LITTIP/Lgr6/HnRNPK complex regulates cementogenesis via Wnt signaling

Article Dentistry, Oral Surgery & Medicine

LncPVT1 regulates osteogenic differentiation of human periodontal ligament cells via miR-10a-5p/brain-derived neurotrophic factor

Xiaobei Li et al.

Summary: This study reveals that lncPVT1 positively regulates the osteogenic differentiation of PDLCs through miR-10a-5p and BDNF, providing a promising target for enhancing the osteogenic potential of PDLCs.

JOURNAL OF PERIODONTOLOGY (2022)

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Article Multidisciplinary Sciences

An optogenetic approach for regulating human parathyroid hormone secretion

Yunhui Liu et al.

Summary: A new optogenetic approach was used to inhibit PTH secretion in human parathyroid cells and prevent bone loss in mice, providing a strategy to regulate PTH release and associated bone loss.

NATURE COMMUNICATIONS (2022)

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Article Dentistry, Oral Surgery & Medicine

LncRNA Nron Inhibits Bone Resorption in Periodontitis

J. Li et al.

Summary: Periodontitis is a common chronic oral disease characterized by bone resorption. The study found that the lncRNA Nron can inhibit osteoclast activity and bone resorption, showing potential for new treatment strategies.

JOURNAL OF DENTAL RESEARCH (2022)

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Article Cell & Tissue Engineering

LncRNA GACAT2 binds with protein PKM1/2 to regulate cell mitochondrial function and cementogenesis in an inflammatory environment

Xuan Li et al.

Summary: Periodontal ligament stem cells (PDLSCs) play a crucial role in restoring/regenerating periodontal tissues, but their functions are compromised in an inflammatory environment. This study identified that the impairment of cementogenesis in PDLSCs induced by inflammation is closely related to their mitochondrial function and long noncoding RNAs (lncRNAs). The lncRNA GACAT2 was found to regulate inflammation-mediated changes in mitochondrial function and cementogenesis by binding to pyruvate kinase M1/2 (PKM1/2). Overexpression of GACAT2 reversed the damage to mitochondrial function and cementoblastic differentiation induced by inflammation.

BONE RESEARCH (2022)

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Article Cell Biology

Intermittent parathyroid hormone promotes cementogenesis via ephrinB2-EPHB4 forward signaling

Tiancheng Li et al.

Summary: Intermittent PTH promotes periodontal repair by accelerating the regeneration of root resorption through ephrinB2-EPHB4 forward signaling pathway, as evidenced by in vivo and in vitro experiments.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Article Dentistry, Oral Surgery & Medicine

Wnt1 Promotes Cementum and Alveolar Bone Growth in a Time-Dependent Manner

C. Nottmeier et al.

Summary: The WNT/beta-catenin signaling pathway is crucial in periodontium biology, with specific extracellular WNT ligands like WNT1 demonstrating a strong promoting effect on cementum and alveolar bone formation in vivo. Experimental results indicate that Wnt1 promotes proliferation but not differentiation of cementoblasts.

JOURNAL OF DENTAL RESEARCH (2021)

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Article Dentistry, Oral Surgery & Medicine

A Biphasic Feature of Gli1+-Mesenchymal Progenitors during Cementogenesis That Is Positively Controlled by Wnt/β-Catenin Signaling

X. Xie et al.

Summary: The study reveals a complex relationship between Gli1(+) PDL progenitor cells and cementum growth, with a negative impact on cementogenesis from Gli1(+) progenitor cell numbers but a positive correlation between Gli1-derived acellular and cellular cementoblast cell numbers and cementum growth. Activation of beta-catenin in Gli1 cells leads to cementum hyperplasia, while deletion of beta-catenin results in reduced postnatal cementum growth.

JOURNAL OF DENTAL RESEARCH (2021)

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Article Multidisciplinary Sciences

The effect of parathyroid hormone on osteogenesis is mediated partly by osteolectin

Jingzhu Zhang et al.

