☆ 4.3 Review

Host and Pathogen-Directed Therapies against Microbial Infections Using Exosome- and Antimicrobial Peptide-derived Stem Cells with a Special look at Pulmonary Infections and Sepsis

STEM CELL REVIEWS AND REPORTS (2023)

相关参考文献

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Review Biochemistry & Molecular Biology

The Machinery of Exosomes: Biogenesis, Release, and Uptake

Sofia V. Krylova et al.

Summary: Exosomes are small membrane-contained vesicles secreted by cells, which play important roles in maintaining cellular homeostasis, facilitating intercellular communication, and removing cellular debris. They are being extensively studied as potential diagnostic markers and therapeutic targets in various diseases. However, the underlying mechanisms of exosome biogenesis, release and uptake are still largely unknown. This review aims to provide updated molecular details of these processes to facilitate the design of future impactful exosome experiments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Review Biotechnology & Applied Microbiology

Recent developments in isolating methods for exosomes

Jiahui Gao et al.

Summary: The development of new methods for exosome isolation, such as microfluidic chips, nanolithography, and electro-deposition, has greatly improved the efficiency and speed of isolation. This review summarizes a series of exosome isolation methods, with a focus on emerging methods, and provides a detailed comparison and analysis of each method, including their principles, merits, and limitations.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2023)

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Review Cell & Tissue Engineering

Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials

Ahmed Lotfy et al.

Summary: Mesenchymal stromal/stem cells (MSCs) are widely used in cell therapy due to their immunomodulatory and regenerative properties. The production of various factors via extracellular vesicles, especially exosomes, governs the efficacy of MSCs. MSC-derived exosomes (MSC-Exos) show advantages over MSCs themselves by reducing adverse effects. Clinical studies are assessing the therapeutic effect of MSC-Exos in different diseases, and production methods, dosage, and administration routes are being explored.

STEM CELL RESEARCH & THERAPY (2023)

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Review Biochemistry & Molecular Biology

Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies

Alessia Catalano et al.

Summary: Multidrug resistance, including resistance to anticancer agents and antimicrobial drugs, is a significant concern in public health. The widespread use of antibiotics has led to the emergence of pathogenic bacteria resistant to multiple drugs, and the ongoing COVID-19 pandemic may worsen antimicrobial resistance. Nanodrug delivery systems have shown promise in overcoming resistance.

MOLECULES (2022)

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Review Microbiology

Mesenchymal Stem Cell-Derived Exosome Therapy of Microbial Diseases: From Bench to Bed

Xiaolan Wu et al.

Summary: This review focuses on the application of exosome therapy, particularly the use of mesenchymal stem cell-derived exosomes (MSC-Exos), in treating microbial diseases. It discusses the difficulties and current strategies in antimicrobial treatments, provides an overview of exosomes in terms of isolation, identification, contents, and applications, and delves into the mechanisms of MSC-Exo therapy in microbial diseases. The review also highlights the progress in clinical translation and the potential for future perspectives.

FRONTIERS IN MICROBIOLOGY (2022)

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Review Microbiology

Potential of Mesenchymal Stem Cell-Derived Exosomes as a Novel Treatment for Female Infertility Caused by Bacterial Infections

Marzieh Zohrabi et al.

Summary: This article discusses the potential application of mesenchymal stem cell-derived exosomes (MSC-Exos) in bacterial diseases of the female reproductive system. MSC-Exos have therapeutic properties such as anti-inflammatory effects, tissue repair, and modulation of immune responses. They can suppress destructive immune responses and enhance the phagocytic activity of host immune cells, which is significant in the treatment of sexually transmitted diseases.

FRONTIERS IN MICROBIOLOGY (2022)

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Review Instruments & Instrumentation

Exosomal targeting and its potential clinical application

Jiao He et al.

Summary: Exosomes, as extracellular vesicles secreted by living cells, possess natural targeting as nano-carriers for drug delivery systems. However, the natural targeting alone is insufficient for precise delivery, requiring engineering transformation and modification to optimize targeting efficiency.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Review Cell Biology

Exosomes Regulate NLRP3 Inflammasome in Diseases

Zhangwang Li et al.

Summary: Exosomes play a unique and critical role as signal molecules vector in various diseases, particularly in immune progression. However, the mechanisms and clinical treatment related to exosomes and NLRP3 are still not fully understood.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Cell Biology

Exosomes from adipose-derived mesenchymal stem cells alleviate sepsis-induced lung injury in mice by inhibiting the secretion of IL-27 in macrophages

Xiaoyan Wang et al.

Summary: The study found that exosomes from adipose-derived MSCs (ADMSCs) have anti-inflammatory effects in sepsis-induced acute lung injury by inhibiting IL-27 secretion and reducing the release of inflammatory cytokines, thereby improving the survival rate of mice.

CELL DEATH DISCOVERY (2022)

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Review Biotechnology & Applied Microbiology

Rescuing humanity by antimicrobial peptides against colistin-resistant bacteria

Majid Taati Moghadam et al.

Summary: The misuse and overuse of antibiotics have led to the emergence of antibiotic-resistant infections. Researchers are looking for alternatives with antimicrobial properties, such as antimicrobial peptides (AMPs), which can fight against different resistant bacteria through various mechanisms.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2022)

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Article Health Care Sciences & Services

On prioritising global health's triple crisis of sepsis, COVID-19 and antimicrobial resistance: a mixed-methods study from Malawi

Paul Kawale et al.

Summary: Sepsis is not prioritized in Malawi's health system due to a lack of local evidence and policies. However, there are strong linkages between sepsis and maternal health, antimicrobial resistance, and COVID-19, which present opportunities for sepsis researchers as policy entrepreneurs.

BMC HEALTH SERVICES RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Molecular Insight into the Therapeutic Effects of Stem Cell-Derived Exosomes in Respiratory Diseases and the Potential for Pulmonary Delivery

Mohammad H. Azhdari et al.

Summary: Respiratory diseases are a leading cause of death globally, and though stem cell therapy has shown promise, there are limitations and challenges to its application. However, stem cell-derived extracellular vesicles, particularly exosomes, exhibit therapeutic properties without the drawbacks of stem cells. Recent studies suggest that the microRNA content of these exosomes may play a crucial role in their therapeutic potential.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Cell Biology

Differential Lung Protective Capacity of Exosomes Derived from Human Adipose Tissue, Bone Marrow, and Umbilical Cord Mesenchymal Stem Cells in Sepsis-Induced Acute Lung Injury

Huimin Deng et al.

Summary: This study compared the efficacy of hMSC-derived exosomes from different sources in the treatment of sepsis-induced ARDS and found that exosomes derived from adipose tissue hMSCs showed the strongest protective effect. All three types of hMSC-derived exosomes effectively reduced glycolysis and inflammation in macrophages and improved lung pathological damage in septic mice.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Obstetrics & Gynecology

Downregulation of miR-21 is Involved in the Pathogenesis of Infection-Induced Preterm Birth by Targeting NF-κB

Lijun Duan et al.

