4.6 Review

Mitochondrial dysfunction as a target in spinal cord injury: intimate correlation between pathological processes and therapeutic approaches

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Editorial Material Cell Biology

Locomotor recovery after spinal cord injury: intimate dependence between axonal regeneration and re-connection

Hector Ramiro Quinta

NEURAL REGENERATION RESEARCH (2022)

Review Biochemistry & Molecular Biology

Mitochondrial function in spinal cord injury and regeneration

Paula G. Slater et al.

Summary: Spinal cord injury (SCI) causes paralysis in many people worldwide, with no current full functional recovery therapies available. Mitochondria play a crucial role in cellular responses after SCI, such as cell death, immune response, axon regeneration, and neural stem cell self-renewal and differentiation. Further investigation into mitochondrial function and regulation is needed to identify potential targets for SCI therapeutic intervention.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

Review Cell Biology

Mitochondria-actin cytoskeleton crosstalk in cell migration

Tarun Yadav et al.

Summary: The interaction between mitochondria and the actin cytoskeleton is crucial for cellular physiology, including cell migration, and is also implicated in pathological events such as cancer metastasis.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

Review Neurosciences

Mesenchymal Stem Cell-Derived Exosomal MiRNAs Promote M2 Macrophages Polarization: Therapeutic Opportunities for Spinal Cord Injury

Ze-Yan Liang et al.

Summary: This review discusses the research progress of MSC-derived exosomal miRNAs in promoting M2 macrophage differentiation in SCI. Research has shown the potential therapeutic effects of exosomal miRNAs in promoting nerve function recovery in SCI patients.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)

Article Biochemistry & Molecular Biology

Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features

Melissa Jasmin et al.

Summary: The netrin-1/DCC ligand/receptor pair plays key roles in CNS development, and although they are expressed in the adult brain, their function in mature neurons is not well understood. Research shows that netrin-1 plays a critical role in the fate of adult dopamine neurons, and targeting netrin-1 signaling may have therapeutic potential in Parkinson's disease. Studies in animal models suggest that overexpression of netrin-1 or administration of recombinant netrin-1 can be neuroprotective and neurorestorative in PD.

EMBO JOURNAL (2021)

Article Critical Care Medicine

Intraspinal Administration of Netrin-1 Promotes Locomotor Recovery after Complete Spinal Cord Transection

Hector R. Quinta

Summary: Complete spinal cord lesions disrupt the axonal connections with neuronal targets, hindering voluntary body control below the injury. The failure of spontaneous regrowth of transected axons prevents reconnection with neuronal targets. The use of the developmental axon guidance molecule netrin-1 shows potential in promoting axonal regrowth, reconnection, and recovery of locomotor function after SCI.

JOURNAL OF NEUROTRAUMA (2021)

Article Biochemistry & Molecular Biology

Exosomal miR-155 from M1-polarized macrophages promotes EndoMT and impairs mitochondrial function via activating NF-κB signaling pathway in vascular endothelial cells after traumatic spinal cord injury

Xuhui Ge et al.

Summary: The study revealed that M1-BMDMs promote EndoMT of vascular endothelial cells, exacerbating BSCB disruption after SCI and causing dysfunction of mitochondria and accumulation of ROS. Exosomal miR-155/SOCS6/p65 axis plays a crucial role in regulating EndoMT process and mitochondrial function in vascular endothelial cells.

REDOX BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Unraveling Axon Guidance during Axotomy and Regeneration

Miguel E. Dominguez-Romero et al.

Summary: The growth cone is a critical structure during neuronal development and regeneration, detecting and integrating signals to reach its final destination. After neuronal injuries in mammals, only axons in the peripheral nervous system are able to regenerate, while the ones from the central nervous system fail to do so.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Clinical Neurology

Recent update on basic mechanisms of spinal cord injury

Syed A. Quadri et al.

NEUROSURGICAL REVIEW (2020)

Review Medicine, Research & Experimental

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

Jarred M. Griffin et al.

EMBO MOLECULAR MEDICINE (2020)

Review Cell Biology

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Helmut Sies et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Clinical Neurology

Neurological recovery following traumatic spinal cord injury: a systematic review and meta-analysis

MirHojjat Khorasanizadeh et al.

JOURNAL OF NEUROSURGERY-SPINE (2019)

Review Clinical Neurology

The origin, fate, and contribution of macrophages to spinal cord injury pathology

Lindsay M. Milich et al.

ACTA NEUROPATHOLOGICA (2019)

Article Neurosciences

Systemic epothilone D improves hindlimb function after spinal cord contusion injury in rats

Beatrice Sandner et al.

EXPERIMENTAL NEUROLOGY (2018)

Review Physiology

THE BIOLOGY OF REGENERATION FAILURE AND SUCCESS AFTER SPINAL CORD INJURY

Amanda Phuong Tran et al.

PHYSIOLOGICAL REVIEWS (2018)

Article Neurosciences

Autophagy Inhibition Favors Survival of Rubrospinal Neurons After Spinal Cord Hemisection

Elisa Bisicchia et al.

MOLECULAR NEUROBIOLOGY (2017)

Article Medicine, Research & Experimental

Mutations in the netrin-1 gene cause congenital mirror movements

Aurelie Meneret et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Review Pharmacology & Pharmacy

Mitochondrial-Based Therapeutics for the Treatment of Spinal Cord Injury: Mitochondrial Biogenesis as a Potential Pharmacological Target

Natalie E. Scholpa et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2017)

Article Neurosciences

Neuronal polarization: From spatiotemporal signaling to cytoskeletal dynamics

Max Schelski et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2017)

Review Biochemistry & Molecular Biology

Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology

Alexander J. Kastaniotis et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2017)

Article Biophysics

Lipid peroxidation in brain or spinal cord mitochondria after injury

Edward D. Hall et al.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2016)

Article Medicine, Research & Experimental

Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension

Giuseppe Faraco et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Review Neurosciences

Intrinsic Control of Axon Regeneration

Zhigang He et al.

