☆ 4.6 Review

Association Between Rapid Antigen Detection Tests and Real-Time Reverse Transcription-Polymerase Chain Reaction Assay for SARS-CoV-2: A Systematic Review and Meta-Analyses

INTERNATIONAL JOURNAL OF PUBLIC HEALTH (2023)

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Article Infectious Diseases

The evaluation results of proposed antigen rapid diagnostic tests for COVID-19: some possible factors might influence

Abdul Hadi Juniastuti et al.

Summary: This study evaluated the validity of three Ag-RDT kits from different companies, finding that they all had high specificity but failed to meet the minimum performance requirements for samples with Ct <= 25. Factors that may influence the results were also identified.

INFECTION (2023)

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Article Multidisciplinary Sciences

Diagnostic accuracy of the Panbio COVID-19 antigen rapid test device for SARS-CoV-2 detection in Kenya, 2021: A field evaluation

Jack Karuga Irungu et al.

Summary: Accurate and timely diagnosis is crucial in controlling SARS-CoV-2 infection. Antigen RDTs can serve as a feasible alternative to rRT-PCR due to their quick and inexpensive nature. However, the Panbio((TM)) Ag RDT showed lower sensitivity and negative predictive value than expected.

PLOS ONE (2023)

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Article Infectious Diseases

A comparison of SARS-CoV-2 rapid antigen testing with realtime RT-PCR among symptomatic and asymptomatic individuals

Jyotsnamayee Sabat et al.

Summary: This study evaluated the application of a rapid antigen test kit in suspected COVID-19 patients, with a sensitivity of 75.17%. False negative results for symptomatic individuals and positive results for asymptomatic contacts are important for isolation and containment of the infection from spreading in a community.

BMC INFECTIOUS DISEASES (2023)

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Article Immunology

Comparison of SARS-CoV-2 diagnosis by rapid antigen detection kit with RT-qPCR in a tertiary care setup in North Eastern India

Saikat Majumder et al.

Summary: This study aims to compare the performance of RT-qPCR and Standard Q COVID-19 antigen detection kit in the diagnosis of COVID-19 in North East India. The results show that the testing kit has acceptable sensitivity and specificity, with a better performance in symptomatic patients. Moderate association was found between the kit and RT-qPCR results.

INDIAN JOURNAL OF MEDICAL MICROBIOLOGY (2023)

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Article Infectious Diseases

Analysis of diagnostic performance and factors causing nonspecific reactions in SARS-CoV-2 rapid antigen detection tests

Natsuki Narumi et al.

Summary: This study assessed the diagnostic performance of SARS-CoV-2 rapid antigen detection (RAD) tests and examined factors causing nonspecific reactions. The results showed that Espline and STANDARD Q had good sensitivity for specimens with Ct values less than 25, but false negative results may still occur within 9 days of symptom onset. Therefore, testing should be performed carefully and results should be interpreted comprehensively, considering clinical symptoms and patient background.

JOURNAL OF INFECTION AND CHEMOTHERAPY (2023)

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Article Medical Laboratory Technology

Analytical performance evaluation of Lumipulse® SARS-CoV-2 antigen assay in 392 asymptomatic patients

Arnolfo Petruzziello et al.

Summary: This study aimed to compare the performance of Lumipulse(R) antigen immunoassay with real-time RT-PCR in diagnosing SARS-CoV-2 infection in asymptomatic individuals. The results showed an overall agreement rate of 97% between Lumipulse(R) antigen assay and real-time RT-PCR, with a sensitivity of 96% and a specificity of 98%. The sensitivity varied based on the cycle threshold (C-t) value, reaching 100% for 15 < C-t < 25 and 86% for C-t >= 25. The study concluded that Lumipulse(R) antigen assay could be an effective tool in identifying and limiting SARS-CoV-2 transmission in large asymptomatic populations.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2023)

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Article Multidisciplinary Sciences

Evaluation of the Abbott Panbio™ COVID-19 antigen detection rapid diagnostic test among healthcare workers in elderly care

Andrea Eikelenboom-Boskamp et al.

Summary: To reduce the transmission risk from healthcare workers to elderly people, it is necessary to identify COVID-19 positive healthcare workers early. This study evaluated the Abbott Panbio((TM)) COVID-19 antigen detection rapid diagnostic test (Ag-RDT) as an alternative to RT-qPCR. The Ag-RDT showed 81.0% sensitivity and 100% specificity, and further screening with RT-qPCR increased the sensitivity.