Summary: The study revealed that PTH promotes osteolectin expression and its interaction mediates part of the bone formation response to PTH, while SOSTi does not affect osteolectin levels or require it for bone formation.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Multidisciplinary Sciences

TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection

Jing Geng et al.

Summary: TLR4 signaling enhances macrophage bactericidal activity through the mechanical sensor Piezo1, with mechanical sensing signals playing a critical role in the innate immune response. The assembly of Piezo1 and TLR4 complex triggers the remodeling of F-actin organization to augment phagocytosis and bacterial clearance, providing insights into macrophage mechanophysiology and host response coordination.

NATURE COMMUNICATIONS (2021)

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Article Dentistry, Oral Surgery & Medicine

Downregulation of Linc-RNA activator of myogenesis LncRNA participates in FGF2 mediated-proliferation of human periodontal ligament stem cells

Xiayi Wu et al.

JOURNAL OF PERIODONTOLOGY (2020)

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Article Biochemistry & Molecular Biology

Peroxisome proliferator activated receptor γ promotes mineralization and differentiation in cementoblasts via inhibiting Wnt/β-catenin signaling pathway

Yingying Hu et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Long noncoding RNA HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and DNA damage repair via YB1

Xiaoyan Wang et al.

NUCLEIC ACIDS RESEARCH (2020)

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Article Biochemistry & Molecular Biology

LINC00467 is up-regulated by TDG-mediated acetylation in non-small cell lung cancer and promotes tumor progression

Yuxing Zhu et al.

ONCOGENE (2020)

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Article Dentistry, Oral Surgery & Medicine

Parathyroid hormone increases alveolar bone homoeostasis during orthodontic tooth movement in rats with periodontitis via crosstalk between STAT3 and β-catenin

Cheng Zhang et al.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2020)

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Article Dentistry, Oral Surgery & Medicine

Intermittent parathyroid hormone promotes cementogenesis in a PKA- and ERK1/2-dependent manner

Yang Xu et al.

JOURNAL OF PERIODONTOLOGY (2019)

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Article Dentistry, Oral Surgery & Medicine

Combined effects of systemic parathyroid hormone (1-34) and locally delivered neutral self-assembling peptide hydrogel in the treatment of periodontal defects: An experimental in vivo investigation

Wataru Yoshida et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2019)

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Review Cell & Tissue Engineering

lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration

Jian Zhu et al.

STEM CELL RESEARCH & THERAPY (2019)

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Article Endocrinology & Metabolism

Aberrantly elevated Wnt signaling is responsible for cementum overgrowth and dental ankylosis

Yan Wu et al.

BONE (2019)

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Article Dentistry, Oral Surgery & Medicine

MicroRNA-3064-3p regulates the differentiation of cementoblasts through targeting DKK1

C. Wang et al.

JOURNAL OF PERIODONTAL RESEARCH (2018)

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Article Oncology

Long intergenic non-coding RNAs have an independent impact on survival in multiple myeloma

Mehmet Kemal Samur et al.

LEUKEMIA (2018)

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Review Pharmacology & Pharmacy

Interactions between microRNAs and long non-coding RNAs in cardiac development and repair

Alessio Rotini et al.

PHARMACOLOGICAL RESEARCH (2018)

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Article Cell Biology

Long noncoding RNA TUG1 facilitates osteogenic differentiation of periodontal ligament stem cells via interacting with Lin28A

Qin He et al.

CELL DEATH & DISEASE (2018)

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Article Cell Biology

Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2

Roland Elling et al.

CELL REPORTS (2018)

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Article Dentistry, Oral Surgery & Medicine

Wnt activity is associated with cementum-type transition

C. -H. Bae et al.

JOURNAL OF PERIODONTAL RESEARCH (2017)

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Article Cell Biology

Intermittent parathyroid hormone (PTH) promotes cementogenesis and alleviates the catabolic effects of mechanical strain in cementoblasts

Yuyu Li et al.