NEURON (2016)

Article Neurosciences

Mitochondria Localize to Injured Axons to Support Regeneration

Sung Min Han et al.

NEURON (2016)

Review Biochemistry & Molecular Biology

MICAL-Family Proteins: Complex Regulators of the Actin Cytoskeleton

Sai Srinivas Panapakkam Giridharan et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Article Biochemistry & Molecular Biology

Glycan-dependent binding of galectin-1 to neuropilin-1 promotes axonal regeneration after spinal cord injury

H. R. Quinta et al.

CELL DEATH AND DIFFERENTIATION (2014)

Review Neurosciences

Signaling regulations of neuronal regenerative ability

Yi Lu et al.

CURRENT OPINION IN NEUROBIOLOGY (2014)

Review Neurosciences

Mechanisms of neuronal membrane sealing following mechanical trauma

Benjamin K. Hendricks et al.

NEUROSCIENCE BULLETIN (2014)

Article Biochemistry & Molecular Biology

Intracellular NAD(H) levels control motility and invasion of glioma cells

Remco van Horssen et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

Review Biochemistry & Molecular Biology

MICAL, the Flavoenzyme Participating in Cytoskeleton Dynamics

Maria A. Vanoni et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Review Neurosciences

The role of angiogenic and wound-healing factors after spinal cord injury in mammals

Sarina Kundi et al.

NEUROSCIENCE RESEARCH (2013)

Review Cardiac & Cardiovascular Systems

The mPTP and its regulatory proteins: final common targets of signalling pathways for protection against necrosis

Tetsuji Miura et al.

CARDIOVASCULAR RESEARCH (2012)

Review Neurosciences

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

Zu-Hang Sheng et al.

NATURE REVIEWS NEUROSCIENCE (2012)

Review Neurosciences

Assembly of a new growth cone after axotomy: the precursor to axon regeneration

Frank Bradke et al.

NATURE REVIEWS NEUROSCIENCE (2012)

Article Clinical Neurology

Necessity for Re-Vascularization after Spinal Cord Injury and the Search for Potential Therapeutic Options

Ursula Graumann et al.

CURRENT NEUROVASCULAR RESEARCH (2011)

Review Neurosciences

Central nervous system pericytes in health and disease

Ethan A. Winkler et al.

NATURE NEUROSCIENCE (2011)

Review Clinical Neurology

Targeting Mitochondrial Function for the Treatment of Acute Spinal Cord Injury

Melanie L. McEwen et al.

NEUROTHERAPEUTICS (2011)

Article Multidisciplinary Sciences

Direct Redox Regulation of F-Actin Assembly and Disassembly by Mical

Ruei-Jiun Hung et al.

SCIENCE (2011)

Review Biochemistry & Molecular Biology

Lipid Oxidation and Peroxidation in CNS Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

Rao Muralikrishna Adibhatla et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

Review Biochemistry & Molecular Biology

Calcium-dependent mitochondrial function and dysfunction in neurons

Natalia B. Pivovarova et al.

FEBS JOURNAL (2010)

Article Critical Care Medicine

Compression Induces Acute Demyelination and Potassium Channel Exposure in Spinal Cord

Hui Ouyang et al.

JOURNAL OF NEUROTRAUMA (2010)

Article Multidisciplinary Sciences

Mical links semaphorins to F-actin disassembly

Ruei-Jiun Hung et al.

NATURE (2010)

Article Neurosciences

Mechanical membrane injury induces axonal beading through localized activation of calpain

Devrim Kilinc et al.

EXPERIMENTAL NEUROLOGY (2009)

Review Biochemistry & Molecular Biology

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

Hsiuchen Chen et al.

HUMAN MOLECULAR GENETICS (2009)

Review Neurosciences

Axon Regeneration in the Absence of Growth Cones: Acceleration by Cyclic AMP

Li-Qing Jin et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2009)

Review Rehabilitation

Spinal cord injury pain: Spinal and supraspinal mechanisms

Robert P. Yezierski

JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT (2009)

Article Neurosciences

Plasticity of interneuronal networks of the functionally isolated human spinal cord

Susan J. Harkema

BRAIN RESEARCH REVIEWS (2008)

Article Clinical Neurology

Glutamine concentration and immune response of spinal cord-injured rats

Ricardo A. Tanhoffer et al.

JOURNAL OF SPINAL CORD MEDICINE (2007)

Article Biochemistry & Molecular Biology

A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord

Shinjiro Kaneko et al.

NATURE MEDICINE (2006)

Article Critical Care Medicine

Pharmacological approaches to repair the injured spinal cord

DC Baptiste et al.

JOURNAL OF NEUROTRAUMA (2006)

Article Neurosciences

Critical interval of somal calcium transient after neurite transection determines B104 cell survival

MP Nguyen et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2005)

Review Biochemistry & Molecular Biology

Cytochrome c release from CNS mitochondria and potential for clinical intervention in apoptosis-mediated CNS diseases

R Jemmerson et al.

ANTIOXIDANTS & REDOX SIGNALING (2005)

Review Biochemistry & Molecular Biology

Cytochrome C-mediated apoptosis

XJ Jiang et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2004)

Review Neurosciences

Plasticity of motor systems after incomplete spinal cord injury

O Raineteau et al.

NATURE REVIEWS NEUROSCIENCE (2001)

Review Physiology

Mitochondria and neuronal survival

DG Nicholls et al.

PHYSIOLOGICAL REVIEWS (2000)