期刊
SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/srep26941
关键词
-
资金
- Russian Science Foundation [14-14-00536]
- programs Molecular and Cellular Biology [01201353567]
- European Union Seventh Framework Programme (FP7), through the European Research Council [RIBOMYLOME_309545]
- Spanish Ministry of Economy and Competitiveness
- Spanish Ministry of Economy and Competitiveness, 'Centro de Excelencia Severo Ochoa' [SEV-2012-0208]
- La Caixa studentship
- ICREA Funding Source: Custom
- Russian Science Foundation [14-14-00536] Funding Source: Russian Science Foundation
The biological function of multiple repetitions of single amino acids, or homo-repeats, is largely unknown, but their occurrence in proteins has been associated with more than 20 hereditary diseases. Analysing 122 bacterial and eukaryotic genomes, we observed that the number of proteins containing homo-repeats is significantly larger than expected from theoretical estimates. Analysis of statistical significance indicates that the minimal size of homo-repeats varies with amino acid type and proteome. In an attempt to characterize proteins harbouring long homo-repeats, we found that those containing polar or small amino acids S, P, H, E, D, K, Q and N are enriched in structural disorder as well as protein- and RNA-interactions. We observed that E, S, Q, G, L, P, D, A and H homo-repeats are strongly linked with occurrence in human diseases. Moreover, S, E, P, A, Q, D and T homo-repeats are significantly enriched in neuronal proteins associated with autism and other disorders. We release a webserver for further exploration of homo-repeats occurrence in human pathology at http://bioinfo.protres.ru/hradis/.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据