Plasma metabolome identifies potential biomarkers of gastric precancerous lesions and gastric cancer risk

Review Medicine, Research & Experimental

Traditional Chinese medicine for precancerous lesions of gastric cancer: A review

Weichao Xu et al.

Summary: The article discusses the treatment of gastric precancerous lesions (PLGC) stage, proving the effectiveness of traditional Chinese medicine in treating and preventing such diseases.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Medicine, Research & Experimental

Serum trimethylamine-N-oxide is associated with incident type 2 diabetes in middle-aged and older adults: a prospective cohort study

Shu-yi Li et al.

Summary: This study aimed to investigate the association between serum TMAO and incident type 2 diabetes in middle-aged and older adults. The results showed that higher serum TMAO levels were associated with an increased risk of type 2 diabetes and elevated fasting glucose.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

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Review Biotechnology & Applied Microbiology

Emerging role of trimethylamine-N-oxide (TMAO) in colorectal cancer

Rekha Jalandra et al.

Summary: TMAO, a metabolite derived from gut microbiota, has attracted attention for its potential role in colorectal cancer carcinogenesis, but lacks empirical mechanistic evidence. This review discusses possible mechanisms of TMAO in CRC, emphasizing the need for further mechanistic studies to solidify the link between TMAO and CRC causation.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Rhamnose in plants - from biosynthesis to diverse functions

Nan Jiang et al.

Summary: This review article covers the distribution and metabolism of rhamnose in plants, with a focus on the differences between dicotyledonous and monocotyledonous plants, as well as the characteristics and functions of rhamnose synthases. Further research is needed to fully understand how plants rescue and catabolize rhamnose.

PLANT SCIENCE (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Peripheral Vascular Disease

Trimethylamine N-Oxide (TMAO), Diet and Cardiovascular Disease

Minu S. Thomas et al.

Summary: The link between plasma TMAO levels and CVD risk is established in epidemiological research, but the role of dietary precursors in determining TMAO levels is still inconclusive. Recent studies show positive associations between plasma TMAO concentrations and various CVD risk factors, but the impact of dietary choline and carnitine on chronic plasma TMAO levels and CVD risk requires further investigation.

CURRENT ATHEROSCLEROSIS REPORTS (2021)

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Article Oncology

Serum Metabolic Profiling Analysis of Chronic Gastritis and Gastric Cancer by Untargeted Metabolomics

Lin Yu et al.

Summary: This study revealed that lipid metabolism may play a crucial role in the progression from chronic gastritis to gastric cancer. Hexadecasphinganine, linoleamide, and N-Hydroxy arachidonoyl amine were identified as candidate diagnostic markers for chronic gastritis and gastric cancer. Additionally, changes in serum lipid levels, including total cholesterol, high-density lipoprotein cholesterol, and apolipoprotein A1, were observed with disease progression.

FRONTIERS IN ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Altered L-Arginine Metabolic Pathways in Gastric Cancer: Potential Therapeutic Targets and Biomarkers

Iwona Bednarz-Misa et al.

Summary: The study identified aberrations in L-arginine metabolism in gastric cancer, reflecting different subtypes and pathology. A metabolite diagnostic panel showed high accuracy in detecting and differentiating gastric cancer from benign disorders, while enzyme gene expression was related to tumor advancement and metastasis. Further functional studies on ASL, PRMT2, and ORNT1 in gastric cancer are warranted.

BIOMOLECULES (2021)

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Article Medicine, General & Internal

Identification and Validation of Plasma Metabolomic Signatures in Precancerous Gastric Lesions That Progress to Cancer

Sha Huang et al.

Summary: This study investigated the role of metabolic deregulation in the development of gastric cancer and identified specific metabolites associated with gastric lesion progression and early gastric cancer risk. Integrating these metabolites into prediction models significantly improved the performance in predicting the progression of gastric lesions and the risk of early gastric cancer.

JAMA NETWORK OPEN (2021)

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Article Oncology

Effect of Helicobacter Pylori on Plasma Metabolic Phenotype in Patients With Gastric Cancer

Yan-Ping Wang et al.

Summary: This study used UPLC-HDMS metabolomics to analyze plasma samples from patients with superficial gastritis, early gastric cancer, and advanced gastric cancer, revealing metabolic phenotype changes and potential biomarkers. The results showed differences in biomarkers related to amino acid, lipid, and fatty acid metabolism pathways, with glycerophosphocholine and neopterin identified as key biomarkers associated with gastric cancer progression. This method could be useful for biomarker identification and potential diagnosis of gastric cancer.