PLOS ONE (2023)

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Article Multidisciplinary Sciences

Evaluation of diagnostic performance of SARS-CoV-2 detection kits: a comparative study

Basma Sherif et al.

Summary: This study evaluated the diagnostic performance of real-time polymerase chain reaction (RT-PCR) and Rapid Antigen detection (RAD) kits for detecting SARS-CoV-2. Fast Track, DNA Technology, QiaPrep, Xpress SARS-CoV-2, and ID Now demonstrated good diagnostic performance, while negative RAD results should be correlated with clinical condition and molecular testing.

BENI-SUEF UNIVERSITY JOURNAL OF BASIC AND APPLIED SCIENCES (2023)

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Article Infectious Diseases

Performance of a rapid antigen test for SARS-CoV-2 in Kenya

Simon N. Onsongo et al.

Summary: Testing for SARS-CoV-2 in resource-poor settings remains challenging. This study assessed the field performance of a rapid antigen test, NowCheck COVID-19 Ag-RDT, in western Kenya. The test showed high sensitivity and specificity, performing well in multiple healthcare facilities and meeting WHO-recommended thresholds.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2022)

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Article Infectious Diseases

Analysis of the diagnostic accuracy of rapid antigenic tests for detection of SARS-CoV-2 in hospital outbreak situation

Jesus Maria Aranaz-Andres et al.

Summary: This study assessed the performance of rapid antigen-based COVID-19 testing in hospital outbreaks, finding that RADT showed good diagnostic performance in patients on non-COVID-19 hospital wards.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2022)

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Article Biochemical Research Methods

Evaluation of antigen-based rapid detection test for the diagnosis of SARS CoV-2 in low-income countries

Toky Rakotomalala Randriamahazo et al.

Summary: With the Covid-19 pandemic overwhelming Malagasy laboratories, the rapid immunochromatographic test for SARS-CoV-2 antigen shows potential for early diagnosis, especially in rural areas with limited access to molecular methods.

JOURNAL OF VIROLOGICAL METHODS (2022)

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Article Multidisciplinary Sciences

Considerable escape of SARS-CoV-2 Omicron to antibody neutralization

Delphine Planas et al.

Summary: The Omicron variant of SARS-CoV-2, identified in November 2021, has spread rapidly worldwide and shows resistance to most therapeutic monoclonal antibodies and vaccine-elicited antibodies. However, it can be neutralized by antibodies generated by a booster vaccine dose.

NATURE (2022)

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Article Medical Laboratory Technology

Clinical Evaluation of the Rapid STANDARD Q COVID-19 Ag Test for the Screening of Severe Acute Respiratory Syndrome Coronavirus 2

Hyung Woo Kim et al.

Summary: This study evaluated the performance of the STANDARD Q COVID-19 Ag test in detecting SARS-CoV-2 infection and found a sensitivity of 89.2% and a specificity of 96.0%. The Ag test showed significantly lower cycle threshold values in positive patients compared to negative patients. Additionally, the sensitivity of the Ag test was higher in samples with Ct <= 30 and those collected one to five days post symptom onset. In conclusion, the STANDARD Q COVID-19 Ag test can serve as an alternative in high-prevalence settings or when rRT-PCR tests are limited.

ANNALS OF LABORATORY MEDICINE (2022)

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News Item Medicine, General & Internal

Covid-19: Omicron drives weekly record high in global infections

Luke Taylor

BMJ-BRITISH MEDICAL JOURNAL (2022)

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News Item Medicine, General & Internal

Covid-19: Warning over transmission risk as self-isolation is cut to five days in England

Susan Mayor

BMJ-BRITISH MEDICAL JOURNAL (2022)

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Article Medicine, General & Internal

Diagnostic Accuracy of STANDARD Q COVID-19 Antigen Detection Kit in Comparison with RT-PCR Assay using Nasopharyngeal Samples in India

Seema Aleem et al.

Summary: This study aimed to evaluate the sensitivity, specificity, and agreement of the STANDARD Q COVID-19 Antigen Detection Kit compared to real-time quantitative RT-PCR (qRT-PCR). The results showed that the STANDARD Q COVID-19 antigen test has a reasonable sensitivity, high specificity, and substantial agreement with qRT-PCR.

