroxybutyrate nano/microfibers for skin regeneration in diabetic wound

Claudia Sanhueza et al.

Summary: This study successfully implemented an electrospinning protocol to produce microand nanofibers simultaneously in a single scaffold to mimic the extracellular matrix. The Ge-PHB scaffolds promoted faster wound healing in diabetic rats, showing higher content of hair follicles and sweat glands.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Nanoscience & Nanotechnology

Injectable, Intrinsically Antibacterial Conductive Hydrogels with Self-Healing and pH Stimulus Responsiveness for Epidermal Sensors and Wound Healing

Ling Fan et al.

Summary: This study developed a chitosan-based hydrogel with self-healing, conductive, and antibacterial properties, which can be used as a sensor to monitor human health in real-time and promote wound healing. The injectable hydrogel, fabricated via Schiff base linkage and hydrogen bond, shows pH responsiveness and broad-spectrum antibacterial properties.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Environmental Sciences

Polyhydroxyalkanoates (PHAs) degradation by the newly isolated marine Bacillus sp. JY14

Jang Yeon Cho et al.

Summary: The study identified a thermotolerant and halotolerant bacteria, Bacillus sp. JY14, capable of degrading various PHBs, including other similar bioplastics, under different environmental conditions.

CHEMOSPHERE (2021)

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Review Biotechnology & Applied Microbiology

Grand Challenges for Industrializing Polyhydroxyalkanoates (PHAs)

Dan Tan et al.

Summary: Traditional microbial platforms for PHA production have high costs, while next-generation industrial biotechnology utilizing Halomonas spp. enables stable continuous processing of low-cost PHAs, which is expected to reduce production costs and improve process economics.

TRENDS IN BIOTECHNOLOGY (2021)

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Article Materials Science, Biomaterials

Bioresorbable and Mechanically Optimized Nerve Guidance Conduit Based on a Naturally Derived Medium Chain Length Polyhydroxyalkanoate and Poly(ε-Caprolactone) Blend

Xabier Mendibil et al.

Summary: A novel blend of natural medium chain length polyhydroxyalkanoate (MCL-PHA) and synthetic aliphatic polyester poly(epsilon-caprolactone) (PCL) was developed for nerve regeneration, showing excellent neuroregenerative properties and bioresorption rate in rat sciatic nerve defects. The material exhibited superior outcomes compared to commercially available synthetic Neurolac NGCs in terms of electrophysiological and histological data, as well as the number of recovered animals.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Engineering, Biomedical

Osteogenic differentiation system based on biopolymer nanoparticles for stem cells in simulated microgravity

Xiao-Hong Zhao et al.

Summary: An efficient long-term intracellular growth factor release system was developed for osteogenic differentiation in simulated microgravity using PLA and PHA nanoparticles loaded with BMP2 and BMP7 for hADSCs. The mixture NPs compound of sB2-PLA-NP and sB7-PHA-NP showed similar osteogenic differentiation results as sustained free-BMP2 and BMP7-supplying, demonstrating its reliability in space medicine and biology.

BIOMEDICAL MATERIALS (2021)

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Article Biotechnology & Applied Microbiology

Enhanced Cells Anchoring to Electrospun Hybrid Scaffolds With PHBV and HA Particles for Bone Tissue Regeneration

Joanna E. Karbowniczek et al.

Summary: The study successfully produced PHBV scaffolds enriched with hydroxyapatite particles, which showed enhanced cell proliferation and filopodia formation, indicating great potential for bone tissue regeneration.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Engineering, Biomedical

Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity

Cijun Shuai et al.

Summary: The addition of PGA into HAP/PLLA scaffold accelerated the degradation process, leading to increased degradation rate and pore formation, which promoted the deposition and growth of bone-like apatite as well as provided a favorable environment for osteoblast adhesion and proliferation. This led to excellent bone defect repair capacity demonstrated by the formation of abundant new bone tissue and blood vessel tissue, ultimately bridging both ends of the defect region after 8 weeks of implantation.

BIOACTIVE MATERIALS (2021)

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Article Polymer Science

The Synthesis, Characterization and Applications of Polyhydroxyalkanoates (PHAs) and PHA-Based Nanoparticles

Antony Samrot et al.

Summary: Polyhydroxyalkanoates (PHAs) are storage granules found in bacteria, which are essentially hydroxy fatty acid polyesters. Among them, polyhydroxybutyrate (PHB) is widely used in various fields due to its biodegradability, biocompatibility, and ecological safety. The unique physicochemical characteristics of PHAs have made them applicable in nanotechnology, tissue engineering, and other biomedical applications.

POLYMERS (2021)

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Review Engineering, Biomedical

Engineering and polymeric composition of drug-eluting suture: A review

Xiaoxuan Deng et al.

Summary: Sutures are the most popular surgical implants used for tissue closure in the global market. The incorporation of active pharmaceutical ingredients with polymeric composition of suture materials efficiently reduces inflammatory reactions and controls bacterial growth for wound healing. Fabrication processes and polymer materials allow control over drug-eluting profiles to effectively address wound healing requirements.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

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Article Engineering, Biomedical

3D bioactive cell-free-scaffolds for in-vitro/in-vivo capture and directed osteoinduction of stem cells for bone tissue regeneration

Mamatali Rahman et al.

Summary: The study developed a novel bone tissue engineering scaffold material, BOPSC, which entrapped and continuously released BMP2 in polymer with the adjuvant biosurfactant soybean-lecithin, allowing for in vivo stem cell capture and osteogenic induction without the need for exogenous cells. BOPSC demonstrated sustained BMP2 release, supporting cell proliferation and osteogenic differentiation, and showed promising osteogenesis in mouse experiments.

BIOACTIVE MATERIALS (2021)

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Article Chemistry, Medicinal

Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering

Anand Mohan et al.

Summary: Nanocomposites based on polyhydroxybutyrate (PHB) show promising applications in drug delivery and tissue engineering, particularly displaying enhanced properties in bone tissue engineering.

PHARMACEUTICALS (2021)

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Article Biotechnology & Applied Microbiology

Antibacterial Composite Materials Based on the Combination of Polyhydroxyalkanoates With Selenium and Strontium Co-substituted Hydroxyapatite for Bone Regeneration

Elena Marcello et al.

Summary: To combat the rising threat of microbial resistance to antibiotics, this study focused on the development of a novel polymer-matrix composite material with antibacterial properties through the incorporation of selenium and strontium-containing HA. The composite samples exhibited strong antibacterial activity against both Gram-positive and Gram-negative bacteria, making them promising candidates for applications in bone healing and tissue engineering.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Preclinical study of peripheral nerve regeneration using nerve guidance conduits based on polyhydroxyalkanaotes

Lorena R. Lizarraga-Valderrama et al.

Summary: The study demonstrated that PHA-NGCs are highly promising in promoting peripheral nerve regeneration, showing comparable outcomes to autografts in functional evaluation and nerve morphology.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2021)

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Article Nanoscience & Nanotechnology

Harnessing Polyhydroxyalkanoates and Pressurized Gyration for Hard and Soft Tissue Engineering

Pooja Basnett et al.

Summary: Organ dysfunction is a major cause of morbidity and mortality, with transplantation being a key cure but facing challenges due to a lack of donor organs. Tissue engineering using biomaterial scaffolds shows promise in promoting cell attachment, proliferation, and differentiation for tissue regeneration in bone, nerve, and cardiovascular applications. The development of scalable scaffolds using polyhydroxyalkanoate fibers presents an exciting opportunity for both hard and soft tissue regeneration.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Biochemistry & Molecular Biology

Evaluation of the effects of starch on polyhydroxybutyrate electrospun scaffolds for bone tissue engineering applications

Maryam Abdollahi Asl et al.

Summary: Efficient design for bone tissue engineering involves selecting biomimetic materials and scalable fabrication technologies. In this study, PHB and starch were used to create novel scaffolds with improved tensile strength and biocompatibility. The addition of starch enhanced scaffold performance and promoted cell proliferation and activity.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biotechnology & Applied Microbiology

Engineering the permeability of Halomonas bluephagenesis enhanced its chassis properties

Ziyu Wang et al.

Summary: The bacterial outer membrane (OM) plays a crucial role in bioproduction, with OM-defected Halomonas bluephagenesis strains showing improved adaptation to lower salinity and increased production of bioproducts. The study highlights the significant impact of OM defection on metabolic engineering, synthetic biology studies, and industrial applications.

METABOLIC ENGINEERING (2021)

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Article Chemistry, Physical

Silver Decorated βTCP-Poly(3hydroxybutyrate) Scaffolds for Bone Tissue Engineering

Joanna Czechowska et al.

Summary: Silver-coated beta tricalcium phosphate porous scaffolds were prepared in this study, showing promising performance for bone tissue regeneration in non-load bearing applications. Materials coated with the biopolymer P(3HB) exhibited higher compressive strength and surgical maneuverability, with the sintering temperature affecting the physicochemical properties of the scaffolds.

