期刊
THERANOSTICS
卷 6, 期 12, 页码 2196-2208出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.16923
关键词
Carbon nanodot; Nitrogen doping; Photoacoustic; Photothermal; Biodegradation
资金
- IITP ICT Consilience Creative Program [IITP-2015-R0346-15-1007]
- NRF Engineering Research Center grant [NRF-2011-0030075]
- Ministry of Science, ICT, Future Planning [NRF-2016R1C1B1011830, KHIDI-HI15C1817, 2015R1A2A1A15053779]
- Korean Health Technology R& D Project from the Ministry of Health Welfare [HI114C1658]
- Marine Biotechnology Program - Ministry of Oceans and Fisheries, Sookmyung Women's University Research Grant [20150220, 1-1603-2001]
- Samsung Research Funding Center of Samsung Electronics [SRFC-MA1401-07]
Multifunctional nanoparticles have been widely investigated for biomedical applications, such as imaging, therapy, and drug delivery. Especially, photoactive nanoparticles have received great attention as theranostic agents because of their heat-generating abilities after exposure to laser irradiation. However, photostability and safety issues have been the technical hurdles for further clinical applications. Here, we designed nitrogen (N)-doped carbon nanodots (N-CNDs) that have strong absorption in the near-infrared region, high photostability, and excellent biodegradability. Optimized N-CNDs can be utilized not only as a new photoacoustic (PA) imaging agent but also as a superior photothermal therapy (PTT) agent in vivo because of their strong optical absorption at a specific wavelength. We used N-CNDs to perform in vivo/ex vivo noninvasive PA imaging of sentinel lymph nodes via local delivery and performed PTT for cancer ablation therapy. Finally, biodegradation and renal clearance were confirmed by performing whole-body PA monitoring and a degradation test.
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