4.4 Article

Screening for clinically relevant drug-drug interactions between direct oral anticoagulants and antineoplastic agents: a pharmacovigilance approach

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Hematology

Updates in the Incidence, Pathogenesis, and Management of Cancer and Venous Thromboembolism

Laura Girardi et al.

Summary: Patients with cancer have a higher risk of developing venous thromboembolism (VTE) due to specific risk factors and thrombotic and hemostatic pathophysiological pathways. Managing cancer-associated VTE can be challenging due to increased risk of recurrent events and bleeding complications. Direct oral anticoagulants have shown effectiveness, safety, and convenience compared to low-molecular-weight heparin in managing cancer-associated VTE. However, there are still unmet needs and potential solutions, such as factor XI inhibitors, to address bleeding risk, drug interactions, and liver dysfunction.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2023)

Article Cardiac & Cardiovascular Systems

Trends in direct oral anticoagulant (DOAC) prescribing in English primary care (2014-2019)

Mark Joy et al.

Summary: This study aims to describe the trends in prescribing direct oral anticoagulants (DOACs) in primary care in England and assess the appropriate dose adjustment and adherence. The study found that the volume and quality of DOAC prescribing has increased yearly, but disparities in adherence exist.
Letter Hematology

Bleeding with concomitant ibrutinib and oral anticoagulant therapy: A population-based cohort study

Neil Dhopeshwarkar et al.

AMERICAN JOURNAL OF HEMATOLOGY (2023)

Article Medicine, General & Internal

Trends in the Use of Oral Anticoagulants for Adults With Venous Thromboembolism in the US, 2010-2020

Geetha S. Iyer et al.

Summary: This cohort study using data from two US health insurance databases found that most patients with VTE continued oral anticoagulant treatment for approximately 6 months, and one-third of patients required modifications in anticoagulant therapy. Identifying reasons for treatment modification is crucial for generating valid evidence on drug safety and effectiveness.

JAMA NETWORK OPEN (2023)

Article Cardiac & Cardiovascular Systems

Risk of major bleeding associated with concomitant use of anticancer drugs and direct oral anticoagulant in patients with cancer and atrial fibrillation

Chun-Li Wang et al.

Summary: This study found that the simultaneous use of DOAC and ACDs in patients with AF and cancer did not increase the risk of major bleeding. Co-medication with DOAC and ACDs with inhibitory or competitive effects on CYP3A4 or P-gp activity was not associated with a higher risk of major bleeding than DOAC alone. These findings may provide clinicians with confidence regarding the safety of concurrent use of DOAC and ACDs in patients with AF and cancer.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2022)

Article Pharmacology & Pharmacy

Use of oral anticoagulants among individuals with cancer and atrial fibrillation in the United States, 2010-2016

Shirin Ardeshirrouhanifard et al.

Summary: Anticoagulation is underutilized among cancer patients with non-valvular atrial fibrillation (NVAF), but the use of direct oral anticoagulants (DOACs) is increasing while warfarin use is decreasing. DOACs are less likely to be used than warfarin among those at higher risk of stroke.

PHARMACOTHERAPY (2022)

Review Pharmacology & Pharmacy

Drug-Drug Interactions of Direct Oral Anticoagulants (DOACs): From Pharmacological to Clinical Practice

Nicola Ferri et al.

Summary: Direct oral anticoagulants (DOACs) are frequently prescribed to prevent ischemic stroke in non-valvular atrial fibrillation (NVAF) patients and treat venous thromboembolism (VTE). They have a favorable risk-benefit profile compared to warfarin but may increase the risk of gastrointestinal bleeding. Polypharmacy and comorbidity in elderly patients can lead to drug-drug interactions (DDIs) with DOACs. This review summarizes potential DDIs and discusses strategies to reduce their occurrence.

PHARMACEUTICS (2022)

Article Medicine, General & Internal

Drug-drug interaction between dexamethasone and direct-acting oral anticoagulants: a nested case-control study in the National COVID Cohort Collaborative (N3C)

Olga Kravchenko et al.

Summary: The aim of this study was to evaluate the risk of thromboembolic events (TEEs) associated with concomitant exposure to dexamethasone and apixaban or rivaroxaban. The results showed that there was no discernible increase in the risk of TEE when dexamethasone and DOACs were used concomitantly.

BMJ OPEN (2022)

Review Respiratory System

Practical recommendations to combine small-molecule inhibitors and direct oral anticoagulants in patients with nonsmall cell lung cancer

Leila S. Otten et al.

Summary: Research has shown that combinations of small-molecule inhibitors (SMIs) and direct oral anticoagulants (DOACs) in nonsmall cell lung cancer (NSCLC) patients may result in relevant drug-drug interactions (DDIs), which can be prevented by taking intervention measures to avoid potential ineffective treatment or toxic reactions.