MATERIALS (2021)

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Article Polymer Science

Tissue-Engineered Carotid Artery Interposition Grafts Demonstrate High Primary Patency and Promote Vascular Tissue Regeneration in the Ovine Model

Larisa V. Antonova et al.

Summary: The biodegradable PHBV/PCL[VEGF-bFGF-SDF](Hep/Ilo) grafts showed better short- and long-term results compared to the bio-stable ePTFE analogues, although reinforcement is needed for efficient prevention of aneurysms. The regenerated arteries displayed a hierarchical three-layer structure similar to native blood vessels, being fully endothelialized, highly vascularized, and populated by vascular smooth muscle cells and macrophages. While most of the regenerated arteries were free of calcifications, they suffered from aneurysmatic dilation.

POLYMERS (2021)

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Article Polymer Science

Fabrication and Characterization of Cinnamaldehyde-Loaded Mesoporous Bioactive Glass Nanoparticles/PHBV-Based Microspheres for Preventing Bacterial Infection and Promoting Bone Tissue Regeneration

Kittipat Chotchindakun et al.

Summary: The incorporation of mesoporous bioactive glass nanoparticles and cinnamaldehyde into polyhydroxybutyrate-co-hydroxyvalerate enhanced bioactivity and antimicrobial activity, making it a promising material for biomedical applications such as bone tissue engineering.

POLYMERS (2021)

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Article

Culture of rat mesenchymal stem cells on PHBV-PCL scaffolds: analysis of conditioned culture medium by FT-Raman spectroscopy

V. A. Nascimento et al.

BRAZILIAN JOURNAL OF BIOLOGY (2021)

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Article Materials Science, Biomaterials

Biosafe, self-adhesive, recyclable, tough, and conductive hydrogels for multifunctional sensors

Ling Fan et al.

Summary: The study introduces a high-performance multifunctional hydrogel PSAB, which shows excellent adhesion and mechanical properties, as well as broad-spectrum antibacterial activity and biocompatibility, making it a promising material for biomedical applications.

BIOMATERIALS SCIENCE (2021)

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Article Materials Science, Biomaterials

Piezoelectric core-shell PHBV/PDX blend scaffolds for reduced superficial wound contraction and scarless tissue regeneration

Nowsheen Goonoo et al.

Summary: The use of non-invasive scaffold materials mimicking the piezoelectric properties of biological tissues is a promising strategy for tissue regeneration. Electrospun core-shell PDX/PHBV mats have been engineered to promote native tissue regeneration, showing enhanced fibroblast stimulation and reduced inflammation in in vitro and in vivo studies. The importance of exploiting cell-material interactions to match tissue biological needs for wound healing cascade is highlighted in this study.

BIOMATERIALS SCIENCE (2021)

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Article Nanoscience & Nanotechnology

Injectable Cell- and Growth Factor-Free Poly(4-hydroxybutyrate) (P4HB) Microspheres with Open Porous Structures and Great Efficiency of Promoting Bone Regeneration

Shuaishuai Yuan et al.

Summary: This study demonstrates that injectable open porous P4HB microspheres have significant potential in bone tissue regeneration by enhancing cell proliferation and accelerating bone defect healing.

ACS APPLIED BIO MATERIALS (2021)

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Proceedings Paper Polymer Science

Filler Content Effect on Water Uptake and Thermal Stability of Poly(3-Hydroxybutyrate-Co-3-Hydroxyhexanoate)/Microcrystalline Cellulose Biocomposites

Nadjet Dehouche et al.

Summary: Biocomposites of PHBHHx/MCC were prepared by melt compounding at different filler content ratios, showing that the thermal stability decreased and crystallinity and water uptake increased with higher MCC content. The agglomeration of MCC particles induced heterogeneities and defects within the polymer matrix.

MACROMOLECULAR SYMPOSIA (2021)

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Article Multidisciplinary Sciences

Modulated Composite Nanofibers with Enhanced Structural Stability for Promotion of Hard Tissue Healing

Mehdi Sadat-Shojai et al.

Summary: The study attempted to combine hydroxyapatite in different forms (nanospheres or nanorods) with poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofibrous scaffolds to enhance the strength and osteoconductivity for potential bone tissue engineering. The results showed that using 1,1,1,3,3,3-hexafluoropropan-2-ol could minimize structural defects in PHBV nanofibers, and adding rod-like HA could significantly enhance the structural strength of composite nanofibers.

IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A-SCIENCE (2021)

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Article Nanoscience & Nanotechnology

Synthesis of an electrospun PHA/RGO/Au scaffold for peripheral nerve regeneration: an in vitro study

Qiang Liu et al.

APPLIED NANOSCIENCE (2020)

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Article Biochemistry & Molecular Biology

Graphene oxide nanosheets versus carbon nanofibers: Enhancement of physical and biological properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) films for biomedical applications

Ariagna L. Rivera-Briso et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Engineering, Biomedical

Bacteria-triggered release of a potent biocide from core-shell polyhydroxyalkanoate (PHA)-based nanofibers for wound dressing applications

Wei Li et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2020)

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Article Engineering, Biomedical

Aloe Vera-Derived Gel-Blended PHBV Nanofibrous Scaffold for Bone Tissue Engineering

Aylin Tahmasebi et al.

ASAIO JOURNAL (2020)

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Article Engineering, Biomedical

Modulation of neuronal cell affinity of composite scaffolds based on polyhydroxyalkanoates and bioactive glasses

Lorena R. Lizarraga-Valderrama et al.

BIOMEDICAL MATERIALS (2020)

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Article Biochemistry & Molecular Biology

Electrospun poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/silk fibroin film is a promising scaffold for bone tissue engineering

Shaik Ling Ang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Nanoscience & Nanotechnology

Antibacterial, Self-Adhesive, Recyclable, and Tough Conductive Composite Hydrogels for Ultrasensitive Strain Sensing

Ling Fan et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Biomedical

Preparation and modeling of electrospun polyhydroxybutyrate/polyaniline composite scaffold modified by plasma and printed by an inkjet method and its cellular study

Mohammad Zamanifard et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2020)

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Article Cell & Tissue Engineering

An easy long-acting BMP7 release system based on biopolymer nanoparticles for inducing osteogenic differentiation of adipose mesenchymal stem cells

Rui Chen et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2020)

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Review Biotechnology & Applied Microbiology

Poly(4-Hydroxybutyrate): Current State and Perspectives

Camila Utsunomia et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Chemistry, Multidisciplinary

Neoteric Solvent Systems as Sustainable Media for Dissolution and Film Preparation of Poly-[(R)-3-hydroxybutyrate]

Rosy Alphons Sequeira et al.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2020)

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Article Chemistry, Multidisciplinary

Influence of Depolymerases and Lipases on the Degradation of Polyhydroxyalkanoates Determined in Langmuir Degradation Studies

Natalia A. Tarazona et al.

ADVANCED MATERIALS INTERFACES (2020)

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Article Engineering, Biomedical

Wet-electrospun PHBV nanofiber reinforced carboxymethyl chitosan-silk hydrogel composite scaffolds for articular cartilage repair

Oylum Colpankan Gunes et al.

JOURNAL OF BIOMATERIALS APPLICATIONS (2020)

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Article Nanoscience & Nanotechnology

Enhanced Crystallinity and Antibacterial of PHBV Scaffolds Incorporated with Zinc Oxide

Cijun Shuai et al.

JOURNAL OF NANOMATERIALS (2020)

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Article Materials Science, Multidisciplinary

Preparation and Characterization of PHBV/PEO/AZ-Gelatin Electrospun Mats with Photochemical Surface Modification: The Role of AZ-Gelatin

Yongjing Xu et al.

MACROMOLECULAR MATERIALS AND ENGINEERING (2020)

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Article Chemistry, Physical

Enzymatic Hydrolysis of Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) Scaffolds

Adriana Kovalcik et al.

MATERIALS (2020)

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Article Chemistry, Applied

Curcumin and Gymnema sylvestre extract loaded graphene oxide-polyhydroxybutyrate-sodium alginate composite for diabetic wound regeneration

E. R. Anishiya Chella Daisy et al.

REACTIVE & FUNCTIONAL POLYMERS (2020)

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Article Chemistry, Multidisciplinary

Biodegradable Patches for Arterial Reconstruction Modified with RGD Peptides: Results of an Experimental Study

Viktoriia V. Sevostianova et al.

ACS OMEGA (2020)

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Article Nanoscience & Nanotechnology

In Vitro Bacterial Adhesion and Biofilm Formation on Fully Absorbable Poly-4-hydroxybutyrate and Nonabsorbable Polypropylene Pelvic Floor Implants

Kim W. J. Verhorstert et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Food Science & Technology

Preparation of cinnamaldehyde-loaded polyhydroxyalkanoate/chitosan porous microspheres with adjustable controlled-release property and its application in fruit preservation

Shenyu Yang et al.

