☆ 4.4 Review

Can vitamin D be an adjuvant therapy for juvenile rheumatic diseases?

RHEUMATOLOGY INTERNATIONAL (2023)

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Article Rheumatology

Vitamin D Levels and Risk of Juvenile Idiopathic Arthritis: A Mendelian Randomization Study

Sarah L. N. Clarke et al.

Summary: Using Mendelian randomization (MR), this study examined the causal relationship between vitamin D levels and juvenile idiopathic arthritis (JIA) incidence. The results showed no evidence of a causal relationship between 25-(OH)D levels and JIA incidence. Therefore, population-level vitamin D supplementation is unlikely to reduce the incidence of JIA.

ARTHRITIS CARE & RESEARCH (2023)

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Review Nutrition & Dietetics

Serum 25-Hydroxyvitamin D and Cancer Risk: A Systematic Review of Mendelian Randomization Studies

Thomas Lawler et al.

Summary: Epidemiological studies suggest that higher levels of serum 25-hydroxyvitamin D are associated with a lower risk of various cancers. However, Mendelian randomization studies using genetic instrumental variables did not find any causal associations between genetically predicted higher levels of 25-hydroxyvitamin D and a lower risk of cancer.

NUTRIENTS (2023)

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Review Nutrition & Dietetics

Guidelines for Preventing and Treating Vitamin D Deficiency: A 2023 Update in Poland

Pawel Pludowski et al.

Summary: It is found that vitamin D deficiency is prevalent among the Polish population based on epidemiological studies. To address this concern, a Polish multidisciplinary group reviewed the evidence and formulated recommendations for prevention and treatment of vitamin D deficiency. The final Polish recommendations included a range of serum vitamin D levels indicating deficiency, guidelines for prophylaxis and treatment, and the importance of improving the overall population's vitamin D status and treating at-risk patient groups.

NUTRIENTS (2023)

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Review Pharmacology & Pharmacy

A Scoping Review of Vitamin D for Nonskeletal Health: A Framework for Evidence-based Clinical Practice

Heitor O. Santos et al.

Summary: This review examines the literature on the effects of vitamin D supplementation on nonskeletal health and finds that vitamin D deficiency is associated with various nonskeletal diseases. However, supplementation does not necessarily improve major medical outcomes, even when low 25(OH)D levels are treated. Screening for 25(OH)D status remains important, especially for high-risk patients. Overall, vitamin D supplementation should be guided by circulating levels to correct deficiency.

CLINICAL THERAPEUTICS (2023)

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Article Rheumatology

Juvenile and adult-onset scleroderma: Different clinical phenotypes

A. Adrovic et al.

Summary: This study compared the clinical features, treatment modalities, and survival rates between juvenile-onset and adult-onset systemic sclerosis. The results showed that adult-onset patients had a higher frequency of interstitial lung disease and systemic hypertension, while juvenile-onset patients had a higher frequency of diffuse cutaneous subset. The mortality rate was higher among adults. Age, interstitial lung disease, and cardiac insufficiency were independent risk factors for mortality. Therefore, pediatric and adult-onset systemic sclerosis have different clinical phenotypes, and pediatric patients have better survival rates.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2023)

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Article Rheumatology

Behcet Syndrome

Gulen Hatemi et al.

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2023)

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Review Oncology

An update on vitamin D signaling and cancer

Carsten Carlberg et al.

Summary: A low vitamin D status is associated with an increased risk of various cancers. The biologically active form of vitamin D, 1,25(OH)2D3, influences the epigenome and transcriptome of healthy and neoplastic cells, affecting their growth and differentiation.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Immunology

Systemic lupus erythematosus - Are children miniature adults?

Tobias Alexander et al.

Summary: This manuscript summarizes the parallels and differences between clinical presentations, pathomechanisms, and treatment options in juvenile-onset SLE versus adult-onset SLE.

CLINICAL IMMUNOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk

Ang Zhou et al.

Summary: The study found a non-linear association between genetically predicted serum 25(OH)D concentration and CVD risk, with CVD risk initially decreasing steeply with increasing concentrations and leveling off at around 50 nmol/L. Correction of serum 25(OH)D level below 50 nmol/L was predicted to result in a 4.4% reduction in CVD incidence.

EUROPEAN HEART JOURNAL (2022)

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Article Nutrition & Dietetics

Critical Appraisal of Large Vitamin D Randomized Controlled Trials

Stefan Pilz et al.

