4.5 Article

Acute Deletion of the Glucocorticoid Receptor in Hepatocytes Disrupts Postprandial Lipid Metabolism in Male Mice

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Editorial Material Endocrinology & Metabolism

Pharmacological inhibition of lipolysis prevents adverse metabolic outcomes during glucocorticoid administration

Melissa A. Linden et al.

Summary: Glucocorticoid therapy can cause iatrogenic diabetes, and activating lipolysis plays a crucial role in its development. Inhibiting lipolysis can reduce glucocorticoid-induced obesity and hyperglycemia. The role of lipolysis differs between skeletal muscle and liver.

MOLECULAR METABOLISM (2023)

Article Cell Biology

A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis

Anne Loft et al.

Summary: This study investigates the contribution of immune cells to metabolic homeostasis during fasting in healthy subjects. It identifies the glucocorticoid receptor (GR) as a key driver of fasting-induced reprogramming of the macrophage secretome, and shows that lack of macrophage GR impairs induction of ketogenesis during fasting and endotoxemia. This research also highlights the direct influence of liver macrophages on ketogenesis in hepatocytes, providing insights into the immune system's role in regulating metabolic activity during inflammatory diseases and infection.

CELL METABOLISM (2022)

Article Biochemistry & Molecular Biology

Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia

Kelsey H. Fisher-Wellman et al.

Summary: This study explores the interplay between sphingolipid metabolism and mitochondrial bioenergetics in cancer cells and suggests that targeting both pathways could be a novel treatment strategy against multidrug resistance. Deficiencies in sphingolipid metabolism and the oxidative phosphorylation system are observed in multidrug resistant leukemia cells, and a combinatorial therapeutic approach targeting both pathways induces synergistic cytotoxicity.

FASEB JOURNAL (2022)

Article Biochemistry & Molecular Biology

Crosstalk of hepatocyte nuclear factor 4a and glucocorticoid receptor in the regulation of lipid metabolism in mice fed a high-fat-high-sugar diet

Hong Lu et al.

Summary: The down-regulation of HNF4 alpha and GR plays an important role in fatty liver and hyperlipidemia. They regulate hepatic gene expression, suppress lipogenesis, and induce lipid catabolism to protect the liver from fat accumulation.

LIPIDS IN HEALTH AND DISEASE (2022)

Article Endocrinology & Metabolism

Glucocorticoids coordinate macrophage metabolism through the regulation of the tricarboxylic acid cycle

Ulrich Stifel et al.

Summary: This study reveals that glucocorticoids control macrophage metabolism by repressing glycolysis and promoting the tricarboxylic acid cycle flux, leading to anti-inflammatory effects. The transcription factor HIF1a is identified as a key regulator of glucocorticoid responsiveness during inflammatory challenge.

MOLECULAR METABOLISM (2022)

Article Cell Biology

Lipid molecular timeline profiling reveals diurnal crosstalk between the liver and circulation

Richard R. Sprenger et al.

Summary: This study investigates the diurnal regulation of whole-body lipid metabolism through time-series multi-omics analyses of liver and plasma, revealing that molecular oscillations are mainly entrained by adaptations to fasting, food intake, and the postprandial state. The research also highlights the key role of the hepatic phosphatidylethanolamine (PE) methylation pathway in diurnal regulation, leading to the production of two pools of oscillating phosphatidylcholine (PC) molecules in the circulation.

CELL REPORTS (2021)

Article Cell Biology

Impaired glucocorticoid receptor expression in liver disrupts feeding-induced gene expression, glucose uptake, and glycogen storage

Stine M. Praestholm et al.

Summary: The transition from a fasted to a fed state leads to extensive transcriptional remodeling in hepatocytes, with a subset of hepatic feeding-induced genes requiring glucocorticoid receptor (GR) for full expression. This includes the important gene Gck, which is involved in hepatic glucose metabolism. GR cooperatively regulates hepatic Gck expression with insulin in a direct manner, affecting postprandial glucose uptake and storage in the liver.

CELL REPORTS (2021)

Article Biochemistry & Molecular Biology

Fasting induces hepatic lipid accumulation by stimulating peroxisomal dicarboxylic acid oxidation

Xiao Zhang et al.

Summary: Fasting induces lipid accumulation in the liver, with endogenous dicarboxylic acids playing a role in controlling mitochondrial beta-oxidation. Excessive beta-oxidation of dicarboxylic acids leads to succinate production, which suppresses mitochondrial beta-oxidation, promotes hepatic lipid deposition, and identifies cross talk between peroxisomal and mitochondrial fatty acid oxidation.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Chemistry, Applied

In vitro skin model for characterization of sunscreen substantivity upon perspiration

Fatemeh Keshavarzi et al.

Summary: The study investigated the impact of sweat on the effectiveness of sunscreen, finding that sweat reduces UV protection through mechanisms of wash-off and redistribution of the sunscreen film. Results showed that the sweat rate and sunscreen application dose significantly affected UV protection upon perspiration.

INTERNATIONAL JOURNAL OF COSMETIC SCIENCE (2021)

Review Endocrinology & Metabolism

Sphingolipids as a Culprit of Mitochondrial Dysfunction in Insulin Resistance and Type 2 Diabetes

Kamila Roszczyc-Owsiejczuk et al.

