Rituximab in steroid-refractory immune-related pancreatitis: a case report

The use of immune checkpoint inhibitors (ICIs) for treating several types of cancer is increasing, but they may be associated with immune-related adverse events (irAEs). Pancreatitis is a rare irAE, mostly responsive to steroid treatment. There are no published data on the management of steroid-refractory ICI-induced pancreatitis. Rituximab has shown efficacy in the setting of relapsing non-ICI-induced autoimmune pancreatitis. However, its use has not been tested for treating immunotherapy-related pancreatitis. Here, we present the case of a patient with steroid-refractory immune-related pancreatitis successfully treated with rituximab as a potential strategy for irAE management.

Automated summary

The use of immune checkpoint inhibitors can cause immune-related adverse events, including pancreatitis. Steroids are commonly used to treat pancreatitis induced by immune checkpoint inhibitors. However, little is known about the management of steroid-refractory cases. This case presentation suggests that rituximab may be an effective treatment option for such cases.