Summary: Based on epidemiological studies, vitamin D deficiency is associated with various adverse health outcomes. Most vitamin D randomized controlled trials did not specifically target individuals with vitamin D deficiency, but potential benefits such as reduced cancer mortality or acute respiratory infections were observed. High-dose vitamin D supplementation trials generally did not show significant safety issues. However, future trials should be designed based on the outcomes and limitations of recent large vitamin D randomized controlled trials.

NUTRIENTS (2022)

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Article Medicine, General & Internal

Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial

Jill Hahn et al.

Summary: Vitamin D supplementation for five years, with or without omega 3 fatty acids, reduced autoimmune disease by 22%, while omega 3 fatty acid supplementation with or without vitamin D reduced the autoimmune disease rate by 15% (not statistically significant). Both treatment arms showed larger effects than the reference arm (vitamin D placebo and omega 3 fatty acid placebo).

BMJ-BRITISH MEDICAL JOURNAL (2022)

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Article Rheumatology

Disease characteristics in patients with juvenile- and adult-onset systemic lupus erythematosus: A multi-center comparative study

Sherif M. Gamal et al.

Summary: This study compared disease characteristics between patients with juvenile-onset systemic lupus erythematosus (JSLE) and adult-onset systemic lupus erythematosus (ASLE). The results showed that JSLE patients had more serious manifestations, higher disease activity, higher damage index, and higher mortality rate compared to ASLE patients. These findings suggest the need for regular follow-up and close surveillance of JSLE patients.

ARCHIVES OF RHEUMATOLOGY (2022)

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Article Rheumatology

Differences Sustained Between Diffuse and Limited Forms of Juvenile Systemic Sclerosis in an Expanded International Cohort

Ivan Foeldvari et al.

Summary: This study evaluated the baseline clinical characteristics of juvenile SSc patients and found significant differences in disease severity and organ involvement between juvenile dcSSc and lcSSlc patients. Additionally, patients with overlap features had a higher frequency of interstitial lung disease.

ARTHRITIS CARE & RESEARCH (2022)

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Article Rheumatology

Vitamin D Levels in Patients with Behcet's Disease: A Systematic Review and Meta-Analysis

Kamila Hashemzadeh et al.

Summary: The study conducted a systematic review and meta-analysis on the vitamin D status in Behcet's disease patients, finding that active BD patients had lower vitamin D levels, while overall BD patients had higher vitamin D levels compared to healthy controls.

CURRENT RHEUMATOLOGY REVIEWS (2022)

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Article Nutrition & Dietetics

Prevalence of Vitamin D Deficiency in Patients Treated for Juvenile Idiopathic Arthritis and Potential Role of Methotrexate: A Preliminary Study

Maciej K. Stawicki et al.

Summary: This study evaluated the prevalence of vitamin D deficiency in children with juvenile idiopathic arthritis (JIA) and found that vitamin D deficiency is independent of disease activity or inflammatory markers. However, MTX treatment may lead to inadequate vitamin D levels. Therefore, vitamin D supplementation should be considered for all children receiving long-term MTX therapy.

NUTRIENTS (2022)

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Article Rheumatology

2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis

Karen B. Onel et al.

Summary: This article provides updated guidelines for the pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on different forms of JIA and providing recommendations for treatment and tapering of medications. The evidence for these recommendations is generally low quality, but the inclusion of patients and caregivers in the decision-making process strengthens the relevance and applicability of the guideline.

ARTHRITIS & RHEUMATOLOGY (2022)

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Article Immunology

Human Inborn Errors of Immunity: 2022 Update on the Classification from the International Union of Immunological Societies Expert Committee

Stuart G. Tangye et al.

Summary: The International Union of Immunological Societies Expert Committee has published an updated classification of inborn errors of immunity, which includes 55 novel monogenic gene defects and 1 phenocopy caused by autoantibodies. This update contributes to our understanding of the molecular, cellular, and immunological mechanisms of human immune diseases, and provides a resource for molecular diagnosis of heritable immunological disorders and scientific research on monogenic and related human immune diseases.

JOURNAL OF CLINICAL IMMUNOLOGY (2022)

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Article Genetics & Heredity

The association between vitamin D levels and oxidative stress markers in Egyptian Behcet's disease patients

Heba S. Omar et al.

Summary: This study confirms the relationship between vitamin D levels and oxidative stress markers in patients with Bechet's Disease (BD), as well as its association with disease activity and severity. Lower levels of vitamin D are associated with increased oxidative stress in BD patients.