Summary: Insulin resistance is a complex pathological condition caused by abnormal cellular and metabolic responses to insulin, often associated with obesity and high-fat diets. The accumulation of bioactive lipids in insulin-sensitive tissues, particularly ceramides and other sphingolipids, plays a significant role in inhibiting insulin signaling pathway and contributing to the development of insulin resistance and type 2 diabetes (T2D). Studies have shown that sphingolipids also negatively affect mitochondrial function, which may further exacerbate the insulin resistance in T2D subjects.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Gastroenterology & Hepatology

Fasting Hormones Synergistically Induce Amino Acid Catabolism Genes to Promote Gluconeogenesis

Noga Korenfeld et al.

Summary: The study reveals that glucagon and glucocorticoids play a role in the transcriptional regulation of amino acid catabolism genes, and their synergistic effect can enhance gluconeogenesis.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2021)

Article Biochemistry & Molecular Biology

MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights

Zhiqiang Pang et al.

Summary: MetaboAnalyst version 5.0 has been introduced to facilitate comprehensive metabolomics data analysis and interpretation, with the aim of narrowing the gap from raw data to functional insights. Three new modules have been developed to assist in this goal, along with various other new functions and improvements in interface, graphics, and codebase. Users can now easily switch between compatible modules for a streamlined data analysis experience.

NUCLEIC ACIDS RESEARCH (2021)

Article Multidisciplinary Sciences

Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis

Helene M. Aegidius et al.

SCIENTIFIC REPORTS (2020)

Article Chemistry, Analytical

MSqRob Takes the Missing Hurdle: Uniting Intensity- and Count-Based Proteomics

Ludger J. E. Goeminne et al.

ANALYTICAL CHEMISTRY (2020)

Article Endocrinology & Metabolism

Hepatic ERα accounts for sex differences in the ability to cope with an excess of dietary lipids

Clara Meda et al.

MOLECULAR METABOLISM (2020)

Review Endocrinology & Metabolism

Glucocorticoid-Induced Fatty Liver Disease

Leili Rahimi et al.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2020)

Article Biotechnology & Applied Microbiology

A lipidome atlas in MS-DIAL 4

Hiroshi Tsugawa et al.

NATURE BIOTECHNOLOGY (2020)

Review Gastroenterology & Hepatology

Bile acid metabolism and circadian rhythm

Yunxia Yang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2020)

Article Biochemical Research Methods

Protein Aggregation Capture on Microparticles Enables Multipurpose Proteomics Sample Preparation

Tanveer S. Batth et al.

MOLECULAR & CELLULAR PROTEOMICS (2019)

Review Endocrinology & Metabolism

The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state

Leanne Hodson et al.

NATURE REVIEWS ENDOCRINOLOGY (2019)

Article Biochemistry & Molecular Biology

Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet

Fabiana Quagliarini et al.

MOLECULAR CELL (2019)

Review Biochemistry & Molecular Biology

Historical perspective: phosphatidylserine and phosphatidylethanolamine from the 1800s to the present

Jean E. Vance

JOURNAL OF LIPID RESEARCH (2018)

Article Endocrinology & Metabolism

Circadian regulation of glucose, lipid, and energy metabolism in humans

Eleonora Poggiogalle et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2018)

Review Biochemistry & Molecular Biology

Data-independent acquisition-based SWATH-MS for quantitative proteomics: a tutorial

Christina Ludwig et al.

MOLECULAR SYSTEMS BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock

Kenneth Allen Dyar et al.

PLOS BIOLOGY (2018)

Review Endocrinology & Metabolism

Glucocorticoid Signaling in Health and Disease: Insights From Tissue-Specific GR Knockout Mice

Shannon Whirledge et al.

ENDOCRINOLOGY (2018)

Review Endocrinology & Metabolism

The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids

Henrik Oster et al.

ENDOCRINE REVIEWS (2017)

Review Gastroenterology & Hepatology

Lipid droplets and liver disease: from basic biology to clinical implications

Nina L. Gluchowski et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

Article Biochemistry & Molecular Biology

Phosphatidylethanolamine Is a Key Regulator of Membrane Fluidity in Eukaryotic Cells

Rosie Dawaliby et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Biochemistry & Molecular Biology

Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides

Akio Kihara

PROGRESS IN LIPID RESEARCH (2016)

Review Cell Biology

Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals

Pawan Kumar Jha et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2015)

Article Endocrinology & Metabolism

Molecular regulation of urea cycle function by the liver glucocorticoid receptor

Juergen G. Okun et al.

MOLECULAR METABOLISM (2015)

Article Sport Sciences

The effect of high-intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue

S. Larsen et al.

SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS (2015)

Article Biochemistry & Molecular Biology

Hepatic fatty acid uptake is regulated by the sphingolipid acyl chain length

Woo-Jae Park et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2014)

Article Multidisciplinary Sciences

11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess

Stuart A. Morgan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Endocrinology & Metabolism

Quantitative analysis of light-phase restricted feeding reveals metabolic dyssynchrony in mice

M. S. Bray et al.

INTERNATIONAL JOURNAL OF OBESITY (2013)

Review Biochemistry & Molecular Biology

The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism

Mary C. Hunt et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

Letter Biotechnology & Applied Microbiology

A cross-platform toolkit for mass spectrometry and proteomics

Matthew C. Chambers et al.

NATURE BIOTECHNOLOGY (2012)

Review Rheumatology

Dynamic regulation of glucocorticoid signalling in health and disease

Simon C. Biddie et al.

RHEUMATOLOGY (2012)

Article Biochemistry & Molecular Biology

Characterization of the Human LPIN1-encoded Phosphatidate Phosphatase Isoforms

Gil-Soo Han et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4

Masja M. van Oort et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2008)

Article Biochemistry & Molecular Biology

Characterization of ceramide synthase 2 - Tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate

Elad L. Laviad et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)