期刊
SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep33661
关键词
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资金
- Fonds National de la Recherche Scientifique (FRS-FNRS, Belgium) [3.4516.11F]
- University of Liege (ULg) special funds
- Wallonia Brussels International (WBI)
- AXA Foundation
- Fondation Medicale Reine Elisabeth (FMRE, Belgium)
- European Regional Development Fund (ERDF)
- Walloon excellence in life sciences and biotechnology (Belgium) [WELBIO-CR-2010-06E]
- Wallonia/Brussels Federation Action de Recherche Concertee [ARC 09/14-03]
- Royal Society Wolfson Research Merit Award [WM120086]
Several neuropsychiatric and neurological disorders have recently been characterized as dysfunctions arising from a 'final common pathway' of imbalanced excitation to inhibition within cortical networks. How the regulation of a cortical E/I ratio is affected by sleep and the circadian rhythm however, remains to be established. Here we addressed this issue through the analyses of TMS-evoked responses recorded over a 29 h sleep deprivation protocol conducted in young and healthy volunteers. Spectral analyses of TMS-evoked responses in frontal cortex revealed non-linear changes in gamma band evoked oscillations, compatible with an influence of circadian timing on inhibitory interneuron activity. In silico inferences of cell-to-cell excitatory and inhibitory connectivity and GABA/Glutamate receptor time constant based on neural mass modeling within the Dynamic causal modeling framework, further suggested excitation/inhibition balance was under a strong circadian influence. These results indicate that circadian changes in EEG spectral properties, in measure of excitatory/inhibitory connectivity and in GABA/glutamate receptor function could support the maintenance of cognitive performance during a normal waking day, but also during overnight wakefulness. More generally, these findings demonstrate a slow daily regulation of cortical excitation/inhibition balance, which depends on circadian-timing and prior sleep-wake history.
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