ORPHANET JOURNAL OF RARE DISEASES (2022)

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Article Pediatrics

Vitamin D Status Among Children With Juvenile Idiopathic Arthritis: A Multicenter Prospective, Non-randomized, Comparative Study

Elena I. Kondratyeva et al.

Summary: This study found a high prevalence of low vitamin D levels among children with juvenile idiopathic arthritis (JIA), with dietary intake below expected norms and prophylactic doses of vitamin D supplementation not meeting the needs of these patients. Clinical therapies to manage the disease and VDR genetic variants had no effect on vitamin D levels in children with JIA. Prophylactic cholecalciferol administration and season of year play a significant role in the development of vitamin D deficiency and insufficiency.

FRONTIERS IN PEDIATRICS (2022)

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Article Rheumatology

Evaluation of vitamin D profile in juvenile idiopathic arthritis

Madhumita Nandi et al.

Summary: The study observed the association between serum vitamin D level and disease activity in juvenile idiopathic arthritis (JIA), finding a significant association between higher disease activity levels and lower serum vitamin D levels.

MODERN RHEUMATOLOGY (2022)

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Article Nutrition & Dietetics

Higher 25-hydroxyvitamin D level is associated with increased risk for Behcet's disease

Zhenyu Zhong et al.

Summary: This study using Mendelian randomization found that genetically increased serum 25-hydroxyvitamin D levels were associated with a higher risk of Behcet's disease, with data from Chinese and Turkish cohorts supporting this conclusion. The contribution to Behcet's disease risk may increase with higher levels of vitamin D.

CLINICAL NUTRITION (2021)

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Article Allergy

Clinical Manifestations and Management of Pediatric Behcet's Disease

Ya-Chiao Hu et al.

Summary: Behcet's disease (BD) is a chronic vasculitic disorder affecting vessels of all sizes, with diverse clinical manifestations in pediatric patients influenced by factors such as age, gender, ethnicity, and geographic region. Limited research is available on pediatric BD, leading to treatment recommendations predominantly based on guidelines for adult BD.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2021)

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Editorial Material Immunology

Is it time to re-think juvenile-onset Rheumatic and Musculoskeletal Diseases? - First steps towards individualised treatments to meet agreed targets

Liza J. McCann et al.

CLINICAL IMMUNOLOGY (2021)

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Article Endocrinology & Metabolism

Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?

John P. Bilezikian et al.

Summary: The conference discussed the important role of vitamin D in skeletal and extra-skeletal systems, recommending personalized management based on the specific mechanisms underlying vitamin D deficiency in different diseases. Furthermore, the supplementation of vitamin D in COVID-19 and the optimal route of administration for vitamin D in different clinical conditions were also discussed.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2021)

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Article Nutrition & Dietetics

Vitamin D Dosing: Basic Principles and a Brief Algorithm (2021 Update)

Andrius Bleizgys

Summary: In modern societies, many people may be at risk of low vitamin D levels, so testing serum 25-hydroxy-vitamin D (25OH-D) levels before prescribing supplementation is crucial. In emergency situations, patients should be advised to take moderate vitamin D doses and have their 25-OH-D levels checked later.

NUTRIENTS (2021)

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Article Immunology

Vitamin D Resistance as a Possible Cause of Autoimmune Diseases: A Hypothesis Confirmed by a Therapeutic High-Dose Vitamin D Protocol

Dirk Lemke et al.

Summary: Vitamin D-3 plays an important role in treating autoimmune diseases, and high-dose vitamin D-3 therapy can improve treatment outcomes. Acquired vitamin D resistance may be a plausible pathomechanism for the development of autoimmune diseases.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Decreased Serum 25-(OH)-D Level Associated With Muscle Enzyme and Myositis Specific Autoantibodies in Patients With Idiopathic Inflammatory Myopathy

Zhen Yu et al.

Summary: The study revealed that patients with idiopathic inflammatory myopathy (IIM) have vitamin D deficiency, which is significantly correlated with muscle enzyme levels, presence of anti-Jo-1 and anti-Mi-2 antibodies, as well as the absolute numbers of total T and Treg cells in IIM. Patients with deficient levels of vitamin D are more likely to have skin symptoms and liver involvement.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Pediatrics

Juvenile Dermatomyositis: Advances in Pathogenesis, Assessment, and Management

Alexander K. C. Leung et al.

