☆ 3.8 Proceedings Paper

Orderly Motor Unit Activation Using Sinusoidal Low Frequency Alternating Current Stimulation

2023 11TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING, NER (2023)

In vivo peripheral nerve activation using sinusoidal low-frequency alternating currents

Awadh Alhawwash et al.

Summary: This study explored whether increasing the amplitude of low-frequency alternating current (LFAC) waveform activates autonomic nerve fibers. The results showed that LFAC was capable of eliciting a biological response known as the Hering-Breuer reflex, and the activation threshold depended on the frequency. These findings offer a new possibility for the field of neurorehabilitation.

ARTIFICIAL ORGANS (2022)

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Article Engineering, Biomedical

Accurate simulation of cuff electrode stimulation predicting in-vivo strength-duration thresholds

Nathaniel Lazorchak et al.

Summary: This study investigates the sensitivity of the simulation models to electrical parameter estimates and volume conductor type. The results show that increasing the realism of the simulations leads to more accurate predictions.

ARTIFICIAL ORGANS (2022)

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Article Engineering, Biomedical

Durable scalable 3D SLA-printed cuff electrodes with high performance carbon plus PEDOT:PSS-based contacts

Onna Marie Doering et al.

Summary: The study developed an upgraded 3D printed cuff electrode design containing a novel intrinsically conductive polymer for stimulating and recording peripheral nerve fibers. Through the use of specific materials and structures, rapid optimization of neural interface performance is achieved.

ARTIFICIAL ORGANS (2022)

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Article Anesthesiology

Nerve growth factor sensitizes nociceptors to C-fibre selective supra-threshold electrical stimuli in human skin

Mark Schnakenberg et al.

Summary: The study demonstrated that NGF-induced sensitization of human skin to electrical and mechanical stimuli is primarily driven by C-nociceptors with little contribution from A-delta fibers. The less pronounced accommodation during ongoing sinusoidal stimulation suggests that NGF could facilitate axonal spike generation and conduction in primary afferent nociceptors in humans. Further studies using this sinusoidal electrical stimulation profile may allow localized assessment of skin C-nociceptors and their putative excitability changes under pathologic conditions.

EUROPEAN JOURNAL OF PAIN (2021)

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Review Engineering, Biomedical