期刊
THERANOSTICS
卷 6, 期 7, 页码 1053-1064出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.14843
关键词
drug delivery; nanomedicine; stimuli-responsive; ATP-responsive; theranostics; conjugated polymers
资金
- National Natural Science Foundation of China [21174060]
- NC TraCS
- NIH's Clinical and Translational Science Awards (CTSA, NIH) at UNC-CH [1UL1TR001111]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1252]
- State of North Carolina
- National Science Foundation (NSF)
- China Scholarship Council
Stimuli-responsive and imaging-guided drug delivery systems hold vast promise for enhancement of therapeutic efficacy. Here we report an adenosine-5'-triphosphate (ATP)-responsive and near-infrared (NIR)-emissive conjugated polymer-based nanocarrier for the controlled release of anticancer drugs and real-time imaging. We demonstrate that the conjugated polymeric nanocarriers functionalized with phenylboronic acid tags on surface as binding sites for ATP could be converted to the water-soluble conjugated polyelectrolytes in an ATP-rich environment, which promotes the disassembly of the drug carrier and subsequent release of the cargo. In vivo studies validate that this formulation exhibits promising capability for inhibition of tumor growth. We also evaluate the metabolism process by monitoring the fluorescence signal of the conjugated polymer through the in vivo NIR imaging.
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