期刊
SCIENCE ADVANCES
卷 9, 期 29, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.adh8839
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Using a citizen science approach, researchers found that at least 40% of azole-resistant A. Fumigatus infections are acquired from environmental exposures. The study also revealed that hotspots and coldspots of aerosolized azole-resistant spores were not stable between seasons. The ubiquity of this measured exposure highlights the importance of determining sources of azole-resistant A. fumigatus to reduce treatment failure in patients with aspergillosis.
Using a citizen science approach, we identify a country-wide exposure to aerosolized spores of a human fungal pathogen, Aspergillus fumigatus, that has acquired resistance to the agricultural fungicide tebuconazole and first-line azole clinical antifungal drugs. Genomic analysis shows no distinction between resistant genotypes found in the environment and in patients, indicating that at least 40% of azole-resistant A. fumigatus infections are acquired from environmental exposures. Hotspots and coldspots of aerosolized azole-resistant spores were not stable between seasonal sampling periods. This suggests a high degree of atmospheric mixing resulting in an estimated per capita cumulative annual exposure of 21 days (+/- 2.6). Because of the ubiquity of this measured exposure, it is imperative thatwe determine sources of azole-resistant A. fumigatus to reduce treatment failure in patients with aspergillosis.
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