SIgA in various pulmonary diseases

Secretory immunoglobulin A (SIgA) is one of the most abundant immunoglobulin subtypes among mucosa, which plays an indispensable role in the first-line protection against invading pathogens and antigens. Therefore, the role of respiratory SIgA in respiratory mucosal immune diseases has attracted more and more attention. Although the role of SIgA in intestinal mucosal immunity has been widely studied, the cell types responsible for SIgA and the interactions between cells are still unclear. Here, we conducted a wide search of relevant studies and sorted out the relationship between SIgA and some pulmonary diseases (COPD, asthma, tuberculosis, idiopathic pulmonary fibrosis, COVID-19, lung cancer), which found SIgA is involved in the pathogenesis and progression of various lung diseases, intending to provide new ideas for the prevention, diagnosis, and treatment of related lung diseases.

Automated summary

Secretory immunoglobulin A (SIgA) is essential for the first-line defense against pathogens and antigens in mucosal immunity, particularly in the respiratory system. This review explores the relationship between SIgA and various respiratory diseases, including COPD, asthma, tuberculosis, idiopathic pulmonary fibrosis, COVID-19, and lung cancer, aiming to provide new insights for the prevention, diagnosis, and treatment of these lung diseases.