期刊
CLINICAL ORAL INVESTIGATIONS
卷 27, 期 6, 页码 3009-3019出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00784-023-04904-8
关键词
Animal experiment; Peri-implantitis; Antiresorptive therapy; Antiangiogenic therapy; Histological technique
This study investigated the extension of experimentally induced peri-implantitis lesions under various antiresorptive and antiangiogenic medications. Forty-eight albino rats were randomly assigned to different medication groups to establish peri-implantitis lesions over a period of 16 weeks. The results showed no significant effects of different medications on the extension of peri-implantitis lesions.
ObjectivesTo investigate the extension of experimentally induced peri-implantitis lesions under various antiresorptive and antiangiogenic medications.Material and methodsFourty-eight albino rats had randomly received the following medications (dual application, n = 8 each): (1) amino-bisphosphonate (zoledronate) (Zo), (2) RANKL inhibitor (denosumab) (De), (3) antiangiogenic (bevacizumab) (Be), (4) Zo+Be, (5) De+Be, or (6) no medication (Co). Ligature- and lipopolysaccharide-induced peri-implantitis lesions were established at 2 maxillary implants over a period of 16 weeks. Histological (e.g., apical extension and surface area of the inflammatory cell infiltrate-aICT, ICT; defect length; defect width; CD68 positive cells) and bone micromorphometric (mu CT) outcomes were assessed. The animal was defined as a statistical unit.ResultsA total of n = 38 animals (Zo = 6, De = 6, Be = 8, Zo + Be = 6, De + Be = 5, Co = 7) were analyzed. ICT's were commonly marked by a positive CD68 antigen reactivity. Comparable median aICT (lowest-Zo: 0.53 mm; highest-Be: 1.22 mm), ICT (lowest-De + Be: 0.00 mm(2); highest-Co: 0.49 mm(2)), defect length (lowest-Zo: 0.90 mm; highest-Co: 1.93 mm) and defect width (lowest-De+Be: 1.27 mm; highest-Be: 1.80 mm) values were noted in all test and control groups. Within an inner (diameter: 0.8 mm) cylindric volume of interest, the bone microstructure did not significantly differ between groups.ConclusionsThe present analysis did not reveal any marked effects of various antiresorptive/ antiangiogenic medications on the extension of experimentally induced peri-implantitis lesions.
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