FOOD PACKAGING AND SHELF LIFE (2020)

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Article Polymer Science

Poly(3-Hydroxybutyrate)-Multiwalled Carbon Nanotubes Electrospun Scaffolds Modified with Curcumin

Nader Tanideh et al.

POLYMERS (2020)

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Article Engineering, Biomedical

Electrosprayed Chitin Nanofibril/Electrospun Polyhydroxyalkanoate Fiber Mesh as Functional Nonwoven for Skin Application

Bahareh Azimi et al.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2020)

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Article Chemistry, Multidisciplinary

A novel long-acting azathioprine polyhydroxyalkanoate nanoparticle enhances treatment efficacy for systemic lupus erythematosus with reduced side effects

Jin Hu et al.

NANOSCALE (2020)

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Article Materials Science, Biomaterials

A new highly transparent injectable PHA-based thermogelling vitreous substitute

Kun Xue et al.

BIOMATERIALS SCIENCE (2020)

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Article Materials Science, Biomaterials

Preparation and mechanical performance of small-diameter PHBHHx vascular graft by electrospinning

Jing Gao et al.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2019)

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Article Materials Science, Biomaterials

Preparation and mechanical performance of small-diameter PHBHHx vascular graft by electrospinning

Jing Gao et al.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2019)

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Article Cell Biology

P34HB electrospun fibres promote bone regeneration in vivo

Na Fu et al.

CELL PROLIFERATION (2019)

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Article Nanoscience & Nanotechnology

Piezoelectric 3-D Fibrous Poly(3-hydroxybutyrate)-Based Scaffolds Ultrasound-Mineralized with Calcium Carbonate for Bone Tissue Engineering: Inorganic Phase Formation, Osteoblast Cell Adhesion, and Proliferation

R. Chernozem et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Biochemistry & Molecular Biology

Polyhydroxybutyrate/Chitosan 3D Scaffolds Promote In Vitro and In Vivo Chondrogenesis

Maria Giretova et al.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2019)

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Article Nanoscience & Nanotechnology

Osteogenic Potential of Electrospun Poly(3-hyd roxybutyrate-co-4-hydroxybutyrate)/Poly(ethylene glycol) Nanofiber Membranes

Zetao Wang et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2019)

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Article Biochemistry & Molecular Biology

Cellular architecture and migration behavior of fibroblast cells on polyhydroxyoctanoate (PHO): A natural polymer of bacterial origin

Tomasz Witko et al.

BIOPOLYMERS (2019)

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Article Cell & Tissue Engineering

Chondrocyte Co-cultures with the Stromal Vascular Fraction of Adipose Tissue in Polyhydroxybutyrate/Poly-(hydroxybutyrate-co-hydroxyhexanoate) Scaffolds: Evaluation of Cartilage Repair in Rabbit

Kai Ba et al.

CELL TRANSPLANTATION (2019)

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Article Biochemistry & Molecular Biology

Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) production from engineered Ralstonia eutropha using synthetic and anaerobically digested food waste derived volatile fatty acids

Shashi Kant Bhatia et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Cell & Tissue Engineering

Unidirectional neuronal cell growth and differentiation on aligned polyhydroxyalkanoate blend microfibres with varying diameters

Lorena R. Lizarraga-Valderrama et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2019)

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Article Materials Science, Biomaterials

Potential of an electrospun composite scaffold of poly (3-hydroxybutyrate)-chitosan/alumina nanowires in bone tissue engineering applications

Elahe Bahremandi Toloue et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Materials Science, Biomaterials

Diatom shell incorporated PHBV/PCL-pullulan co-electrospun scaffold for bone tissue engineering

Ali Deniz Dalgic et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Materials Science, Biomaterials

Highly porous PHB-based bioactive scaffolds for bone tissue engineering by in situ synthesis of hydroxyapatite

Micaela Degli Esposti et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Chemistry, Physical

Drug Release Kinetics of Electrospun PHB Meshes

Vojtech Kundrat et al.

MATERIALS (2019)

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Article Food Science & Technology

Production and characterization of biodegradable films of a novel polyhydroxyalkanoate (PHA) synthesized from peanut oil

A. O. Perez-Arauz et al.

FOOD PACKAGING AND SHELF LIFE (2019)

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Review Biochemical Research Methods

Recent Progress in Polyhydroxyalkanoates-Based Copolymers for Biomedical Applications

Zheng Luo et al.

BIOTECHNOLOGY JOURNAL (2019)

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Article Biochemistry & Molecular Biology

Enhancement of the properties of biosourced poly(3-hydroxybutyrate-co-4-hydroxybutyrate) by the incorporation of natural orotic acid

Yancun Yu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Agricultural Engineering

Functionalized polyhydroxyalkanoate nano-beads as a stable biocatalyst for cost-effective production of the rare sugar D-allulose

Ganqiao Ran et al.

BIORESOURCE TECHNOLOGY (2019)

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Article Materials Science, Textiles

Effect of Wall Structures on Mechanical Properties of Small Caliber PHBHHx Vascular Grafts

Jing Gao et al.

FIBERS AND POLYMERS (2019)

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Article Biochemistry & Molecular Biology

GPTMS-Modified Bredigite/PHBV Nanofibrous Bone Scaffolds with Enhanced Mechanical and Biological Properties

Monireh Kouhi et al.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2019)

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Review Biotechnology & Applied Microbiology

Biomedical applications of microbially engineered polyhydroxyalkanoates: an insight into recent advances, bottlenecks, and solutions

Akhilesh Kumar Singh et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2019)

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Article Polymer Science

Structural, topographical, and mechanical characteristics of purified polyhydroxyoctanoate polymer

Kamila Sofinska et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2019)

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Article Engineering, Biomedical

Poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/fibrinogen/bredigite nanofibrous membranes and their integration with osteoblasts for guided bone regeneration

Monireh Kouhi et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2019)

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Article Ophthalmology

Effect of Rapamycin Microspheres in Sjogren Syndrome Dry Eye: Preparation and Outcomes

Shasha Wang et al.

OCULAR IMMUNOLOGY AND INFLAMMATION (2019)

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Article Nanoscience & Nanotechnology

New Dual Functional PHB-Grafted Lignin Copolymer: Synthesis, Mechanical Properties, and Biocompatibility Studies

Dan Kai et al.

ACS APPLIED BIO MATERIALS (2019)

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Article Nanoscience & Nanotechnology

PHA-Based Thermogel as a Controlled Zero-Order Chemotherapeutic Delivery System for the Effective Treatment of Melanoma

Lu Jiang et al.

ACS APPLIED BIO MATERIALS (2019)

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Article Chemistry, Applied

Evaluation of the effects of multiwalled carbon nanotubes on electrospun poly(3-hydroxybutirate) scaffold for tissue engineering applications

Moein Zarei et al.

JOURNAL OF POROUS MATERIALS (2018)

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Review Engineering, Biomedical

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Claudia Martins et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Article Nanoscience & Nanotechnology

In Vivo Tracking and 1H/19F Magnetic Resonance Imaging of Biodegradable Polyhydroxyalkanoate/Polycaprolactone Blend Scaffolds Seeded with Labeled Cardiac Stem Cells

Christakis Constantinides et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Review Pharmacology & Pharmacy

Microfluidics for producing poly (lactic-co-glycolic acid)-based Check for pharmaceutical nanoparticles

Xuanyu Li et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

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Article Chemistry, Multidisciplinary

A Micro-Ark for Cells: Highly Open Porous Polyhydroxyalkanoate Microspheres as Injectable Scaffolds for Tissue Regeneration

Dai-Xu Wei et al.

ADVANCED MATERIALS (2018)

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Article Engineering, Biomedical

PHBV wet-spun scaffold coated with ELR-REDV improves vascularization for bone tissue engineering

Ayse Selcen Alagoz et al.

BIOMEDICAL MATERIALS (2018)

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Review Biochemical Research Methods

Engineering microorganisms for improving polyhydroxyalkanoate biosynthesis

Guo-Qiang Chen et al.

CURRENT OPINION IN BIOTECHNOLOGY (2018)

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Article Materials Science, Biomaterials

Electrospun carboxyl multi-walled carbon nanotubes grafted polyhydroxybutyrate composite nanofibers membrane scaffolds: Preparation, characterization and cytocompatibility

Cai Zhijiang et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Article Biotechnology & Applied Microbiology

CRISPR/Cas9 editing genome of extremophile Halomonas spp.

Qin Qin et al.

METABOLIC ENGINEERING (2018)

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Article Chemistry, Multidisciplinary

Soybean Lecithin-Mediated Nanoporous PLGA Microspheres with Highly Entrapped and Controlled Released BMP-2 as a Stem Cell Platform

Daixu Wei et al.