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2022)

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Article Medicine, General & Internal

Diagnostic accuracy of rapid point-of-care tests for diagnosis of current SARS-CoV-2 infections in children: a systematic review and meta-analysis

Naomi Fujita-Rohwerder et al.

Summary: This study systematically assessed the diagnostic accuracy of rapid point-of-care tests for current SARS-CoV-2 infections in children under real-life conditions. The results showed significant variation in the performance of antigen tests in pediatric populations, with low diagnostic sensitivity. Further research and improvement are needed in this area.

BMJ EVIDENCE-BASED MEDICINE (2022)

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Article Infectious Diseases

Sensitivity and specificity of two WHO approved SARS-CoV2 antigen assays in detecting patients with SARS-CoV2 infection

Chandima Jeewandara et al.

Summary: In a community setting in Sri Lanka, both rapid antigen tests showed high sensitivity in detecting individuals with lower Ct values. However, further research on the relationship to infectivity is important.

BMC INFECTIOUS DISEASES (2022)

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Hospital

Nancy Bellei et al.

Summary: The study evaluated the performance of the PanbioTM COVID-19 Ag test against RT-PCR, and found that it had high sensitivity and specificity for the detection of COVID-19. The test is suitable for rapid screening of patients with COVID-19 symptoms and for diagnosing suspected cases.

BRAZILIAN JOURNAL OF INFECTIOUS DISEASES (2022)

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Review Environmental Sciences

Emergence of SARS-CoV-2 Omicron (B.1.1.529) variant, salient features, high global health concerns and strategies to counter it amid ongoing COVID-19 pandemic

Rekha Khandia et al.

Summary: Since December 2019, SARS-CoV-2 has been rapidly evolving and mutating, leading to various variants with different levels of infectivity and lethality. The most recent variant of concern is Omicron (B.1.1.529), which has raised concerns about its ability to evade pre-existing immunity and overcome antibody-based therapies. Several theories have been proposed to explain the high number of mutations in Omicron. To successfully handle the ongoing pandemic, a multifaceted approach including rapid diagnosis, genome analysis, vaccination, and updated medical facilities is needed.

ENVIRONMENTAL RESEARCH (2022)

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Review Infectious Diseases

False-positivity results in rapid antigen tests for SARS-CoV-2: an umbrella review of meta-analyses and systematic reviews

Yu-Pei Yang et al.

Summary: This umbrella review aimed to explore the accuracy and sensitivity of rapid antigen detection tests (RADTs) for SARS-CoV-2 by assessing the incidence of false positivity associated with them. The study found that the false positivity rates in RADTs were less than 4.0%, indicating that RADTs can be an appropriate, economic, and rapid detection method for mass screening of COVID-19.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2022)

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Article Medical Laboratory Technology

Performance evaluation of STANDARD Q COVID-19 Ag home test for the diagnosis of COVID-19 during early symptom onset

Hyoshim Shin et al.

Summary: This study compared the performance of rapid antigen home test (RAHT) with real-time polymerase chain reaction (RT-PCR) in detecting COVID-19. RAHT showed higher sensitivity for COVID-19 patients with symptoms, especially in the early phase of symptom onset. Sensitivity of RAHT decreased when the Ct value was over 25.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2022)

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Article Multidisciplinary Sciences

Field evaluation of the performance of seven Antigen Rapid diagnostic tests for the diagnosis of SARs-CoV-2 virus infection in Uganda

Josephine Bwogi et al.

Summary: This study evaluated the performance of seven antigen rapid diagnostic tests (Ag RDTs) in a clinical setting. The results showed that one of the tests performed well at high viral load and could be recommended for diagnosing SARS-CoV-2 infection in Uganda.

PLOS ONE (2022)

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Article Medicine, General & Internal

Accuracy of rapid point-of-care antigen-based diagnostics for SARS-CoV-2: An updated systematic review and meta-analysis with meta-regression analyzing influencing factors

Lukas E. Bruemmer et al.

Summary: This study analyzed the accuracy of antigen rapid diagnostic tests (Ag-RDTs) for SARS-CoV-2 and found that they have high sensitivity and excellent specificity. Viral load is the main factor influencing test sensitivity, and Ag-RDTs can detect almost all individuals with high viral load who are most likely to transmit the virus. However, further research is needed to examine the effects of different virus variants, sample types, and test methods on the accuracy of Ag-RDTs.

