☆ 4.6 Review

2022 Joint ESC/EACTS review of the 2018 guideline recommendations on the revascularization of left main coronary artery disease in patients at low surgical risk and anatomy suitable for PCI or CABG

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2023)

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Impact of myocardial injury after coronary artery bypass grafting on long-term prognosis

L. Poelzl et al.

Summary: This study analyzed the incidence and prognosis of perioperative myocardial infarction (pMI) after coronary artery bypass graft surgery using different definitions. The study found significant differences in the occurrence of pMI depending on the definition used, and the 4th Universal Definition of Myocardial Infarction and Academic Research Consortium criteria were strong independent predictors of all-cause mortality. In addition, new electrocardiographic abnormalities, regional wall motion abnormalities, or coronary angiography detected signs of ischemia were also prognostic factors for primary and secondary endpoints.

EUROPEAN HEART JOURNAL (2022)

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Article Cardiac & Cardiovascular Systems

Frequency and Outcomes of Periprocedural MI in Patients With Chronic Coronary Syndromes Undergoing PCI

Yasushi Ueki et al.

Summary: This study evaluated the frequency and impact of periprocedural myocardial infarction (MI) using different MI definitions in patients with chronic coronary syndrome (CCS) undergoing percutaneous coronary intervention (PCI). The results showed that periprocedural MI defined by the ARC-2 and SCAI criteria was less frequent compared to the third and fourth UDMI, and was more prognostic for cardiac death at 1 year.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Cardiac procedural myocardial injury, infarction, and mortality in patients undergoing elective percutaneous coronary intervention: a pooled analysis of patient-level data

Johanne Silvain et al.

Summary: The prognostic importance of cardiac procedural myocardial injury and myocardial infarction (MI) in chronic coronary syndrome (CCS) patients undergoing elective percutaneous coronary intervention (PCI) is still debated. Post-PCI cTn elevation of >= 5 x 99th percentile URL used to define Type 4a MI is associated with increased 1-year mortality in CCS patients with normal baseline cTn levels.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Long-Term Clinical Impact of Intravascular Ultrasound Guidance in Stenting for Left Main Coronary Artery Disease

Do-Yoon Kang et al.

Summary: The study found that IVUS-guided PCI for unprotected left main coronary artery disease was associated with lower long-term risks of mortality and the composite of death, Q-wave MI, or stroke compared to angiography-guided PCI.

CIRCULATION-CARDIOVASCULAR INTERVENTIONS (2021)

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Article Medicine, General & Internal

Percutaneous coronary intervention with drug-eluting stents versus coronary artery bypass grafting in left main coronary artery disease: an individual patient data meta-analysis

Marc S. Sabatine et al.

Summary: A comparison of long-term outcomes between PCI with drug-eluting stents and CABG in patients with left main coronary artery disease showed no significant difference in 5-year all-cause mortality. However, differences were observed in rates of myocardial infarction, stroke, and repeat revascularisation, with higher risks associated with PCI. A Bayesian approach suggested a slight advantage favoring CABG in terms of mortality.

LANCET (2021)

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Review Cardiac & Cardiovascular Systems

Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis

Eliano P. Navarese et al.

Summary: In stable coronary artery disease patients, elective coronary revascularisation plus medical therapy led to reduced cardiac mortality and spontaneous myocardial infarction compared with medical therapy alone. The cardiac survival benefit after revascularisation improved with longer follow-up times and was associated with fewer spontaneous MIs.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Prognostically relevant periprocedural myocardial injury and infarction associated with percutaneous coronary interventions: a Consensus Document of the ESCWorking Group on Cellular Biology of the Heart and European Association of Percutaneous Cardiovascular Interventions (EAPCI)

Heerajnarain Bulluck et al.

Summary: The article recommends measuring baseline and post-PCI cTn values in all CCS patients undergoing PCI and confirms the prognostic relevance of post-PCI cTn elevation >5x 99th percentile URL for defining type 4a MI. In the absence of related complications, the same cTn cut-off threshold can be used to define major periprocedural myocardial injury, which are strong predictors of all-cause mortality post-PCI and can be used as quality metrics in clinical trials. Further research is needed to evaluate treatment strategies for reducing the risk of major periprocedural myocardial injury, type 4a MI, and MACE in CCS patients undergoing PCI.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

External Validation of the SYNTAX Score II 2020

Hironori Hara et al.

Summary: The study found that SSII-2020 accurately predicted 5-year mortality rates after PCI and CABG, showing a significantly higher survival rate in favor of CABG in patients with higher predicted mortality rates. However, the accuracy of SSII-2020 in recommending specific treatments for MACE was insufficient.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Prognostic Effect of the SYNTAX Score on 10-Year Outcomes After Left Main Coronary Artery Revascularization in a Randomized Population: Insights From the Extended PRECOMBAT Trial

Junghoon Lee et al.

Summary: According to the study, there was no significant difference in the 10-year clinical outcomes between PCI and CABG for patients with left main coronary artery disease based on the SYNTAX Score (SS). The SS was found to be predictive of major adverse cardiac or cerebrovascular events after PCI, but not after CABG.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Article Cardiac & Cardiovascular Systems

Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis

Eliano P. Navarese et al.

Summary: In stable coronary artery disease patients, elective coronary revascularisation plus medical therapy leads to reduced cardiac mortality compared with medical therapy alone. The cardiac survival benefit after revascularisation improves with longer follow-up times and is associated with fewer spontaneous MIs.

