4.7 Article

Body composition modify the association between ambient particulate matter and lung function among asthma patients

出版社

SPRINGER HEIDELBERG
DOI: 10.1007/s11356-023-28597-4

关键词

PM2 5; PM10; Particulate matter; Lung functions; Asthma; Body composition

向作者/读者索取更多资源

The effect of ambient PM10 and PM2.5 on lung function modified by body muscle and adipose tissue is not fully understood. This study investigated the association between seasonal average air pollutants and lung function in asthmatic patients modified by body composition indicators. The results showed that total body muscle significantly modified the negative association between PM10 and lung function among asthma patients, while obesity and low total body muscle increased susceptibility to the adverse effects of PM10 on lung function.
The effect of ambient PM10 and PM2.5 on lung function modified by body muscle and adipose tissue is not fully understood at present. Our aims were to investigate the association between seasonal average air pollutants and lung function in asthmatic patients modified by body composition indicators. In this cross-sectional study, we recruited 914 doctor-diagnosed asthmatic patients, and performed interaction and stratified analysis using the median values of total body muscle (TBM), total body fat (TBF), and percentage body fat (PBF) as well as body mass index (BMI) =25 as the cutoff points of the high/low body composition groups. The adjusted R-2 values of the developed LUR models of PM2.5 and PM10 were 91.4% and 90.5% and also verified by cross-validation, respectively. After adjusting for confounding factors, we found that TBM significantly modified the association between PM10 and lung function among asthma patients (interaction P value <0.05). In the low TBM group, seasonal average concentrations of PM10 estimated by the LUR model increased by 10 & mu;g/m(3), and negative associations with lung function indicators were observed. For obese patients with BMI>25 and high TBF, the increase in PM10 was associated with the decrease in lung function. The asthma patients with obesity and low total body muscle were more susceptible to adverse effects of PM10 on lung function.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据