PLOS MEDICINE (2022)

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Review Medicine, General & Internal

Diagnostic Accuracy of Rapid Antigen Tests for COVID-19 Detection: A Systematic Review With Meta-analysis

Maniya Arshadi et al.

Summary: This study evaluated the accuracy of rapid antigen tests (RATs) in diagnosing COVID-19. The results showed that RATs had high sensitivity and specificity compared to the reference test (real-time PCR), making them suitable for early detection and resource-limited countries.

FRONTIERS IN MEDICINE (2022)

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Article Medicine, General & Internal

Evaluation of the Diagnostic Accuracy of Nasal Cavity and Nasopharyngeal Swab Specimens for SARS-CoV-2 Detection via Rapid Antigen Test According to Specimen Collection Timing and Viral Load

Seungjun Lee et al.

Summary: This study evaluated the accuracy of rapid antigen tests in the nasal cavity and nasopharynx for the diagnosis of COVID-19. The results showed that the sensitivity of the test exceeded 89% in nasal cavity specimens, particularly in the early stage of symptoms.

DIAGNOSTICS (2022)

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Article Public, Environmental & Occupational Health

An Assessment of a Rapid SARS-CoV-2 Antigen Test in Bangladesh

Zannat Kawser et al.

Summary: Early detection of SARS-CoV-2 infection is crucial. This study evaluated the performance of the BD Veritor rapid antigen detection test compared to Standard Q and RT-PCR. The BD Veritor test showed high sensitivity and specificity, making it a potential tool for quick assessment of SARS-CoV-2.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2022)

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Article Immunology

Diagnostic utility and performance of rapid antigen test in SARS CoV-2 in symptomatic and asymptomatic patients during the second pandemic wave in Kashmir, North India

Anjum Farhana et al.

Summary: This study found that the rapid antigen test (RAT) is a reliable method for diagnosing SARS CoV-2, especially for asymptomatic patients. However, caution should be exercised when interpreting negative RAT results in suspected patients and their contacts. Additionally, the study highlights the usefulness of using RAT as a screening test in community settings.

INDIAN JOURNAL OF MEDICAL MICROBIOLOGY (2022)

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Article Infectious Diseases

Comparison of the Diagnostic Performance of a Rapid Antigen Test with Real-Time Polymerase Chain Reaction for Detection of SARS-CoV-2 Among Patients Diagnosed with COVID-19 at Selected Hospitals in Addis Ababa, Ethiopia

Zelalem Desalegn et al.

Summary: This study evaluated the diagnostic performance of the Standard Q COVID-19 Ag Kit in Ethiopia. The results demonstrated that the test device has high sensitivity and specificity and is suitable for diagnostic and clinical purposes in resource-constrained settings.

INFECTION AND DRUG RESISTANCE (2022)

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Article Medicine, General & Internal

Diagnostic accuracy of SARS-CoV-2 Panbio™ rapid antigen diagnostic tests in a 4,440-case clinical follow-up

Agoston Hamar et al.

Summary: The diagnostic performance of the SARS-CoV-2 rapid antigen detection testing (RADT) was evaluated in this study. The results showed that the test had low sensitivity and specificity, and it was suitable for patients with high infection prevalence and symptoms. In cases where there was a high risk of developing severe infection complications, parallel RT-qPCR testing was recommended to achieve accurate diagnosis.

FRONTIERS IN MEDICINE (2022)

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Article Infectious Diseases

Diagnostic accuracy of a novel SARS CoV-2 rapid antigen test and usefulness of specimens collected from the anterior nasal cavity

Daisuke Tamura et al.

Summary: This study aimed to validate a newly developed antigen-detecting rapid diagnostic test (Ag-RDT) for SARS-CoV-2 using anterior nasal specimens. The results showed that the Ag-RDT had high sensitivity in the early stage of the disease and remained specific at 100%. Therefore, anterior nasal specimens can be considered as a reliable sample source.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

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Article Virology

Performance evaluation of antigen detection rapid diagnostic test (Ag-RDT) for COVID-19 diagnosis in a primary healthcare center during the Shanghai COVID-19 quarantine period

Lan Dong et al.