EUROPEAN RESPIRATORY REVIEW (2022)

Editorial Material Cardiac & Cardiovascular Systems

Cancer treatment and atrial fibrillation: use of pharmacovigilance databases to detect cardiotoxicity

Kalliopi Keramida et al.

EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY (2021)

Article Obstetrics & Gynecology

Comparison of contraceptive failures associated with CYP3A4-inducing drug-drug interactions by route of hormonal contraceptive in an adverse event reporting system

Tomiko Sunaga et al.

Summary: The study found that levonorgestrel oral and implant products were associated with increased contraceptive failure risk, while intrauterine products were not; etonogestrel/desogestrel oral and vaginal products were not associated with contraceptive failure, but etonogestrel-containing implants were linked to higher risk of contraceptive failure.

CONTRACEPTION (2021)

Letter Cardiac & Cardiovascular Systems

Trends in Anticoagulation Prescription Spending Among Medicare Part D and Medicaid Beneficiaries Between 2014 and 2019

Angela Duvalyan et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Article Medicine, General & Internal

Clinician Trends in Prescribing Direct Oral Anticoagulants for US Medicare Beneficiaries

Kevin M. Wheelock et al.

Summary: Despite the increasing use of DOAC among Medicare beneficiaries, many clinicians in the study continued to prefer warfarin over DOACs as their primary or only anticoagulant. Addressing barriers to the uptake of these medications is necessary to realize their potential benefits for patients.

JAMA NETWORK OPEN (2021)

Review Cardiac & Cardiovascular Systems

Cancer and atrial fibrillation: Epidemiology, mechanisms, and anticoagulation treatment

Danilo Menichelli et al.

Summary: Cancer patients are at higher risk of developing atrial fibrillation (AF) and thrombosis, which presents challenges in managing anticoagulation. Direct oral anticoagulants may be a particularly attractive option for these patients due to their rapid onset/offset action and lower bleeding risk.

PROGRESS IN CARDIOVASCULAR DISEASES (2021)

Article Medicine, General & Internal

Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer

Giancarlo Agnelli et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Pharmacology & Pharmacy

Review of Statistical Methodologies for Detecting Drug-Drug Interactions Using Spontaneous Reporting Systems

Yoshihiro Noguchi et al.

FRONTIERS IN PHARMACOLOGY (2019)

Letter Oncology

Cabozantinib and apixaban: an hitherto unreported interaction

Daniele Santini et al.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2019)

Review Oncology

Palbociclib and ribociclib in breast cancer: consensus workshop on the management of concomitant medication

Meritxell Bellet et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2019)

Article Medicine, General & Internal

Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism

Gary E. Raskob et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Hematology

Anticancer Drug-Related Nonvalvular Atrial Fibrillation: Challenges in Management and Antithrombotic Strategies

Antonella Tufano et al.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2018)

Article Cardiac & Cardiovascular Systems

Provider Specialty, Anticoagulation, and Stroke Risk in Patients With Atrial Fibrillation and Cancer

Wesley T. O'Neal et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

Editorial Material Oncology

Anticoagulants Could Be a Victim of Enzalutamide

Krishna Gundabolu

JOURNAL OF ONCOLOGY PRACTICE (2017)

Review Oncology

Management of Anticoagulation in Patients With Prostate Cancer Receiving Enzalutamide

Joseph J. Shatzel et al.

JOURNAL OF ONCOLOGY PRACTICE (2017)

Editorial Material Oncology

Anticoagulation and Enzalutamide: Caution Over Convenience

Hanny Al-Samkari et al.

JOURNAL OF ONCOLOGY PRACTICE (2017)

Article Cardiac & Cardiovascular Systems

Direct Oral Anticoagulants: A Quick Guide

Julia Sikorska et al.

EUROPEAN CARDIOLOGY REVIEW (2017)

Review Medicine, General & Internal

A Comprehensive Overview of Direct Oral Anticoagulants for the Management of Venous Thromboembolism

Anthony J. Comerota et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2016)

Article Computer Science, Interdisciplinary Applications

Mining association patterns of drug-interactions using post marketing FDA's spontaneous reporting data

Heba Ibrahim et al.

JOURNAL OF BIOMEDICAL INFORMATICS (2016)

Review Hematology

Epidemiology of cancer-associated venous thrombosis

Jasmijn F. Timp et al.

Review Medicine, General & Internal

Data Mining of the Public Version of the FDA Adverse Event Reporting System

Toshiyuki Sakaeda et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2013)

Article Public, Environmental & Occupational Health

Identifying patterns of adverse event reporting for four members of the angiotensin II receptor blockers class of drugs: revisiting the Weber effect

Mara A. McAdams et al.

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2008)

Review Pharmacology & Pharmacy

In vitro tests for predicting drug-drug interactions:: The need for validated procedures

P Kremers

PHARMACOLOGY & TOXICOLOGY (2002)

Article Public, Environmental & Occupational Health

A comparison of measures of disproportionality for signal detection in spontaneous reporting systems for adverse drug reactions

EP van Puijenbroek et al.

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2002)