期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 -, 期 -, 页码 -出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3ob01072d
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In this study, an efficient chemosensor (PCF) based on the pyridine-carbazole moiety was developed for the differential detection of aspartic acid in biological systems. PCF showed strong binding affinity towards aspartic acid, with a nanomolar detection limit. The binding stoichiometry of aspartic acid and PCF was determined to be 1:1 from Jobs plot analysis. Furthermore, the efficacy of PCF was successfully demonstrated in in vitro experiments in MCF-7 breast cancer cells.
Aspartic acid is a non-essential amino acid obtained in the neuroendocrine tissues of vertebrates and invertebrates. Aspartic acid, a major excitatory neurotransmitter in the mammalian central nervous system, plays a key role in memory and acts in many other normal and abnormal physiological processes. In this work, we have developed an efficient chemosensor (PCF) based on the pyridine-carbazole moiety for the differential detection of aspartic acid in biological systems. PCF has a strong binding affinity towards aspartic acid, with a detection limit in the nanomolar range. The binding stoichiometry of aspartic aid and PCF was obtained as 1 : 1 from a Jobs plot analysis. Furthermore, the efficacy of PCF has been successfully demonstrated in in vitro experiments in MCF-7 breast cancer cells.
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