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Association Between Rapid Antigen Detection Tests and Real-Time Reverse Transcription-Polymerase Chain Reaction Assay for SARS-CoV-2: A Systematic Review and Meta-Analyses

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FRONTIERS MEDIA SA
DOI: 10.3389/ijph.2023.1605452

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cycle threshold; false-positive; meta-analyses; rapid antigen test; RT-PCR

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This study aimed to assess the association between rapid antigen detection tests (RADTs) and real-time reverse transcription-polymerase chain reaction (RT-PCR) assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A meta-analysis of fifty-one studies showed a satisfactory overall false positive rate of RADTs compared to RT-PCR. Subgroup analysis based on different RT-PCR Ct value cut-offs (<40 or ≥40) also showed consistent results with no increase in the false positive rates of RADTs.
Objectives: We aimed to assess the association between rapid antigen detection tests and real-time reverse transcription-polymerase chain reaction assay for severe acute respiratory syndrome coronavirus 2.Methods: We searched PubMed, Cochrane Library, EMBASE, and the Web of Science from their inception to 31 May 2023. A random-effects meta-analysis was used to estimate false positives in the RADTs group, relative to those in the RT-PCR group, and subgroup analyses were conducted based on the different Ct value cut-offs (<40 or & GE;40). We performed this study in accordance with the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).Results: Fifty-one studies were included and considered to be of moderate quality. We found a satisfactory overall false positive rate (0.01, 95% CI: 0.00-0.01) for the RADTs compared to RT-PCR. In the stratified analysis, we also found that the false positive rates of the RADTs did not increase when Ct values of RT-PCR (Ct < 40, 0.01, 95% CI: 0.00-0.01; Ct & GE; 40, 0.01, 95% CI: 0.00-0.01).Conclusion: In conclusion, the best available evidence supports an association between RADTs and RT-PCR. When Ct-values were analyzed using cut-off <40 or & GE;40, this resulted in an estimated false positive rate of only 1%.

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