Summary: Infection-induced preterm birth is a major factor contributing to increased maternal and fetal morbidity and mortality. This study found that miR-21 may be involved in the pathogenesis of infection-induced preterm birth by regulating NF-kappa B.

REPRODUCTIVE SCIENCES (2022)

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Review Cell & Tissue Engineering

Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties

Hadi Rajabi et al.

Summary: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally, mainly due to chronic inflammation and pathological remodeling leading to decreased life span. Recent studies have found that immune cell-derived exosomes play a negative role in the pathogenesis of COPD.

STEM CELL RESEARCH & THERAPY (2022)

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Review Chemistry, Multidisciplinary

Exosome Processing and Characterization Approaches for Research and Technology Development

James J. Lai et al.

Summary: Exosomes, as extracellular vesicles, have potential as disease biomarkers and therapeutic agents. However, manufacturing high-quality exosomes is challenging due to the lack of standardized practices and reference materials. This review compares exosome processing and characterization methods, recommends exosome workflows, and provides an introduction to exosomes, including their properties and roles in biological processes and disease progression. It also summarizes ongoing clinical trials.

ADVANCED SCIENCE (2022)

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Review Cell & Tissue Engineering

Mesenchymal stem cell-derived exosomes: A novel and potential remedy for cutaneous wound healing and regeneration

Jia-Chen Hu et al.

Summary: Poor healing of cutaneous wounds is a common medical problem. Recent evidence suggests that MSC-exosomes have therapeutic potentials in wound healing through various mechanisms. Therefore, MSC-exosomes could be a promising alternative for the treatment of cutaneous wounds.

WORLD JOURNAL OF STEM CELLS (2022)

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Review Cell Biology

Exosomal Composition, Biogenesis and Profiling Using Point-of-Care Diagnostics-Implications for Cardiovascular Disease

Denise Burtenshaw et al.

Summary: Arteriosclerosis is an age-dependent disease that can lead to intimal-medial thickening, lipid retention, and vessel remodelling. Detecting biomarkers in the blood can help diagnose arteriosclerosis and assess cardiovascular risk. Extracellular vesicles play a crucial role in intercellular communication, maintaining tissue homeostasis, and responding to stress. Researching extracellular vesicles is important for understanding cardiovascular disease and guiding clinical decisions.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Current Knowledge on Exosome Biogenesis, Cargo-Sorting Mechanism and Therapeutic Implications

Shenmin Xie et al.

Summary: Extracellular vesicles, specifically exosomes, are nanoscale membrane vesicles released by cells and have the potential to uncover unknown cellular and molecular mechanisms in intercellular communication and disease. They are effective drug delivery systems and display complexity in their formation, release, and bioengineering.

MEMBRANES (2022)

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Review Neurosciences

Challenges and future scope of exosomes in the treatment of cardiovascular diseases

Prabhat Ranjan et al.

Summary: The article introduces the concept of exosomes and their applications in disease treatment. Current technological advances provide better ways for monitoring exosomes, but further research is needed to ensure effective clinical applications.

JOURNAL OF PHYSIOLOGY-LONDON (2022)

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Article Cell Biology

MiR-181a-5p Delivered by Adipose-Derived Mesenchymal Stem Cell Exosomes Alleviates Klebsiella pneumonia Infection-Induced Lung Injury by Targeting STAT3 Signaling

Ren-Jing Hu et al.

Summary: In this study, the researchers investigated the role of ADSC-derived exosomal miR-181a-5p in Klebsiella pneumonia infection-induced lung injury. They found that ADSC-derived exosomal miR-181a-5p could alleviate pulmonary outgrowth and dissemination of K. pneu infection by targeting the STAT3 signaling pathway.

MEDIATORS OF INFLAMMATION (2022)

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Article Urology & Nephrology

The Pathophysiology of Sepsis-Associated AKI

Shuhei Kuwabara et al.

Summary: This article summarizes the key factors in the pathophysiology of sepsis-associated AKI, including microcirculatory dysfunction, inflammation, etc., and potential treatment strategies. Understanding these mechanisms is of great importance for the early diagnosis and treatment of sepsis-associated AKI.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

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Review Cell Biology

Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

Meng Kou et al.

Summary: Mesenchymal stem cells (MSCs) have paracrine effects in therapy, and extracellular vesicles (EVs) play a crucial role in intercellular communication. MSC-EVs have potential therapeutic applications and play an important role in fibrosis treatment and tissue repair.

CELL DEATH & DISEASE (2022)

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Review Food Science & Technology

A CONCISE REVIEW ON THE ANTIMICROBIAL PEPTIDES AND THEIR CRITICAL ACTIVITY AGAINST INTRACELLULAR TARGETS OF BACTERIA

Mohammad Moradi et al.

Summary: Multi-drug resistance resulting from overuse of antibiotics has become a common problem in medical environments. Finding alternatives to daily used antibiotics is a topic of interest in medical microbiology and biotechnology. Antimicrobial peptides (AMPs) are considered critical in combating pathogenic microorganisms. This review examines the importance of intracellular targeting AMPs and discusses their potential for improving the treatment of infected patients.

JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES (2022)

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Review Immunology

Advances in the use of exosomes for the treatment of ALI/ARDS

Chang Liu et al.

Summary: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a critical and high-mortality clinical syndrome. Current treatment mainly focuses on symptomatic therapy, but prognosis is poor. The discovery of exosomes provides a promising perspective for the treatment of ALI/ARDS by exerting anti-inflammatory effects, inhibiting apoptosis, and promoting cell regeneration.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Advances in the Regulation of Macrophage Polarization by Mesenchymal Stem Cells and Implications for ALI/ARDS Treatment

Chang Liu et al.

Summary: Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a common and highly fatal condition. Current treatment options lack specificity and effectiveness. However, studies have shown that mesenchymal stem cells (MSCs) can improve the prognosis of ALI/ARDS by regulating macrophage polarization balance.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Cell Biology

Role of SNAREs in Unconventional Secretion-Focus on the VAMP7-Dependent Secretion

Somya Vats et al.

Summary: Intracellular membrane protein trafficking plays a crucial role in cellular physiology and communication. Unconventional protein secretion (UPS) provides alternative routes for protein release, bypassing the Golgi apparatus. This review focuses on Type III UPS, which involves the transport of cytoplasmic proteins in membrane carriers and their release through SNARE-dependent membrane fusion. The role of vesicular SNAREs, particularly VAMP7, in exosome, lysosome, and autophagy mediated secretion is discussed, along with the importance of unconventional secretion in cancer and neurodegeneration.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Review Cell Biology

Mesenchymal Stem Cell-Derived Antimicrobial Peptides as Potential Anti-Neoplastic Agents: New Insight into Anticancer Mechanisms of Stem Cells and Exosomes

Kasra Moeinabadi-Bidgoli et al.

Summary: Mesenchymal stem cells-derived antimicrobial peptides have demonstrated anti-neoplastic effects by disrupting the membrane and interfering with intracellular pathways of neoplastic cells. This review discusses the potential anti-neoplastic effects of MSCs-derived antimicrobial peptides and their mechanisms, as well as the challenges in enhancing their production and delivery for clinical applications.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review

Aniello Maiese et al.