Summary: This study evaluated the performance of antigen rapid diagnostic test (Ag-RDT) in diagnosing COVID-19 infection and found that Ag-RDT was highly sensitive in asymptomatic individuals with a Ct value less than 20.

VIROLOGY JOURNAL (2022)

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Article Medicine, General & Internal

How Significant Are Xpert Xpress SARS-CoV-2 Test Findings When Only an N2 Gene Is Detected?

Min-Kyung So et al.

Summary: This study evaluated the clinical performance of Xpert Xpress SARS-CoV-2 testing for COVID-19 screening. The results showed a high concordance between Xpert testing and qRT-PCR results, with a good true-positive rate. However, caution should be exercised when interpreting results with only N2 gene signals and high Ct values, and retesting should be considered.

DIAGNOSTICS (2022)

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Article Infectious Diseases

Accuracy of a nucleocapsid protein antigen rapid test in the diagnosis of SARS-CoV-2 infection

Bo Diao et al.

Summary: The FIC assay for NP antigen testing shows high specificity and relatively high sensitivity in early-phase SARS-CoV-2 diagnosis, according to a study conducted in Wuhan and Chongqing between February 10 and 15, 2020.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Article Public, Environmental & Occupational Health

Limited Sensitivity of a Rapid SARS-CoV-2 Antigen Detection Assay for Surveillance of Asymptomatic Individuals in Thailand

Anek Mungomklang et al.

Summary: Thailand faced a new wave of COVID-19 outbreaks, prompting the evaluation of a rapid SARS-CoV-2 antigen test which showed sensitivity of 47.97% and specificity of 99.71%. Real-world performance of the test can be affected by various factors, emphasizing the importance of reevaluating testing before national implementation.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2021)

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Article Multidisciplinary Sciences

The challenges of containing SARS-CoV-2 via test-trace-and-isolate

Sebastian Contreras et al.

Summary: Research shows that under challenges such as limited cooperation, missing contacts, and imperfect isolation, test-trace-and-isolate (TTI) strategies alone are insufficient to control the spread of SARS-CoV-2, highlighting the necessity of complementary measures such as social distancing and improved hygiene.

NATURE COMMUNICATIONS (2021)

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Letter Public, Environmental & Occupational Health

Comparative evaluation of four rapid SARS-CoV-2 antigen detection tests using universal transport medium

Thomas Weitzel et al.

TRAVEL MEDICINE AND INFECTIOUS DISEASE (2021)

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Article Multidisciplinary Sciences

Evaluation of two fluorescence immunoassays for the rapid detection of SARS-CoV-2 antigen-new tool to detect infective COVID-19 patients

Lorena Porte et al.

Summary: Real-Time Reverse-Transcription Polymerase Chain Reaction (RT-PCR) is currently the recommended diagnostic method for SARS-CoV-2, but rapid immunoassays for SARS-CoV-2 antigen could significantly alleviate the burden on laboratories. The evaluated rapid fluorescence immunoassays showed high sensitivity in detecting COVID-19 cases, especially in the early stages of infection, with 100% sensitivity in samples with high viral loads.

PEERJ (2021)

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Article Infectious Diseases

Evaluation of Lumipulse® G SARS-CoV-2 antigen assay automated test for detecting SARS-CoV-2 nucleocapsid protein (NP) in nasopharyngeal swabs for community and population screening

Alessio Gili et al.

Summary: The Lumipulse (R) SARS-CoV-2 antigen assay showed high sensitivity and specificity in diagnosing SARS-CoV-2 infection, making it a safe option for screening strategies in both small and large communities as well as in the general population.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Letter Microbiology

Evaluation of Performance of the BD Veritor SARS-CoV-2 Chromatographic Immunoassay Test in Patients with Symptoms of COVID-19

Abdullah Kilic et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Article Virology

High performance of a novel antigen detection test on nasopharyngeal specimens for diagnosing SARS-CoV-2 infection

L. Courtellemont et al.

Summary: The study evaluated a new antigen-based rapid detection test in a real-life setting, showing high sensitivity and specificity. These rapid tests may be particularly useful for large-scale screening in emergency departments, low-resource settings, and airports.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Infectious Diseases

Scaling up COVID-19 rapid antigen tests: promises and challenges

Rosanna W. Peeling et al.

