4.6 Article

Akt-mediated mitochondrial metabolism regulates proplatelet formation and platelet shedding post vasopressin exposure

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

CRLF3 plays a key role in the final stage of platelet genesis and is a potential therapeutic target for thrombocythemia

Cavan Bennett et al.

Summary: Platelet production has been understood as a two-stage process, but new research reveals that the maturation of preplatelets is a critical third process that regulates platelet count. Deficiency in the cytokine receptor-like factor 3 (CRLF3) leads to a sustained decrease in platelet count, possibly due to increased microtubule stability. Targeting CRLF3 may have therapeutic potential for treating thrombocythemia.
Review Hematology

Integrins and their role in megakaryocyte development and function

Xiaosheng Yang et al.

Summary: This review discusses the different integrins expressed on bone marrow megakaryocytes and their roles in lineage development and cellular functions, such as cell adhesion and proplatelet formation. The review also reviews the pathologies associated with dysregulated megakaryocyte integrin expression.

EXPERIMENTAL HEMATOLOGY (2022)

Article Cell Biology

Significance of mild thrombocytopenia in maintenance hemodialysis patients; a retrospective cohort study

Yukiko Toyoda et al.

Summary: Platelet activation during hemodialysis can lead to thrombocytopenia, which is associated with cardiovascular events. Thrombocytopenia is correlated with underuse of antiplatelet therapy and macrocytosis. Further research is needed to understand the dynamics of platelet biological aging in hemodialysis patients.

PLATELETS (2022)

Review Hematology

Platelet-inspired nanomedicine in hemostasis thrombosis and thromboinflammation

Shruti Raghunathan et al.

Summary: Platelets, derived from megakaryocytes, play a vital role in hemostasis and can be used as a platform for disease-targeted drug delivery. Platelet defects can lead to bleeding complications, while platelet-inspired technologies have the potential to improve therapeutic efficacy.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2022)

Article Cell Biology

The plant hormone abscisic acid stimulates megakaryocyte differentiation from human iPSCs in vitro

Weihua Huang et al.

Summary: The study revealed that the plant hormone abscisic acid (ABA) can enhance the generation of platelets from induced pluripotent stem cells (hiPSCs), promoting the proliferation of CD34(+)/CD45(+) HPCs and the differentiation of CD41(+) MKs.

PLATELETS (2022)

Article Multidisciplinary Sciences

Gasdermin-A3 pore formation propagates along variable pathways

Stefania A. Mari et al.

Summary: Gasdermin-A3 pore formation propagates along diverse pathways, and the assembly and pore-forming mechanisms have been characterized using high-resolution time-lapse atomic force microscopy. The results reveal the role of amphiphilic beta-hairpins and structurally adapting hydrophilic head domains in stabilizing variable oligomeric conformations and opening the pore.

NATURE COMMUNICATIONS (2022)

Article Biochemistry & Molecular Biology

AKT/AMPK-mediated phosphorylation of TBC1D4 disrupts the interaction with insulin-regulated aminopeptidase

Samaneh Eickelschulte et al.

Summary: TBC1D4 is a multidomain Rab GTPase-activating protein that plays a role in GLUT4 trafficking. Phosphorylation by AKT and AMPK does not affect enzymatic activity but disrupts interaction with other proteins. Insulin and contraction regulate TBC1D4 primarily by disrupting recruitment to GLUT4 vesicles.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Review Hematology

New insights into cytoskeletal remodeling during platelet production

Dorsaf Ghalloussi et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2019)

Article Immunology

27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation

Muhammad-Al-Mustafa Ismail et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Review Medical Laboratory Technology

Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond

Xiaohong Ruby Xu et al.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2016)

Article Biochemistry & Molecular Biology

Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3

Pauline Rimmele et al.

EMBO REPORTS (2015)

Article Multidisciplinary Sciences

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate

Maria Maryanovich et al.

NATURE COMMUNICATIONS (2015)

Review Hematology

Thrombopoietin from beginning to end

Ian S. Hitchcock et al.

BRITISH JOURNAL OF HAEMATOLOGY (2014)

Article Biochemistry & Molecular Biology

IκBα inhibits apoptosis at the outer mitochondrial membrane independently of NF-κB retention

Evangelos Pazarentzos et al.

EMBO JOURNAL (2014)

Article Medicine, Research & Experimental

Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation

Dominique Bluteau et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Multidisciplinary Sciences

mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology

Charles Betz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Immunology

The role of insulin-regulated aminopeptidase in MHC class I antigen presentation

Loredana Saveanu et al.

FRONTIERS IN IMMUNOLOGY (2012)

Article Medicine, General & Internal

Thrombopoietin-Receptor Agonists for Primary Immune Thrombocytopenia

Paul Imbach et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Review Pharmacology & Pharmacy

PI-3-K and AKT: Onto the mitochondria

Bangyan L. Stiles

ADVANCED DRUG DELIVERY REVIEWS (2009)

Review Biochemistry & Molecular Biology

Shared principles in NF-κB signaling

Matthew S. Hayden et al.

Article Biochemistry & Molecular Biology

Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II

S. Miyamoto et al.

CELL DEATH AND DIFFERENTIATION (2008)

Review Immunology

The anti-death machinery in IKK/NF-κB signaling

JL Luo et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2005)

Article Biochemistry & Molecular Biology

Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis

JG Pastorino et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides

H Matsumoto et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2001)