Summary: Juvenile dermatomyositis is an autoimmune condition that primarily affects the skin and muscles, with potential involvement of other organs. Early diagnosis and aggressive treatment are crucial, with high-dose corticosteroids and methotrexate being the mainstays of therapy. Other immunosuppressive agents may be considered for refractory cases.

CURRENT PEDIATRIC REVIEWS (2021)

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Review Rheumatology

Global epidemiology of systemic lupus erythematosus

Megan R. W. Barber et al.

Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease that predominantly affects young women, with certain ethnic groups experiencing higher vulnerability and mortality rates. Global incidence and prevalence of SLE vary widely due to differences in population, environment, and socioeconomic factors. Inconsistent reporting is also influenced by variations in study design and case definitions.

NATURE REVIEWS RHEUMATOLOGY (2021)

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Review Pediatrics

Juvenile idiopathic arthritis: from aetiopathogenesis to therapeutic approaches

Lina N. Zaripova et al.

Summary: Juvenile idiopathic arthritis (JIA) is classified into different subtypes based on the number of affected joints, extra-articular manifestations, systemic symptoms, serology and genetic factors; advances have been made in understanding the pathogenesis of JIA, including etiology, histopathology, and treatment options.

PEDIATRIC RHEUMATOLOGY (2021)

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Review Rheumatology

Consensus-based recommendations for the management of juvenile systemic sclerosis

Ivan Foeldvari et al.

Summary: Juvenile systemic sclerosis (JSSc) is a rare disease in children, and the SHARE initiative provides recommendations for assessment and treatment based on expert opinion and evidence. Focus is on early signs of internal organ involvement, proposing a disease severity score and a stepwise treatment approach to unify care standards in Europe, aiming to reduce morbidity and mortality.

RHEUMATOLOGY (2021)

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Article Rheumatology

Cytokines, 25-OH vit D and disease activity in patients with juvenile-onset systemic lupus erythematosus

Assem M. Abo-Shanab et al.

Summary: In juvenile onset systemic lupus erythematosus (JO-SLE) patients, levels of IFN-gamma and IL-17 were significantly higher, while 25-OH vitamin D levels were significantly lower compared to controls. There was a significant negative correlation between 25-OH vitamin D levels and SLE disease activity index (SLEDAI-2K) and IFN-gamma levels in JO-SLE patients.

LUPUS (2021)

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Review Nutrition & Dietetics

Vitamin D deficiency 2.0: an update on the current status worldwide

Karin Amrein et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2020)

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Article Rheumatology

Behcet: the syndrome

Alessandra Bettiol et al.

RHEUMATOLOGY (2020)

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Article Rheumatology

Juvenile lupus and serum vitamin D levels: A cross-sectional study

Samar abd Alhamed Tabra et al.

LUPUS (2020)

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Article Multidisciplinary Sciences

Study of vitamin D status and vitamin D receptor polymorphisms in a cohort of Italian patients with juvenile idiopathic arthritis

Francesca Marini et al.

SCIENTIFIC REPORTS (2020)

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Article Medicine, General & Internal

Effect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clinical Outcomes in Older Adults The DO-HEALTH Randomized Clinical Trial

Heike A. Bischoff-Ferrari et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Review Rheumatology

Immunopathogenesis of Behcet Disease

Israel Ganan Nieto et al.

CURRENT RHEUMATOLOGY REVIEWS (2020)

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Article Rheumatology

Classification criteria for autoinflammatory recurrent fevers

Marco Gattorno et al.

ANNALS OF THE RHEUMATIC DISEASES (2019)

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Article Otorhinolaryngology

Vitamin D deficiency as a risk factor for PFAPA syndrome

Aysin Nalbantoglu et al.

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY (2019)

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Review Immunology

Immunopathogenesis of Juvenile Systemic Sclerosis

Anne M. Stevens et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Medicine, Research & Experimental

Adjunctive vitamin D for the treatment of active juvenile idiopathic arthritis: An open-label, prospective, randomized controlled trial

Tao Tang et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2019)

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Targeting cytokines to treat autoinflammatory diseases

Jonathan S. Hausmann

CLINICAL IMMUNOLOGY (2019)

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Review Endocrinology & Metabolism

Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions

Roger Bouillon et al.

