A review of the application of mesenchymal stem cells in the field of hematopoietic stem cell transplantation

Hematopoietic stem cell transplantation (HSCT) is an effective treatment for many malignant hematological diseases. Mesenchymal stem cells (MSCs) are nonhematopoietic stem cells with strong self-renewal ability and multidirectional differentiation potential. They have the characteristics of hematopoietic support, immune regulation, tissue repair and regeneration, and homing. Recent studies have shown that HSCT combined with MSC infusion can promote the implantation of hematopoietic stem cells and enhance the reconstruction of hematopoietic function. Researchers have also found that MSCs have good preventive and therapeutic effects on acute and chronic graft-versus-host disease (GVHD), but there is still a lack of validation in large-sample randomized controlled trials. When using MSCs clinically, it is necessary to consider their dose, source, application time, application frequency and other relevant factors, but the specific impact of the above factors on the efficacy of MSCs still needs further clinical trial research. This review introduces the clinical roles of MSCs and summarizes the most recent progress concerning the use of MSCs in the field of HSCT, providing references for the later application of the combination of MSCs and HSCT in hematological diseases.

Automated summary

Hematopoietic stem cell transplantation (HSCT) is an effective treatment for malignant hematological diseases. Mesenchymal stem cells (MSCs) play a role in promoting hematopoietic stem cell implantation and enhancing hematopoietic function reconstruction. They also show promise in preventing and treating graft-versus-host disease (GVHD), but larger randomized controlled trials are needed for validation. Factors such as dose, source, application time, and frequency need to be considered when using MSCs clinically.