A framework for future national pediatric pandemic respiratory disease severity triage: The HHS pediatric COVID-19 data challenge

Article Immunology

Comparison of Influenza and COVID-19-Associated Hospitalizations Among Children Younger Than 18 Years Old in the United States: FluSurv-NET (October-April 2017-2021) and COVID-NET (October 2020-September 2021)

Miranda J. Delahoy et al.

Summary: During the COVID-19 pandemic, children had higher hospitalization rates for COVID-19 compared to influenza, with adolescents at higher risk. COVID-19 adds a greater burden of hospitalizations and severe outcomes for children compared to influenza.

CLINICAL INFECTIOUS DISEASES (2023)

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Article Medicine, General & Internal

Characteristics, Outcomes, and Severity Risk Factors Associated With SARS-CoV-2 Infection Among Children in the US National COVID Cohort Collaborative

Blake Martin et al.

Summary: This study examined characteristics, outcomes, and risk factors of SARS-CoV-2 in US children. Differences in demographics, comorbidities, and initial vital signs/lab values were observed among severity subgroups. Early identification of high-risk children could improve outcomes.

JAMA NETWORK OPEN (2022)

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Article Pediatrics

Severity of Acute COVID-19 in Children <18 Years Old March 2020 to December 2021

Christopher B. Forrest et al.

Summary: Although there is a risk of moderate to severe illness among children infected with the SARS-CoV-2 virus, the risk of severe disease did not change with the emergence of the Delta variant, despite its high transmissibility.

PEDIATRICS (2022)

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Letter Pediatrics

Acute Upper Airway Disease in Children With the Omicron (B.1.1.529) Variant of SARS-CoV-2-A Report From the US National COVID Cohort Collaborative

Blake Martin et al.

Summary: This study utilizes data from the US National COVID Cohort Collaborative to investigate upper airway infections in children during the surge of the Omicron (B.1.1.529) variant of SARS-CoV-2 in the US.

JAMA PEDIATRICS (2022)

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Article Public, Environmental & Occupational Health

Seroprevalence of Infection-Induced SARS-CoV-2 Antibodies — United States, September 2021–February 2022

Kristie E.N. Clarke et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2022)

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Article Medicine, General & Internal

Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19

Leora R. Feldstein et al.

Summary: Comparing the clinical characteristics and outcomes of patients with MIS-C and COVID-19 can help distinguish between the two conditions and improve health outcomes. Patterns of clinical presentation and organ system involvement were identified in this case series, providing valuable information for differentiation of MIS-C and COVID-19.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Computer Science, Information Systems

The National COVID Cohort Collaborative (N3C): Rationale, design, infrastructure, and deployment

Melissa A. Haendel et al.

Summary: N3C is an open science community focused on analyzing patient-level data from multiple centers to address the challenges posed by COVID-19. By overcoming technical, regulatory, policy, and governance barriers, N3C has successfully established a secure data enclave for efficient, transparent, and reproducible collaborative analytics.

JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION (2021)

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Article Medicine, General & Internal

Multisystem Inflammatory Syndrome in US Children and Adolescents

Leora R. Feldstein et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

Epidemiology of pediatric hospitalizations at general hospitals and freestanding children's hospitals in the United States

JoAnna K. Leyenaar et al.

JOURNAL OF HOSPITAL MEDICINE (2016)

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A framework for future national pediatric pandemic respiratory disease severity triage: The HHS pediatric COVID-19 data challenge

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