期刊
CURRENT ONCOLOGY
卷 30, 期 8, 页码 7542-7552出版社
MDPI
DOI: 10.3390/curroncol30080547
关键词
malignant melanoma; cell-in-cell structures; non-professional phagocytosis; cell cannibalism; E-cadherin; metastasis
类别
Non-professional phagocytosis, specifically cell-in-cell structures, are increasingly studied in malignant melanoma metastasis. This study examined primary melanoma cell lines and tissue samples and found that all primary melanoma cell lines were capable of phagocytosis, with higher rates observed during suspension co-incubation. The presence of cell-in-cell structures was also detected in most tissue samples, indicating that non-professional phagocytosis mechanism is ubiquitous in malignant melanoma.
Non-professional phagocytosis in cancer has been increasingly studied in recent decades. In malignant melanoma metastasis, cell-in-cell structures have been described as a sign of cell cannibalism. To date, only low rates of cell-in-cell structures have been described in patients with malignant melanoma. To investigate these findings further, we examined twelve primary melanoma cell lines in both adherent and suspended co-incubation for evidence of engulfment. In addition, 88 malignant melanoma biopsies and 16 healthy tissue samples were evaluated. E-cadherin levels were determined in the cell lines and tissues. All primary melanoma cell lines were capable of phagocytosis, and phagocytosis increased when cells were in suspension during co-incubation. Cell-in-cell structures were also detected in most of the tissue samples. Early T stages and increasingly advanced N and M stages have correspondingly lower rates of cell-in-cell structures. Non-professional phagocytosis was also present in normal skin tissue. Non-professional phagocytosis appears to be a ubiquitous mechanism in malignant melanoma. The absence of phagocytosis in metastases may be one reason for the high rate of metastasis in malignant melanoma.
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