Summary: WHO recommends antigen-detection rapid diagnostic tests (Ag-RDTs) with at least 80% sensitivity and 97% specificity for patients with symptoms consistent with COVID-19. Ag-RDTs may show high false negative rates after the acute phase, suggesting the need for a combination of molecular and serological tests. In low prevalence settings and situations where infection needs to be ruled out, Ag-RDTs with high negative predictive values can be used confidently, but high false positive rates in low prevalence areas require further confirmation.

LANCET INFECTIOUS DISEASES (2021)

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Article Multidisciplinary Sciences

Evaluation of the clinical performance of a magnetic force-assisted electrochemical immunoassay for the detection of SARS-CoV-2 antigens

Sung Jin Jo et al.

Summary: Rapid antigen tests, such as the MARK-B COVID-19 Ag test, show high sensitivity and specificity in detecting SARS-CoV-2 infections. The use of magnetic force-assisted electrochemical immunoassay-based tests can provide quick and reliable results for the prevention of COVID-19 spread.

PLOS ONE (2021)

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Article Multidisciplinary Sciences

Validation of the STANDARD Q COVID-19 antigen test in Vojvodina, Serbia

Mioljub Ristic et al.

Summary: The study evaluated the clinical performance of STANDARD Q COVID-19 Ag Test in 120 symptomatic patients, showing higher sensitivity in the early phase of disease and strong agreement with RT-qPCR results within the first five days of illness. The rapid antigenic test can be very useful for COVID-19 diagnosis in the early phase of disease.

PLOS ONE (2021)

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Article Infectious Diseases

Clinical performance of the Abbott Panbio with nasopharyngeal, throat, and saliva swabs among symptomatic individuals with COVID-19

William Stokes et al.

Summary: The Panbio antigen test helps combat COVID-19 by reliably detecting SARS-CoV-2 in symptomatic adults within 7 days of symptom onset using nasopharyngeal swabs. However, throat and saliva swabs are not suitable for Panbio testing.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2021)

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Article Microbiology

Comparison of the Quantitative DiaSorin Liaison Antigen Test to Reverse Transcription-PCR for the Diagnosis of COVID-19 in Symptomatic and Asymptomatic Outpatients

Stefanie Lefever et al.

Summary: The DiaSorin Liaison antigen test showed a sensitivity of 65.7% and specificity of 100% compared to RT-PCR. It was found to be highly sensitive in samples with high viral loads, and the correlation between antigen concentration and viral load was similar in symptomatic and asymptomatic individuals.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Letter Infectious Diseases

Ct value is not enough to discriminate patients harbouring infective virus

Maria Pilar Romero-Gomez et al.

JOURNAL OF INFECTION (2021)

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Article Virology

Rapid COVID-19 antigenic tests: Usefulness of a modified method for diagnosis

Reza Soleimani et al.

Summary: This study evaluated the performances of two rapid antigen testing devices in detecting SARS-CoV-2 in nasopharyngeal samples, showing relatively high sensitivity, especially with lower cycle threshold values, and 100% specificity for both devices.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Medicine, General & Internal

Clinical Evaluation of a New Antigen-Based COVID-19 Rapid Diagnostic Test from Symptomatic Patients

Saiful Arefeen Sazed et al.

Summary: Accurate diagnosis is crucial for the treatment of any disease, particularly during the COVID-19 pandemic. A new rapid detection device was evaluated in this study, demonstrating high potential for clinical diagnosis of symptomatic patients.

DIAGNOSTICS (2021)

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Article Medical Laboratory Technology

Utility of Antigen-Based Rapid Diagnostic Test for Detection of SARS-CoV-2 Virus in Routine Hospital Settings

Preeti Thakur et al.

Summary: This study evaluated the performance of an antigen-based rapid diagnostic test (RDT) for detecting the SARS-CoV-2 virus, finding low sensitivity and suggesting it is not suitable for screening patients with low viral load, emphasizing the continued use of RT-qPCR as the gold standard test.

LABORATORY MEDICINE (2021)

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Article Multidisciplinary Sciences

Evaluation of rapid SARS-CoV-2 antigen tests, AFIAS COVID-19 Ag and ichroma COVID-19 Ag, with serial nasopharyngeal specimens from COVID-19 patients

Oh Joo Kweon et al.

