期刊
SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep37919
关键词
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资金
- National Natural Science Foundation of the People's Republic of China [81573495, 81530098, 81421005]
- National Key Special Project of Science and Technology for Innovation Drugs of China [2013zx09402202, 2013zx09402203, 2015zx09501001]
- Project for Jiangsu Province Key Lab of Drug Metabolism and Pharmacokinetics [BM2012012]
- project of university collaborative innovation center of Jiangsu province (Modern Chinese medicine center and biological medicine center)
- project of Science and Technology Integration Demonstration of Beichen district of Tianjin [2015-JCSF-KFQ-005]
The continuous administration of compound danshen dripping pills (CDDP) showed good efficacy in relieving myocardial ischemia clinically. To probe the underlying mechanism, metabolic features were evaluated in a rat model of acute myocardial ischemia induced by isoproterenol (ISO) and administrated with CDDP using a metabolomics platform. Our data revealed that the ISO-induced animal model showed obvious myocardial injury, decreased energy production, and a marked change in metabolomic patterns in plasma and heart tissue. CDDP pretreatment increased energy production, ameliorated biochemical indices, modulated the changes and metabolomic pattern induced by ISO, especially in heart tissue. For the first time, we found that ISO induced myocardial ischemia was accomplished with a reduced fatty acids metabolism and an elevated glycolysis for energy supply upon the ischemic stress; while CDDP pretreatment prevented the tendency induced by ISO and enhanced a metabolic shift towards fatty acids metabolism that conventionally dominates energy supply to cardiac muscle cells. These data suggested that the underlying mechanism of CDDP involved regulating the dominant energy production mode and enhancing a metabolic shift toward fatty acids metabolism in ischemic heart. It was further indicated that CDDP had the potential to prevent myocardial ischemia in clinic.
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