ENDOCRINE REVIEWS (2019)

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Article Biochemistry & Molecular Biology

Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience

Patrick J. McCullough et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2019)

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Article Medicine, General & Internal

Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer

JoAnn E. Manson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Association of Increased Sun Exposure Over the Life-course with a Reduced Risk of Juvenile Idiopathic Arthritis

Rachel C. Chiaroni-Clarke et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2019)

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Review Rheumatology

Diagnostic/classification criteria in pediatric Behcet's disease

Ezgi Deniz Batu

RHEUMATOLOGY INTERNATIONAL (2019)

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Article Rheumatology

Are diffuse and limited juvenile systemic sclerosis different in clinical presentation? Clinical characteristics of a juvenile systemic sclerosis cohort

Ivan Foeldvari et al.

JOURNAL OF SCLERODERMA AND RELATED DISORDERS (2019)

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Article Endocrinology & Metabolism

A randomized double-blind placebo-controlled trial of vitamin D supplementation in juvenile-onset systemic lupus erythematosus: positive effect on trabecular microarchitecture using HR-pQCT

G. L. Lima et al.

OSTEOPOROSIS INTERNATIONAL (2018)

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Review Endocrinology & Metabolism

Vitamin D: Classic and Novel Actions

Angel Gil et al.

ANNALS OF NUTRITION AND METABOLISM (2018)

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Article Rheumatology

The incidence, prevalence, and survival of systemic sclerosis in the UK Clinical Practice Research Datalink

Jeremy G. Royle et al.

CLINICAL RHEUMATOLOGY (2018)

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Oxidative stress in the pathogenesis of systemic scleroderma: An overview

Rosa Vona et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

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Scleroderma in Children and Adolescents Localized Scleroderma and Systemic Sclerosis

Suzanne C. Li

PEDIATRIC CLINICS OF NORTH AMERICA (2018)

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Article Pediatrics

Pathogenesis of Pediatric Rheumatologic Diseases

Kathleen E. Sullivan

PEDIATRIC CLINICS OF NORTH AMERICA (2018)

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Review Pediatrics

Vitamin D and juvenile idiopathic arthritis

Sarah L. Finch et al.

PEDIATRIC RHEUMATOLOGY (2018)

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Review Immunology

Unraveling SSc Pathophysiology; The Myofibroblast

Arjan van Caam et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Rheumatology

Assessing the prevalence of juvenile systemic sclerosis in childhood using administrative claims data from the United States

Timothy Beukelman et al.

JOURNAL OF SCLERODERMA AND RELATED DISORDERS (2018)

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Review Oncology

The role of vitamin D in hepatic metastases from colorectal cancer

E. Shaw et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2018)

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Article Rheumatology

Vitamin D deficiency is associated with higher disease activity and the risk for uveitis in juvenile idiopathic arthritis - data from a German inception cohort

Claudia Sengler et al.

ARTHRITIS RESEARCH & THERAPY (2018)

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Article Rheumatology

No association between vitamin D levels around time of birth and later risk of developing oligo- and polyarticular juvenile idiopathic arthritis: a Danish case-cohort study

S. U. Thorsen et al.

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2017)

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Article Pediatrics

Serum vitamin d levels during activation and remission periods of patients with juvenile idiopathic arthritis and familial mediterranean fever

Aydilek Dağdeviren-Çakır et al.

TURKISH JOURNAL OF PEDIATRICS (2017)

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Review Biochemistry & Molecular Biology

The role of vitamin D and VDR in carcinogenesis: Through epidemiology and basic sciences

Borja Bandera Merchan et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2017)

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Review Medicine, General & Internal

Vitamin D supplementation and disease activity in patients with immune-mediated rheumatic diseases: A systematic review and meta-analysis

Andre Silva Franco et al.

MEDICINE (2017)

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Review Endocrinology & Metabolism

The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention

Michael F. Holick

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2017)

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Review Chemistry, Medicinal

Vitamin D levels in systemic sclerosis patients: a meta-analysis

Lin An et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2017)

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Article Dermatology

The effect of 25(OH)D on endothelial and immunological markers in Behcet's disease

Sule Gungor et al.

JOURNAL OF DERMATOLOGICAL TREATMENT (2016)

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Article Rheumatology

Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial

Glauce L. Lima et al.

ARTHRITIS CARE & RESEARCH (2016)

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Article Nutrition & Dietetics

Vitamin D deficiency in Europe: pandemic?

