相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Gq/11α and Gsα mediate distinct physiological responses to central melanocortins
Yong-Qi Li et al.
JOURNAL OF CLINICAL INVESTIGATION (2016)
Ca2+ influx through L-type Ca2+ channels and Ca2+-induced Ca2+ release regulate cAMP accumulation and Epacl-dependent ERK 1/2 activation in INS-1 cells
Evan P. S. Pratt et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2016)
Transforming Growth Factor β2 Promotes Transcription of COX2 and EP4, Leading to a Prostaglandin E2-Driven Autostimulatory Loop That Enhances Virulence of Theileria annulata-Transformed Macrophages
Malak Haidar et al.
INFECTION AND IMMUNITY (2015)
Melanocortin 4 receptor activates ERK-cFos pathway to increase brain-derived neurotrophic factor expression in rat astrocytes and hypothalamus
D. Ramirez et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2015)
Serine-727 Phosphorylation Activates Hypothalamic STAT-3 Independently From Tyrosine-705 Phosphorylation
Andreas Breit et al.
MOLECULAR ENDOCRINOLOGY (2015)
G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons
Masoud Ghamari-Langroudi et al.
NATURE (2015)
The future of EPAC-targeted therapies: agonism versus antagonism
Euan Parnell et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2015)
α-Melanocyte-stimulating hormone ameliorates ocular surface dysfunctions and lesions in a scopolamine-induced dry eye model via PKA-CREB and MEK-Erk pathways
Yusha Ru et al.
SCIENTIFIC REPORTS (2015)
Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 Therapeutic Window''
Yingmin Zhu et al.
SCIENTIFIC REPORTS (2015)
Cyclic AMP (cAMP) signaling in melanocytes and melanoma
Carlos Ivan Rodriguez et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2014)
Melanocortins and the melanocortin 1 receptor, moving translationally towards melanoma prevention
Zalfa A. Abdel-Malek et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2014)
Activation of EPAC1/2 is essential for osteoclast formation by modulating NFκB nuclear translocation and actin cytoskeleton rearrangements
Aranzazu Mediero et al.
FASEB JOURNAL (2014)
Recent Advances in the Discovery of Small Molecules Targeting Exchange Proteins Directly Activated by cAMP (EPAC)
Haijun Chen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Central Vagal Afferent Endings Mediate Reduction of Food Intake by Melanocortin-3/4 Receptor Agonist
Carlos A. Campos et al.
JOURNAL OF NEUROSCIENCE (2014)
Multiple Treatments With L-3,4-Dihydroxyphenylalanine Modulate Dopamine Biosynthesis and Neurotoxicity Through the Protein Kinase A-Transient Extracellular Signal-Regulated Kinase and Exchange Protein Activation by Cyclic AMP-Sustained Extracellular Signal-Regulated Kinase Signaling Pathways
Keun Hong Park et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2014)
Cyclic adenosine 3′-5′-monophosphate (cAMP) exerts proliferative and anti-proliferative effects in pituitary cells of different types by activating both cAMP-dependent protein kinase A (PKA) and exchange proteins directly activated by cAMP (Epac)
E. Vitali et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2014)
cAMP controls the restoration of endothelial barrier function after thrombin-induced hyperpermeability via Rac1 activation
Muhammad Aslam et al.
PHYSIOLOGICAL REPORTS (2014)
Mechanisms by which the orexigen NPY regulates anorexigenic α-MSH and TRH
Nicole E. Cyr et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)
Exchange protein activated by cAMP 1 (Epac1)-deficien mice develop β-cell dysfunction and metabolic syndrome
Alan K. L. Kai et al.
FASEB JOURNAL (2013)
Enhanced Leptin Sensitivity, Reduced Adiposity, and Improved Glucose Homeostasis in Mice Lacking Exchange Protein Directly Activated by Cyclic AMP Isoform 1
Jingbo Yan et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
The Adenylyl Cyclase Inhibitor MDL-12,330A Potentiates Insulin Secretion via Blockade of Voltage-Dependent K+ Channels in Pancreatic Beta Cells
Xiaodong Li et al.
PLOS ONE (2013)
Melanocortin 4 Receptors in the Paraventricular Nucleus Modulate the Adipose Afferent Reflex in Rat
Peng Li et al.
