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Becky Chandler et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2007)
Tacrolimus pharmacokinetics and pharmacogenetics:: influence of adenosine triphosphate-binding cassette B1 (ABCB1) and cytochrome (CYP) 3A polymorphisms
Robert A. M. Op den Buijsch et al.
FUNDAMENTAL & CLINICAL PHARMACOLOGY (2007)
Polymorphisms of tumor necrosis factor-α, interleukin-10, cytochrome P450 3A5 and ABCB1 in Chinese liver transplant patients treated with immunosuppressant tacrolimus
Dan Li et al.
CLINICA CHIMICA ACTA (2007)
Pharmacokinetics and pharmacodynamics of paclitaxel with carboplatin or gemcitabine, and effects of CYP3A5 and MDR1 polymorphisms in patients with urogenital cancers
Mari Jiko et al.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2007)
Influence of the CYP3A5 and MDR1 genetic polymorphisms on the pharmacokinetics of tacrolimus in healthy Korean subjects
Ji H. Choi et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2007)
Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer
Ji-Youn Han et al.
CANCER (2007)
Imatinib disposition and ABCB1 (MDR1, p-glycoprotein) genotype
H. Gurney et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2007)
ABCB1 genotype and PGP expression, function and therapeutic drug response:: a critical review and recommendations for future research
G. D. Leschziner et al.
PHARMACOGENOMICS JOURNAL (2007)
MDR1 polymorphism influences the outcome of multiple myeloma patients
Gabriele Buda et al.
BRITISH JOURNAL OF HAEMATOLOGY (2007)
Function-altering SNPs in the human multidrug transporter gene ABCB1 identified using a Saccharomyces-based assay
Hotcherl Jeong et al.
PLOS GENETICS (2007)
Multidrug resistance 1 polymorphisms and trough concentrations of atazanavir and lopinavir in patients with HIV
Qing Ma et al.
PHARMACOGENOMICS (2007)
CYP3A5 genotype markedly influences the pharmacokinetics of tacrolimus and sirolimus in kidney transplant recipients
L. Renders et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2007)
Differences in the transport of the antiepileptic drugs phenytoin, levetiracetarn and carbamazepine by human and mouse P-glycoprotein
Steffen Baltes et al.
NEUROPHARMACOLOGY (2007)
A silent polymorphism in the MDR1 gene changes substrate specificity
Chava Kimchi-Sarfaty et al.
SCIENCE (2007)
Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays
Steffen Baltes et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
The effect of MDR1 G2677T/A polymorphism on pharmacokinetics of gabapentin in healthy Korean subjects
Hyun-Ah Kang et al.
ARCHIVES OF PHARMACAL RESEARCH (2007)
A novel MDR1 G1199T variant alters drug resistance and efflux transport activity of P-glycoprotein in recombinant HEK cells
Matthew H. Crouthamel et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2006)
ABCB1 gene polymorphisms are not associated with treatment outcome in elderly acute myeloid leukemia patients
Bronno van der Holt et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2006)
Impact of P-glycoprotein on clopidogrel absorption
Dirk Taubert et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2006)
Association of ABCB1 genotypes with paclitaxel-mediated peripheral neuropathy and neutropenia
Tristan M. Sissung et al.
EUROPEAN JOURNAL OF CANCER (2006)
Effects of genetic polymorphisms of CYP3A4, CYP3A5 and MDR1 on cyclosporine pharmacokinetics after renal transplantation
Yong-Fang Hu et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2006)
CYP3A5 and ABCB1 polymorphisms and tacrolimus pharmacokinetics in renal transplant candidates:: Guidelines from an experimental study
V. Haufroid et al.
AMERICAN JOURNAL OF TRANSPLANTATION (2006)
MDR1 C3435T polymorphisms correlate with cyclosporine levels in de novo renal recipients
C. J. Foote et al.
TRANSPLANTATION PROCEEDINGS (2006)
Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs
Ingolf Cascorbi
PHARMACOLOGY & THERAPEUTICS (2006)
Polymorphisms of the ABCB1 gene are associated with the therapeutic response to risperidone in Chinese schizophrenia patients
Qinghe Xing et al.
PHARMACOGENOMICS (2006)
The influence of genetic polymorphisms of cytochrome P450 3A5 and ABCB1 on starting dose- and weight-standardized tacrolimus trough concentrations after kidney transplantation in relation to renal function
Michel Mourad et al.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2006)
The relationship between P-glycoprotein (PGP) polymorphisms and response to olanzapine treatment in schizophrenia
Ying-Chi Lin et al.
THERAPEUTIC DRUG MONITORING (2006)
Multidrug resistance gene-1 (MDR-1) haplotypes have a minor influence on tacrolimus dose requirements
Salim Fredericks et al.
TRANSPLANTATION (2006)
Cyp3A4, Cyp3A5, and MDR-1 genetic influences on tacrolimus pharmacokinetics in renal transplant recipients
Jean Nicholas Roy et al.
