Impact of Donor and Recipient SARS-CoV-2 Vaccination or Infection on Immunity after Hematopoietic Cell Transplantation

Article Immunology

Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccines in Allogeneic Hematopoietic Stem Cell Transplant Recipients: Immunogenicity and Reactogenicity

Amy C. Sherman et al.

Summary: This study describes the humoral response and reactogenicity profile of the severe acute respiratory syndrome coronavirus 2 messenger RNA vaccine in allogeneic hematopoietic stem cell transplant recipients. The findings showed that 75.0% to 80.0% of HSCT recipients had a positive antibody response after vaccination, compared to 100% in the healthy cohort.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Multidisciplinary Sciences

Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain

Katherine G. Nabel et al.

Summary: This study evaluates the impact of SARS-CoV-2 variants on neutralizing antibody activity and reveals that simultaneous antibody escape mutations make the virus more resistant to neutralization. Additionally, the study finds that the virus can acquire glycan to escape neutralization.

SCIENCE (2022)

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Article Medical Laboratory Technology

Vaccine-Induced Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Response and the Path to Accelerating Development (Determining a Correlate of Protection)

Amy C. Sherman et al.

CLINICS IN LABORATORY MEDICINE (2022)

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Editorial Material Hematology

Impact of donor vaccination on recipient response to early SARS-CoV-2 mRNA vaccination after allogeneic HSCT

Mathieu Leclerc et al.

LANCET HAEMATOLOGY (2022)

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Letter Biophysics

Antibody responses to SARS-CoV2 vaccination in allogeneic hematopoietic stem cell transplant recipients

Anne-Claire Mamez et al.

BONE MARROW TRANSPLANTATION (2021)

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Article Hematology

Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: an observational cohort study

Akshay Sharma et al.

Summary: This study examined the characteristics and outcomes of HSCT recipients after developing COVID-19. It found that recipients of autologous and allogeneic HSCT who develop COVID-19 have poor overall survival rates. Factors such as age, sex, and time since transplantation were associated with higher risk of mortality in HSCT recipients.

LANCET HAEMATOLOGY (2021)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms

Sarah A. Clark et al.

Summary: The study reveals that mutations occurring during the evolution of SARS-CoV-2 virus may lead to resistance against antibodies, posing challenges to long-term efficacy.

CELL (2021)

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Article Engineering, Biomedical