SMALL (2018)

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Article Biotechnology & Applied Microbiology

Suspended polyhydroxyalkanoate microspheres as 3D carriers for mammalian cell growth

Dai-Xu Wei et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

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Article Engineering, Biomedical

Biomineralized Conductive PEDOT:PSS-Coated PLA/PHBV/HA Nanofibrous Membranes

Mohd Izzat Hassan et al.

ASAIO JOURNAL (2018)

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Article Chemistry, Applied

Integrating 3D-printed PHBV/Calcium sulfate hemihydrate scaffold and chitosan hydrogel for enhanced osteogenic property

Xiangling Ye et al.

CARBOHYDRATE POLYMERS (2018)

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Article Biotechnology & Applied Microbiology

Combined antibacterial and osteogenic in situ effects of a bifunctional titanium alloy with nanoscale hydroxyapatite coating

Hua-Wei Liu et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

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Article Engineering, Biomedical

Surfactant Free Delivery of Docetaxel by Poly[(R)-3-hydroxybutyrate-(R)-3-hydroxyhexanoate]-Based Polymeric Micelles for Effective Melanoma Treatments

Zheng Luo et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Review Biotechnology & Applied Microbiology

Ralstonia eutropha H16 in progress: Applications beside PHAs and establishment as production platform by advanced genetic tools

Matthias Raberg et al.

CRITICAL REVIEWS IN BIOTECHNOLOGY (2018)

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Article Chemistry, Multidisciplinary

Long-Term Real-Time In Vivo Drug Release Monitoring with AIE Thermogelling Polymer

Sing Shy Liow et al.

SMALL (2017)

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Article Polymer Science

Effects of various monomers and micro-structure of polyhydroxyalkanoates on the behavior of endothelial progenitor cells and endothelial cells for vascular tissue engineering

Chao-Ling Yao et al.

JOURNAL OF POLYMER RESEARCH (2017)

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Article Biochemistry & Molecular Biology

Codelivery for Paclitaxel and Bcl-2 Conversion Gene by PHB-PDMAEMA Amphiphilic Cationic Copolymer for Effective Drug Resistant Cancer Therapy

Xiaoyuan Wang et al.

MACROMOLECULAR BIOSCIENCE (2017)

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Article Materials Science, Biomaterials

Laminated electrospun nHA/PHB-composite scaffolds mimicking bone extracellular matrix for bone tissue engineering

Zhuoyue Chen et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Article Materials Science, Biomaterials

Nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/collagen/graphene oxide scaffolds for wound coverage

Rashtrapal Zine et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Article Biotechnology & Applied Microbiology

Novel T7-like expression systems used for Halomonas

Han Zhao et al.

METABOLIC ENGINEERING (2017)

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Article Biotechnology & Applied Microbiology

Engineering Halomonas species TD01 for enhanced polyhydroxyalkanoates synthesis via CRISPRi

Wei Tao et al.

MICROBIAL CELL FACTORIES (2017)

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Article Chemistry, Multidisciplinary

PHBV/bioglass composite scaffolds with co-cultures of endothelial cells and bone marrow stromal cells improve vascularization and osteogenesis for bone tissue engineering

Jun Wu et al.

RSC ADVANCES (2017)

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Article Pharmacology & Pharmacy

Poly(HydroxyButyrate-co-HydroxyValerate) (PHBHV) Nanocarriers for Silymarin Release as Adjuvant Therapy in Colo-rectal Cancer

Ionut-Cristian Radu et al.

FRONTIERS IN PHARMACOLOGY (2017)

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Article Agricultural Engineering

Engineering Halomonas bluephagenesis TD01 for non-sterile production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate)

Xiangbin Chen et al.

BIORESOURCE TECHNOLOGY (2017)

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Article Chemistry, Physical

Biocomposite coatings based on Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/calcium phosphates obtained by MAPLE for bone tissue engineering

O. Rasoga et al.

APPLIED SURFACE SCIENCE (2017)

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Review Microbiology

A holistic view of polyhydroxyalkanoate metabolism in Pseudomonas putida

Auxiliadora Prieto et al.

ENVIRONMENTAL MICROBIOLOGY (2016)

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Article Engineering, Environmental

A new strategy for fabrication of bone scaffolds using electrospun nano-HAp/PHB fibers and protein hydrogels

Mehdi Sadat-Shojai et al.

CHEMICAL ENGINEERING JOURNAL (2016)

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Article Polymer Science

Dense stable suspensions of medium-chain-length poly(3-hydroxyalkanoate) nanoparticles

Benjamin A. Peprah et al.

EUROPEAN POLYMER JOURNAL (2016)

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Article Microbiology

Immunogencity of antigens from Mycobacterium tuberculosis self-assembled as particulate vaccines

Patricia Rubio Reyes et al.

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2016)

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Article Polymer Science

Development of tunable biodegradable polyhydroxyalkanoates microspheres for controlled delivery of tetracycline for treating periodontal disease

Nootchanartch Panith et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2016)

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Article Polymer Science

Electrospun poly(hydroxybutyrate)/chitosan blend fibrous scaffolds for cartilage tissue engineering

Davoud Sadeghi et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2016)

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Article Engineering, Biomedical

Biocompatible polyhydroxyalkanoates/bacterial cellulose composites: Preparation, characterization, and in vitro evaluation

Ioana Chiulan et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2016)

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Article Chemistry, Applied

Concanavaline A conjugated bacterial polyester-based PHBHHx nanoparticles loaded with curcumin for breast cancer therapy

Ebru Kilicay et al.

JOURNAL OF MICROENCAPSULATION (2016)

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Article Engineering, Biomedical

Adhesive strength of bone-implant interfaces and in-vivo degradation of PHB composites for load-bearing applications

M. Meischel et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2016)

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Article Materials Science, Biomaterials

Poly(hydroxybutyrate)/cellulose acetate blend nanofiber scaffolds: Preparation, characterization and cytocompatibility

Cai Zhijiang et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2016)

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Article Materials Science, Biomaterials

Simultaneous dual syringe electrospinning system using benign solvent to fabricate nanofibrous P(3HB-co-4HB)/collagen peptides construct as potential leave-on wound dressing

S. Vigneswari et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2016)

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Review Microbiology

Bacterial polyhydroxyalkanoates: Still fabulous?

Justyna Mozejko-Ciesielska et al.

MICROBIOLOGICAL RESEARCH (2016)

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Review Materials Science, Multidisciplinary

Polyhydroxyalkanoates: opening doors for a sustainable future

Zibiao Li et al.

NPG ASIA MATERIALS (2016)

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Article Chemistry, Multidisciplinary

Evaluating the biological impact of polyhydroxyalkanoates (PHAs) on developmental and exploratory profile of zebrafish larvae

Xiang Li et al.

RSC ADVANCES (2016)

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Article Biochemical Research Methods

Semirational Approach for Ultrahigh Poly(3-hydroxybutyrate) Accumulation in Escherichia coli by Combining One-Step Library Construction and High-Throughput Screening

Teng Li et al.

ACS SYNTHETIC BIOLOGY (2016)

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Review Microbiology

Halophilic microorganism resources and their applications in industrial and environmental biotechnology

Rungaroon Waditee-Sirisattha et al.

AIMS MICROBIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Conjugation with RGD Peptides and Incorporation of Vascular Endothelial Growth Factor Are Equally Efficient for Biofunctionalization of Tissue-Engineered Vascular Grafts

Larisa V. Antonova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Nanoscience & Nanotechnology

Electrospun Nanofibrous P(DLLA-CL) Balloons as Calcium Phosphate Cement Filled Containers for Bone Repair: in Vitro and in Vivo Studies

Xunwei Liu et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

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Article Agricultural Engineering

Dark fermentative bioconversion of glycerol to hydrogen by Bacillus thuringiensis

Prasun Kumar et al.

BIORESOURCE TECHNOLOGY (2015)

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Review Biotechnology & Applied Microbiology

Halophiles, coming stars for industrial biotechnology

Jin Yin et al.

BIOTECHNOLOGY ADVANCES (2015)

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Review Chemistry, Multidisciplinary

Water soluble polyhydroxyalkanoates: future materials for therapeutic applications

Zibiao Li et al.

CHEMICAL SOCIETY REVIEWS (2015)

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Article Chemistry, Physical

One-pot facile preparation of PEG-modified PLGA nanoparticles: Effects of PEG and PLGA on release properties of the particles

Nao Yoneki et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2015)

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Article Engineering, Biomedical

Biocomposite scaffolds for bone regeneration: Role of chitosan and hydroxyapatite within poly-3-hydroxybutyrate-co-3-hydroxyvalerate on mechanical properties and in vitro evaluation

Sai Zhang et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2015)

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Article Biotechnology & Applied Microbiology

Application of CRISPRi for prokaryotic metabolic engineering involving multiple genes, a case study: Controllable P(3HB-co-4HB) biosynthesis

Li Lv et al.

