Six Extensively Drug- Resistant Bacteria in an Injured Soldier, Ukraine

Article Genetics & Heredity

Genomic analysis of the international high-risk clonal lineage Klebsiella pneumoniae sequence type 395

Elvira R. Shaidullina et al.

Summary: This study is the first to investigate a large international collection of K. pneumoniae ST395 genomes, revealing the phylogenetics and detailed genomic characteristics of this emerging high-risk clonal lineage.

GENOME MEDICINE (2023)

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Article Infectious Diseases

Defining Baseline Mechanisms of Cefiderocol Resistance in the Enterobacterales

Patricia J. Simner et al.

Summary: This study aimed to identify potential mechanisms contributing to baseline cefiderocol resistance among carbapenem-resistant Enterobacterales (CRE). Our findings suggest that there are no consistent antimicrobial resistance markers contributing to baseline cefiderocol resistance in CRE isolates, and instead, resistance to cefiderocol results from a combination of heterogeneous mechanisms.

MICROBIAL DRUG RESISTANCE (2022)

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Article Infectious Diseases

Increase in NDM-1 and NDM-1/OXA-48-producing Klebsiella pneumoniae in Germany associated with the war in Ukraine, 2022

Mirco Sandfort et al.

Summary: German surveillance systems in 2022 have observed a rapid increase in the numbers of NDM-1 and NDM-1/OXA48 producing Klesbiella pneumoniae. Cases in Germany have shown a frequent presence in Ukraine before diagnosis. Whole genome sequencing of 200 isolates has revealed a high prevalence of sequence types ST147, ST307, ST395, and ST23, indicating clonal dissemination and onward transmission in Germany. Screening and isolating patients from Ukraine may help prevent further transmission.

EUROSURVEILLANCE (2022)

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Article Infectious Diseases

Multidrug-resistant organisms in patients from Ukraine in the Netherlands, March to August 2022

Romy D. Zwittink et al.

Summary: Since March 2022, multidrug-resistant organisms (MDRO) originating from Ukraine have been detected in patients in the Netherlands. Genomic surveillance revealed that the majority of these MDRO strains belong to globally spread epidemic lineages, with 60% containing New Delhi metallo-β-lactamase (NDM) genes. This highlights the importance of monitoring and addressing the increase of MDRO associated with migration and medical evacuation from Ukraine.

EUROSURVEILLANCE (2022)

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Article Surgery

Ukraine's Experience with Management of Combat Casualties Using NATO's Four-Tier Changing as Needed Healthcare System

Anatoliy Kazmirchuk et al.

Summary: This article summarizes the issues related to care of the wounded during the conflict in Ukraine, comparing the situation in 2014-2021 and 2022. It was found that there was an increase in the percentage of patients with extremity wounds who had long bone fractures and bone defects in the 2022 conflict, possibly due to higher blast energy from the weapons used. The article also discusses the organizational viewpoint of caring for the wounded and lessons learned.

WORLD JOURNAL OF SURGERY (2022)

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Article Public, Environmental & Occupational Health

Phenotypic and genotypic characterization of antibiotic resistance in military hospital-associated bacteria from war injuries in the Eastern Ukraine conflict between 2014 and 2020

V Kondratiuk et al.

Summary: This study investigated the antibiotic resistance of pathogens associated with war injuries in the Ukraine conflict, revealing high levels of resistance in Acinetobacter baumannii. Multi-drug-resistant strains carried an abundance of antibiotic resistance genes, with some strains co-producing carbapenemases and RmtASEs.

JOURNAL OF HOSPITAL INFECTION (2021)

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Review Infectious Diseases