Summary: In this narrative review, the expression of miRNAs in different tissues and organs during sepsis and the molecular processes they are involved in are summarized. MiRNAs may serve as potential diagnostic and prognostic biomarkers in sepsis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Pathophysiology of Sepsis and Genesis of Septic Shock: The Critical Role of Mesenchymal Stem Cells (MSCs)

Matthieu Daniel et al.

Summary: The treatment of sepsis and septic shock remains a major public health issue. Mesenchymal stem cells (MSCs) are emerging as a potential approach for cell therapy in sepsis, but the mechanisms underlying their beneficial effects are still unclear.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Immunology

Recent advances to enhance the immunomodulatory potential of mesenchymal stem cells

Madina Sarsenova et al.

Summary: The review summarizes various approaches to enhance the clinical outcomes of mesenchymal stem cell (MSC) therapy and revises current and future perspectives for the creation of improved cellular products with potential for diverse clinical applications.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Microbiology

Current Treatment Strategies Against Multidrug-Resistant Bacteria: A Review

Ankita Parmanik et al.

Summary: This article provides up-to-date treatment strategies against major superbugs, including pathogen-directed and host-directed therapeutics. It also discusses the potential of medicinal plants and nanotechnology in combating superbugs.

CURRENT MICROBIOLOGY (2022)

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Review Medicine, General & Internal

Extracellular vesicles in the pathogenesis and treatment of acute lung injury

Qian Hu et al.

Summary: “Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common and life-threatening lung diseases associated with acute and severe inflammation. Study on extracellular vesicles (EVs) has shown their potential role in regulating pulmonary inflammation, including ALI/ARDS, and predicting the development of these diseases.”

MILITARY MEDICAL RESEARCH (2022)

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Review Microbiology

Stem Cell-Derived Exosome as Potential Therapeutics for Microbial Diseases

Somayeh Keshtkar et al.

Summary: Exosomes, particularly stem cell-derived exosomes (stem cell-Exo), have shown great promise in the diagnosis and treatment of microbial diseases due to their immunomodulatory properties, regenerative capacity, and anti-inflammatory and anti-microbial functions.

FRONTIERS IN MICROBIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Therapeutic Application of Exosomes in Inflammatory Diseases

Ju Hun Suh et al.

Summary: Exosomes, as an advanced therapeutic strategy for treating an overactive immune system, are gaining attention and have the potential to be applied in the treatment of various inflammatory and autoimmune diseases, showing promising prospects for the future.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Radiology, Nuclear Medicine & Medical Imaging

Severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), influenza, and COVID-19, beyond the lungs: a review article

Alecio F. Lombardi et al.

Summary: This article reviewed the extra-pulmonary complications of SARS, Influenza, MERS, and COVID-19, finding that these viral diseases are associated with dysfunction of multiple organs, including the kidneys, endocrine system, neuromuscular symptoms, perinatal complications, and myocardial injury. Progression from pulmonary disease to a systemic condition often leads to poor outcomes and multi-organ failure.

RADIOLOGIA MEDICA (2021)

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Review Cell & Tissue Engineering

Advances in mesenchymal stem cell exosomes: a review

Yaya Tang et al.

Summary: Stem cells are valuable in regenerative medicine and disease treatment, but face challenges such as storage limitations and cell senescence. Exosomes, as an alternative, have similar effects to stem cells and offer advantages such as targeted delivery, low immunogenicity, and high repairability.

STEM CELL RESEARCH & THERAPY (2021)

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Article Cell & Tissue Engineering

microRNA-27b shuttled by mesenchymal stem cell-derived exosomes prevents sepsis by targeting JMJD3 and downregulating NF-κB signaling pathway

Jia Sun et al.

Summary: The study revealed that miR-27b highly expressed in exosomes derived from MSCs decreased the expression of pro-inflammatory genes by inhibiting the recruitment of JMJD3 and NF-kappa B, thereby reducing the production of pro-inflammatory cytokines in septic mice and LPS-treated BMDMs.

STEM CELL RESEARCH & THERAPY (2021)

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Review Biochemistry & Molecular Biology

The versatile role of exosomes in human retroviral infections: from immunopathogenesis to clinical application

Jafar Rezaie et al.

Summary: Eukaryotic cells produce extracellular vesicles (EVs) that mediate intercellular communication and are utilized by viruses like HIV-1 and HTLV-1 for spreading and infection. Exosomes from virus-infected cells have the potential to be used for vaccine development and early diagnosis of viral infections. Ongoing research on exosomes shed from virus-infected cells may provide insights into the mechanisms of pathogenesis associated with retroviruses.

CELL AND BIOSCIENCE (2021)

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Review Respiratory System

Mesenchymal stromal cells for acute respiratory distress syndrome (ARDS), sepsis, and COVID-19 infection: optimizing the therapeutic potential

Ellen Gorman et al.

Summary: Mesenchymal stromal (stem) cell (MSC) therapies show promising potential for the treatment of Acute Respiratory Distress Syndrome (ARDS) and sepsis due to their reparative, immunomodulatory, and antimicrobial properties. Both preclinical and clinical evidence support the use of MSC therapy in these conditions, with further optimization strategies such as altered gene expression and cell-free MSC-derived products offering additional benefits. Overall, MSC products hold considerable therapeutic promise for ARDS and sepsis treatment, with ongoing research aiming to enhance their efficacy in clinical settings.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2021)

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Review Cell Biology

Mesenchymal Stem Cell-Derived Exosomes: Biological Function and Their Therapeutic Potential in Radiation Damage

Xiaoyu Pu et al.

Summary: Radiation-induced damage is common in cancer patients undergoing radiotherapy, with mesenchymal stem cells and exosomes derived from them being ideal candidates for repair. Exosomes carry various bioactive substances that can affect immunomodulation, angiogenesis, cell survival, and proliferation, potentially providing new insights into the management of radiation damage.

CELLS (2021)

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Review Food Science & Technology

The structure-mechanism relationship and mode of actions of antimicrobial peptides: A review

Shuqin Li et al.

Summary: The structures of AMPs are closely related to their efficacy, with main mechanisms divided into membrane targets and intracellular targets. Some advanced and new techniques are applied in the mechanism study.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2021)

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Review Immunology

Immunomodulatory and Regenerative Effects of Mesenchymal Stem Cells and Extracellular Vesicles: Therapeutic Outlook for Inflammatory and Degenerative Diseases

Sylwia Dabrowska et al.

Summary: Mesenchymal stem cells (MSCs) possess supportive, differentiating, and immunoregulatory functions, while the extracellular vesicles (EVs) they produce can serve as a potential cellular therapy tool.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Cell Biology

Therapeutic Use of Mesenchymal Stromal Cells: The Need for Inclusive Characterization Guidelines to Accommodate All Tissue Sources and Species

Adrienne Wright et al.