METABOLIC ENGINEERING (2015)

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Review Biotechnology & Applied Microbiology

The 'PHAome'

Guo-Qiang Chen et al.

TRENDS IN BIOTECHNOLOGY (2015)

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Article Chemistry, Multidisciplinary

P34HB film promotes cell adhesion, in vitro proliferation, and in vivo cartilage repair

Na Fu et al.

RSC ADVANCES (2015)

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Article Materials Science, Biomaterials

Fabrication of biodegradable synthetic perfusable vascular networks via a combination of electrospinning and robocasting

Ilida Ortega et al.

BIOMATERIALS SCIENCE (2015)

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Article Engineering, Biomedical

Sustained PDGF-BB release from PHBHHx loaded nanoparticles in 3D hydrogel/stem cell model

Cui-Ling Dong et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2015)

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Article Multidisciplinary Sciences

New Perspective in the Formulation and Characterization of Didodecyldimethylammonium Bromide (DMAB) Stabilized Poly(Lactic-co-Glycolic Acid) (PLGA) Nanoparticles

Rebecca Gossmann et al.

PLOS ONE (2015)

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Article Nanoscience & Nanotechnology

3D Artificial Bones for Bone Repair Prepared by Computed Tomography-Guided Fused Deposition Modeling for Bone Repair

Ning Xu et al.

ACS APPLIED MATERIALS & INTERFACES (2014)

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Article Engineering, Biomedical

Epidermal Differentiation of Stem Cells on Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) Nanofibers

Dhakshinamoorthy Sundaramurthi et al.

ANNALS OF BIOMEDICAL ENGINEERING (2014)

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Article Engineering, Biomedical

Tissue engineered esophagus scaffold constructed with porcine small intestinal submucosa and synthetic polymers

Mei-Rong Fan et al.

BIOMEDICAL MATERIALS (2014)

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Article Biophysics

Mesoporous bioactive glass doped-poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) composite scaffolds with 3-dimensionally hierarchical pore networks for bone regeneration

Shengbing Yang et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2014)

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Article Engineering, Biomedical

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)-based nanofibrous scaffolds to support functional esophageal epithelial cells towards engineering the esophagus

Purushothaman Kuppan et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2014)

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Article Biochemical Research Methods

A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles

Jidong Wang et al.

LAB ON A CHIP (2014)

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Article Nanoscience & Nanotechnology

Peptide functionalized polyhydroxyalkanoate nanofibrous scaffolds enhance Schwann cells activity

Elahe Masaeli et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2014)

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Article Materials Science, Biomaterials

PHBVHHx scaffolds loaded with umbilical cord-derived mesenchymal stem cells or hepatocyte-like cells differentiated from these cells for liver tissue engineering

Zhongchun Su et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2014)

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Article Biotechnology & Applied Microbiology

Engineering Escherichia coli for enhanced production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in larger cellular space

Ying Wang et al.

METABOLIC ENGINEERING (2014)

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Article Biotechnology & Applied Microbiology

Engineering Halomonas TD01 for the low-cost production of polyhydroxyalkanoates

Dan Tan et al.

METABOLIC ENGINEERING (2014)

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Article Biotechnology & Applied Microbiology

Synthesis of polyhydroxyalkanoates from glucose that contain medium-chain-length monomers via the reversed fatty acid β-oxidation cycle in Escherichia coli

Qianqian Zhuang et al.

METABOLIC ENGINEERING (2014)

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Article Biotechnology & Applied Microbiology

Development of Halomonas TD01 as a host for open production of chemicals

Xiao-Zhi Fu et al.

METABOLIC ENGINEERING (2014)

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Article Cell & Tissue Engineering

A Comparison of Electrospun Polymers Reveals Poly(3-Hydroxybutyrate) Fiber as a Superior Scaffold for Cardiac Repair

Delia Castellano et al.

STEM CELLS AND DEVELOPMENT (2014)

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Review Polymer Science

Start a Research on Biopolymer Polyhydroxyalkanoate (PHA): A Review

Giin-Yu Amy Tan et al.

POLYMERS (2014)

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Article Biotechnology & Applied Microbiology

The healing effect of unrestricted somatic stem cells loaded in collagen-modified nanofibrous PHBV scaffold on full-thickness skin defects

Saeed Heidari Keshel et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2014)

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Article Materials Science, Biomaterials

Three dimensionally printed mesoporous bioactive glass and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) composite scaffolds for bone regeneration

Shichang Zhao et al.

JOURNAL OF MATERIALS CHEMISTRY B (2014)

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Article Engineering, Biomedical

Chitosan-Cross-Linked Nanofibrous PHBV Nerve Guide for Rat Sciatic Nerve Regeneration Across a Defect Bridge

Esmaeil Biazar et al.

ASAIO JOURNAL (2013)

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Article Engineering, Biomedical

The application of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds for tendon repair in the rat model

William R. Webb et al.

BIOMATERIALS (2013)

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Article Engineering, Biomedical

Induced apoptosis of osteoblasts proliferating on polyhydroxyalkanoates

Yang Wang et al.

BIOMATERIALS (2013)

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Article Engineering, Biomedical

Paclitaxel-PHBV nanoparticles and their toxicity to endometrial and primary ovarian cancer cells

Cristian Vilos et al.

BIOMATERIALS (2013)

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Article Engineering, Biomedical

Poly-4-hydroxybutyrate (P4HB): a new generation of resorbable medical devices for tissue repair and regeneration

Simon F. Williams et al.

BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK (2013)

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Article Agricultural Engineering

Conversion of grass biomass into fermentable sugars and its utilization for medium chain length polyhydroxyalkanoate (mcl-PHA) production by Pseudomonas strains

Reeta Davis et al.

BIORESOURCE TECHNOLOGY (2013)

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Article Biotechnology & Applied Microbiology

Electrospun Aligned PHBV/Collagen Nanofibers as Substrates for Nerve Tissue Engineering

Molamma P. Prabhakaran et al.

BIOTECHNOLOGY AND BIOENGINEERING (2013)

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Article Engineering, Chemical

Improvement of the antifouling properties of poly (lactic acid) hollow fiber membranes with poly (lactic acid)-polyethylene glycol-poly (lactic acid) copolymers

Peng Shen et al.

DESALINATION (2013)

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Review Polymer Science

Bioplastics from waste glycerol derived from biodiesel industry

Chengjun Zhu et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2013)

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Article Nanoscience & Nanotechnology

Biocompatibility of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) Nanofibers for Skin Tissue Engineering

Dhakshinamoorthy Sundaramurthi et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2013)

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Article Biotechnology & Applied Microbiology

Impact of carbon source and variable nitrogen conditions on bacterial biosynthesis of polyhydroxyalkanoates: Evidence of an atypical metabolism in Bacillus megaterium DSM 509

Salma Shahid et al.

JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2013)

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Article Nanoscience & Nanotechnology

Novel biodegradable electrospun nanofibrous P(DLLA-CL) balloons for the treatment of vertebral compression fractures

Gang Sun et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2013)

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Article Materials Science, Biomaterials

Electrospun composites of PHBV, silk fibroin and nano-hydroxyapatite for bone tissue engineering

Elena I. Pascu et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2013)

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Article Materials Science, Biomaterials

Nano-hydroxyapatite reinforced polyhydroxybutyrate composites: A comprehensive study on the structural and in vitro biological properties

Mehdi Sadat-Shojai et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2013)

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Article Materials Science, Biomaterials

Development and characterization of coaxially electrospun gelatin coated poly (3-hydroxybutyric acid) thin films as potential scaffolds for skin regeneration

Naveen Nagiah et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2013)

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Article Materials Science, Biomaterials

Electrospun PHBV/PEO co-solution blends: Microstructure, thermal and mechanical properties

Alessandra Bianco et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2013)

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Article Materials Science, Biomaterials

Encapsulation of Ellipticine in poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) based nanoparticles and its in vitro application

Farha Masood et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2013)

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Article Biochemical Research Methods

Polyhydroxyalkanoate biosynthesis by Hydrogenophaga pseudoflava DSM1034 from structurally unrelated carbon sources

Silvana Povolo et al.

NEW BIOTECHNOLOGY (2013)

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Article Multidisciplinary Sciences

Improvement of PHBV Scaffolds with Bioglass for Cartilage Tissue Engineering

Jun Wu et al.

PLOS ONE (2013)

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Article Polymer Science

Fabrication of carbon nanotube (CNT)/poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) nanocomposite films for human mesenchymal stem cell (hMSC) differentiation

Lin-Ping Wu et al.

POLYMER CHEMISTRY (2013)

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Article Biochemical Research Methods

Secretion of polyhydroxybutyrate in Escherichia coli using a synthetic biological engineering approach

Asif Rahman et al.

JOURNAL OF BIOLOGICAL ENGINEERING (2013)

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Article Engineering, Biomedical

PHBV microspheres as neural tissue engineering scaffold support neuronal cell growth and axon-dendrite polarization

Wenhui Chen et al.

