Synthesis of amides directly from carboxylic acids and hydrazines

The method for amide bond synthesis described here utilizes carboxylic acids and hydrazines in the presence of a catalytic amount of ZnCl2. This is the first report that highlights the use of hydrazine as an amine partner for amide synthesis directly with carboxylic acids. Ammonia (gas) is the only by-product in this method. The methodology is simple and could help in the synthesis of peptides and natural product derivatives. Zinc chloride catalyzed amide synthesis using various aliphatic/aromatic, carboxylic acid and hydrazine derivatives.

Automated summary

This article presents a method for amide bond synthesis using carboxylic acids and hydrazines in the presence of ZnCl2. It is the first reported use of hydrazine as an amine partner for directly synthesizing amides with carboxylic acids. The only by-product in this method is ammonia gas. This simple methodology could be useful in synthesizing peptides and natural product derivatives.