Summary: The promise of MSCs as a therapeutic modality has not yet translated to consistent, successful clinical trial results in humans, despite preclinical data demonstrating their potential. MSC shareholders aim to improve the quality of life for patients with suboptimal or ineffective standard care. Although there are no FDA-approved MSC therapies in the US market, several MSC products have received regulatory approval in other countries.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Cell & Tissue Engineering

Applications, challenges and prospects of mesenchymal stem cell exosomes in regenerative medicine

Aysa Rezabakhsh et al.

Summary: Advances in identifying and using different types of stem cells have provided new therapeutic options for clinicians. Despite the potential benefits of exosomes in regenerative medicine, challenges remain in isolating and purifying them due to their heterogeneous nature and the lack of standardized protocols, limiting their extensive application in clinical settings.

STEM CELL RESEARCH & THERAPY (2021)

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Article Cell Biology

Exosomes derived from mycobacterium tuberculosis-infected MSCs induce a pro-inflammatory response of macrophages

Min Liu et al.

Summary: This study demonstrated that M.tb infection promoted the generation of Exo-MSCs-M.tb, which induced a pro-inflammatory response in macrophages by enhancing the production of inflammatory factors. The effect exhibited a time-dependent pattern with the peak inflammatory response observed at 72 hours post-infection of MSCs.

AGING-US (2021)

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Review Microbiology

Application of Stem Cell-Derived Extracellular Vesicles as an Innovative Theranostics in Microbial Diseases

Hani Keshavarz Alikhani et al.

Summary: Extracellular vesicles are nano-/micro-scale membranous particles containing various cargoes, stem cell-derived EVs show promising potential for treatment of infectious diseases and early diagnosis, and have demonstrated efficacy against clinical complications caused by different viruses and bacteria.

FRONTIERS IN MICROBIOLOGY (2021)

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Review Microbiology

Mechanism and Potential of Extracellular Vesicles Derived From Mesenchymal Stem Cells for the Treatment of Infectious Diseases

Jingyi You et al.

Summary: Extracellular vesicles (EVs) are nano-sized membrane vesicles secreted by cells, serving as a mediator for cell-to-cell communication. Mesenchymal stem cells-derived EVs (MSC-EVs) have shown therapeutic value in treating infectious diseases by eliminating pathogens, regulating immunity, and repairing tissue damage.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Cell & Tissue Engineering

Extracellular Vesicles Released from Neprilysin Gene-Modified Human Umbilical Cord-Derived Mesenchymal Stem Cell Enhance Therapeutic Effects in an Alzheimer's Disease Animal Model

HyeJu Jeong et al.

Summary: The study found that NEP gene-modified MSCs have potential therapeutic effects in AD treatment, and can affect AD animal models through EVs released by stem cells.

STEM CELLS INTERNATIONAL (2021)

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Review Immunology

miR-223: An Immune Regulator in Infectious Disorders

Shun Yuan et al.

Summary: miR-223 is a crucial microRNA that plays important regulatory roles in the immune response, with abnormal expression associated with various infectious diseases such as viral hepatitis, HIV-1, and tuberculosis. The understanding of miR-223 physiopathology and its molecular mechanism in regulating immune responses to infectious diseases could lead to targeted diagnosis and treatment strategies.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Medicine, General & Internal

Dysregulated Immunity and Immunotherapy after Sepsis

Dijoia B. Darden et al.

Summary: Protocolized surveillance, diagnosis, and management of septic patients, especially surgical sepsis patients, can significantly increase the number of patients surviving their initial hospitalization. However, some patients may develop chronic critical illness, with elderly and comorbid patients being particularly susceptible to poor outcomes.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Immunology

Exosomal miR-132-3p from mesenchymal stem cells alleviated LPS-induced acute lung injury by repressing TRAF6

Jian-Hua Liu et al.

Summary: The study demonstrated that miR-132-3p mediated the protective effect of MSC-derived exosomes on LPS-induced ALI, targeting TRAF6 and inactivating PI3K/Akt signaling pathway.

AUTOIMMUNITY (2021)

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Review Immunology

The roles of macrophage polarization in the host immune response to sepsis

Xinsen Chen et al.

Summary: Sepsis is a life-threatening clinical syndrome caused by infection, resulting in immune imbalance. Research has found that macrophage polarization plays a crucial role in the pathogenesis of sepsis, with an imbalance causing inflammation and dysregulation of anti-inflammatory responses.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

Extracellular Vesicles and Thrombosis: Update on the Clinical and Experimental Evidence

Konstantinos Zifkos et al.

Summary: Extracellular vesicles (EVs) are an important mechanism for intercellular communication and exchange of molecules, playing crucial roles in both physiological and pathological situations as well as in clot formation and resolution. They have potential implications as biomarkers and therapeutic vectors in arterial and venous thrombosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Critical Review of the Evolution of Extracellular Vesicles' Knowledge: From 1946 to Today

Erica Bazzan et al.

Summary: Extracellular vesicles (EVs) are a family of particles/vesicles found in blood and body fluids, playing important roles in cell communication and regulation of cell processes. Recent years have seen increased interest in the content and function of EVs, but this has also led to confusion in their classification and naming. This review analyzes the evolution of knowledge and definition of EVs over the years.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Mesenchymal Stem Cell-Based Therapy as an Alternative to the Treatment of Acute Respiratory Distress Syndrome: Current Evidence and Future Perspectives

Silvia Fernandez-Francos et al.

Summary: Acute respiratory distress syndrome (ARDS) is a medical challenge that requires the urgent development of cost-effective, safe, and effective treatments. Mesenchymal stem cells (MSCs) show potential in ARDS therapy, but various limitations need to be addressed.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

BMSC-Derived Exosomes Ameliorate LPS-Induced Acute Lung Injury by miR-384-5p-Controlled Alveolar Macrophage Autophagy

Xuan Liu et al.

Summary: The study showed that BMSC-derived exosomes were taken up by alveolar macrophages and relieved LPS-induced autophagy disorder by targeting Beclin-1 through enrichment of miR-384-5p. Exosomal miR-384-5p could be a promising therapeutic strategy for ALI/ARDS.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Cardiac & Cardiovascular Systems

Role of non-coding RNAs as biomarkers of deleterious cardiovascular effects in sepsis

Jesus Beltran-Garcia et al.

Summary: This article highlights the importance of non-coding RNAs in mediating mechanisms underlying cardiovascular dysfunction after sepsis, including sepsis-induced cardiomyopathy. Non-coding RNAs are novel regulators of cardiovascular disease risk factors and have the potential to improve diagnostics and prognosis of sepsis-induced cardiomyopathy and other cardiovascular events that occur after sepsis.

PROGRESS IN CARDIOVASCULAR DISEASES (2021)

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Review Cell Biology

The role of lipids in exosome biology and intercellular communication: Function, analytics and applications

Javier Donoso-Quezada et al.

Summary: Exosomes are important extracellular vesicles with compositions related to the progression of various diseases. Lipids, as crucial components of exosomes, play significant roles in exosome biology and intercellular communication. Exosome lipidomics is an emerging discipline that offers insights into the discovery of new lipid species for biomedical applications.

