Protective effect of ethanolic extract of Elettaria Cardamomum against gentamicin hepato-renal toxicity in male albino rats

OBJECTIVE: Cardamom is one of the spices containing a wide range of an-tioxidants and is used in medicinal prepara-tions. Thus, in this study, we want to explore the protective effect of ethanolic cardamom extract on the liver-kidney toxicity caused by gentamicin in male albino rats.MATERIALS AND METHODS: The exper-iment was applied to twenty-eight male albi-no rats divided randomly into four groups. The control group was given 1 ml/kg of saline orally. The gentamicin (GM) group was giv-en a daily 80 mg/kg i.p of GM for seven days. Another group was given 100 or 200 mg/kg b.wt. p.o. ethanolic extract of Elettaria Carda-mom um (EC) for seven days. Blood and liv-er-kidney samples were taken after the end of the study for analyses to test for liver-kidney function and lipid profile (LP). RESULTS: Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and bili-rubin activities were higher in the GM group than in the control group. However, the groups' differences in globulin levels and total protein (TP) were not statistically sig-nificant. Compared to the control group, the albumin level in the gentamicin group was considerably lower. On the other hand, cre-atinine and urea levels, lipid, serum total cholesterol levels, and high-density lipopro-tein (HDL) significantly increased in the gen-tamicin group but decreased in the control group and co-treated groups with gentami-cin and ethanolic extract EC. Low-density li-poprotein (LDL) significantly dropped, while the control group showed high levels of lipid and serum total cholesterol. CONCLUSIONS: EC ethanolic extract shields the liver-kidney against GM harmful effects in male rats. Recent research demonstrated that the effects of the plant cardamom were the same at both low-high doses. The phe-nolic elements in EC may be responsible for this protective effect.

Automated summary

The objective of this study was to explore the protective effect of ethanolic cardamom extract on liver-kidney toxicity caused by gentamicin in male albino rats. The results showed that the ethanolic cardamom extract can effectively protect the liver and kidney against the harmful effects of gentamicin at different doses.