期刊
THERANOSTICS
卷 6, 期 12, 页码 2170-2182出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.16633
关键词
helical poly(phenyl isocyanide); micelles; cell penetration; photoacoustic imaging; theranostics
资金
- National Natural Scientific Foundation of China [51303044, 81571744, 81301257]
- National Basic Research Program of China (863 Program) [2015AA020502]
- Natural Scientific Foundation of Anhui Province [1408085QE80]
- Science Foundation of Fujian Province [2014Y2004]
- Xiamen University Startup [0260-ZK1029]
- Specialized Research Fund for the Doctoral Program of Higher Education [20130111120013]
With high optical absorption efficiency, near infrared (NIR) dyes have been proposed as theranostic agents for fluorescence imaging, photoacoustic imaging (PAI), and photothermal therapy (PTT). However, inherent hydrophobicity and short circulation time of small molecule hinder the further biomedical application. Herein smart amphiphilic copolymer was synthesized containing IR780/camptothecin@poly(e-caprolactone) (IR780/CPT@PCL) as core, helical poly(phenyl isocyanide) (PPI) blocks as shell with the pH-responsive rhodamine B (RhB) moieties in the core-shell interface. With hydrophilic helical PPI coronas, these micelles present significantly enhanced cell-penetrating capacity that plays a key role in facilitating intracellular delivery of various cargos. By encapsulating CPT and IR780 molecules, the multifunctional self-assemble probe has huge potential to realize functional cooperativity and adaptability for cancer diagnosis and therapy. The in vitro and in vivo experimental results demonstrate that the pH-triggered fluorescent responsiveness and strong acoustic generation permit them efficient fluorescent and PA signal sensing for cancer diagnosis. Moreover, with 808 nm laser irradiation, the generated heat significantly improves the drug release from PCL core, leading to synergetic chemo-photothermal therapy and decreases tumor recurrence rates in mice. Overall, the biocompatible multifunctional micelles with these combined advantages can potentially be utilized for PAI guided disease diagnosis and tumor ablation.
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