TRAFFIC (2021)

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Review Immunology

Roles of Macrophage Polarization and Macrophage-Derived miRNAs in Pulmonary Fibrosis

Amit Kishore et al.

Summary: This review highlights the significant impact of macrophage polarization on the development and progression of lung fibrosis by regulating the production and function of inflammatory and fibrogenic mediators. It also emphasizes the role of miRNAs in regulating lung injury and fibrotic responses, with extracellular exosomal-miRNAs potentially promoting disease progression, particularly those derived from M2 macrophages.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Chemistry, Medicinal

Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation

Chi-Han Huang et al.

Summary: Piplartine exhibits anti-inflammatory activities in sepsis by suppressing inflammatory mediators, reducing tissue damage, and improving survival rates in in vitro and in vivo studies.

PHARMACEUTICALS (2021)

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Review Critical Care Medicine

Initial antimicrobial management of sepsis

Michael S. Niederman et al.

Summary: Sepsis is a common consequence of infection with a mortality rate > 25%. Immediate, empiric, broad-spectrum therapy is necessary for severe sepsis and/or shock, but antimicrobial stewardship is important to prevent overuse and resistance. Biomarkers and newer antimicrobial agents can help guide antibiotic therapy.

CRITICAL CARE (2021)

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Review Biochemistry & Molecular Biology

Emerging Significance and Therapeutic Potential of Extracellular vesicles

Ruhua Luo et al.

Summary: EVs are membrane-bound vesicles that offer advantages over traditional nanocarriers for drug and gene delivery, with therapeutic potential through chemical or biological modifications. Modified EVs can be used to load various therapeutic agents for disease intervention, providing new avenues for effective treatment strategies.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Chemistry, Multidisciplinary

A perspective on the isolation and characterization of extracellular vesicles from different biofluids

Reshma Bano et al.

Summary: Extracellular vesicles (EVs) are small membrane-bound particles released by cells, including exosomes which are nanosize vesicles of endocytic origin. They contain a variety of biomolecules with potential diagnostic and therapeutic value. Research on EVs ranges from understanding their functions to exploring clinical applications, with different isolation methods available for maximizing recovery depending on experimental needs.

RSC ADVANCES (2021)

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Article Cell & Tissue Engineering

Effects of Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Lung Diseases: Current Status and Future Perspectives

Haiyan Guo et al.

Summary: MSC-derived secretome plays a crucial role in tissue repair and regeneration in lung diseases, showing promising potential as a new pharmaceutical agent. Understanding the underlying mechanisms of MSC-EV modulation may lead to new directions for MSC-centered treatment in lung diseases.

STEM CELL REVIEWS AND REPORTS (2021)

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Article Cell & Tissue Engineering

Immunosuppressive Effects of Mesenchymal Stem Cells-derived Exosomes

Xiaoli Qian et al.

Summary: Mesenchymal stem cells (MSCs) play a therapeutic role through anti-inflammatory effects and immune system regulation. They exert these effects mainly through the transmission of diverse bioactive molecules via exosomes, affecting the functions of recipient cells.

STEM CELL REVIEWS AND REPORTS (2021)

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Article Anatomy & Morphology

Mesenchymal Stem Cell (MSC)-Derived Extracellular Vesicles: Potential Therapeutics as MSC Trophic Mediators in Regenerative Medicine

Qi-ling Yuan et al.

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2020)

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Review Cell & Tissue Engineering

Mesenchymal stem cell-derived extracellular vesicles for the treatment of acute respiratory distress syndrome: Concise Review

Aswin Abraham et al.

STEM CELLS TRANSLATIONAL MEDICINE (2020)

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Article Cell & Tissue Engineering

Antibacterial activity of human mesenchymal stem cells mediated directly by constitutively secreted factors and indirectly by activation of innate immune effector cells

Lyndah Chow et al.

STEM CELLS TRANSLATIONAL MEDICINE (2020)

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Review Respiratory System

The potential of mesenchymal stem cell therapy for chronic lung disease

Fernanda Ferreira Cruz et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2020)

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Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis

Pengfei Liu et al.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2020)

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Article Biochemistry & Molecular Biology

IL-27 is elevated in sepsis with acute hepatic injury and promotes hepatic damage and inflammation in the CLP model

Jing Fan et al.

CYTOKINE (2020)

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Review Biochemistry & Molecular Biology

Current Knowledge and Future Perspectives on Mesenchymal Stem Cell-Derived Exosomes as a New Therapeutic Agent

Hyeon Su Joo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Review Biochemistry & Molecular Biology

From sepsis to acute respiratory distress syndrome (ARDS): emerging preventive strategies based on molecular and genetic researches

Qinghe Hu et al.

BIOSCIENCE REPORTS (2020)

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Role of exosomal microRNAs in lung cancer biology and clinical applications

Chengping Hu et al.

CELL PROLIFERATION (2020)

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Article Critical Care Medicine

Mesenchymal Stem Cell-Derived Extracellular Vesicles Alleviate Acute Lung Injury Via Transfer of miR-27a-3p*

Jiangmei Wang et al.

CRITICAL CARE MEDICINE (2020)

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Review Immunology

Immunoregulatory Effects of Stem Cell-Derived Extracellular Vesicles on Immune Cells

Min Xie et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Infectious Diseases

Role Of Vitamin-D Supplementation In TB/HIV Co-Infected Patients

Birhanu Ayelign et al.

INFECTION AND DRUG RESISTANCE (2020)

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Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Attenuate LPS-Induced ARDS by Modulating Macrophage Polarization Through Inhibiting Glycolysis in Macrophages

Huimin Deng et al.

SHOCK (2020)

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Review Cell Biology

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Challenges in Clinical Applications

Austin Gowen et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Cell Biology

Exosome biogenesis, secretion and function of exosomal miRNAs in skeletal muscle myogenesis

Binglin Yue et al.

CELL PROLIFERATION (2020)

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Article Biochemistry & Molecular Biology

Antimicrobial peptide LL-37 ameliorates a murine sepsis model via the induction of microvesicle release from neutrophils

Yumi Kumagai et al.

INNATE IMMUNITY (2020)

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Article Immunology

Protective and predictive role of Mucin1 in sepsis-induced ALI/ARDS

Yu-Ming Wang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Stem cell derived exosomes-based therapy for acute lung injury and acute respiratory distress syndrome: A novel therapeutic strategy

Bin Xu et al.

LIFE SCIENCES (2020)

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Antimicrobial activity of mesenchymal stem cells against Staphylococcus aureus

Haruyo Yagi et al.

STEM CELL RESEARCH & THERAPY (2020)

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Review Cell & Tissue Engineering

Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress

Xiaomo Wu et al.

STEM CELL RESEARCH & THERAPY (2020)

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Review Biochemistry & Molecular Biology

Therapeutic Potential of Cathelicidin Peptide LL-37, an Antimicrobial Agent, in a Murine Sepsis Model

Isao Nagaoka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

Mesenchymal stem cells reverse EMT process through blocking the activation of NF-κB and Hedgehog pathways in LPS-induced acute lung injury

Kun Xiao et al.

