4.7 Article

Novel Hydrogel Material as a Potential Embolic Agent in Embolization Treatments

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SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -

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NATURE PUBLISHING GROUP
DOI: 10.1038/srep32145

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资金

  1. National Basic Research Program of China [2013CB733700]
  2. China National Funds for Distinguished Young Scientists [21125104]
  3. National Natural Science Foundation of China [51373039]
  4. Specialized Research Fund for the Doctoral Program of Higher Education [20120071130008]
  5. New Century Excellent Talents in University [XYQ2011019]
  6. Shanghai Rising Star Program [13QH1400900]

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We report a novel graphene-oxide (GO) enhanced polymer hydrogel (GPH) as a promising embolic agent capable of treating cerebrovascular diseases and malignant tumors, using the trans-catheter arterial embolization (TAE) technique. Simply composed of GO and generation five poly(amidoamine) dendrimers (PAMAM-5), our rheology experiments reveal that GPH exhibits satisfactory mechanical strength, which resist the high pressures of blood flow. Subcutaneous experiments on Sprague-Dawley (SD) rats demonstrate the qualified biocompatibility of GPH. Finally, our in vivo experiments on New Zealand rabbits, which mix GPH with the X-ray absorbing contrast agent, Iohexol, reveal complete embolization of the artery. We also note that GPH shortens embolization time and exhibits low toxicity in follow-up experiments. Altogether, our study demonstrates that GPH has many advantages over the currently used embolic agents and has potential applications in clinical practice.

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