Summary: The study evaluated the diagnostic accuracy of two newly developed rapid antigen tests for SARS-CoV-2, finding that they showed excellent specificity and acceptable sensitivity for specimens with higher viral loads and those collected within 7 days post-symptom onset.

PLOS ONE (2021)

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Article Medicine, General & Internal

Saliva Is a Valid Alternative to Nasopharyngeal Swab in Chemiluminescence-Based Assay for Detection of SARS-CoV-2 Antigen

Alessandra Amendola et al.

Summary: The study evaluated the performance of a chemiluminescence-based SARS-CoV-2 antigen detection method in saliva samples, showing high reliability and accuracy, especially in individuals with high viral loads. However, in a low prevalence setting, confirmatory testing is still necessary to improve the positive predictive value.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Infectious Diseases

Evaluation of the AMP SARS-CoV-2 rapid antigen test in a hospital setting

Georg Leixner et al.

Summary: The study showed that the AMP RAT has high sensitivity in specific cases and may be helpful for frontline testing when rRT-PCR is not readily available.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Infectious Diseases

Performance of SARS-CoV-2 rapid antigen test compared with real-time RT-PCR in asymptomatic individuals

Monica Pena et al.

Summary: This study compared a SARS-CoV-2 RAT and RT-PCR in 842 asymptomatic individuals from Tarapaca, Chile, reporting RAT might have a significant impact in some regions, especially in situations lacking laboratory conditions or requiring rapid results.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Medical Laboratory Technology

Diagnostic performance of the Elecsys SARS-CoV-2 antigen assay in the clinical routine of a tertiary care hospital: Preliminary results from a single-center evaluation

Thomas Mueller et al.

Summary: This study found that the Elecsys SARS-CoV-2 antigen assay has low sensitivity for detecting SARS-CoV-2 from nasopharyngeal swabs, leading to the decision not to use this assay in the clinical routine of the hospital.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

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Article Virology

Efficacy comparison of three rapid antigen tests for SARS-CoV-2 and how viral load impact their performance

Laurent Blairon et al.

Summary: This study evaluated the performance of three rapid antigen tests for SARS-CoV-2 diagnosis under varying viral loads, showing higher sensitivities in samples with higher viral loads. However, the sensitivities of all three tests dropped significantly when viral loads decreased, with GSD NovaGen showing lower specificity. Although not suitable for routine testing in high throughput laboratories, these tests can still be useful in quickly identifying highly infectious patients and screening close contacts in environments without easy access to molecular tests.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Medicine, General & Internal

Performance of the Innova SARS-CoV-2 antigen rapid lateral flow test in the Liverpool asymptomatic testing pilot: population based cohort study

Marta Garcia-Finana et al.

Summary: The study revealed that the sensitivity of LFT compared to RT-qPCR was low but with high specificity in asymptomatic adults. LFT may have better detection rates for individuals with high viral loads. However, the potential for missing cases, even at high viral loads, should be considered when using a single LFT in high-risk settings.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Medicine, General & Internal

Evaluation of Two Rapid Antigenic Tests for the Detection of SARS-CoV-2 in Nasopharyngeal Swabs

Ysaline Seynaeve et al.

Summary: The study evaluated the performance of two new antigen detection kits in laboratory settings, with HeRDT showing a higher sensitivity compared to CoRDT. Despite excellent specificity, the poor sensitivity of CoRDT makes it unsuitable for rapid diagnosis of COVID-19.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Medicine, General & Internal

Diagnostic Accuracy of Rapid Antigen Test Kits for Detecting SARS-CoV-2: A Systematic Review and Meta-Analysis of 17,171 Suspected COVID-19 Patients

Shahad Saif Khandker et al.

Summary: The study evaluated the overall performance of rapid antigen tests (RAT) in the diagnosis of SARS-CoV-2, finding a specificity and sensitivity of 99.4% and 68.4% respectively. Nasopharyngeal specimens and symptomatic patient's samples were found to be more sensitive in RAT, while the cycle threshold (Ct) values had an inverse relationship with sensitivity. RAT showed better performance in European and American populations, indicating it could be used as an alternative diagnostic tool.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Medicine, General & Internal

Rapid, point-of-care antigen and molecular-based tests for diagnosis of SARS-CoV-2 infection

Jacqueline Dinnes et al.