CELL DEATH & DISEASE (2020)

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Review Biotechnology & Applied Microbiology

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Opportunities and Challenges for Clinical Translation

Marie Maumus et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Review Medicine, Research & Experimental

Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine

Sepideh Nikfarjam et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Review Cell Biology

Systematic review of extracellular vesicle-based treatments for lung injury: are EVs a potential therapy for COVID-19?

Kasra Khalaj et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Review Cell Biology

Modulation of toll-like receptor signaling by antimicrobial peptides

Ernest Y. Lee et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2019)

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Article Cell Biology

Lung-Resident Mesenchymal Stem Cells Promote Repair of LPS-Induced Acute Lung Injury via Regulating the Balance of Regulatory T cells and Th17 cells

Linlin Wang et al.

INFLAMMATION (2019)

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Article Cell Biology

Antimicrobial effects of mesenchymal stem cells primed by modified LPS on bacterial clearance in sepsis

Pardis Saeedi et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Review Biochemistry & Molecular Biology

Thematic Review Series: Exosomes and Microvesicles: Lipids as Key Components of their Biogenesis and Functions Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology

Tore Skotland et al.

JOURNAL OF LIPID RESEARCH (2019)

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Review Biochemical Research Methods

Exosomes in Inflammation and Inflammatory Disease

Brandon Dow Chan et al.

PROTEOMICS (2019)

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Review Biochemistry & Molecular Biology

Exosomes: biogenesis, biologic function and clinical potential

Yuan Zhang et al.

CELL AND BIOSCIENCE (2019)

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Review Cell Biology

Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes

Sangiliyandi Gurunathan et al.

CELLS (2019)

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Article Oncology

Exosomes derived from microRNA-30b-3p-overexpressing mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3

Xiaomeng Yi et al.

EXPERIMENTAL CELL RESEARCH (2019)

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Review Cell & Tissue Engineering

Concise Review: Challenges in Clinical Development of Mesenchymal Stromal/Stem Cells

Ilenia Mastrolia et al.

STEM CELLS TRANSLATIONAL MEDICINE (2019)

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Review Biophysics

Mesenchymal stem cell-derived exosomes for clinical use

Mayela Mendt et al.

BONE MARROW TRANSPLANTATION (2019)

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Article Immunology

Mesenchymal Stem Cell-Derived Extracellular Vesicles Decrease Lung Injury in Mice

Qi Hao et al.

JOURNAL OF IMMUNOLOGY (2019)

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Article Biochemistry & Molecular Biology

Role of ferroptosis in the process of acute radiation-induced lung injury in mice

Xuan Li et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Review Pharmacology & Pharmacy

Exosomes in Sepsis and Inflammatory Tissue Injury

Eun J. Park et al.

CURRENT PHARMACEUTICAL DESIGN (2019)

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Review Cell Biology

Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis

Chao Cao et al.

CELL DEATH & DISEASE (2019)

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Article Cell & Tissue Engineering

Mesenchymal stem cells preconditioned by staphylococcal enterotoxin B enhance survival and bacterial clearance in murine sepsis model

Pardis Saeedi et al.

CYTOTHERAPY (2019)

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Article Medicine, General & Internal

Exosomal miR-451 from human umbilical cord mesenchymal stem cells attenuates burn-induced acute lung injury

Ji-Song Liu et al.

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION (2019)

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Article Cell & Tissue Engineering

Human Fetal Liver Mesenchymal Stem Cell-Derived Exosomes Impair Natural Killer Cell Function

Ye Fan et al.

STEM CELLS AND DEVELOPMENT (2019)

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Article Hematology

Therapeutic use of mesenchymal stem cell-derived extracellular vesicles in acute lung injury

Jae Hoon Lee et al.

TRANSFUSION (2019)

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Review Oncology

Connexins and Integrins in Exosomes

Motomu Shimaoka et al.

CANCERS (2019)

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Review Cell Biology

Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases

Carl Randall Harrell et al.

CELLS (2019)

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Review Biochemistry & Molecular Biology

The roles of exosomal miRNAs and lncRNAs in lung diseases

Yang Li et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)

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Article Medicine, Research & Experimental

Delayed Remote Ischemic Preconditioning Confers Renoprotection against Septic Acute Kidney Injury via Exosomal miR-21

Tianyi Pan et al.

THERANOSTICS (2019)

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Review Cell & Tissue Engineering

Mesenchymal stem cell perspective: cell biology to clinical progress

Mark F. Pittenger et al.

NPJ REGENERATIVE MEDICINE (2019)

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Review Multidisciplinary Sciences

Performance evaluation of antimicrobial peptide ll-37 and hepcidin and β-defensin-2 secreted by mesenchymal stem cells

Reza Esfandiyari et al.

HELIYON (2019)

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Review Biochemistry & Molecular Biology

Contribution of microRNAs to the immunosuppressive function of mesenchymal stem cells

Yves-Marie Pers et al.

BIOCHIMIE (2018)

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Article Cardiac & Cardiovascular Systems

Extracellular Vesicles and the Application of System Biology and Computational Modeling in Cardiac Repair

Venkata Naga Srikanth Garikipati et al.

CIRCULATION RESEARCH (2018)

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Review Oncology

Exosomes derived from endothelial progenitor cells ameliorate acute lung injury by transferring miR-126

Xu Wu et al.

EXPERIMENTAL CELL RESEARCH (2018)

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Review Medicine, General & Internal

Ethical and Safety Issues of Stem Cell-Based Therapy

Vladislav Volarevic et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2018)

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Article Cell Biology

A Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4

Scott W. Messenger et al.

JOURNAL OF CELL BIOLOGY (2018)

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Article Infectious Diseases

Antimicrobial Peptides: Features, Action, and Their Resistance Mechanisms in Bacteria

Hoda Moravej et al.

MICROBIAL DRUG RESISTANCE (2018)

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Review Biotechnology & Applied Microbiology

Exosomes in Myocardial Repair: Advances and Challenges in the Development of Next-Generation Therapeutics

Marta Adamiak et al.

MOLECULAR THERAPY (2018)

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Review Cell Biology

Biogenesis and function of ESCRT-dependent extracellular vesicles

Thomas Juan et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2018)

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Review Medical Laboratory Technology

Exosomes and regenerative medicine: state of the art and perspectives

Hui Jing et al.

TRANSLATIONAL RESEARCH (2018)

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Article Physiology

miR-21 Protects Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Preventing Epithelial Cell Apoptosis and Inhibiting Dendritic Cell Maturation

Nana Song et al.

FRONTIERS IN PHYSIOLOGY (2018)

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Review Immunology

Exosomes in Pathogen Infections: A Bridge to Deliver Molecules and Link Functions

Wenchao Zhang et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Critical Care Medicine

The interleukin-27-964A>G polymorphism enhances sepsis-induced inflammatory responses and confers susceptibility to the development of sepsis

Junbing He et al.