BMC CELL BIOLOGY (2017)

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Article Oncology

Long non-coding RNA CASC11 interacts with hnRNP-K and activates the WNT/β-catenin pathway to promote growth and metastasis in colorectal cancer

Zheying Zhang et al.

CANCER LETTERS (2016)

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Article Medicine, General & Internal

The WNT system: background and its role in bone

U. H. Lerner et al.

JOURNAL OF INTERNAL MEDICINE (2015)

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Article Dentistry, Oral Surgery & Medicine

Enhanced M1/M2 Macrophage Ratio Promotes Orthodontic Root Resorption

D. He et al.

JOURNAL OF DENTAL RESEARCH (2015)

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Article Dentistry, Oral Surgery & Medicine

Downregulation of Wnt causes root resorption

Won Hee Lim et al.

AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS (2014)

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Article Dentistry, Oral Surgery & Medicine

Intermittent Parathyroid Hormone Administration Improves Periodontal Healing in Rats

Daniel Fernando Pereira Vasconcelos et al.

JOURNAL OF PERIODONTOLOGY (2014)

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Article Biochemistry & Molecular Biology

Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation

Jen-Hao Yang et al.

NUCLEIC ACIDS RESEARCH (2014)

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Article Biochemistry & Molecular Biology

Disruption of Wnt/beta-catenin Signaling in Odontoblasts and Cementoblasts Arrests Tooth Root Development in Postnatal Mouse Teeth

Ran Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2013)

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Article Multidisciplinary Sciences

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

Wim de Lau et al.

NATURE (2011)

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Letter Biochemical Research Methods

Predicting protein associations with long noncoding RNAs

Matteo Bellucci et al.

NATURE METHODS (2011)

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Review Dentistry, Oral Surgery & Medicine

Root resorption associated with orthodontic tooth movement: A systematic review

Belinda Weltman et al.

AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS (2010)

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Article Dentistry, Oral Surgery & Medicine

Anabolic effect of intermittent PTH(1-34) on the local microenvironment during the late phase of periodontal repair in a rat model of tooth root resorption

S. Lossdoerfer et al.

CLINICAL ORAL INVESTIGATIONS (2010)

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Article Medicine, General & Internal

Teriparatide and Osseous Regeneration in the Oral Cavity.

Jill D. Bashutski et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

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Article Endocrinology & Metabolism

Wnt signaling inhibits cementoblast differentiation and promotes proliferation

Eiji Nemoto et al.

BONE (2009)

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Review Cell Biology

Long noncoding RNAs: functional surprises from the RNA world

Jeremy E. Wilusz et al.

GENES & DEVELOPMENT (2009)

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Article Dentistry, Oral Surgery & Medicine

Inheritance of susceptibility to root resorption associated with orthodontic force in mice

Shaza K. Abass et al.

AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS (2008)

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Article Oncology

Androgen receptor overexpression in prostate cancer linked to Purα loss from a novel repressor complex

Longgui G. Wang et al.

CANCER RESEARCH (2008)

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Article Dentistry, Oral Surgery & Medicine

RANKL, osteopontin, and osteoclast homeostasis in a hyperocclusion mouse model

Cameron G. Walker et al.

EUROPEAN JOURNAL OF ORAL SCIENCES (2008)

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Article Biochemistry & Molecular Biology

hnRNP K: An HDM2 target and transcriptional coactivator of p53 in response to DNA damage

A Moumen et al.

CELL (2005)

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Review Dentistry, Oral Surgery & Medicine

Are cementoblasts a subpopulation of osteoblasts or a unique phenotype?

DD Bosshardt

JOURNAL OF DENTAL RESEARCH (2005)

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Article Endocrinology & Metabolism

Cementum-forming cells are phenotypically distinct from bone-forming cells

WJ Grzesik et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2000)

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LITTIP/Lgr6/HnRNPK complex regulates cementogenesis via Wnt signaling

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