EUROPEAN HEART JOURNAL (2021)

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Article Medicine, General & Internal

Percutaneous coronary angioplasty versus coronary artery bypass grafting in the treatment of unprotected left main stenosis: updated 5-year outcomes from the randomised, non-inferiority NOBLE trial

Niels R. Holm et al.

LANCET (2020)

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Article Cardiac & Cardiovascular Systems

Ten-Year Outcomes After Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Left Main Coronary Disease: Extended Follow-Up of the PRECOMBAT Trial

Duk-Woo Park et al.

CIRCULATION (2020)

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Article Cardiac & Cardiovascular Systems

Prognostic performance of the Society of Thoracic Surgeons risk score in patients with left main coronary artery disease undergoing revascularisation: a post hoc analysis of the EXCEL trial

Daniel J. F. M. Thuijs et al.

EUROINTERVENTION (2020)

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Review Cardiac & Cardiovascular Systems

Routine Revascularization Versus Initial Medical Therapy for Stable Ischemic Heart Disease A Systematic Review and Meta-Analysis of Randomized Trials

Sripal Bangalore et al.

CIRCULATION (2020)

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Article Cardiac & Cardiovascular Systems

Intravascular ultrasound to guide left main stem intervention: a NOBLE trial substudy

Andrew Ladwiniec et al.

EUROINTERVENTION (2020)

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Letter Cardiac & Cardiovascular Systems

Surgeons' Coronary Bypass Practice Patterns in the United States

Mario Gaudino et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Implications of Alternative Definitions of Peri-Procedural Myocardial Infarction After Coronary Revascularization

John Gregson et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Impact of Peri-Procedural Myocardial Infarction on Outcomes After Revascularization

Hironori Hara et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Article Medicine, General & Internal

Redevelopment and validation of the SYNTAX score II to individualise decision making between percutaneous and surgical revascularisation in patients with complex coronary artery disease: secondary analysis of the multicentre randomised controlled SYNTAXES trial with external cohort validation

Kuniaki Takahashi et al.

LANCET (2020)

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Article Medicine, General & Internal

Overall and Cause-Specific Mortality in Randomized Clinical Trials Comparing Percutaneous Interventions With Coronary Bypass Surgery A Meta-analysis

Mario Gaudino et al.

JAMA INTERNAL MEDICINE (2020)

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2018 ESC/EACTS Guidelines on myocardial revascularization

Franz-Josef Neumann et al.

EUROPEAN HEART JOURNAL (2019)

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Outcomes following surgical revascularization with single versus bilateral internal thoracic arterial grafts in patients with left main coronary artery disease undergoing coronary artery bypass grafting: insights from the EXCEL trial

Daniel J. F. M. Thuijs et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2019)

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Article Medicine, General & Internal

Percutaneous coronary intervention versus coronary artery bypass grafting in patients with three-vessel or left main coronary artery disease: 10-year follow-up of the multicentre randomised controlled SYNTAX trial

Daniel J. F. M. Thuijs et al.

LANCET (2019)

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Article Medicine, General & Internal

Five-Year Outcomes after PCI or CABG for Left Main Coronary Disease

G. W. Stone et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Review Medicine, General & Internal

Patients' preferences for coronary revascularization: a systematic review

Carlos Alberto da Silva Magliano et al.

PATIENT PREFERENCE AND ADHERENCE (2019)

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Article Cardiac & Cardiovascular Systems

Standardized End Point Definitions for Coronary Intervention Trials

Hector M. Garcia-Garcia et al.

EUROPEAN HEART JOURNAL (2018)

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Quality-of-Life After Everolimus-Eluting Stents or Bypass Surgery for Left-Main Disease Results From the EXCEL Trial

Suzanne J. Baron et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

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Quality of Life After Surgery or DES in Patients With 3-Vessel or Left Main Disease

Mouin S. Abdallah et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

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Intravascular ultrasound-guided vs angiography-guided drug-eluting stent implantation in complex coronary lesions: Meta-analysis of randomized trials

Chirag Bavishi et al.

AMERICAN HEART JOURNAL (2017)

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Everolimus-Eluting Stents or Bypass Surgery for Left Main Coronary Artery Disease

G. W. Stone et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Randomized Trial of Stents Versus Bypass Surgery for Left Main Coronary Artery Disease 5-Year Outcomes of the PRECOMBAT Study

Jung-Min Ahn et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

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Prognostic Value of Site SYNTAX Score and Rationale for Combining Anatomic and Clinical Factors in Decision Making Insights From the SYNTAX Trial

Yao-Jun Zhang et al.

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Article Medicine, General & Internal

Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial

Friedrich W. Mohr et al.

LANCET (2013)

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Third Universal Definition of Myocardial Infarction

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SYNTAX Score Reproducibility and Variability Between Interventional Cardiologists, Core Laboratory Technicians, and Quantitative Coronary Measurements

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Percutaneous Coronary Intervention versus Coronary-Artery Bypass Grafting for Severe Coronary Artery Disease

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NEW ENGLAND JOURNAL OF MEDICINE (2009)

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Determining the most appropriate components for a composite clinical trial outcome

M. Angelyn Bethel et al.

AMERICAN HEART JOURNAL (2008)

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Choice of clinical outcomes in randomized trials of heart failure therapies: Disease-specific or overall outcomes?

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