CRITICAL CARE (2018)

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Review Biotechnology & Applied Microbiology

Immune Regulation of Tissue Repair and Regeneration via miRNAs-New Therapeutic Target

Celeste Piotto et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2018)

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Review Transplantation

Emerging role of exosomes in allorecognition and allograft rejection

Bruno Gonzalez-Nolasco et al.

CURRENT OPINION IN ORGAN TRANSPLANTATION (2018)

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Review Cell Biology

The Role of Defensins in HIV Pathogenesis

Barcley T. Pace et al.

MEDIATORS OF INFLAMMATION (2017)

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Article Immunology

Anti-cancer effects of Staphylococcal Enterotoxin type B on U266 cells co-cultured with Mesenchymal Stem Cells

Mostafa Ejtehadifar et al.

MICROBIAL PATHOGENESIS (2017)

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Article Immunology

Macrophage cell-derived exosomes/staphylococcal enterotoxin B against fibrosarcoma tumor

Elham Behzadi et al.

MICROBIAL PATHOGENESIS (2017)

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Article Cell & Tissue Engineering

Exosomal miR-146a Contributes to the Enhanced Therapeutic Efficacy of Interleukin-1-Primed Mesenchymal Stem Cells Against Sepsis

Yuxian Song et al.

STEM CELLS (2017)

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Review Immunology

Host Antimicrobial Peptides: The Promise of New Treatment Strategies against Tuberculosis

Javier Arranz-Trullen et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Immunology

Antimicrobial Activity of Mesenchymal Stem Cells: Current Status and New Perspectives of Antimicrobial Peptide-Based Therapies

Francisca Alcayaga-Miranda et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Review Anesthesiology

Stem Cell-based Therapies for Sepsis

Colm Keane et al.

ANESTHESIOLOGY (2017)

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Article Medicine, Research & Experimental

Hepcidin-mediated iron sequestration protects against bacterial dissemination during pneumonia

Kathryn R. Michels et al.

JCI INSIGHT (2017)

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Review Medicine, General & Internal

Vitamin D receptor gene FokI polymorphisms and tuberculosis susceptibility: a meta-analysis

Yan Cao et al.

ARCHIVES OF MEDICAL SCIENCE (2016)

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Review Biochemistry & Molecular Biology

Ferroptosis: process and function

Y. Xie et al.

CELL DEATH AND DIFFERENTIATION (2016)

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Editorial Material Cell Biology

Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake

Erik R. Abels et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2016)

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Review Biochemistry & Molecular Biology

Antimicrobial potentials and structural disorder of human and animal defensins

Ehab H. Mattar et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2016)

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Article Biochemical Research Methods

Peripheral blood microvesicles secretion is influenced by storage time, temperature, and anticoagulants

Lukas Wisgrill et al.

CYTOMETRY PART A (2016)

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Article Respiratory System

Control of lung defence by mucins and macrophages: ancient defence mechanisms with modern functions

William J. Janssen et al.

EUROPEAN RESPIRATORY JOURNAL (2016)

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Review Immunology

Molecular Determinants in Phagocyte-Bacteria Interactions

Stefan H. E. Kaufmann et al.

IMMUNITY (2016)

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Article Immunology

Immunomodulatory effects of mesenchymal stromal cells-derived exosome

Wancheng Chen et al.

IMMUNOLOGIC RESEARCH (2016)

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Review Immunology

The immune system's role in sepsis progression, resolution, and long-term outcome

Matthew J. Delano et al.

IMMUNOLOGICAL REVIEWS (2016)

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Article Immunology

MiR-146a modulates macrophage polarization by inhibiting Notch1 pathway in RAW264.7 macrophages

Cheng Huang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2016)

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Editorial Material Medicine, General & Internal

New Definitions for Sepsis and Septic Shock Continuing Evolution but With Much Still to Be Done

Edward Abraham

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

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Article Gastroenterology & Hepatology

Neutrophil gelatinase-associated lipocalin is a biomarker of acute-on-chronic liver failure and prognosis in cirrhosis

X. Ariza et al.

JOURNAL OF HEPATOLOGY (2016)

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Review Cell Biology

Exosomes and Exosomal miRNA in Respiratory Diseases

Shamila D. Alipoor et al.

MEDIATORS OF INFLAMMATION (2016)

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Review Pharmacology & Pharmacy

LL-37: Cathelicidin-related antimicrobial peptide with pleiotropic activity

Adam Fabisiak et al.

PHARMACOLOGICAL REPORTS (2016)

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Review Critical Care Medicine

MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response

Kobina Essandoh et al.

SHOCK (2016)

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Article Cell & Tissue Engineering

LL-37 boosts immunosuppressive function of placenta-derived mesenchymal stromal cells

Martha Oliveira-Bravo et al.

STEM CELL RESEARCH & THERAPY (2016)

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Article Cell Biology

KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes

Andrew J. McKenzie et al.

CELL REPORTS (2016)

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Article Anesthesiology

The role of neutrophil gelatinase-associated lipocalin in predicting acute kidney injury in patients undergoing off-pump coronary artery bypass graft: A pilot study

Vishal Jain et al.

ANNALS OF CARDIAC ANAESTHESIA (2016)

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Review Critical Care Medicine

Sepsis-induced myocardial dysfunction: pathophysiology and management

Yasuyuki Kakihana et al.

JOURNAL OF INTENSIVE CARE (2016)

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Article Critical Care Medicine

Diagnosis and prognosis of neutrophil gelatinase-associated lipocalin for acute kidney injury with sepsis: a systematic review and meta-analysis

An Zhang et al.

CRITICAL CARE (2016)

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Review Biochemistry & Molecular Biology

Exosomes as miRNA Carriers: Formation-Function-Future

Xiaojie Yu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Gastroenterology & Hepatology

Microbiota-Inducible Innate Immune Siderophore Binding Protein Lipocalin 2 Is Critical for Intestinal Homeostasis

Vishal Singh et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2016)

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Review Pathology

miRNA Control of Tissue Repair and Regeneration

Chandan K. Sen et al.

AMERICAN JOURNAL OF PATHOLOGY (2015)

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Article Critical Care Medicine

Therapeutic Effects of Human Mesenchymal Stem Cell-derived Microvesicles in Severe Pneumonia in Mice

Antoine Monsel et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

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Article Immunology

The immunomodulatory function of mesenchymal stem cells: mode of action and pathways

Antonio Uccelli et al.

NEUROIMMUNOMODULATION IN HEALTH AND DISEASE (2015)

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Review Urology & Nephrology

Amplifying renal immunity: the role of antimicrobial peptides in pyelonephritis

Brian Becknell et al.

NATURE REVIEWS NEPHROLOGY (2015)

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Article Microbiology

The development of antimicrobial peptides as an approach to prevention of antibiotic resistance

Mehrdad M. Moghaddam et al.

