期刊
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
卷 -, 期 -, 页码 -出版社
SOC BRASILEIRA QUIMICA
DOI: 10.21577/0103-5053.20230134
关键词
bioactive porous TiO 2 surface; antimicrobial TiO 2 coating; silver nanoparticles; poly(lactic acid) coating; silver-ions release
Silver nanoparticles (AgNp) were deposited on porous TiO2 surfaces to provide antimicrobial activity, and the surfaces were coated with bioresorbable polymer for controlled release of silver ions while maintaining biocompatibility. The AgNp-containing surfaces showed antimicrobial activity against Staphylococcus aureus, with better results for surfaces without the polymer coating. However, all surfaces exhibited good biocompatibility and the polymer-coated surfaces promoted greater cell differentiation. The electrospun polymer fibers allowed controlled release of silver ions in a phosphate-buffered saline (PBS) medium.
Silver nanoparticles (AgNp) were deposited on highly porous TiO2 surfaces by the dripping of a colloidal AgNp solution to provide antimicrobial activity. Micro-porous TiO2 surfaces were obtained on commercially pure titanium by micro-arc oxidation in an electrolyte containing Ca and P precursors. In addition, as silver can be toxic to cells, these surfaces were uniformly covered with the biocompatible and bioresorbable poly(lactic acid) (PLA) polymer by electrospinning, aiming at promoting a controlled release of silver ions to the medium. The resulting AgNp-containing surfaces were characterized by scanning electron microscopy (SEM), energy dispersive spectrometry (EDS) and X-ray diffraction (XRD), and in vitro assays were performed to evaluate their antimicrobial activity and bioactivity. Tests revealed that the surfaces showed antimicrobial activity against Staphylococcus aureus, with better results for the surfaces without PLA. However, all the surfaces presented good biocompatibility in assays with mouse MC3T3-E1 pre-osteoblasts, and greater cell differentiation for the polymer-coated surfaces. Finally, the PLA ultrafine fibers electrospun on the TiO2/AgNp surfaces allowed a controlled release of silver ions in the phosphate-buffered saline (PBS) medium.
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