Kevin D. Cashman et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2016)

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Review Chemistry, Medicinal

Vitamin D receptor 2016: novel ligands and structural insights

Miguel A. Maestro et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2016)

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Review Immunology

Infections as risk factor for autoimmune diseases - A nationwide study

Philip Rising Nielsen et al.

JOURNAL OF AUTOIMMUNITY (2016)

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Review Medicine, General & Internal

The juvenile idiopathic inflammatory myopathies: pathogenesis, clinical and autoantibody phenotypes, and outcomes

L. G. Rider et al.

JOURNAL OF INTERNAL MEDICINE (2016)

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Article Rheumatology

Differences in disease phenotype and severity in SLE across age groups

N. Ambrose et al.

LUPUS (2016)

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Article Pediatrics

Vitamin D levels in children with familial Mediterranean fever

Hatice Onur et al.

PEDIATRIC RHEUMATOLOGY (2016)

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Review Physiology

VITAMIN D: METABOLISM, MOLECULAR MECHANISM OF ACTION, AND PLEIOTROPIC EFFECTS

Sylvia Christakos et al.

PHYSIOLOGICAL REVIEWS (2016)

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Article Rheumatology

Brief Report: HLA-DRB1, DQA1, and DQB1 in Juvenile-Onset Systemic Sclerosis

Anne M. Stevens et al.

ARTHRITIS & RHEUMATOLOGY (2016)

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Article Rheumatology

Bone mineral density reduction in adolescents with systemic erythematosus lupus: association with lack of vitamin D supplementation

M. Caetano et al.

CLINICAL RHEUMATOLOGY (2015)

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Links between Vitamin D Deficiency and Cardiovascular Diseases

Ioana Mozos et al.

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Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium

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PLOS ONE (2015)

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Genetic background of juvenile idiopathic arthritis

Dimitry A. Chistiakov et al.

AUTOIMMUNITY (2014)

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Vitamin D concentrations and disease activity in Moroccan children with juvenile idiopathic arthritis

Ilham Bouaddi et al.

BMC MUSCULOSKELETAL DISORDERS (2014)

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Low serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosus

O. A. B. Peracchi et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2014)

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Article Otorhinolaryngology

Vitamin D levels and effects of vitamin D replacement in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome

Stefano Stagi et al.

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Article Rheumatology

Vitamin D levels in children, adolescents, and young adults with juvenile-onset systemic lupus erythematosus: a cross-sectional study

S. Stagi et al.

LUPUS (2014)

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Review Physiology

Impact of vitamin D on immune function: lessons learned from genome-wide analysis

Rene F. Chun et al.

FRONTIERS IN PHYSIOLOGY (2014)

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Article Endocrinology & Metabolism

Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study

Karani S. Vimaleswaran et al.

LANCET DIABETES & ENDOCRINOLOGY (2014)

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Article Rheumatology

Vitamin D Levels Are Associated with Expression of SLE, but Not Flare Frequency

Marline L. Squance et al.

INTERNATIONAL JOURNAL OF RHEUMATOLOGY (2014)

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Review Rheumatology

What do we know about juvenile idiopathic arthritis and vitamin D? A systematic literature review and meta-analysis of current evidence

Muhammad K. Nisar et al.

CLINICAL RHEUMATOLOGY (2013)

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Article Dermatology

Autoinflammatory Diseases in Pediatrics

Jonathan S. Hausmann et al.

DERMATOLOGIC CLINICS (2013)

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Article Endocrinology & Metabolism

Ligand-Dependent Actions of the Vitamin D Receptor Are Required for Activation of TGF-β Signaling during the Inflammatory Response to Cutaneous Injury

Hilary F. Luderer et al.

ENDOCRINOLOGY (2013)

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Article Otorhinolaryngology

Vitamin D linked to PFAPA syndrome

Mahmud Mahamid et al.

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY (2013)

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Review Endocrinology & Metabolism

Vitamin D: effects on childhood health and disease

Steven A. Abrams et al.

NATURE REVIEWS ENDOCRINOLOGY (2013)

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Article Biochemistry & Molecular Biology

Enhanced deposition of cartilage oligomeric matrix protein is a common feature in fibrotic skin pathologies

Pallavi Agarwal et al.

MATRIX BIOLOGY (2013)

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Article Medicine, General & Internal

The Clinical Phenotypes of the Juvenile Idiopathic Inflammatory Myopathies

Mona Shah et al.