ACTA BIOMATERIALIA (2012)

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Article Biochemistry & Molecular Biology

Biosynthesis and Properties of Medium-Chain-Length Polyhydroxyalkanoates with Enriched Content of the Dominant Monomer

Xuan Jiang et al.

BIOMACROMOLECULES (2012)

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Article Engineering, Biomedical

The differential effects of aligned electrospun PHBHHx fibers on adipogenic and osteogenic potential of MSCs through the regulation of PPAR gamma signaling

Yang Wang et al.

BIOMATERIALS (2012)

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Article Engineering, Biomedical

A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles

Qiang Peng et al.

BIOMATERIALS (2012)

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Article Engineering, Biomedical

Proliferation and skeletal myotube formation capability of C2C12 and H9c2 cells on isotropic and anisotropic electrospun nanofibrous PHB scaffolds

Leonardo Ricotti et al.

BIOMEDICAL MATERIALS (2012)

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Article Chemistry, Applied

Crystallization behavior and hydrophobic properties of biodegradable ethyl cellulose-g-poly(3-hydroxybutyrate-co-3-hydroxyvalerate): The influence of the side-chain length and grafting density

Hou-Yong Yu et al.

CARBOHYDRATE POLYMERS (2012)

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Article Biophysics

Neuronal differentiation of induced pluripotent stem cells in hybrid polyester scaffolds with heparinized surface

Yung-Chih Kuo et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2012)

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Article Polymer Science

Novel block copolymers of atactic PHB with natural PHA for cardiovascular engineering: Synthesis and characterization

Grazyna Adamus et al.

EUROPEAN POLYMER JOURNAL (2012)

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Article Biochemistry & Molecular Biology

Nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/chitosan scaffolds for skin regeneration

Beatriz Veleirinho et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2012)

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Article Nanoscience & Nanotechnology

Preparation and Characterization of Magnetically Responsive Bacterial Polyester Based Nanospheres for Cancer Therapy

Ebru Erdal et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2012)

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Article Engineering, Environmental

Utilizing of Sugar Refinery Waste (Cane Molasses) for Production of Bio-Plastic Under Submerged Fermentation Process

Abhishek Dutt Tripathi et al.

JOURNAL OF POLYMERS AND THE ENVIRONMENT (2012)

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Article Materials Science, Biomaterials

Characterization of poly(3-hydroxybutyrate)/nano-hydroxyapatite composite scaffolds fabricated without the use of organic solvents for bone tissue engineering applications

Amir Nemati Hayati et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2012)

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Proceedings Paper Engineering, Environmental

Characterization of anti-cancer drug materials loaded poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) microspheres for drug delivery system in biochemical material system

Jing Hui et al.

ADVANCED RESEARCH ON ENVIRONMENTAL SCIENCE AND MATERIAL APPLICATION (2012)

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Article Polymer Science

3D Printing of Poly(3-hydroxybutyrate) Porous Structures Using Selective Laser Sintering

Tatiana F. Pereira et al.

MACROMOLECULAR SYMPOSIA (2012)

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Article Biotechnology & Applied Microbiology

Production of a Particulate Hepatitis C Vaccine Candidate by an Engineered Lactococcus lactis Strain

Natalie A. Parlane et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2011)

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Article Biotechnology & Applied Microbiology

Biosynthesis of polyhydroxyalkanoate homopolymers by Pseudomonas putida

Hong-hui Wang et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2011)

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Article Biotechnology & Applied Microbiology

Application of polyhydroxyalkanoate binding protein PhaP as a bio-surfactant

Dai-Xu Wei et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2011)

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Article Biotechnology & Applied Microbiology

Sustained release of PI3K inhibitor from PHA nanoparticles and in vitro growth inhibition of cancer cell lines

Xiao-Yun Lu et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2011)

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Article Biochemistry & Molecular Biology

Biosynthesis and Characterization of Poly(3-hydroxydodecanoate) by β-Oxidation Inhibited Mutant of Pseudomonas entomophila L48

Ah-Leum Chung et al.

BIOMACROMOLECULES (2011)

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Article Engineering, Biomedical

MicroRNAs in the regulation of interfacial behaviors of MSCs cultured on microgrooved surface pattern

Yang Wang et al.

BIOMATERIALS (2011)

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Article Engineering, Biomedical

An assessment of the risks of carcinogenicity associated with polyhydroxyalkanoates through an analysis of DNA aneuploid and telomerase activity

Si-Wu Peng et al.

BIOMATERIALS (2011)

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Article Chemistry, Medicinal

Tumor-specific hybrid polyhydroxybutyrate nanoparticle: Surface modification of nanoparticle by enzymatically synthesized functional block copolymer

Jin Lee et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

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Article Agricultural Engineering

Unsterile and continuous production of polyhydroxybutyrate by Halomonas TD01

Dan Tan et al.

BIORESOURCE TECHNOLOGY (2011)

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Article Materials Science, Multidisciplinary

Biocompatible nanocomposites prepared by impregnating bacterial cellulose nanofibrils into poly(3-hydroxybutyrate)

Cai Zhijiang et al.

CURRENT APPLIED PHYSICS (2011)

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Article Pharmacology & Pharmacy

Preparation and characterization of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHX) based nanoparticles for targeted cancer therapy

Ebru Kilicay et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2011)

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Article Biochemistry & Molecular Biology

Effect of human beta-defensin-3 on the proliferation of fibroblasts on periodontally involved root surfaces

Haiyan Wang et al.

PEPTIDES (2011)

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Article Biotechnology & Applied Microbiology

Conversion of Glycerol to Poly(3-Hydroxypropionate) in Recombinant Escherichia coli

Bjoern Andreessen et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2010)

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Article Biochemistry & Molecular Biology

Nanofibers from Blends of Polyvinyl Alcohol and Polyhydroxy Butyrate As Potential Scaffold Material for Tissue Engineering of Skin

Ashraf Sh. Asran et al.

BIOMACROMOLECULES (2010)

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Article Engineering, Biomedical

The use of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds for tarsal repair in eyelid reconstruction in the rat

Jing Zhou et al.

BIOMATERIALS (2010)

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Article Engineering, Biomedical

Differentiation of human bone marrow mesenchymal stem cells grown in terpolyesters of 3-hydroxyalkanoates scaffolds into nerve cells

Lei Wang et al.

BIOMATERIALS (2010)

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Article Engineering, Biomedical

The behaviour of neural stem cells on polyhydroxyalkanoate nanofiber scaffolds

Xian-Yi Xu et al.

BIOMATERIALS (2010)

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Review Agricultural Engineering

An overview of the recent developments in polylactide (PLA) research

K. Madhavan Nampoothiri et al.

BIORESOURCE TECHNOLOGY (2010)

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Article Pharmacology & Pharmacy

Folate-mediated poly(3-hydroxybutyrate-co-3-hydroxyoctanoate) nanoparticles for targeting drug delivery

Chan Zhang et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2010)

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Article Polymer Science

Organic-Soluble Chitosan/Polyhydroxybutyrate Ultrafine Fibers as Skin Regeneration Prepared by Electrospinning

Guiping Ma et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2010)

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Article Engineering, Biomedical

Biocompatibility of polyhydroxyalkanoate as a potential material for ligament and tendon scaffold material

S. Rathbone et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2010)

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Article Pediatrics

Esophagus tissue engineering: in situ generation of rudimentary tubular vascularized esophageal conduit using the ovine model

Amulya K. Saxena et al.

JOURNAL OF PEDIATRIC SURGERY (2010)

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Article Chemistry, Physical

Designing Poly[(R)-3-hydroxybutyrate]-Based Polyurethane Block Copolymers for Electrospun Nanofiber Scaffolds with Improved Mechanical Properties and Enhanced Mineralization Capability

Kerh Li Liu et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2010)

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Article Materials Science, Biomaterials

In vitro blood compatibility of poly (hydroxybutyrate-co-hydroxyhexanoate) and the influence of surface modification by alkali treatment

Feng Shen et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2010)

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Article Biotechnology & Applied Microbiology

Production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) from unrelated carbon sources by metabolically engineered Escherichia coli

Zheng-Jun Li et al.

METABOLIC ENGINEERING (2010)

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Article Polymer Science

Different thermal behaviors of microbial polyesters poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)

Hai-Mu Ye et al.

POLYMER (2010)

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Article Polymer Science

Processing of poly(lactic acid): Characterization of chemical structure, thermal stability and mechanical properties

F. Carrasco et al.

POLYMER DEGRADATION AND STABILITY (2010)

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Article Engineering, Biomedical

Biocompatibility of poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate)with bone marrow mesenchymal stem cells

Ya-Jun Hu et al.

ACTA BIOMATERIALIA (2009)

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Article Otorhinolaryngology

Poly(3-hydroxybutyrate) (PHB) patches for covering anterior skull base defects - an animal study with minipigs

Hans Edgar Bernd et al.

