Promoting neurite outgrowth and neural stem cell migration using aligned nanofibers decorated with protrusions and galectin-1 coating

Biomaterials integrated with both topological cues and biological modifications are urgently needed in regenerative medicine. Here, aligned nanofibrous scaffolds decorated with nanoscale SiO2 protrusions and galectin-1 coating are reported. Prospects in neurite outgrowth and neural stem cell migration are discussed for suitable use in neural tissue engineering.

Automated summary

Biomaterials that combine topological cues and biological modifications are in high demand for regenerative medicine. This study presents aligned nanofibrous scaffolds decorated with nanoscale SiO2 protrusions and galectin-1 coating. The potential applications in neurite outgrowth and neural stem cell migration for neural tissue engineering are discussed.