Summary: Accurate and rapid diagnostic tests for SARS-CoV-2 infection are crucial for managing the COVID-19 pandemic. Point-of-care antigen and molecular tests can increase access to testing and expedite clinical and public health management decisions. Studies show that antigen tests have varying sensitivity, with higher accuracy in the first week of infection, and the efficacy of molecular tests depends on the specific brand used.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2021)

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Article Public, Environmental & Occupational Health

Validation and implementation of the Panbio COVID-19 Ag rapid test for the diagnosis of SARS-CoV-2 infection in symptomatic hospital healthcare workers

E. Kolwijck et al.

Summary: The study evaluated the effectiveness of PanbioCAgRT in hospital HCW and found high sensitivity and specificity. The antigen-based testing strategy showed promising results in screening symptomatic HCW.

INFECTION PREVENTION IN PRACTICE (2021)

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Article Medicine, General & Internal

Real-life validation of the Panbio™ COVID-19 antigen rapid test (Abbott) in community-dwelling subjects with symptoms of potential SARS-CoV-2 infection

Hendrik Gremmels et al.

Summary: The antigen rapid test showed high specificity and sensitivity in community-dwelling residents in the Netherlands and Aruba, especially when using a Ct value <32 cycles as the cut-off for RT-qPCR positivity. This test could play a significant role in controlling viral spread.

ECLINICALMEDICINE (2021)

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Article Infectious Diseases

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

Victor M. Corman et al.

EUROSURVEILLANCE (2020)

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Article Virology

Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis

Zhengtu Li et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Editorial Material Immunology

To Interpret the SARS-CoV-2 Test, Consider the Cycle Threshold Value

Michael R. Tom et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Review Immunology

Asymptomatic Transmission During the Coronavirus Disease 2019 Pandemic and Implications for Public Health Strategies

Hanalise Huff et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Letter Infectious Diseases

COVID-19 transmission through asymptomatic carriers is a challenge to containment

Xingxia Yu et al.

INFLUENZA AND OTHER RESPIRATORY VIRUSES (2020)

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Article Virology

Low performance of rapid antigen detection test as frontline testing for COVID-19 diagnosis

Anais Scohy et al.

JOURNAL OF CLINICAL VIROLOGY (2020)

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Article Medicine, General & Internal

Development and Potential Usefulness of the COVID-19 Ag Respi-Strip Diagnostic Assay in a Pandemic Context

Pascal Mertens et al.

FRONTIERS IN MEDICINE (2020)

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Editorial Material Public, Environmental & Occupational Health

Strategies for qualified triage stations and fever clinics during the outbreak of COVID-2019 in the county hospitals of Western Chongqing

X. Wu et al.

JOURNAL OF HOSPITAL INFECTION (2020)

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Editorial Material Medicine, General & Internal

Rethinking Covid-19 Test Sensitivity - A Strategy for Containment

Michael J. Mina et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Virology

Rapid SARS-CoV-2 antigen detection assay in comparison with real-time RT-PCR assay for laboratory diagnosis of COVID-19 in Thailand

Chutikarn Chaimayo et al.

VIROLOGY JOURNAL (2020)

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Review Medicine, Research & Experimental

COVID-19 rapid diagnostic test could contain transmission in low- and middle-income countries

Adesola Olalekan et al.

AFRICAN JOURNAL OF LABORATORY MEDICINE (2020)

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Editorial Material Medicine, General & Internal

Meta-analyses: what is heterogeneity?

Philip Sedgwick

BMJ-BRITISH MEDICAL JOURNAL (2015)

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Editorial Material Medicine, General & Internal

Meta-analyses: what is heterogeneity?

Philip Sedgwick

BMJ-BRITISH MEDICAL JOURNAL (2015)

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Article Gastroenterology & Hepatology

Prevalence and Associated Metabolic Factors of Gallstone Disease in the Elderly Agricultural and Fishing Population of Taiwan

Hsi-Che Shen et al.

GASTROENTEROLOGY RESEARCH AND PRACTICE (2014)

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Editorial Material Medicine, General & Internal

GRADE:: an emerging consensus on rating quality of evidence and strength of recommendations

Gordon H. Guyatt et al.

BRITISH MEDICAL JOURNAL (2008)

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Article Medicine, General & Internal

Measuring inconsistency in meta-analyses

JPT Higgins et al.

BMJ-BRITISH MEDICAL JOURNAL (2003)

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