PLOS ONE (2013)
Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses
Bin Gong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Epac-Inhibitors: Facts and Artefacts
Holger Rehmann
SCIENTIFIC REPORTS (2013)
A Novel EPAC-Specific Inhibitor Suppresses Pancreatic Cancer Cell Migration and Invasion
Muayad Almahariq et al.
MOLECULAR PHARMACOLOGY (2013)
5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP
Haijun Chen et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Melanocortin 4 receptor activation induces brain-derived neurotrophic factor expression in rat astrocytes through cyclic AMP - Protein kinase A pathway
Carla Caruso et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2012)
Induction of Leptin Resistance by Activation of cAMP-Epac Signaling
Makoto Fukuda et al.
CELL METABOLISM (2011)
Lack of cAMP-response Element-binding Protein 1 in the Hypothalamus Causes Obesity
Franck Chiappini et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Alternative G protein coupling and biased agonism: New insights into melanocortin-4 receptor signalling
Andreas Breit et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2011)
α-Melanocyte-stimulating hormone modulates lipopolysaccharide plus interferon-γ-induced tumor necrosis factor-α expression but not tumor necrosis factor-α receptor expression in cultured hypothalamic neurons
Carla Caruso et al.
JOURNAL OF NEUROIMMUNOLOGY (2010)
Epac in melanoma: a contributor to tumor cell physiology? Focus on Epac increases melanoma cell migration by a heparin sulfate-related mechanism
Frank Lezoualc'h
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)
Memory impairment induced by IL-1β is reversed by α-MSH through central melanocortin-4 receptors
Patricia Veronica Gonzalez et al.
BRAIN BEHAVIOR AND IMMUNITY (2009)
The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and-4 receptors
Andreas Breit et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Both early and delayed treatment with melanocortin 4 receptor-stimulating melanocortins produces neuroprotection in cerebral ischemia
D Giuliani et al.
ENDOCRINOLOGY (2006)
Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus
C Fekete et al.
ENDOCRINOLOGY (2006)
Divergence of melanocortin pathways in the control of food intake and energy expenditure
N Balthasar et al.
CELL (2005)
Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus
GM Sutton et al.
ENDOCRINOLOGY (2005)
Roles of the melanocortin-4 receptor in antipyretic and hyperthermic actions of centrally administered α-MSH
PS Sinha et al.
BRAIN RESEARCH (2004)
Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male rats
C Caruso et al.
NEUROENDOCRINOLOGY (2004)
Epac: a new cAMP target and new avenues in cAMP research
JL Bos
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat
T Kishi et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2003)
Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms
GSH Yeo et al.
HUMAN MOLECULAR GENETICS (2003)
Central administration of neuropeptide Y reduces alpha-melanocyte-stimulating hormone-induced cyclic adenosine 5 '-monophosphate response element binding protein (CREB) phosphorylation in pro-thyrotropin-releasing hormone neurons and increases CREB phosphorylation in corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus
S Sarkar et al.
ENDOCRINOLOGY (2003)
Melanocortin-4 receptor messenger ribonucleic acid expression in rat cardiorespiratory, musculoskeletal, and integumentary systems
KG Mountjoy et al.
ENDOCRINOLOGY (2003)
Analysis on the promoter region of exon IV brain-derived neurotrophic factor in NG108-15 cells
Y Takeuchi et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Intracerebroventricular administration of α-melanocyte stimulating hormone increases phosphorylation of CREB in TRH- and CRH-producing neurons of the hypothalamic paraventricular nucleus
S Sarkar et al.
BRAIN RESEARCH (2002)
The melanocortin receptors: Lessons from knockout models
AA Butler et al.
NEUROPEPTIDES (2002)
Further evidence for a significant participation of the melanocortin 4 receptor in the preovulatory prolactin surge in the rat
H Watanobe et al.
BRAIN RESEARCH BULLETIN (2001)
Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling
M Harris et al.
JOURNAL OF CLINICAL INVESTIGATION (2001)
Hypothalamic localization of the feeding effect of agouti-related peptide and α-melanocyte-stimulating hormone
MS Kim et al.
DIABETES (2000)
分享论文