PHARMACOGENETICS AND GENOMICS (2006)
The role of the transporter P-glycoprotein for disposition and effects of centrally acting drugs and for the pathogenesis of CNS diseases
Norbert Thuerauf et al.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2006)
Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response:: a prospective cohort study
Guy Leschziner et al.
LANCET NEUROLOGY (2006)
Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver
Yvonne Meier et al.
HEPATOLOGY (2006)
Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance
Guy Leschziner et al.
PHARMACOGENETICS AND GENOMICS (2006)
ABCB1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patients
Takayuki Seo et al.
PHARMACOGENOMICS (2006)
Influence of different allelic variants of the CYP3A and ABCB1 genes on the tacrolimus pharmacokinetic profile of Chinese renal transplant recipients
Chi Yuen Cheung et al.
PHARMACOGENOMICS (2006)
Tacrolimus dose requirement in relation to donor and recipient ABCB1 and CYP3A5 gene polymorphisms in Chinese liver transplant patients
Wang Wei-lin et al.
LIVER TRANSPLANTATION (2006)
Multidrug resistance-1 gene polymorphisms associated with treatment outcomes in de novo acute myeloid leukemia
DH Kim et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
Quantification and characterization of P-glycoprotein-substrate interactions
E Gatlik-Landwojtowicz et al.
BIOCHEMISTRY (2006)
The molecular basis of multidrug resistance in cancer: The early years of P-glycoprotein research
MM Gottesman et al.
FEBS LETTERS (2006)
Interpatient variability in the pharmacokinetics of the HIV non-nucleoside reverse transcriptase inhibitor efavirenz:: the effect of gender, race, and CYP2B6 polymorphism
D Burger et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2006)
Factors associated with health-related quality of life among outpatients with major depressive disorder: A STAR*D report.
MH Trivedi et al.
JOURNAL OF CLINICAL PSYCHIATRY (2006)
mdr-1 single nucleotide polymorphisms in ovarian cancer tissue:: G2677T/A correlates with response to paclitaxel chemotherapy
H Gréen et al.
CLINICAL CANCER RESEARCH (2006)
Impact of ABCB1 (MDR1) haplotypes on tacrolimus dosing in adult lung transplant patients who are CYP3A5*3/*3 nonexpressors
J Wang et al.
TRANSPLANT IMMUNOLOGY (2006)
Sirolimus and tacrolimus trough concentrations and dose requirements after kidney transplantation in relation to CYP3A5 and MDR1 polymorphisms and steroids
M Mourad et al.
TRANSPLANTATION (2005)
Influence of CYP3A5 and MDR1 polymorphisms on tacrolimus concentration in the early stage after renal transplantation
X Zhang et al.
CLINICAL TRANSPLANTATION (2005)
Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability
DX Wang et al.
PHARMACOGENETICS AND GENOMICS (2005)
Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo
S Colombo et al.
PHARMACOGENETICS AND GENOMICS (2005)
MDR1 genetic polymorphisms and comparison of MDR1 haplotype profiles in Korean and Vietnamese populations
SS Lee et al.
THERAPEUTIC DRUG MONITORING (2005)
Meta-analysis of the influence of MDR1 C3435T polymorphism on digoxin pharmacokinetics and MDR1 gene expression
B Chowbay et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2005)
Pharmacokinetics of paclitaxel in ovarian cancer patients and genetic polymorphisms of CYP2C8, CYP3A4, and MDR1
M Nakajima et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2005)
Complex haplotypic effects of the ABCB1 gene on epilepsy treatment response
CC Hung et al.
PHARMACOGENOMICS (2005)
Impact of CYP3A5 and MDR1(ABCB1) C3435T polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients
H Tada et al.
TRANSPLANTATION PROCEEDINGS (2005)
ABCB1 genotype of the donor but not of the recipient is a major risk factor for cyclosporine-related nephrotoxicity after renal transplantation
IA Hauser et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2005)
Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancer
QY Zhou et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2005)
Relationship between the C3435T and G2677T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver
A Owen et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2005)
Variable expression of P-glycoprotein in the human placenta and its association with mutations of the multidrug resistance 1 gene (MDR1, ABCB1)
M Hitzl et al.
PHARMACOGENETICS (2004)
CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantation
D Anglicheau et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2004)
Genomic evidence for recent positive selection at the human MDR1 gene locus
K Tang et al.
HUMAN MOLECULAR GENETICS (2004)
Clinical aspects of the MDRI (ABCB1) gene polymorphism
M Eichelbaum et al.
THERAPEUTIC DRUG MONITORING (2004)
Cytochrome P450 3A4 and P-glycoprotein expression in human small intestinal enterocytes and hepatocytes:: A comparative analysis in paired tissue specimens
O von Richter et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2004)
The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients
V Haufroid et al.
PHARMACOGENETICS (2004)
Oral contraception does not alter single dose saquinavir pharmacokinetics in women
M Fröhlich et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2004)
Tacrolimus dosing in adult lung transplant patients is related to cytochrome P4503A5 gene polymorphism
HX Zheng et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2004)
Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy
NCK Tan et al.
