期刊
THERANOSTICS
卷 6, 期 7, 页码 969-985出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.14856
关键词
Click chemistry; nanosensor; bio-conjugation; signal amplification system
资金
- National Natural Science Foundation of China [81361140345, 21505027, 51373043, 21535001]
- Chinese Academy of Sciences [XDA09030305]
- Ministry of Health [2012ZX10001-008]
- CAS/SAFEA International Partnership Program for Creative Research Teams
Click chemistry combined with functional nanoparticles have drawn increasing attention in biochemical assays because they are promising in developing biosensors with effective signal transformation/amplification and straightforward signal readout for clinical diagnostic assays. In this review, we focus on the latest advances of biochemical assays based on Cu (I)-catalyzed 1, 3-dipolar cycloaddition of azides and alkynes (CuAAC)-mediated nanosensors, as well as the functionalization of nanoprobes based on click chemistry. Nanoprobes including gold nanoparticles, quantum dots, magnetic nanoparticles and carbon nanomaterials are covered. We discuss the advantages of click chemistry-mediated nanosensors for biochemical assays, and give perspectives on the development of click chemistry-mediated approaches for clinical diagnosis and other biomedical applications.
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