CANCER CONTROL (2021)

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Article Oncology

A clinical metabolomics-based biomarker signature as an approach for early diagnosis of gastric cardia adenocarcinoma

Yuanfang Sun et al.

ONCOLOGY LETTERS (2020)

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Article Medicine, General & Internal

Heilcobacter pylori-related precancerous lesions in Turkey: a retrospective endoscopic surveillance study

Bilge Bas et al.

CROATIAN MEDICAL JOURNAL (2020)

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Article Gastroenterology & Hepatology

Long-Term Follow-up of Gastric Precancerous Lesions in a Low GC Incidence Area

Nicolas Chapelle et al.

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY (2020)

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Review Oncology

A systematic review of metabolomic profiling of gastric cancer and esophageal cancer

Sha Huang et al.

CANCER BIOLOGY & MEDICINE (2020)

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Article Gastroenterology & Hepatology

Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update 2019

Pedro Pimentel-Nunes et al.

ENDOSCOPY (2019)

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Review Multidisciplinary Sciences

Gastric cancer in patients with gastric atrophy and intestinal metaplasia: A systematic review and meta-analysis

Maryam Akbari et al.

PLOS ONE (2019)

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Article Biochemistry & Molecular Biology

Use of Metabolomics as a Complementary Omic Approach to Implement Risk Criteria for First-Degree Relatives of Gastric Cancer Patients

Giuseppe Corona et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Nutrition & Dietetics

Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target

Manuel H. Janeiro et al.

NUTRIENTS (2018)

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Review Oncology

Gastric cancer: Metabolic and metabolomics perspectives

Shiyu Xiao et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2017)

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Article Multidisciplinary Sciences

Plasma sample based analysis of gastric cancer progression using targeted metabolomics

Sergio Lario et al.

SCIENTIFIC REPORTS (2017)

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Article Gastroenterology & Hepatology

Pathobiology of Helicobacter pylori-Induced Gastric Cancer

Manuel Amieva et al.

GASTROENTEROLOGY (2016)

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Article Biochemical Research Methods

Metabolomic Analysis of Gastric Cancer Progression within the Correa's Cascade Using Ultraperformance Liquid Chromatography-Mass Spectrometry

Julia Kuligowski et al.

JOURNAL OF PROTEOME RESEARCH (2016)

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Review Chemistry, Analytical

Metabolomics for laboratory diagnostics

Renata Bujak et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2015)

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Article Biotechnology & Applied Microbiology

Developing Urinary Metabolomic Signatures as Early Bladder Cancer Diagnostic Markers

Chong Shen et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2015)

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Review Oncology

Gastric Cancer: Descriptive Epidemiology, Risk Factors, Screening, and Prevention

Parisa Karimi et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2014)

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Review Gastroenterology & Hepatology

Prevalence of gastric precancerous conditions: a systematic review and meta-analysis

Luis Marques-Silva et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2014)

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Review Gastroenterology & Hepatology

Metabolomic studies of human gastric cancer: Review

Naresh Doni Jayavelu et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

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Article Oncology

Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2011

Kyu-Won Jung et al.

CANCER RESEARCH AND TREATMENT (2014)

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Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

CELL (2011)

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Article Oncology

Population-based Survival of Cancer Patients Diagnosed Between 1993 and 1999 in Japan: A Chronological and International Comparative Study

Tomohiro Matsuda et al.

JAPANESE JOURNAL OF CLINICAL ONCOLOGY (2011)

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Article Gastroenterology & Hepatology

Metabolomic phenotype of gastric cancer and precancerous stages based on gas chromatography time-of-flight mass spectrometry

Lianzhen Yu et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2011)

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Article Gastroenterology & Hepatology

Gastric cancer risk in patients with premalignant gastric lesions: A nationwide cohort study in the Netherlands

Annemarie C. de Vries et al.

GASTROENTEROLOGY (2008)

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Editorial Material Multidisciplinary Sciences

Systems biology - Metabonomics

Jeremy K. Nicholson et al.

NATURE (2008)

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Review Biotechnology & Applied Microbiology

Metabolomics by numbers: acquiring and understanding global metabolite data

R Goodacre et al.

TRENDS IN BIOTECHNOLOGY (2004)

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Plasma metabolome identifies potential biomarkers of gastric precancerous lesions and gastric cancer risk

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