4.7 Article

Transcriptomic analysis on the formation of the viable putative non-culturable state of beer-spoilage Lactobacillus acetotolerans

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SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -

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NATURE RESEARCH
DOI: 10.1038/srep36753

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资金

  1. National 973-Plan of China [2012CB720800]
  2. National Natural Science Foundation of China [31201362, 31101278]
  3. International Science & Technology Cooperation Program [2013B051000014]
  4. National Outstanding Doctoral Dissertation Funding [201459]
  5. Guangdong Outstanding Doctoral Dissertation Funding [K3140030]
  6. Open Project Program of State Key Laboratory of Food Science and Technology, Jiangnan University [SKLF-KF-201513]
  7. Open Project Program of Key Laboratory for Green Chemical Process of Ministry of Education in Wuhan Institute of Technology [GCP201506]

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Lactic acid bacteria (LAB) are the most common beer-spoilage bacteria regardless of beer type, and thus pose significant problems for the brewery industry. The aim of this study was to investigate the genetic mechanisms involved in the ability of the hard-to-culture beer-spoilage bacterium Lactobacillus acetotolerans to enter into the viable putative non-culturable (VPNC) state. A genome-wide transcriptional analysis of beer-spoilage L. acetotolerans strains BM-LA14526, BM-LA14527, and BM-LA14528 under normal, mid-term and VPNC states were performed using RNA-sequencing (RNA-seq) and further bioinformatics analyses. GO function, COG category, and KEGG pathway enrichment analysis were conducted to investigate functional and related metabolic pathways of the differentially expressed genes. Functional and pathway enrichment analysis indicated that heightened stress response and reduction in genes associated with transport, metabolic process, and enzyme activity might play important roles in the formation of the VPNC state. This is the first transcriptomic analysis on the formation of the VPNC state of beer spoilage L. acetotolerans.

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