期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 98, 期 3, 页码 309-320出版社
WILEY
DOI: 10.1002/cpt.159
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资金
- NICHD NIH HHS [T32 HD069038] Funding Source: Medline
- NIGMS NIH HHS [T32 GM066691] Funding Source: Medline
Opiate-dependent pregnant women receive opiate maintenance medications to prevent illicit use and withdrawal. Fetal opiate exposure causes central nervous system (CNS) alterations which manifest as postnatal physical withdrawal. The extensive variability in the Neonatal Abstinence Syndrome phenotype remains unexplained and may be related to variability in fetal exposure and response. Improved understanding of functionally significant genetic variants in pathways influencing placental opiate transfer and fetal response can lead to personalized maternal therapy and optimized neonatal outcomes.
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