ACTA OTO-LARYNGOLOGICA (2009)

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Article Biotechnology & Applied Microbiology

Bacterial Polyester Inclusions Engineered To Display Vaccine Candidate Antigens for Use as a Novel Class of Safe and Efficient Vaccine Delivery Agents

Natalie A. Parlane et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2009)

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Article Biotechnology & Applied Microbiology

Production of Functionalized Biopolyester Granules by Recombinant Lactococcus lactis

Jun Mifune et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2009)

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Article Biotechnology & Applied Microbiology

Effect of anaerobic promoters on the microaerobic production of polyhydroxybutyrate (PHB) in recombinant Escherichia coli

Xiao-Xing Wei et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2009)

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Article Engineering, Biomedical

Evaluation of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) conduits for peripheral nerve regeneration

Yu-Zhu Bian et al.

BIOMATERIALS (2009)

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Article Engineering, Biomedical

Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) as an injectable implant system for prevention of post-surgical tissue adhesion

Zhong-W. Dai et al.

BIOMATERIALS (2009)

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Article Agricultural Engineering

Purification, immobilization, and characterization of nattokinase on PHB nanoparticles

Venkataraman Deepak et al.

BIORESOURCE TECHNOLOGY (2009)

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Article Agricultural Engineering

Production and characterization of homopolymer poly(3-hydroxyvalerate) (PHV) accumulated by wild type and recombinant Aeromonas hydrophila strain 4AK4

Xiao-Wen Shen et al.

BIORESOURCE TECHNOLOGY (2009)

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Review Chemistry, Multidisciplinary

A microbial polyhydroxyalkanoates (PHA) based bio- and materials industry

Guo-Qiang Chen

CHEMICAL SOCIETY REVIEWS (2009)

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Article Chemistry, Medicinal

Design of high payload PLGA nanoparticles containing melittin/sodium dodecyl sulfate complex by the hydrophobic ion-pairing technique

Linlin Yang et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2009)

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Review Microbiology

Polyhydroxyalkanoate Granules Are Complex Subcellular Organelles (Carbonosomes)

Dieter Jendrossek

JOURNAL OF BACTERIOLOGY (2009)

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Article Engineering, Biomedical

Physical Properties and Biocompatibility of Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) Blended with Poly(3-hydroxybutyrate-co-4-hydroxybutyrate)

Ling Luo et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2009)

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Article Engineering, Biomedical

In vitro characterization of hepatocyte growth factor release from PHBV/PLGA microsphere scaffold

Xin Hao Zhu et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2009)

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Article Engineering, Biomedical

Toughness decrease of PLA-PHBHHx blend films upon surface-confined photopolymerization

Rahul M. Rasal et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2009)

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Article Engineering, Biomedical

Influence of poly(3-hydroxybutyrate-co-4-hydroxybutyrate-co-3-hydroxyhexanoate) on growth and osteogenic differentiation of human bone marrow-derived mesenchymal stem cells

Xing Wei et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2009)

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Article Chemistry, Multidisciplinary

Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering

Xiaoqin Wang et al.

JOURNAL OF CONTROLLED RELEASE (2009)

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Article Biochemistry & Molecular Biology

Poly(3-hydroxybutyrate) production by Cupriavidus necator using waste glycerol

Joao M. B. T. Cavalheiro et al.

PROCESS BIOCHEMISTRY (2009)

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Article Engineering, Biomedical

The expression of cross-linked elastin by rabbit blood vessel smooth muscle cells cultured in polyhydroxyalkanoate scaffolds

Shao-Ting Cheng et al.

BIOMATERIALS (2008)

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Article Engineering, Biomedical

Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass® composites

Superb K. Misra et al.

BIOMATERIALS (2008)

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Article Engineering, Biomedical

Evaluation of three-dimensional scaffolds prepared from poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) for growth of allogeneic chondrocytes for cartilage repair in rabbits

Yang Wang et al.

BIOMATERIALS (2008)

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Article Engineering, Biomedical

Biodegradable poly-β-hydroxybutyrate scaffold seeded with Schwann cells to promote spinal cord repair

Liudmila N. Novikova et al.

BIOMATERIALS (2008)

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Article Engineering, Biomedical

Interactions between a poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) terpolyester and human keratinocytes

Yan Ji et al.

BIOMATERIALS (2008)

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Article Engineering, Biomedical

Nanofibrous polyhydroxyalkanoate matrices as cell growth supporting materials

Xiao-Tao Li et al.

BIOMATERIALS (2008)

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Article Engineering, Biomedical

A specific drug targeting system based on polyhydroxyalkanoate granule binding protein PhaP fused with targeted cell ligands

Yong-Chao Yao et al.

BIOMATERIALS (2008)

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Article Engineering, Biomedical

Peripheral nerve regeneration within an asymmetrically porous PLGA/Pluronic F127 nerve guide conduit

Se Heang Oh et al.

BIOMATERIALS (2008)

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Article Engineering, Environmental

Up-Cycling of PET (Polyethylene Terephthalate) to the Biodegradable Plastic PHA (Polyhydroxyalkanoate)

Shane T. Kenny et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2008)

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Article Microbiology

Genetic and biochemical characterization of the poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthase in Haloferax mediterranei

Qiuhe Lu et al.

JOURNAL OF BACTERIOLOGY (2008)

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Article Engineering, Biomedical

Growth of keratinocytes on porous films of poly(3-hydroxybutyrate) and poly(4-hydroxybutyrate) blended with hyaluronic acid and chitosan

Gundela Peschel et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2008)

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Article Surgery

Fibrin matrix for suspension of regenerative cells in an artificial nerve conduit

D. F. Kalbermatten et al.

JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY (2008)

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Article Engineering, Environmental

A Processing, Characterization and Marine Biodegradation Study of Melt-Extruded Polyhydroxyalkanoate (PHA) Films

Christopher Thellen et al.

JOURNAL OF POLYMERS AND THE ENVIRONMENT (2008)

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Article Polymer Science

Synthesis, characterization and biocompatibility of novel biodegradable poly[((R)-3-hydroxybutyrate)-block-(D,L-lactide)-block-(ε-caprolactone)] triblock copolymers

Linping Wu et al.

POLYMER INTERNATIONAL (2008)

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Article Cell & Tissue Engineering

ECM molecules mediate both Schwann cell proliferation and activation to enhance neurite outgrowth

Stephanie J. Armstrong et al.

TISSUE ENGINEERING (2007)

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Article Engineering, Biomedical

Effect of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanofiber matrices cocultured with hair follicular epithelial and dermal cells for biological wound dressing

Insook Han et al.

ARTIFICIAL ORGANS (2007)

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Article Cardiac & Cardiovascular Systems

Healing and remodeling of bioengineered pulmonary artery patches implanted in sheep

Karen Mendelson et al.

CARDIOVASCULAR PATHOLOGY (2007)

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Article Engineering, Biomedical

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) composite biomaterials for bone tissue regeneration:: In vitro performance assessed by osteoblast proliferation, osteoclast adhesion and resorption, and macrophage proinflammatory response

S. M. Cool et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2007)

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Article Engineering, Biomedical

Study on decellularized porcine aortic Valve/Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) hybrid heart valve in sheep model

Song Wu et al.

ARTIFICIAL ORGANS (2007)

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Article Biology

Tissue engineering of heart valves using decellularized xenogeneic or polymeric starter matrices

Doerthe Schmidt et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2007)

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Article Engineering, Biomedical

Growing tissue-like constructs with Hep3B/HepG2 liver cells on PHBV microspheres of different sizes

Xin Hao Zhu et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2007)

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Article Biochemistry & Molecular Biology

Mechanical properties of comonomer-compositionally fractionated poly[(3-hydroxybutyrate)-co-(3-mercaptopropionate)] with low 3-mercaptopropionate unit content

Fang Yu et al.

MACROMOLECULAR BIOSCIENCE (2007)

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Article Biochemistry & Molecular Biology

Potential of various archae- and eubacterial strains as industrial polyhydroxyalkanoate producers from whey

Martin Koller et al.

MACROMOLECULAR BIOSCIENCE (2007)

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Article Engineering, Biomedical

Characteristic comparison of bioactive scaffolds based on polyhydroxyalkoanate/bioceramic hybrids

Yudong Zheng et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2007)

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Meeting Abstract Biotechnology & Applied Microbiology

Resorbable polyhydroxyalkanoates as a carrier of antitumor drugs

Ekaterina Shishatskaya et al.

JOURNAL OF BIOTECHNOLOGY (2007)

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Review Microbiology

Polyhydroxyalkanoates in Gram-positive bacteria: insights from the genera Bacillus and Streptomyces

Sabeel P. Valappil et al.

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2007)

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Article Polymer Science

Preparation and characterization of biodegradable nanoparticles based on amphiphilic poly(3-hydroxybutyrate)-poly(ethylene glycol)-poly(3-hydroxybutyrate) triblock copolymer

Cheng Chen et al.

