期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 97, 期 6, 页码 553-558出版社
WILEY-BLACKWELL
DOI: 10.1002/cpt.115
关键词
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资金
- NIDA NIH HHS [P01 DA009158, R37 DA023142] Funding Source: Medline
The endocannabinoid system comprises the two well characterized G(i/o)-protein coupled receptors (cannabinoid receptor 1 (CB1) and CB2), their endogenous lipid ligands, and the enzymes involved in their biosynthesis and biotransformation. Drug discovery efforts relating to the endocannabinoid system have been focused mainly on the two cannabinoid receptors and the two endocannabinoid deactivating enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL). This review provides an overview of cannabinergic agents used in drug research and those being explored clinically.
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