MEDICINE (2013)

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Article Multidisciplinary Sciences

The Vitamin D Receptor Agonist BXL-01-0029 as a Potential New Pharmacological Tool for the Treatment of Inflammatory Myopathies

Luigi Di Luigi et al.

PLOS ONE (2013)

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Article Gastroenterology & Hepatology

Therapeutic Effect of Vitamin D Supplementation in a Pilot Study of Crohn's Patients

Linlin Yang et al.

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY (2013)

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Review Biochemistry & Molecular Biology

Bone effects of vitamin D - Discrepancies between in vivo and in vitro studies

Tatsuo Suda et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2012)

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Article Pediatrics

Disease Activity, Proteinuria, and Vitamin D Status in Children with Systemic Lupus Erythematosus and Juvenile Dermatomyositis

Angela Byun Robinson et al.

JOURNAL OF PEDIATRICS (2012)

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Article Ophthalmology

Effect of 1,25-Dihydroxyvitamin D3 on Th17 and Th1 Response in Patients with Behcet's Disease

Yuan Tian et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2012)

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Article Endocrinology & Metabolism

Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline

Michael F. Holick et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)

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Review Cell Biology

Vitamin D metabolism in the kidney: Regulation by phosphorus and fibroblast growth factor 23

Farzana Perwad et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2011)

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Article Multidisciplinary Sciences

1,25(OH)2D3 Alters Growth Plate Maturation and Bone Architecture in Young Rats with Normal Renal Function

Anna Idelevich et al.

PLOS ONE (2011)

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Article Rheumatology

Low bone mass in juvenile onset sclerosis systemic: the possible role for 25-hydroxyvitamin D insufficiency

Samuel Katsuyuki Shinjo et al.

RHEUMATOLOGY INTERNATIONAL (2011)

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Article Nutrition & Dietetics

Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren

Mitsuyoshi Urashima et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2010)

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Review Pharmacology & Pharmacy

Vitamin D: modulator of the immune system

Femke Baeke et al.

CURRENT OPINION IN PHARMACOLOGY (2010)

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Review Nutrition & Dietetics

The Relationship between Ultraviolet Radiation Exposure and Vitamin D Status

Ola Engelsen

NUTRIENTS (2010)

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Review Immunology

Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists

Luciano Adorini et al.

HUMAN IMMUNOLOGY (2009)

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Article Endocrinology & Metabolism

Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals

M. Pfeifer et al.

OSTEOPOROSIS INTERNATIONAL (2009)

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Article Medicine, General & Internal

Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials

H. A. Bischoff-Ferrari et al.

BMJ-BRITISH MEDICAL JOURNAL (2009)

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Article Rheumatology

Difference in disease features between childhood-onset and adult-onset systemic lupus erythematosus

Hermine I. Brunner et al.

ARTHRITIS AND RHEUMATISM (2008)

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Review Rheumatology

Update on pediatric systemic sclerosis: similarities and differences from adult disease

Ivan Foeldvari

CURRENT OPINION IN RHEUMATOLOGY (2008)

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Article Pharmacology & Pharmacy

Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile

Carolin Daniel et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)

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Review Medicine, General & Internal

Vitamin D deficiency

Michael F. Holick

NEW ENGLAND JOURNAL OF MEDICINE (2007)

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Review Medicine, General & Internal

Juvenile idiopathic arthritis

Angelo Ravelli et al.

LANCET (2007)

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Article Biochemistry & Molecular Biology

Extra-renal 25-hydroxyvitamin D3-1α-hydroxylase in human health and disease

Martin Hewison et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2007)

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Review Medicine, Research & Experimental

Resurrection of vitamin D deficiency and rickets

Michael F. Holick

JOURNAL OF CLINICAL INVESTIGATION (2006)

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Article Biochemistry & Molecular Biology

Immunoregulation by 1,25-dihydroxyvitamin D3:: Basic concepts

E van Etten et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2005)

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Article Biochemistry & Molecular Biology

Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3

AF Gombart et al.

FASEB JOURNAL (2005)

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Article Rheumatology

Vitamin D intake is inversely associated with rheumatoid arthritis - Results from the Iowa Women's Health Study

LA Merlino et al.

ARTHRITIS AND RHEUMATISM (2004)

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Article Medicine, General & Internal

Positive association between 25-hydroxy, vitamin D levels and bone mineral density: A population-based study of younger and older adults

HA Bischoff-Ferrari et al.

AMERICAN JOURNAL OF MEDICINE (2004)

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