Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis

Sepsis is a serious disease with high mortality and has been a hot research topic in medical research in recent years. With the continuous reporting of in-depth research on the pathological mechanisms of sepsis, various compounds have been developed to prevent and treat sepsis. Natural small-molecule compounds play vital roles in the prevention and treatment of sepsis; for example, compounds such as resveratrol, emodin, salidroside, ginsenoside, and others can modulate signaling through the NF-?B, STAT3, STAT1, PI3K, and other pathways to relieve the inflammatory response, immunosuppression, and organ failure caused by sepsis. Here, we discuss the functions and mechanisms of natural small-molecule compounds in preventing and treating sepsis. This review will lay the theoretical foundation for discovering new natural small-molecule compounds that can potentially prevent and treat sepsis.

Automated summary

Sepsis is a serious and highly fatal disease that has been a focus of medical research. Various compounds, including natural small-molecule compounds like resveratrol and ginsenoside, have been developed to prevent and treat sepsis by modulating signaling pathways. This review discusses the functions and mechanisms of these natural small-molecule compounds, providing a theoretical foundation for discovering new compounds for sepsis prevention and treatment.