NEUROLOGY (2004)
Importance of P-glycoprotein at blood-tissue barriers
MF Fromm
TRENDS IN PHARMACOLOGICAL SCIENCES (2004)
MDR-1 C3435T polymorphism influences cyclosporine A dose requirement in liver-transplant recipients
L Bonhomme-Faivre et al.
TRANSPLANTATION (2004)
Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic-polymorphisms in the MDR-1, CYP3A4, and CYP3A5 genes
DA Hesselink et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2004)
CYP3A5*1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation
M Goto et al.
PHARMACOGENETICS (2004)
MDR1 haplotypes derived from exons 21 and 26 do not affect the steady-state pharmacokinetics of tacrolimus in renal transplant patients
I Mai et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2004)
Modulation of multidrug resistance P-glycoprotein 1 (ABCB1) expression in human heart by hereditary polymorphisms
K Meissner et al.
PHARMACOGENETICS (2004)
The influence of pharmacogenetics on the time to achieve target tacrolimus concentrations after kidney transplantation
IAM MacPhee et al.
AMERICAN JOURNAL OF TRANSPLANTATION (2004)
Influence of CYP3A5 and MDR1 (ABCB1) polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients
N Tsuchiya et al.
TRANSPLANTATION (2004)
The MDR1 (ABCB1) gene polymorphism and its clinical implications
I Ieiri et al.
CLINICAL PHARMACOKINETICS (2004)
Effects of various factors on steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: lack of impact of MDR-1 genotypes
N Yasui-Furukori et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2004)
CYP3A5 polymorphism and the ethnic differences in cyclosporine pharmacokinetics in healthy subjects
DI Min et al.
THERAPEUTIC DRUG MONITORING (2004)
Common single nucleotide polymorphisms of the MDR1 gene have no influence on its mRNA expression level of normal kidney cortex and renal cell carcinoma in Japanese nephrectomized patients
Y Uwai et al.
JOURNAL OF HUMAN GENETICS (2004)
Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption
M Uhr et al.
BIOLOGICAL PSYCHIATRY (2003)
MDR1 haplotypes do not affect the steady-state pharmacokinetics of cyclosporine in renal transplant patients
I Mai et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2003)
Amlodipine, but not MDR1 polymorphisms, alters the pharmacokinetics of cyclosporine A in Japanese kidney transplant recipients
T Kuzuya et al.
TRANSPLANTATION (2003)
Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus
DA Hesselink et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2003)
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene
DL Kroetz et al.
PHARMACOGENETICS (2003)
Association of the multidrug resistance-1 gene single-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients
D Anglicheau et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)
The effect of CYP3A5 and MDR1 polymorphic expression on cyclosporine oral disposition in renal transplant patients
CR Yates et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2003)
abcblab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice
M Uhr et al.
JOURNAL OF PSYCHIATRIC RESEARCH (2003)
Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1
A Siddiqui et al.
NEW ENGLAND JOURNAL OF MEDICINE (2003)
MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models
FX Mahon et al.
BLOOD (2003)
Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients
B Chowbay et al.
PHARMACOGENETICS (2003)
Dipyridamole enhances digoxin bioavailability via P-glycoprotein inhibition
C Verstuyft et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2003)
Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan
K Sai et al.
PHARMACOGENETICS (2003)
Tacrolimus pharmacogenetics: Polymorphisms associated with expression of cytochrome P4503A5 and P-glycoprotein correlate with dose requirement
IAM Macphee et al.
TRANSPLANTATION (2002)
The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol
W Siegmund et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2002)
Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene
A Johne et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2002)
Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677:: Functional relevance to pharmacokinetics of digoxin
M Horinouchi et al.
PHARMACEUTICAL RESEARCH (2002)
Neurotoxicity induced by tacrolimus after liver transplantation:: Relation to genetic polymorphisms of the ABCB1 (MDR1) gene
A Yamauchi et al.
TRANSPLANTATION (2002)
Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein
Y Kurata et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2002)
C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation
M Goto et al.
PHARMACOGENETICS (2002)
Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects
T Nakamura et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2002)
Role of multidrug transporters in pharmacoresistance to antiepileptic drugs
W Löscher et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study
J Fellay et al.
LANCET (2002)
MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects
T Sakaeda et al.
PHARMACEUTICAL RESEARCH (2001)
Frequency of C3435T polymorphism of MDR1 gene in African people
E Schaeffeler et al.
LANCET (2001)
Identification of functionally variant MDR1 alleles among European Americans and African Americans
RB Kim et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2001)
Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
A Geick et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
MDR1 pharmacogenetics:: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity
MM Ameyaw et al.
PHARMACOGENETICS (2001)
Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects
I Cascorbi et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2001)
Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients
C Marzolini et al.
AIDS (2001)
Regulation of volume-activated chloride channels by P-glycoprotein: phosphorylation has the final say!
HT Idriss et al.
JOURNAL OF PHYSIOLOGY-LONDON (2000)
Early identification of refractory epilepsy.
P Kwan et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
Functional characterization of glycosylation-deficient human P-glycoprotein using a vaccinia virus expression system
JJ Gribar et al.
JOURNAL OF MEMBRANE BIOLOGY (2000)
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