A new approach for the heat source estimation in cancerous tissue treatment with hyperthermia

Proper estimation of the heat source during hyperthermia can destroy cancerous cells. One of the most important challenges in treating cancer with hyperthermia is estimating the quantity of heat absorbed to eliminate the cancer tissue. Assessing the success or failure of treatment necessitates precise information about the temperature distribution of all points within the tissue. However, it is practically impossible to measure the temperature of all tissue points. In such cases, inverse analysis can access the heat source within the tissue by having the target temperature of the tissue treated with hyperthermia. The temperature of cancer tissue rises to 42 degrees C during this treatment and stays constant for a certain period. In this study, as the novelty, the inverse analysis of the nonFourier heat conduction problem of the porous media as a model with most actual conditions is solved by conjugate gradient method which has not been applied in any study of bio-heat transfer so far. The results indicate the required quantity of heat source to eliminate the cancerous tissue.

Automated summary

Proper estimation of the heat source is crucial for destroying cancerous cells through hyperthermia. While treating cancer with hyperthermia, accurately assessing the amount of absorbed heat required to eliminate the cancer tissue is a major challenge. Measuring the temperature of all tissue points is practically impossible, making inverse analysis a valuable tool for accessing the heat source within the tissue by using the target temperature of the treated tissue.