REVIEWS IN MEDICAL MICROBIOLOGY (2015)

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Review Cell Biology

Mesenchymal stem cell exosomes

Ruenn Chai Lai et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2015)

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Article Multidisciplinary Sciences

Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis

Xiaohong Wang et al.

SCIENTIFIC REPORTS (2015)

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Article Fisheries

Antimicrobial activity of trout hepcidin

Claudio A. Alvarez et al.

FISH & SHELLFISH IMMUNOLOGY (2014)

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Article Medicine, General & Internal

Anti-TNF-α therapy for patients with sepsis: a systematic meta-analysis

S. Lv et al.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2014)

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Article Cell & Tissue Engineering

Human Mesenchymal Stem Cell Microvesicles for Treatment of Escherichia coli Endotoxin- Induced Acute Lung Injury in Mice

Ying-gang Zhu et al.

STEM CELLS (2014)

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Article Oncology

Staphylococcal entorotoxin B anchored exosome induces apoptosis in negative esterogen receptor breast cancer cells

Hamideh Mahmoodzadeh Hosseini et al.

TUMOR BIOLOGY (2014)

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Review Biotechnology & Applied Microbiology

Defensins and Sepsis

Guo-Hao Xie et al.

BIOMED RESEARCH INTERNATIONAL (2014)

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Review Immunology

MicroRNA-146a: a dominant, negative regulator of the innate immune response

Reuben Saba et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Review Chemistry, Medicinal

Human Antimicrobial Peptides and Proteins

Guangshun Wang

PHARMACEUTICALS (2014)

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Article Biochemistry & Molecular Biology

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

Nobuyoshi Kosaka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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Review Medicine, General & Internal

miR-223: infection, inflammation and cancer

M. Haneklaus et al.

JOURNAL OF INTERNAL MEDICINE (2013)

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Review Cell Biology

Rab27 Effectors, Pleiotropic Regulators in Secretory Pathways

Mitsunori Fukuda

TRAFFIC (2013)

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Article Cell Biology

Exosome Secretion Is Enhanced by Invadopodia and Drives Invasive Behavior

Daisuke Hoshino et al.

CELL REPORTS (2013)

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Article Oncology

Blood Cell Origin of Circulating MicroRNAs: A Cautionary Note for Cancer Biomarker Studies

Colin C. Pritchard et al.

CANCER PREVENTION RESEARCH (2012)

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Neutrophil gelatinase-associated lipocalin (NGAL) in inflammatory bowel disease: association with pathophysiology of inflammation, established markers, and disease activity

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MicroRNA-138 Suppresses Neutrophil Gelatinase-Associated Lipocalin Expression and Inhibits Tumorigenicity

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PLOS ONE (2012)

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Importance of the disulfide bridges in the antibacterial activity of human hepcidin

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PEPTIDES (2012)

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Antimicrobial peptides: Clinical relevance and therapeutic implications

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PEPTIDES (2012)

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Novel Therapeutic Targets for Sepsis: Regulation of Exaggerated Inflammatory Responses

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Exosomal miRNAs: Biological Properties and Therapeutic Potential

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Frontiers in Genetics (2012)

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The source of human mesenchymal stromal cells influences their TLR profile as well as their functional properties

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CELLULAR IMMUNOLOGY (2011)

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IMMUNOBIOLOGY (2011)

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The Potential of Antimicrobial Peptides as Biocides

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Antimicrobial and Membrane Disrupting Activities of a Peptide Derived from the Human Cathelicidin Antimicrobial Peptide LL37

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BIOPHYSICAL JOURNAL (2010)

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Lipocalin2 protects against airway inflammation and hyperresponsiveness in a murine model of allergic airway disease

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CLINICAL AND EXPERIMENTAL ALLERGY (2010)

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Review Biochemistry & Molecular Biology

Defensins and cathelicidins in lung immunity

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INNATE IMMUNITY (2010)

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Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C

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JOURNAL OF CELL BIOLOGY (2010)

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Human defensins and LL-37 in mucosal immunity

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Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: Past, present and future

John H. White

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2010)

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Neutrophil Gelatinase-Associated Lipocalin and Hepcidin: What Do They Have in Common and Is There a Potential Interaction?

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KIDNEY & BLOOD PRESSURE RESEARCH (2010)

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Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

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NATURE IMMUNOLOGY (2010)

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Review Cell Biology

Modulation of Adult Mesenchymal Stem Cells Activity by Toll-Like Receptors: Implications on Therapeutic Potential

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MEDIATORS OF INFLAMMATION (2010)

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Antimicrobial activity of human hepcidin 20 and 25 against clinically relevant bacterial strains Effect of copper and acidic pH

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PEPTIDES (2010)

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Antibacterial Effect of Human Mesenchymal Stem Cells Is Mediated in Part from Secretion of the Antimicrobial Peptide LL-37

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STEM CELLS (2010)

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A Brief Review on the Mechanisms of miRNA Regulation

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Are defensin beta 1 gene polymorphisms associated with HIV infection and virus replication?

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AIDS (2009)

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Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

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CELL (2009)

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MicroRNAs: Target Recognition and Regulatory Functions

David P. Bartel

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Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin

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The roles of cathelicidin LL-37 in immune defences and novel clinical applications

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CURRENT OPINION IN HEMATOLOGY (2009)

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Trafficking and function of the tetraspanin CD63

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EXPERIMENTAL CELL RESEARCH (2009)

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Plasma 1,25 Dihydroxy Vitamin D3 Level and Expression of Vitamin D Receptor and Cathelicidin in Pulmonary Tuberculosis

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Multivesicular Endosome Biogenesis in the Absence of ESCRTs

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TRAFFIC (2009)

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AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense

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TRENDS IN IMMUNOLOGY (2009)

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Innate lymphocyte subsets and their immunoregulatory roles in burn injury and sepsis

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Inducibility of the endogenous antibiotic peptide β-defensin 2 is impaired in patients with severe sepsis

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CRITICAL CARE (2007)

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Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

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NATURE CELL BIOLOGY (2007)

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Article Gastroenterology & Hepatology

Effects of mouse and human lipocalin homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin on gastrointestinal mucosal integrity and repair

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GASTROENTEROLOGY (2006)

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Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia

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CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2006)

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Neutrophil gelatinase-associated lipocalin, a siderophore-binding eukaryotic protein

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BIOMETALS (2006)

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Role of exosomes in immune regulation

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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2006)

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SNAREs - engines for membrane fusion

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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

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A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake

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CELL (2005)

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Expression and activity of β-defensins and LL-37 in the developing human lung

TD Starner et al.

JOURNAL OF IMMUNOLOGY (2005)

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Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia

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GUT (2004)

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Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

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Defensins: Antimicrobial peptides of innate immunity

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NATURE REVIEWS IMMUNOLOGY (2003)

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Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver

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PROTEIN SCIENCE (2003)

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The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition

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MOLECULAR CELL (2002)

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Hepcidin, a urinary antimicrobial peptide synthesized in the liver

CH Park et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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The lipocalin protein family: structural and sequence overview

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BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY (2000)

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LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

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FEBS LETTERS (2000)

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