EUROPEAN POLYMER JOURNAL (2006)

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Review Biochemistry & Molecular Biology

Polyhydroxyalkanoate (PHA)/inorganic phase composites for tissue engineering applications

Superb K. Misra et al.

BIOMACROMOLECULES (2006)

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Article Biochemistry & Molecular Biology

Nonspecific hydrophobic interactions of a repressor protein, PhaR, with poly[(R)-3-hydroxybutyrate] film studied with a quartz crystal microbalance

Koichi Yamashita et al.

BIOMACROMOLECULES (2006)

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Article Engineering, Biomedical

The effect of D,L-β-hydroxybutyric acid on cell death and proliferation in L929 cells

S Cheng et al.

BIOMATERIALS (2006)

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Article Polymer Science

Improvement of mechanical properties of poly(DL-lactide) films by blending of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)

Y Gao et al.

EUROPEAN POLYMER JOURNAL (2006)

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Article Engineering, Biomedical

Improvement in hydrophilicity of PHBV films by plasma treatment

YJ Wang et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2006)

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Article Engineering, Biomedical

A hybrid PHB-hydroxyapatite composite for biomedical application: production, in vitro and in vivo investigation

E. I. Shishatskaya et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2006)

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Article Engineering, Biomedical

In vitro study on hemocompatibility and cytocompatibility of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)

Xiang-Hua Qu et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2006)

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Article Biotechnology & Applied Microbiology

Contact angle, WAXS, and SAXS analysis of poly(β-hydroxybutyrate) and poly(ethylene glycol) block copolymers obtained via Azotobacter vinelandii UWD

KJ Townsend et al.

BIOTECHNOLOGY PROGRESS (2005)

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Article Engineering, Biomedical

Effects of surface modification of poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) on physicochemical properties and on interactions with MC3T3-E1 cells

J Li et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2005)

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Review Pathology

Cardiovascular tissue engineering: state of the art

DS Vara et al.

PATHOLOGIE BIOLOGIE (2005)

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Article Engineering, Biomedical

Enhanced vascular-related cellular affinity on surface modified copolyesters of 3-hydroxybutyrate and 3-hydroxyhexanoate (PHBHHx)

XH Qu et al.

BIOMATERIALS (2005)

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Review Engineering, Biomedical

The application of polyhydroxyalkanoates as tissue engineering materials

GQ Chen et al.

BIOMATERIALS (2005)

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Article Surgery

Composite PHB-GGF conduit for long nerve gap repair: A long-term evaluation

PN Mohanna et al.

SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY (2005)

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Review Engineering, Biomedical

Chemosynthesis of bioresorbable poly(γ-butyrolactone) by ring-opening polymerisation:: a review

T Moore et al.

BIOMATERIALS (2005)

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Article Engineering, Biomedical

Evaluation of three-dimensional scaffolds made of blends of hydroxyapatite and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) for bone reconstruction

YW Wang et al.

BIOMATERIALS (2005)

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Article Biochemistry & Molecular Biology

Influence of DL-β-hydroxybutyric acid on cell proliferation and calcium influx

S Cheng et al.

BIOMACROMOLECULES (2005)

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Article Engineering, Biomedical

Hydroxyapatite reinforced poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) based degradable composite bone plate

S Coskun et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2005)

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Article Biotechnology & Applied Microbiology

Poly(beta-hydroxybutyrate) production by a moderate halophile, Halomonas boliviensis LC1 using starch hydrolysate as substrate

J Quillaguaman et al.

JOURNAL OF APPLIED MICROBIOLOGY (2005)

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Article Biotechnology & Applied Microbiology

Transcription level of granule-associated phaP and phaR genes and granular morphogenesis of poly-β-hydroxyalkanoate granules in Ralstonia eutropha

MC Seo et al.

BIOTECHNOLOGY LETTERS (2004)

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Article Engineering, Biomedical

Attachment, proliferation and differentiation of osteoblasts on random biopolyester poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds

YW Wang et al.

BIOMATERIALS (2004)

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Article Cardiac & Cardiovascular Systems

Decellularization protocols of porcine heart valves differ importantly in efficiency of cell removal and susceptibility of the matrix to recellularization with human vascular cells

E Rieder et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2004)

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Article Polymer Science

Biodegradation studies of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)

YW Wang et al.

POLYMER DEGRADATION AND STABILITY (2004)

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Article Cardiac & Cardiovascular Systems

Biomatrix/polymer composite material for heart valve tissue engineering

C Stamm et al.

ANNALS OF THORACIC SURGERY (2004)

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Article Cell & Tissue Engineering

In vivo tissue engineering of bone using poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) and collagen scaffolds

GT Köse et al.

TISSUE ENGINEERING (2004)

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Article Engineering, Biomedical

Fabrication and characterization of bioactive wollastonite/PHBV composite scaffolds

HY Li et al.

BIOMATERIALS (2004)

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Article Biochemistry & Molecular Biology

Impact of decellularization of xenogeneic tissue on extracellular matrix integrity for tissue engineering of heart valves

K Schenke-Layland et al.

JOURNAL OF STRUCTURAL BIOLOGY (2003)

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Article Microscopy

In vivo response to HA-polyhydroxybutyrate/polyhydroxyvalerate composite

ZB Luklinska et al.

JOURNAL OF MICROSCOPY (2003)

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Article Polymer Science

Medium-chain-length polyhydroxyalkanoic acids (PHAmcl) produced by Pseudomonas putida IPT 046 from renewable sources

RJ Sánchez et al.

EUROPEAN POLYMER JOURNAL (2003)

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Article Engineering, Biomedical

A novel bioreactor for the dynamic flexural stimulation of tissue engineered heart valve biomaterials

GC Engelmayr et al.

BIOMATERIALS (2003)

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Article Cell & Tissue Engineering

Addition of fibronectin to alginate matrix improves peripheral nerve regeneration in tissue-engineered conduits

A Mosahebi et al.

TISSUE ENGINEERING (2003)

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Article Anatomy & Morphology

A composite poly-hydroxybutyrate-glial growth factor conduit for long nerve gap repairs

PN Mohanna et al.

JOURNAL OF ANATOMY (2003)

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Article Biotechnology & Applied Microbiology

Results of biomedical investigations of PHB and PHB/PHV fibers

T Volova et al.

BIOCHEMICAL ENGINEERING JOURNAL (2003)

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Review Biotechnology & Applied Microbiology

Medical applications of poly-4-hydroxybutyrate: a strong flexible absorbable biomaterial

DP Martin et al.

BIOCHEMICAL ENGINEERING JOURNAL (2003)

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Article Engineering, Biomedical

Study on the three-dimensional proliferation of rabbit articular cartilage-derived chondrocytes on polyhydroxyalkanoate scaffolds

Y Deng et al.

BIOMATERIALS (2002)

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Article Engineering, Biomedical

Production and evaluation of biodegradable composites based on PHB-PHV copolymer

LJ Chen et al.

BIOMATERIALS (2002)

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Article Surgery

Poly-3-hydroxybutyrate (PHB): a resorbable conduit for long-gap repair in peripheral nerves

RC Young et al.

BRITISH JOURNAL OF PLASTIC SURGERY (2002)

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Article Microbiology

Polyhydroxybutyrate biosynthesis in Caulobacter crescentus:: molecular characterization of the polyhydroxybutyrate synthase

QS Qi et al.

MICROBIOLOGY-SGM (2001)

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Review Engineering, Environmental

A literature review of poly(lactic acid)

D Garlotta

JOURNAL OF POLYMERS AND THE ENVIRONMENT (2001)

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Article Biochemistry & Molecular Biology

Surface modification of polyhydroxyalkanoate films and their interaction with human fibroblasts

IK Kang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2001)

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Article Cardiac & Cardiovascular Systems

Patch augmentation of the pulmonary artery with bioabsorbable polymers and autologous cell seeding

UA Stock et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2000)

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Review Polymer Science

Synthesis, structure and properties of polyhydroxyalkanoates: biological polyesters

K Sudesh et al.

PROGRESS IN POLYMER SCIENCE (2000)

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Article Cardiac & Cardiovascular Systems

Tissue engineering of heart valves: In vitro experiences

R Sodian et al.

ANNALS OF THORACIC SURGERY (2000)

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Article Engineering, Biomedical

Adhesion of bioactive glass coating to Ti6Al4V oral implant

J Schrooten et al.

BIOMATERIALS (2000)

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Article Cell & Tissue Engineering

Fabrication of a trileaflet heart valve scaffold from a polyhydroxyalkanoate biopolyester for use in tissue engineering

R Sodian et al.

TISSUE ENGINEERING (2000)

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Article Engineering, Biomedical

Evaluation of biodegradable, three-dimensional matrices for tissue engineering of heart valves

R Sodian et al.

ASAIO JOURNAL (2000)

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